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Molecular Plant 2020年第1期13卷 144-156页

作者： Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing Yulin Sun Alberto Ruiz Orduna Hainan Tian Xingchuan Huang Shitou Xia Laurel Schafer Reinhard Jetter yuelin zhang Xin Li Michael Smith Laboratories University of British ColumbiaVancouverBC V6T 1Z4Canada Department of Botany University of British ColumbiaVancouverBC V6T 1Z4Canada Department of Chemistry University of British ColumbiaVancouverBC V6T 1Z4Canada National Institute of Biological Sciences Eeijing 102206China School of Life Sciences Northeast Normal UniversityChangchunChina Hunan Provincial Key Laboratory of Phytohormones and Growth Development Hunan Agricultural UniversityChangshaHunan 410128China

Two signal molecules, salicylic acid (SA) and N-hydroxypipecolic acid (NHP), play critical roles in plant immunity. The biosynthetic genes of both compounds are positively regulated by master immune-regulating transcription factors SARD1 and CBP60g. However, the relationship between the SA and NHP pathways is unclear. CALMODULIN-BINDING TRANSCRIPTION FACTOR 1 (CAMTA1), CAMTA2, and CAMTA3 are known redundant negative regulators of plant immunity, but the underlying mechanism also remains largely unknown. In this study, through chromatin immunoprecipitation and electrophoretic mobility shift assays, we uncovered that CBP60g is a direct target of CAMTA3, which also negatively regulates the expression of SARD1, presumably via an indirect effect. The autoimmunity of camta3-1 is suppressed by sard1 cbp60g double mutant as well as ald1 and fmo1, two single mutants defective in NHP biosynthesis. Interestingly, a suppressor screen conducted in the camta1/ 2/ 3 triple mutant background yielded various mutants blocking biosynthesis or signaling of either SA or NHP, leading to nearly complete suppression of the extreme autoimmunity of camta1/ 2/ 3, suggesting that the SA and NHP pathways can mutually amplify each other. Together, these results reveal that CAMTAs repress the biosynthesis of SA and NHP by modulating the expression of SARD1 and CBP60g, and that the SA and NHP pathways are coordinated to optimize plant immune response.

关键词： CAMTA1/2/3 SARD1 CBP60g salicylic acid NHP systemic acquired resistance

Deterministic reversal of single magnetic vortex circulation by an electric field

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Science Bulletin 2020年第15期65卷 1260-1267,M0003页

作者： yuelin zhang Chuanshou Wang Houbing Huang Jingdi Lu Renrong Liang Jian Liu Renci Peng Qintong zhang Qinghua zhang Jing Wang Lin Gu Xiu-Feng Han Long-Qing Chen Ramamoorthy Ramesh Ce-Wen Nan Jinxing zhang Department of Physics Beijing Normal UniversityBeijing 100875China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Tsinghua National Laboratory for Information Science and Technology Institute of MicroelectronicsTsinghua UniversityBeijing 100084China Department of Materials Science and Engineering and Department of Physics University of CaliforniaBerkeley and Materials Science DivisionLawrence Berkeley National LaboratoryBerkeleyCA 94720USA State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Beijing National Laboratory of Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA

The ability to control magnetic vortex is critical for their potential applications in spintronic *** methods including magnetic field,spin-polarized current *** been used to flip the core and/or reverse circulation of ***,it is challenging for deterministic electric-field control of the single magnetic vortex textures with time-reversal broken symmetry and no planar magnetic *** it is reported that a deterministic reversal of single magnetic vortex circulation can be driven back and forth by a space-varying strain in multiferroic heterostructures,which is controlled by using a bi-axial pulsed electric ***-field simulation reveals the mechanism of the emerging magnetoelastic energy with the space variation and visualizes the reversal pathway of the *** deterministic electric-field control of the single magnetic vortex textures demonstrates a new approach to integrate the low-dimensional spin texture into the magnetoelectric thin film devices with low energy consumption.

关键词： Deterministic reversal Electric-field control Space-varying strain Single magnetic vortex Multiferroic heterostructures

Analysis of the efficacy of transcatheter arterial infusion chemotherapy in the treatment of pancreatic carcinoma

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Journal of Interventional Medicine 2021年第1期4卷 21-26页

作者： Chunhui Nie yuelin zhang Guanhui Zhou Tanyang Zhou Tongyin Zhu Baoquan Wang Shengqun Chen Hongliang Wang Ziniu Yu Li Jing Junhui Sun Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou310003Zhejiang ProvinceChina Zhejiang Provincial Research Center for Diagnosis and Treatment of Hepatobiliary Diseases Hangzhou310003Zhejiang ProvinceChina Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases Hangzhou310003Zhejiang ProvinceChina

