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In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou Chen Mo Chen Chengxuan Yu Huizhu Li Liman Sai Nguyen T.K.Thanh Yueming Wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin hao De Min Tang Shiyi Chen Yunxia Li yuefeng hao Sijia Feng Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

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生物活性玻璃:调整制备工艺和掺入元素来实现不同的应用形式和功能

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中国组织工程研究 2024年第29期28卷 4726-4733页

作者：高桦车荟胡丹郝跃峰南京医科大学附属苏州医院江苏省苏州市215000

背景:生物活性玻璃是一种多功能人工复合材料,可与组织亲和后缓释活性离子并表现一定的生物活性,其多样性源于制备工艺和组分的多变性,使其能够应用于不同的临床场景。目的:综述目前生物活性玻璃的主要应用形式、应用领域以及掺杂不同... 详细信息

背景:生物活性玻璃是一种多功能人工复合材料,可与组织亲和后缓释活性离子并表现一定的生物活性,其多样性源于制备工艺和组分的多变性,使其能够应用于不同的临床场景。目的:综述目前生物活性玻璃的主要应用形式、应用领域以及掺杂不同元素对其功能的影响。方法:以“生物活性玻璃,缓释离子,骨组织工程,复合支架,组织再生修复,生物医学工程”为检索词在中国知网及万方医学网检索;以“Bioactive glass,Slow-release Ions,Bone Tissue Engineering,Composite Scaffold,Tissue Regeneration and Repair,Biomedical Engineering”为检索词在PubMed和Web of Science数据库检索自2000-2023年收录的相关文献,最终纳入88篇文献进行综述。结果与结论:①在应用形式方面,生物活性玻璃可以根据不同临床场景的需要制作成包括涂层、颗粒、骨水泥及支架等形式,其中涂层能提高植入物生物活性,但易因降解导致植入物不稳定;颗粒适用于不规则骨缺损的修复,但传统方式制备的颗粒功能单一;骨水泥具备微创及可注射的优点,但不适用大尺寸骨缺损;支架具备优异的机械性能,常用于较大尺寸骨缺损,但韧性有限。②在应用领域方面,生物活性玻璃可用于包括口腔科、骨科、软组织工程以及癌症等多种组织再生修复和疾病治疗领域。③在元素掺杂方面,特定元素掺入生物活性玻璃后,不仅能提升其机械性能,还赋予了它特殊生物学功能,如生物活性、可降解性和抗菌性等。④生物活性玻璃作为一种多功能材料,可通过调整制备工艺和元素掺入来实现不同的应用形式和功能,满足不同的骨组织工程等临床需求,广泛应用于生物医学工程领域。

关键词：生物活性玻璃缓释离子涂层颗粒骨水泥支架硅钙生物医学工程组织再生修复

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冲击振动激励下GIS内自由金属微粒运动及其诱发间隙击穿特性

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高电压技术 2024年第1期50卷 339-347页

作者：胡新文李晓昂王舒啸李志兵郝越峰张乔根西安交通大学电力设备电气绝缘国家重点实验室西安710049 中国电力科学研究院有限公司北京100192 贵州电网有限责任公司贵阳供电局贵阳550001

大量GIS故障案例表明,断路器带电操作后的一段时间内,气室中常突发由金属微粒引起的间隙击穿故障。断路器操作产生的冲击振动可以有效地激励GIS中多个潜伏性微粒的起跳,但多个微粒起跳后在运动过程中诱发间隙击穿的过程尚不明确。针对于... 详细信息

大量GIS故障案例表明,断路器带电操作后的一段时间内,气室中常突发由金属微粒引起的间隙击穿故障。断路器操作产生的冲击振动可以有效地激励GIS中多个潜伏性微粒的起跳,但多个微粒起跳后在运动过程中诱发间隙击穿的过程尚不明确。针对于此,本研究在252kV真型GIS实验平台上进行了多微粒共存时的断路器带电操作实验,以复现GIS运行过程中微粒在冲击振动激励下的运动过程,并探究多微粒被激励起跳后诱发GIS放电故障的机理。研究表明,在带电实验中未操作断路器时,耐压期间自由金属微粒存在较大的概率可运动至气室的末端,并保持静止,形成了多微粒的聚集;在带电操作断路器后,多微粒受到壳体冲击振动的激励而起跳,并在起跳后的运动过程中于气隙间形成了多微粒串联击穿现象,而且断路器带电操作时多微粒引起的击穿电压总是低于耐压期间的击穿电压。基于流注放电理论,研究认为相较于耐压期间分散性的多微粒,带电操作前已形成聚集的多微粒彼此靠近,在操作后的运动过程中对电场的畸变能力更强,因此形成多微粒的串联击穿电压更低。

