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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

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Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan Shuai tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

Breakdown of Landau Fermi liquid theory： Restrictions on the degrees of freedom of quantum electrons

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Frontiers of physics 2018年第2期13卷 119-137页

作者： yue-Hua Su Han-tao Lu Department of Physics Yantai University Yantai 264005 China Center for Interdisciplinary Studies Lanzhou University Lanzhou 730000 China

One challenge in contemporary condensed matter physics is to understand unconventional electronic physics beyond the paradigm of Landau Fermi-liquid theory. Here, we present a perspective that posits that most such examples of unconventional electronic physics stem from restrictions on the degrees of freedom of quantum electrons in Landau Fermi liquids. Since the degrees of freedom are deeply connected to the system＇s symmetries and topology, these restrictions can thus be realized by external constraints or by interaction-driven processes via the following mechanisms：（i） symmetry breaking, （ii） new emergent symmetries, and （iii） nontrivial topology. Various examples of unconventionM elec- tronic physics beyond the reach of traditional Landau Fermi liquid theory are extensively investigated from this point of view. Our perspective yields basic pathways to study the breakdown of Landau Fermi liquids and also provides a guiding principle in the search for novel electronic systems and devices.

关键词： breakdown of the Landau Fermi liquids degrees of freedom symmetry topology

BRVAAF and performance analysis for target detection

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Science China(Technological Sciences) 2009年第7期52卷 2096-2103页

作者： Nan Zhang Ran tao yue Wang Department of Electronic Engineering Beijing Institute of Technology Beijing 100081 China

A bistatic range-velocity-acceleration ambiguity function (BRVAAF) is proposed. The model of radar measurements of an accelerating target involving the time delay, Doppler frequency and Doppler rate is given. The relationships between these measurements and the parameters of the bistatic geometry, target position, velocity and acceleration are derived. Moreover, the effects of the bistatic geometry factors on these measurements are analyzed. Besides, the two relationships of the bistatic integration loss and the bistatic optimum integration time with these factors are built and their change trends are described respectively. This research is helpful to analyze the influences of the bistatic geometry factors on the target detection and signal processing.

关键词： bistatic radar ambiguity function integration loss resolution acceleration

Multi-channel sampling theorems for band-limited signals with fractional Fourier transform

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Science China(Technological Sciences) 2008年第6期51卷 790-802页

作者： ZHANG Feng tao Ran WANG yue Department of Electronic Engineering Beijing Institute of TechnologyBeijing 100081China

Multi-channel sampling for band-limited signals is fundamental in the theory of multi-channel parallel A/D environment and multiplexing wireless communication environment. As the fractional Fourier transform has been found wide applications in signal processing fields, it is necessary to consider the multi-channel sampling theorem based on the fractional Fourier transform. In this paper, the multi-channel sampling theorem for the fractional band-limited signal is firstly proposed, which is the generalization of the well-known sampling theorem for the fractional Fourier transform. Since the periodic nonuniformly sampled signal in the fractional Fourier domain has valuable applications, the reconstruction expression for the periodic nonuniformly sampled signal has been then obtained by using the derived multi-channel sampling theorem and the specific space-shifting and phase-shifting properties of the fractional Fourier transform. Moreover, by designing different fractional Fourier filters, we can obtain reconstruction methods for other sampling strategies.

关键词： fractional Fourier transform fractional band-limited signals fractional filter interpolation series periodic nonuniformly sampled signal

Real-time anomaly detection for very short-term load forecasting

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Journal of Modern Power Systems and Clean Energy 2018年第2期6卷 235-243页

作者： Jian LUO tao HONG Meng yue School of Management Science and Engineering Dongbei University of Finance and Economics Department of Systems Engineering and Engineering Management University of North Carolina at Charlotte Brookhaven National Laboratory

Although the recent load information is critical to very short-term load forecasting(VSTLF), power companies often have difficulties in collecting the most recent load values accurately and timely for VSTLF *** paper tackles the problem of real-time anomaly detection in most recent load information used by *** paper proposes a model-based anomaly detection method that consists of two components, a dynamic regression model and an adaptive anomaly threshold. The case study is developed using the data from ISO New England. This paper demonstrates that the proposed method significantly outperforms three other anomaly detection methods including two methods commonly used in the field and one state-of-the-art method used by a winning team of the Global Energy Forecasting Competition 2014. Finally, a general anomaly detection framework is proposed for the future research.

关键词： Real-time anomaly detection Very short-term load forecasting Multiple linear regression Data cleansing

Insulin resistance and occurrence and prognosis of ischemic stroke A non-randomized concurrent control and intra-group comparison

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Neural Regeneration Research 2008年第3期3卷 324-328页

作者： Xiaohong Zhao Shaojun Jiang yue tan Department of Geriatric Disease Second Affiliated Hospital Kunming Medical College Kunming 650101 Yunnan Province China Department of Neurology People＇s Hospital of Langzhong Langzhong 637400 Sichuan Province China