Objective:To evaluate the clinical efficacy of infusion of gemcitabine(GEM) and fluorouracil(5-FU)through the celiac artery and superior mesenteric artery in the treatment of pancreatic carcinoma(PC).Methods:We analyzed 20 patients diagnosed clinically or pathologically with PC,without metastases,who had an estimated survival duration of>3 months in our department from May 2009 to December *** patients were treated directly without surgical resection of the tumor,while the other 11 patients were treated after *** all patients,the femoral artery was punctured using the Seldinger technique,and a catheter was placed in the opening of the celiac artery or the superior mesenteric *** administered 500 mg/m2 GEM and 500 mg/m2 *** data included data on clinical efficacy and survival rates during the follow-up period of 3-72 ***:Twenty patients were treated 85 times with transcatheter arterial infusion chemotherapy(TAI).The survival rates were 80%,40%,35%,20%,10%,and 5% at 3,6,12,24,and 72 months,***: TAI chemotherapy with GEM and 5-FU may be a therapeutic option for the treatment of PC.

关键词： Transcatheter arterial infusion Chemotherapy Pancreatic carcinoma

Establishing VIGS and CRISPR/Cas9 techniques to verify RsPDS function in radish

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Journal of Integrative Agriculture 2024年第5期23卷 1557-1567页

作者： Jiali Ying Yan Wang Liang Xu Tiaojiao Qin Kai Xia Peng zhang Yinbo Ma Keyun zhang Lun Wang Junhui Dong Lianxue Fan yuelin Zhu Liwang Liu National Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization/Key Laboratory of Horticultural Crop Biology and Genetic Improvement(East China)of Ministry of Agriculture and Rural Affairs/College of Horticulture Nanjing Agricultural UniversityNanjing210095China College of Horticulture and Landscape Architecture Yangzhou UniversityYangzhou 225009China College of Life Sciences Nanjing Agricultural UniversityNanjing 210095China

Virus-induced gene silencing(VIGS)and clustered regularly interspaced short palindromic repeats/CRISPR-associated protein(CRISPR/Cas)systems are effective technologies for rapid and accurate gene function verification in modern plant ***,the investigation of gene silencing and editing in radish remains *** this study,a bleaching phenotype was generated through the knockdown of RsPDS using tobacco rattle virus(TRV)-and turnip yellow mosaic virus(TYMV)-mediated gene silencing *** TYMV-mediated gene silencing efficiency was higher than the TRV-based VIGS system in *** expression level of RsPDS was significantly inhibited using VIGS in'NAU-067'radish *** rootless seedlings of‘NAU-067'were infected with Agrobacterium rhizogenes using the 2300GN-Ubi-RsPDS-Cas9 vector with two target *** adventitious roots were blue with GUs staining,and four of these adventitious roots were edited at target sequence 1 of the RsPDS gene as indicated by Sanger ***,albino lines were generated with ***-mediated transformation of radish *** base substitutions and three base deletions occurred at target sequence 2 in Line 1,and three base insertions and three base substitutions occurred at target sequence 1 in Line *** study shows that VIGS and CRISPR/Cas9 techniques can be employed to precisely verify the biological functions of genes in radish,which will facilitate the genetic improvement of vital horticultural traits in radish breeding programs.

关键词： Raphanus sativus L. VIGS CRISPR/Cas9 Agrobacterium rhizogenes A.tumefaciens RsPDS

“文章”经国与“作者”自觉——《典论·论文》原文学批评的话语建构

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文艺理论研究 2019年第1期39卷 138-145页

作者：张岳林杨洋皖西学院文化与传媒学院皖西学院文传学院

"文学自觉""文学不自觉"都不是曹丕清醒意识到的问题,今人以此批评曹丕的文学观,存在"以西律例""以今律古""碎片化"等问题。从建安时代的文学话语建构角度来说,《典论·论文》是以"文章经国"的视野,和"作者自觉"的论述为轴心进行的原文... 详细信息

"文学自觉""文学不自觉"都不是曹丕清醒意识到的问题,今人以此批评曹丕的文学观,存在"以西律例""以今律古""碎片化"等问题。从建安时代的文学话语建构角度来说,《典论·论文》是以"文章经国"的视野,和"作者自觉"的论述为轴心进行的原文学批评话语建构,是建立在国家意识基础上的总体化的文学纲领。其"文气""文人""文章""文体"等概念及其建构的整体性批评都是具有丰富意义的原文学批评话语,体现了汉魏时期文学观生成过程的复杂性、含混性和整体性。

关键词：文学自觉文章经国作者自觉原批评话语建构

NUMERICAL INVESTIGATION OF UNSTEADY DROPLET COMBUSTION PROCESS IN HOT QUIESCENT AIR ENVIRONMENTS (HQAE)

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Chinese Journal of Aeronautics 1997年第3期10卷 35-41页