关键词： GIS 金属微粒断路器操作冲击振动串联击穿

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反重力跑台在踝关节镜下外侧韧带修补术后早期应用的临床疗效

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足踝外科电子杂志 2024年第2期11卷 12-17页

作者：陈涛顾雪平宁迩玉马魁郝跃峰南京医科大学附属苏州医院骨科与运动医学中心江苏苏州215000

目的分析早期应用反重力跑台对踝关节镜下外侧韧带修补术后患者功能恢复的影响。方法纳入2020年8月至2023年8月在南京医科大学附属苏州医院骨科与运动医学中心行踝关节外侧韧带修补术的患者36例为研究对象,使用随机数表法分为研究组和... 详细信息

目的分析早期应用反重力跑台对踝关节镜下外侧韧带修补术后患者功能恢复的影响。方法纳入2020年8月至2023年8月在南京医科大学附属苏州医院骨科与运动医学中心行踝关节外侧韧带修补术的患者36例为研究对象,使用随机数表法分为研究组和对照组,各18例。对照组术后采用常规训练,研究组术后采用常规训练联合反重力跑台训练。术后6个月,对比两组患者的疼痛评分、功能评分、平衡功能及踝关节肌力恢复情况。结果术后6个月,研究组疼痛评分、踝关节星状偏移测试(star excursion balance test,SEBT)差值及踝关节外翻、跖屈肌力缺失均低于对照组,踝关节Kofoed评分高于对照组,差异有统计学意义(P<0.05)。结论踝关节韧带修补术后早期应用反重力跑台进行训练,可以缓解患者疼痛,提高患者下肢运动功能及平衡功能,有助于患者外翻及跖屈肌力恢复。

关键词：踝关节韧带修补反重力跑台等速肌力平衡功能

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Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway

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Science China(Life Sciences) 2022年第3期65卷 588-603页

作者： Gaoran Ge Jiaxiang Bai Qing Wang Xiaolong Liang Huaqiang Tao hao Chen Minggang Wei Junjie Niu Huilin Yang Yaozeng Xu yuefeng hao Yi Xue Dechun Geng Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Traditional Chinese Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Orthopaedics and Sports Medicine Center Suzhou Municipal Hospital(North District)Nanjing Medical University Affiliated Suzhou HospitalSuzhou 215006China Department of Orthopaedics Changshu Hospital Affiliated to Nanjing University of Traditional Chinese MedicineSuzhou 215500China

Rheumatoid arthritis(RA)is a chronic inflammatory disease that eventually leads to *** cell infiltration,severe joint breaking and systemic bone loss are the main clinical *** this study,we established a collagen-induced arthritis(CIA)model and found a large number of M1 macrophages and pyroptosis,which are important sources of proinflammatory ***(PUN)is an active substance extracted from pomegranate *** found that it inhibited joint inflammation,cartilage damage and systemic bone destruction in CIA *** effectively alleviated the high expression of inflammatory cytokines in synovial tissue in *** treatment shifted macrophages from the M1 phenotype to the M2 phenotype after stimulation with lipopolysaccharide(LPS)and interferon(IFN)-γ.The expression of inducible nitric oxide synthase(i NOS)and other proinflammatory cytokines released by M1 macrophages was decreased in the PUN treatment ***,simultaneously,the expression of markers of anti-inflammatory M2 macrophages,such as arginase(Arg)-1 and interleukin(IL)-10,was *** addition,PUN treatment attenuated pyroptosis by downregulating the expression of NLRP3 and caspase-1,thereby preventing inflammatory cell death resulting from the release of IL-1βand ***,PUN inhibited the activation of receptor activators of the nuclear factor-κB(NF-κB)signaling pathway,which contributes to M1 polarization and pyroptosis of *** concluded that PUN ameliorated pathological inflammation by inhibiting M1 phenotype polarization and pyroptosis and has great potential as a therapeutic treatment for human RA.

