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地舒单抗在高钙血症治疗中的应用

中华骨质疏松和骨矿盐疾病杂志 2022年第3期15卷 279-288页

作者：姜悦王鸥中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室北京100730

地舒单抗是一种全人源性单克隆抗体,目前在我国仅用于治疗骨质疏松症、恶性肿瘤患者的骨骼相关事件,作为强骨吸收抑制剂,国外有一些关于其在高钙血症治疗中应用的报告,多为病例报告或小样本病例系列研究。本文就地舒单抗在不同病因引起... 详细信息

地舒单抗是一种全人源性单克隆抗体,目前在我国仅用于治疗骨质疏松症、恶性肿瘤患者的骨骼相关事件,作为强骨吸收抑制剂,国外有一些关于其在高钙血症治疗中应用的报告,多为病例报告或小样本病例系列研究。本文就地舒单抗在不同病因引起高钙血症中的应用进行综述。

关键词：地舒单抗高钙血症药物治疗甲状旁腺功能亢进症恶性肿瘤

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FRP加筋混凝土短柱受压性能试验研究

西安建筑科技大学学报（自然科学版） 2006年第4期38卷 467-472,485页

作者：张新越欧进萍哈尔滨工业大学土木工程学院黑龙江哈尔滨150090

纤维聚合物筋FRP(Fiber Reinforced Polymer)的耐腐蚀、抗拉强度高、重量轻、非磁性等特点使其在土木工程中的应用前景十分广阔.首先对我们自己研制的GFRP(Glass Fiber Reinforced Polymer)筋和CFRP(Carbon Fiber Reinforced Polymer)筋进行了常温下的受压试验,得到了GFRP筋和CFRP筋的抗压强度与抗压弹性模量;然后对GFRP、CFRP、CFRP与GFRP混合加筋混凝土短柱以及钢筋混凝土短柱进行了轴心受压试验,得到了加筋混凝土短柱的极限承载力、荷载-变形关系曲线、破坏形式和加强筋与混凝土的荷载-应变分布曲线,并将试验结果进行比较.结果表明:在没有约束的条件下,GFRP筋的抗压强度高于CFRP筋;在有约束的条件下,CFRP加筋混凝土短柱的抗压强度高于GFRP加筋混凝土短柱的抗压强度;FRP加筋混凝土短柱的抗压强度高于钢筋混凝土短柱的抗压强度;FRP加筋混凝土短柱的协同工作性和钢筋混凝土短柱的协同工作性相比较差.

关键词： FRP筋混凝土短柱抗压性能破坏形式

运动调节细胞因子改善缺血性脑卒中后认知功能的研究进展

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中医康复 2024年第7期1卷 56-60页

作者：蔡晓晴薛亚静潘越妤陈艾珈尤婷婷姜山杉欧海宁广州医科大学附属第五医院广东广州510700 广州医科大学康复实验室广东广州510700 广州医科大学广东广州511436 茂名市人民医院广东茂名525099

适宜的运动训练可有效改善缺血性脑卒中后认知功能,目前已有临床和动物研究发现运动可以通过调控多种细胞因子的表达来改善缺血性脑卒中后的认知功能障碍。动物研究提出了可能与这些关键细胞因子有关的信号通路和机制,为运动对缺血性脑... 详细信息

适宜的运动训练可有效改善缺血性脑卒中后认知功能,目前已有临床和动物研究发现运动可以通过调控多种细胞因子的表达来改善缺血性脑卒中后的认知功能障碍。动物研究提出了可能与这些关键细胞因子有关的信号通路和机制,为运动对缺血性脑卒中后认知功能的有益影响提供了理论基础。现本文对与运动明显相关的亲认知效应的潜在细胞因子在改善缺血性脑卒中后认知功能中发挥的作用及其机制进行综述,为改善缺血性脑卒中后认知功能障碍的运动康复策略提供理论支持。

关键词：运动缺血性脑卒中认知功能细胞因子康复

Traumatic brain injury induced by exposure to blast overpressure via ear canal

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Neural Regeneration Research 2022年第1期17卷 115-121页

作者： Yang ou Brad AClifton Jinghui Li David Sandlin Na Li Li Wu Chunming Zhang Tianwen Chen Jun Huang yue Yu Jerome Allison Fan Fan Richard JRoman James Shaffery Wu Zhou Yi Pang Hong Zhu Departmant of Otolaryngology and Head Neck Surgery Department of Neurobiology and Anatomical Sciences MD Program School of Medicine Graduate Program in Neuroscience Department of Pediatrics Department of Pharmacology and Toxicology Department of Psychiatry and Human Behavior University of Mississippi Medical CenterJacksonMSUSA Kunming Medical University KunmingYunnan ProvinceChina Department of Otolaryngology First Affiliated HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina

Exposure to explosive shockwave often leads to blast-induced traumatic brain injury in military and civilian *** ears are most often damaged following exposure to *** there is an association between tympanic membrane perforation and TBI in blast exposure victims,little is known about how and to what extent blast energy is transmitted to the central nervous system via the external ear *** present study investigated whether exposure to blasts directed through the ear canal causes brain injury in LongEvans *** were exposed to a single blast(0–30 pounds per square inch(psi))through the ear canal,and brain injury was evaluated by histological and behavioral outcomes at multiple *** exposure not only caused tympanic membrane perforation but also produced substantial neuropathological changes in the brain,including increased expression of c-Fos,induction of a profound chronic neuroinflammatory response,and apoptosis of *** blast-induced injury was not limited only to the brainstem most proximal to the source of the blast,but also affected the forebrain including the hippocampus,amygdala and the habenula,which are all involved in cognitive ***,the animals exhibited long-term neurological deficits,including signs of anxiety in open field tests 2 months following blast exposure,and impaired learning and memory in an 8-arm maze 12 months following blast *** results suggest that the unprotected ear canal provides a locus for blast waves to cause *** study was approved by the Institutional Animal Care and Use Committee at the University of Mississippi Medical Center(Animal protocol#0932 E,approval date:September 30,2016 and 0932 F,approval date:September 27,2019).

关键词： anxiety blast ear ear protection learning memory microglia neuroinflammation neuron rat traumatic brain injury

Cloning of Humanα-defensin-1(HNP-1) Gene and Construction of Its Eukaryotic Expression Vector

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生物医学工程学杂志 2005年第S1期22卷 97-98页

作者： Hua-Hua CHEN Jing-Ping ou YANG Bao-Hua WANG yue Yang Han-Qiao ZHENG(Pathophysiology Department of Medical Institute of Wuhan University, Wuhan 430071, China) Pathophysiology Department of Medical Institute of Wuhan University Wuhan 430071 China

1 IntroductionDefensins are small cationic antimicrobial peptides that function in the host's innate immune system. The human defensin family includes three small peptides from the azurophil granules of polymorphonuclear cells named human neutrophil peptide (HNP)-1, HNP-2, HNP-3,which consist 5%-7% of the protein of human neutrophil. HNP-4 is approximately one hundred times less abundant. They demonstrate antibacterial, antifungal and antiviral properties in vitro. HNPs are important component of nonoxidative mechanism in macrophages, and can direct inactivate the enveloped viruses. Because only special cells express defensins. And it is hard to extract them naturally and the production is few. So researcher expect to obtain defensins highly through heterogenous expression by gene engineering technology. In order to express HNP-1, we cloned the cDNA of HNP-1 from human polymorphonuclear cells in peripheral blood, and constructed its eukaryotic expression vector, which provided a base for the further study on its mechanism of antimicrobial effect.

关键词： HNP-1 Gene and Construction of Its Eukaryotic Expression Vector defensin-1 Cloning of Human

槲树不同发育时期胚珠石蜡切片制备体系的优化

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西北农林科技大学学报（自然科学版） 2024年第7期52卷 64-72页

作者：祁永梁李亚鹏李世安刘克林岳涵郑为军余海胡瑞阳任俊杰欧国范张淑敏于立新孙宇涵李云北京林业大学生物科学与技术学院林木遗传育种全国重点实验室国家林业和草原局刺槐工程技术研究中心林木育种与生态修复国家工程研究中心北京100083 北京市绿地养护管理事务中心北京102200 中国林业科学研究院华北林业研究中心北京102399 河北省洪崖山国有林场河北保定071000 平泉市国有黄土梁子林场河北承德067506

【目的】建立并优化适宜槲树子房或胚珠石蜡切片的制作体系,为后续槲树胚胎发育学研究提供技术支撑。【方法】以不同发育时期的槲树雌花为试验材料,将材料以60 d为界分为60 d前和60 d后两部分,对材料处理方式(授粉60 d前后的材料分别进... 详细信息