BACKGROUND： Clinical evidence has demonstrated that insulin resistance might be an independent risk factor for ischemic stroke, which has not been recognized. At present, insulin resistance has been proven to be an independent risk factor for coronary arteriosclerotic heart disease. However, the relationship between the onset and prognosis of ischemic stroke remains unclear. OBJECTIVE： This study was designed to analyze the relationship between insulin resistance and ischemic stroke and the correlation between insulin resistance and stroke risk factor, and to investigate the relationship between insulin resistance and ischemic stroke prognosis as well as whether insulin resistance is an independent prognostic factor. DESIGN： A non-randomized concurrent control experiment. SETTING： Department of Geriatric Disease, Second Affiliated Hospital of Kunming Medical College. PARTICIPANTS： A total of 106 inpatients with ischemic stroke of the cervical internal carotid artery, who had suffered from the disease within the previous 72 hours, were admitted to the Department of Neurology, First Affiliated Hospital of Kunming Medical College from March to December in 2005 and, recruited for the present study. All 106 inpatients corresponded to the diagnostic criteria of ischemic stroke, formulated at the Fourth National Cerebrovascular Disease Conference in 1995, and were confirmed as having had an ischemic stroke by CT/MRI examinations. The patient group consisted of 54 males and 52 females. An additional 50 healthy individuals, who received health examinations simultaneously, were included as controls. Among the control subjects, there were 26 males and 24 females. Informed consent for laboratory measurements was obtained from all subjects; this study was approved by the Hospital Ethics Committee. METHODS： Following admission, all subjects were inquired of age, gender, previous history, blood pressure, body temperature, admission time, and smoking habits. Meanwhile, they were sc

关键词： insulin resistance ischemic stroke stroke risk factor prognosis

Removal of Pb(Ⅱ) from aqueous solutions using waste textiles/poly(acrylic acid) composite synthesized by radical polymerization technique

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Journal of Environmental Sciences 2018年第5期30卷 368-377页

作者： tao Zhou Fafa Xia yue Deng Youcai Zhao The State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and Engineering Tongji University

Waste textiles（WTs） are the inevitable outcome of human activity and should be separated and recycled in view of sustainable development. In this work, WT was modified through grafting with acrylic acid（AA） via radical polymerization process using ceric ammonium nitrate（CAN） as an initiator and microwave and/or UV irradiation as energy supply. The acrylic acid-grafted waste textiles（WT-g-AA） thus obtained was then used as an adsorbent to remove Pb（Ⅱ） from Pb（Ⅱ）-containing wastewater. The effects of p H, initial concentrations of Pb（Ⅱ） and adsorbent dose were investigated, and around 95% Pb（Ⅱ） can be removed from the aqueous solution containing 10 mg/L at p H 6.0–8.0. The experimental adsorption isotherm data was fitted to the Langmuir model with maximum adsorption capacity of35.7 mg Pb/g WT-g-AA. The Pb-absorbed WT-g-AA was stripped using dilute nitric acid solution and the adsorption capacity of Pb-free material decreased from 95.4%（cycle 1） to91.1%（cycle 3）. It was considered that the WT-g-AA adsorption for Pb（Ⅱ） may be realized through the ion-exchange mechanism between ／COOH and Pb（Ⅱ）. The promising results manifested that WT-g-AA powder was an efficient, eco-friendly and reusable adsorbent for the removal of Pb（Ⅱ） from wastewater.

关键词： Adsorption Pb(Ⅱ) Waste textiles Graft copolymefization

EXPERIMENTAL STUDY OF CONDENSATION HEAT TRANSFER CHA- RACTERISTICS OF HORIZONTAL TUBE BUNDLES IN VACUUM STATES

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Journal of Hydrodynamics 2012年第4期24卷 628-634页

作者： CHENG Shen SUN Feng-zhong SHI yue-tao School of Energy Source and Power Engineering Shandong UniversityJinan 250061China

TO develop an excellent heat transfer element under the vacuum condition, experiments about the heat transfer performance of horizontal tube bundles of different materials under various vacuum conditions were carried out, including the stainless steel tube, the brass tube, the Ni-based implanted steel tube and the ion implanted brass tube. The relative trends show that the condensation heat transfer coefficient and the overall heat transfer coefficient of bundles of four materials all increase with the vacuum degree, especially, those of the Ni-based implanted steel tube and the ion implanted brass tube. Under a high vacuum condition （0.07 MPa）, the condensation heat transfer coefficient of the Ni-based implanted steel tube bundle is about 1.4 times of that of the stainless steel tube bundle, the condensation heat transfer coefficient of the ion implanted brass tube bundle is found to be about 1.3 times of that of the common brass tube bundle. Therefore, according to the condensation heat transfer characteristics studied under high vacuum conditions, it is believed that a dropwise condensation is partly achieved on the surface of these two implanted tube bundles, and the ion implantation is shown to be an effective method to achieve the dropwise condensation. Based on this study, it is believed that the Ni-based steel tube may replace the brass tube, which is more expensive as a heat transfer component.

关键词： vacuum heat transfer characteristics condensation heat transfer coefficient dropwise condensation

Distributed bias-compensated normalized least-mean squares algorithms with noisy input

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Science China(Information Sciences) 2018年第11期61卷 193-207页

作者： Lu FAN Lijuan JIA Ran tao yue WANG School of Information and Electronics Beijing Institute of Technology

In this paper, we study the problem of distributed normalized least-mean squares(NLMS) estimation over multi-agent networks, where all nodes collaborate to estimate a common parameter of *** consider the situations that all nodes in the network are corrupted by both input and output noise. This yields into biased estimates by the distributed NLMS algorithms. In our analysis, we take all the noise into consideration and prove that the bias is dependent on the input noise variance. Therefore, we propose a bias compensation method to remove the noise-induced bias from the estimated results. In our development, we first assume that the variances of the input noise are known a priori and develop a series of distributed-based bias-compensated NLMS(BCNLMS) methods. Under various practical scenarios, the input noise variance is usually unknown a priori, therefore it is necessary to first estimate for its value before bias removal. Thus, we develop a real-time estimation method for the input noise variance, which overcomes the unknown property of this noise. Moreover, we perform some main analysis results of the proposed distributed BCNLMS algorithms. Furthermore, we illustrate the performance of the proposed distributed bias compensation method via graphical simulation results.

关键词： distributed parameter estimation normalized least-mean squares bias-compensated algorithms