关键词： rheumatoid arthritis pomegranate M1 macrophage pyroptosis

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Rational Design of Cost-Effective Metal-Doped ZrO_(2)for Oxygen Evolution Reaction

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Nano-Micro Letters 2024年第9期16卷 385-396页

作者： yuefeng Zhang Tianyi Wang Liang Mei Ruijie Yang Weiwei Guo hao Li Zhiyuan Zeng Department of Materials Science and Engineering and State Key Laboratory of Marine PollutionCity University of Hong Kong83 Tat Chee AvenueKowloon 999077Hong KongPeople’s Republic of China Advanced Institute for Materials Research(WPI‑AIMR) Tohoku UniversitySendai 980‑8577Japan Shenzhen Research Institute City University of Hong KongShenzhen 518057People’s Republic of China Shanxi Supercomputing Center Lvliang 033000ShanxiPeople’s Republic of China

The design of cost-effective electrocatalysts is an open challenging for oxygen evolution reaction(OER)due to the“stable-oractive”*** dioxide(ZrO_(2)),a versatile and low-cost material that can be stable under OER operating conditions,exhibits inherently poor OER activity from experimental ***,we doped a series of metal elements to regulate the ZrO_(2)catalytic activity in OER via spin-polarized density functional theory calculations with van der Waals *** modeling as a function of the OER activity descriptor(G_(O*)-G_(HO*))displays that 16 metal dopants enable to enhance OER activities over a thermodynamically stable ZrO_(2)surface,among which Fe and Rh(in the form of single-atom dopant)reach the volcano peak(*** optimal activity of OER under the potential of interest),indicating excellent OER *** energy diagram calculations,density of states,and ab initio molecular dynamics simulations further showed that Fe and Rh are the effective dopants for ZrO_(2),leading to low OER overpotential,high conductivity,and good *** cost-effectiveness,single-atom Fe doped ZrO_(2)emerged as the most promising catalyst for *** finding offers a valuable perspective and reference for experimental researchers to design cost-effective catalysts for the industrial-scale OER production.

关键词： Oxygen evolution reaction Metal oxide Electrocatalysis Surface Pourbaix analysis Doping

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关节软骨厚度影像学测量研究进展

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国际骨科学杂志 2024年第2期45卷 109-113页

作者：鲁灵凤宁迩玉张绘莉周静马冰杨兴郝跃峰南京医科大学附属苏州医院骨科与运动医学中心 215008 南京医科大学附属苏州医院超声科 215008

关节软骨退化及损伤是骨关节炎的核心病理表现,而软骨厚度变化与骨关节炎发病和进展密切相关。近期有众多研究通过X线、CT、磁共振成像(MRI)、超声等多种影像学检查对骨关节炎软骨厚度进行直接或间接测量,用于检测骨关节炎软骨退变程度... 详细信息

关节软骨退化及损伤是骨关节炎的核心病理表现,而软骨厚度变化与骨关节炎发病和进展密切相关。近期有众多研究通过X线、CT、磁共振成像(MRI)、超声等多种影像学检查对骨关节炎软骨厚度进行直接或间接测量,用于检测骨关节炎软骨退变程度并监测骨关节炎治疗效果。随着影像学检查技术的进步,关节软骨厚度测量的准确性及敏感性均得到显著提高。该文对影像学检查在关节软骨厚度测量中的研究进展进行综述。

关键词：骨关节炎软骨厚度影像学测量关节退变

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OVCF患者椎旁肌密度与椎体骨密度的相关性研究

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实用骨科杂志 2024年第7期30卷 594-599,631页

作者：侯俊俊侯福山车艳军张连迂陈琪钱宗娜沈佳莉刘华清司卫兵郝跃峰杨晶苏州大学附属第一医院江苏苏州215006 苏州工业园区星湖医院江苏苏州215000 山西医科大学第二医院山西太原030001 南京医科大学附属苏州医院江苏苏州215000 苏州市姑苏区卫生监督所江苏苏州215000