【目的】建立并优化适宜槲树子房或胚珠石蜡切片的制作体系,为后续槲树胚胎发育学研究提供技术支撑。【方法】以不同发育时期的槲树雌花为试验材料,将材料以60 d为界分为60 d前和60 d后两部分,对材料处理方式(授粉60 d前后的材料分别进行仅保留子房与胚珠处理)、浸蜡时间(18,24,36 h)与浸蜡条件(60℃烘箱内抽真空处理0,6,8,12 h)、切片厚度(6,8,10μm)进行优化;在此基础上,以授粉70 d样品切片为材料,对染色方法(染色液分别为5 g/L苏木精、1 g/L甲苯胺蓝和10 g/L番红-固绿)及染色时间(1,2,5,10,15 min)进行优化,建立适合槲树胚珠的石蜡切片制备体系。【结果】授粉60 d前的样品仅保留子房部分,授粉60 d后的样品仅保留胚珠,两者在50℃烘箱经甘油乙醇浸泡48 h的软化处理后,所得切片效果最佳,可避免蜡带破裂等不良现象出现。将浸蜡时间延长至36 h,并于第1次浸纯蜡过程中在60℃烘箱内先进行12 h抽真空处理,可保证发育后期体积较大材料的充分浸蜡;脱蜡前将玻片进行3 h抽真空处理,可明显降低脱片率;授粉60 d前样品的切片厚度以8μm为宜,授粉60 d及以后的样品以10μm最佳。槲树胚株石蜡切片制备时,采用5 g/L苏木精染色5 min时的制片效果最好。【结论】建立并优化了槲树不同发育时期子房或胚珠石蜡切片的制备体系,采用该优化体系可获得蜡带连续、结构完整、染色均匀、背景清晰的槲树子房或胚珠切片。

关键词：槲树胚珠胚胎发育石蜡切片制备体系

Numerical well test for well with finite conductivity vertical fracture in coalbed

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Applied Mathematics and Mechanics(English Edition) 2014年第6期35卷 729-740页

作者：刘曰武欧阳伟平赵培华鹿倩方惠军 Institute of Mechanics Chinese Academy of Sciences PetroChina Coalbed Methane Company Limited Well Test Department of Geermu Oil Factory of Qinghai Oil Field

A new well test model is developed for the hydraulic fractured well in coalbed by considering the following aspects： methane desorption phenomena, finite conductivity vertical fractures, and asymmetry of the fracture about the well. A new parameter is introduced to describe the storage of the fracture, which is named as a combined fracture storage. Another new concept called the fracture asymmetry coefficient is used to define the asymmetry of the fracture about the well. Finite element method （FEM） is used to solve the new mathematical model. The well test type curves and pressure fields are obtained and analyzed. The effects of the combined fracture storage, desorption factor, fracture conductivity, and fracture asymmetry coefficient on the well test type curves are discussed in detail. In order to verify the new model, a set of field well test data is analyzed.

关键词： combed fractured well numerical method finite element method (FEM) finite conductivity

“庶建乃真民主”——严复译《法意》“庶建”的创制使用及传播

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福建师范大学学报（哲学社会科学版） 2019年第2期 57-63页

作者：欧梦越复旦大学历史学系上海200433

"民主"是英文Democracy的近现代通行汉译,严复早期著述也一直沿袭。直至《法意》,他创制并诠释"庶建"以表达"民主",认为"庶建乃真民主"。他巧妙地将"庶"的双重意涵("平民"和"众多")结合,并与"建国"的"建"字组合,"庶建"即庶民的自建,用... 详细信息

"民主"是英文Democracy的近现代通行汉译,严复早期著述也一直沿袭。直至《法意》,他创制并诠释"庶建"以表达"民主",认为"庶建乃真民主"。他巧妙地将"庶"的双重意涵("平民"和"众多")结合,并与"建国"的"建"字组合,"庶建"即庶民的自建,用古汉语将英语的民主内核(即主权在民)展现出来,既典雅简洁,又杜绝了由于古代意义上的"民主"与现代汉语意义上的"民主"内涵截然相反(即"民之主"还是"民自做主")而带来的歧义。不过,严复使用最多的仍是"民主",且频率远远高于"庶建",学界多批评严复一味排斥通行译词(尤其是日语借词),这种说法并不准确。近现代,仅有马叙伦、颜惠庆沿用或接受严译"庶建",说明它的传播与接受有限。

关键词：庶建民主严复译《法意》创制传播

Quinazoline Derivative SYSUQ-03:A Specific Ligand that Regulate the Cap-Independent Translation Initiation in Human VEGF IRES-A

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Quinazoline Derivative SYSUQ-03:A Specific Ligand that Regul...