作者： Zhu Guangsheng, Lin Junyi, zhang yuelin (Nanjing University of Science and Technology, Nanjing, 210094, China) Wu Chuijie (Air Force Institute of Meteorology, Nanjing, 211101, China)

A mathematical model has been presented for describing single droplet unsteady processes of vaporization, ignition and combustion in a hot quiescent air environment. The arbitrary Lagrangian Eulerian numerical method, incorporated with an effective adaptive mesh method, is applied. From the obtained time space distributions of gas temperature and species densities, the characteristics of droplet ignition and combustion process are clarified. It is also demonstrated that, due to the strong damping of the high temperature flame region around the droplet, the ambient conditions have little effects on the properties of the drop's surface; and that, due to the unsteady prediction of droplet heating time being much less than the corresponding quasi steady prediction under burning condition, the differences between unsteady and quasi steady results are much greater than those under pure vaporization.

关键词： drops (liquids) combustion ignition droplet unsteady theory droplet quasi steady theory

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宽带薪酬制度设计及其应用

现代财经（天津财经大学学报） 2006年第7期26卷 40-43页

作者：张月玲天津财经大学工商管理博士后流动站天津300222

宽带薪酬是兴起于西方的新型的薪酬管理模式,其实质是绩效薪酬。传统的薪酬模式存在诸多弊端,宽带薪酬具有多种优势。宽带薪酬要求企业有较好的人力资源管理基础,设计时应考虑公平性等因素,宽带数量和浮动范围的确定是宽带薪酬的核心问... 详细信息

宽带薪酬是兴起于西方的新型的薪酬管理模式,其实质是绩效薪酬。传统的薪酬模式存在诸多弊端,宽带薪酬具有多种优势。宽带薪酬要求企业有较好的人力资源管理基础,设计时应考虑公平性等因素,宽带数量和浮动范围的确定是宽带薪酬的核心问题。宽带薪酬的应用效果是明显的,但应用时需要注意几方面的问题。

关键词：宽带薪酬绩效优势应用

基于I-DEAS的三维参数化绘图及其在火炮身管设计中的应用

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南京理工大学学报 1999年第3期23卷 209-211页

作者：张莉芳张月林南京理工大学机械学院

分析了程序驱动法参数化绘图和利用参数化绘图软件进行参数化绘图２种方法的优缺点，提出了通过将复杂零件分解为体素，用参数化绘图软件将体素定义为参数化零件，然后用参数化绘图程序调用体素，通过体素拼合将２种参数化绘图方法结合... 详细信息

分析了程序驱动法参数化绘图和利用参数化绘图软件进行参数化绘图２种方法的优缺点，提出了通过将复杂零件分解为体素，用参数化绘图软件将体素定义为参数化零件，然后用参数化绘图程序调用体素，通过体素拼合将２种参数化绘图方法结合起来的方法。以火炮身管设计为例，介绍了通过在Ｉ－ＤＥＡＳ软件上进行二次开发实现这种方法的具体过程。该方法有效降低了单一程序驱动法参数化绘图的编程工作量，弥补了参数化绘图软件不能有效定义结构不规则零件的不足，为参数化绘图的研究提供了一条新的思路。

关键词：火包身管设计 CAD I-DEAS 参数化绘图

Preliminary assessment of the data appropriateness of electronic health records for real-world studies:A survey of hospitals in a developing region in China

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Chinese Medical Journal 2024年第9期137卷 1130-1131页

作者： yuelin Yu Lin Zhuo Ruogu Meng Wanqian Guo Yuanyuan Chen Yunjing zhang Ying Chen Hongjing Shi Zhi Lin Siyan Zhan Shengfeng Wang Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China National Institute of Health Data Science Peking UniversityBeijing 100191China Health Science Center Peking UniversityBeijing 100191China

To the Editor:Assessment of data appropriateness is a process to answer whether electronic health records(EHRs)from routine healthcare practices couldt intended study purposes,for example,available to be proceeded,with enough individual records,with relevant information able to be extracted from records,etc.[1-3]This has been increasingly underscored as a prerequisite when using EHRs(one important type of real-world data[RWD])for scientic purposes.[4-6]Although controversies remain on the denitions,types and assessment methods of the dimensions of RWD appropriateness,the latest ofcial guidelines(i.e.,from the *** and Drug Administration[FDA][4]and China National Medical Products Administration[NMPA][6])suggest that the assessment start from a preliminary stage on variable existence,and subsequently deepen into the issue of data value(such as missing value,outliers,etc.),as the preliminary assessment is the foundation of the overall RWD appropriateness.[7]Little is known about the appropriateness of EHRs in developing regions,which feature high visit volumes and a great number of ***,this study aimed to preliminarily investigate RWD appropriateness from hospitals in developing regions from the perspective of core variables’comparison.

关键词： electronic dimensions records