目的探讨骨质疏松性椎体压缩骨折(osteoporotic vertebral compression fracture,OVCF)患者腰骶区椎旁肌密度与椎体骨密度(vertebral bone mineral density,vBMD)之间的关系。方法回顾性分析了OVCF患者的前瞻性机构数据库(NCT05848167)。纳入2021年1月至2022年12月共167例患者资料,其中101例定量CT(quantitative computed tomography,QCT)检查资料可用的OVCF患者,女80例,男21例;女性中位年龄73(68.00,82.50)岁,男性中位年龄71(67.00,80.00)岁。在L_(3~5)椎体上终板水平进行椎旁肌密度和面积测量,并使用人工分割和定制编写的程序进行计算。利用QCT Pro软件在L_(1~2)水平进行vBMD测量和计算。按性别、年龄对所有分析进行分层分析。结果本研究发现男性患者的椎旁肌密度与vBMD有统计学相关。在调整年龄和性别后,L_(1~2)vBMD与L_(3)左侧多裂肌、L_(4)左侧竖脊肌、L_(4)右侧多裂肌、L_(5)左右双侧多裂肌密度之间存在统计学意义上的正相关,而在女性患者中未发现显著相关性。结论男性多裂肌密度和vBMD在不同的腰椎水平存在显著的正相关,这与年龄无关。在解释腰椎椎体和椎旁肌关联时,应考虑性别及区域性差异。

关键词：椎旁肌密度骨质疏松症肌少症骨质疏松性椎体压缩骨折定量CT

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In vivo and in situ real-time fluorescence imaging of peripheral nerves in the NIR-II window

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Nano Research 2019年第12期12卷 3059-3068页

作者： Zhujun Feng Yimeng Yang Jian Zhang Kan Wang Yunxia Li Heng Xu Zhen Wang Ewelina Biskup Shixian Dong Xing Yang yuefeng hao Jun Chen Yan Wo Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Sports Medicine Institute ofFudan University Department of Orthopedic Sports MedicineHuashan HospitalFudan UniversityShanghaiChina Department of Instrument Science and Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao long UniversityShanghai Engineering Research Center for Intelligent diagnosis and treatment instrumentKey Laboratory of Thin Film and Microfabrication(Ministry of Education)Shanghai 200240China Department of Plastic Surgery Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department cf physical education Fudan UniversityShanghai 200040China Department of Internal Medicine University Hospital of BaselPetersgraben 44051 BaselSwitzerland Department of orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China

The peripheral nervous system(PNS)is essential for performing and maintaining various motor and sensory *** can lead to a series of peripheral neurological conditions,such as paraesthesia,pain,or spasms,which are debilitating and lowering the quality of *** guidelines for diagnosis rely predominantly on clinical symptoms resulting from PNS dysfunction,which occur already at an *** are currently no effective methods that visually reflect the extent of peripheral *** our study,we present a novel in vivoand in situ real-time imaging of peripheral nerves based on the second near-infrared window(NIR-II)fluoresce *** NIR-II system,lead sulfidequa ntum dots(PbS Qds)with NIR-II fluoresce nee specifically bound to motor neuro rvspecific protein agrin,acting as image con *** micemodel,peripheral nerves were visible as soon as after 2 h post *** provide evidenee for the efficacy of this approach,which allows todirectly dem on strate peripheral nerves,their structure,and pote ntial damagesites and ***,our products were of goodbiocompatibility,while the n eural fluoresce nee signal was solid,bright and stable for 4 h in ***,overall,our results suggest that NIR-II isan effective new method for direct imaging of peripheral nerves in vivo,opening new horizons on early,improved and more precise,targeteddiag no sis.A resulti ng more rapid installatio n of perso nalized therapy facilitates a better prognosis of clinical peripheral neuropathy.

关键词： peripheral nerve the second near-infrared window(NIR-II) fluorescent imaging Agrin@PbS Qds biocompatibility

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Erratum to: In vivo and in situ real-time fluorescence imaging of peripheral nerves in the NIR-II window

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Nano Research 2021年第12期14卷 4901-4902页

作者： Feng, Zhujun Yang, Yimeng Zhang, Jian Wang, Kan Li, Yunxia Xu, Heng Wang, Zhen Biskup, Ewelina Dong, Shixian Yang, Xing hao, yuefeng Chen, Jun Wo, Yan Department of Anatomy and Physiology School of Medicine Shanghai Jiao Tong University Shanghai China Sports Medicine Institute of Fudan University Department of Orthopedic Sports Medicine Huashan Hospital Fudan University Shanghai China Department of Instrument Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai Engineering Research Center for Intelligent diagnosis and treatment instrument Key Laboratory of Thin Film and Microfabrication (Ministry of Education) Shanghai China Department of Plastic Surgery Ninth People’s Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of physical education Fudan University Shanghai China Department of Internal Medicine University Hospital of Basel Basel Switzerland Department of orthopedics Affiliated Suzhou Hospital of Nanjing Medical University Suzhou China

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