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Increased susceptibility of algal symbionts to photo-inhibition resulting from the perturbation of coral gastrodermal membrane trafficking

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Science China(Life Sciences) 2012年第7期55卷 599-611页

作者： CHEN Chii-Shiarng YEH Shih-Pin WANG Li-Hsueh LI hsing-Hui CHEN Uang Wan-Nan Taiwan Coral Research Center "National" Museum of Marine Biology & AquariumPingtung 944TaiwanChina Institute of Marine Biotechnology "National" Dong Hwa UniversityPingtung 944TaiwanChina Department of Marine Biotechnology and Resources "National" Sun Yat-Sen UniversityKaohsiung 804TaiwanChina Department of Biological Science and Technology I-Shou UniversityKaohsiung 824TaiwanChina

The stability of cnidarian-dinoflagellate endosymbioses is dependent upon communication between the host gastrodermal cell and the symbionts housed within it. Although the molecular mechanisms remain to be elucidated, existing evidence suggests that the establishment of these endosymbioses may involve the sorting of membrane proteins. The present study examined the role of host gastrodermal membranes in regulating symbiont （genus Symbiodinium） photosynthesis in the stony coral Euphyllia glabrescens. In comparison with the photosynthetic behavior of Symbiodinium in culture, the Symbiodinium populations within isolated symbiotic gastrodermal cells （SGCs） exhibited a significant degree of photo-inhibition, as determined by a decrease in the photochemical efficiency of photosystem II （Fv/Fm）. This photo-inhibition coincided with increases in plasma membrane perturbation and oxidative activity in the SGCs. Membrane trafficking in SGCs was examined using the metabolism of a fluo- rescent lipid analog, N-[5-（5,7-dimethyl boron dipyrromethene difluoride）-l-pentanoyl]-D-erythro-Sphingosylpbosphoryl- choline （BODIPY-Sphingomyelin or BODIPY-SM）. Light irradiation altered both membrane distribution and trafficking of BODIPY-SM, resulting in metabolic changes. Cholesterol depletion of the SGC plasma membranes by methyl-13-cyclodextrin retarded BODIPY-SM degradation and further augmented Symbiodinium photo-inhibition. These results indicate that Symbio- dinium photo-inhibition may be related to perturbation of the host gastrodermal membrane, providing evidence for the pivotal role of host membrane trafficking in the regulation of this environmentally important coral-dinoflagellate endosymbiosis.

关键词： Cnidaria endosymbiosis fluorescent lipids lipid trafficking PAM photosynthesis Symbiodinium

Protective effect of supplementation with Lycium ruthenicum Murray extract from exhaustive exercise-induced cardiac injury in rats

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Chinese Medical Journal 2019年第8期132卷 1005-1006页

作者： Chien-Wei Hou I-Chen Chen Fang-Rui Shu Chin-hsing Feng Chang-Tsen Hung Department of Biotechnology and Pharmaceutical Technology Yuanpei University of Medical TechnologyHsinchuTaiwan 30015China Division of Plastic and Reconstructive Surgery Department of SurgeryTaichung Veterans General HospitalTaichungTaiwan 40705China Department of Health and leisure Management Yuanpei University of Medical TechnologyHsinchuTaiwan 30015China

To the Editor:Lycium ruthenicum(***)Murray contains abundant *** purpose of the present research was to investigate the protective effect of *** extract supplementation on the damage from exhaustive exercise in rats which were treated for seven days before the exhaustive *** exercise induced an increase of Serum nitrate(NO)and reactive oxygen species(ROS)levels,but supplementation of *** extract reduced them significantly(Pleukin(IL)-1 and IL-6 were also significantly reduced by *** as compared to the control(Plementation with *** extract also decreased the creatine kinase isoenzyme MB(CK-MB)generation significantly and ameliorated the myocardial histopathology.

关键词： Serum nitrate(NO) reactive oxygen species(ROS) creatine kinase isoenzyme MB(CK-MB)

Application of double-balloon enteroscopy in jejunal diverticular bleeding

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World Journal of Gastroenterology 2010年第44期16卷 5616-5620页

作者： Tsung-hsing Chen Cheng-Tang Chiu Wei-Pin Lin Ming-Yao Su Chen-Ming Hsu Pang-Chi Chen Department of Gastroenterology and Hepatology Linkou Chang Gung Memorial Hospital Chang Gung University College of MedicineTaoyuan 333TaiwanChina

AIM:To evaluate the efficacy of endoscopic diagnosis and therapy for jejunal diverticular ***:From January 2004 to September 2009,154 patients underwent double-balloon enteroscopy (DBE) for obscure gastrointestinal *** consecutive patients with jejunal diverticula (5 males and 5 females) at the age of 68.7 ± 2.1 years (range 1995 years) at Chang Gung Memorial Hospital,Academic Tertiary Referral Center,were enrolled in this ***:Of the 10 patients,5 had melena,2 had hematochezia,2 had both melena and hematochezia,1 had anemia and *** revealed ulcers with stigmata of recent hemorrhage in 6 patients treated by injection of epinephrine diluted at 1:10 000,Dieulafoylike lesions in 4 patients treated by deploying hemoclips on the vessels,colonic diverticula in 2 patients,and duodenal diverticula in 3 patients,*** the 2patients who underwent surgical intervention,1 had a large diverticulum and was referred by the surgeon for DBE,1 received endoscopic therapy but failed due to massive *** patient had a second DBE for recurrent hemorrhage 7 mo later,which was successfully treated with a repeat *** mean follow-up time of patients was 14.7 ± 7.8 ***:DBE is a safe and effective treatment modality for jejunal diverticular bleeding.

关键词： Double-balloon enteroscopy Jejunal diverticular bleeding Obscure gastrointestinal bleeding

Automatically Constructing an Effective Domain Ontology for Document Classification

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Computer Technology and Application 2011年第3期2卷 182-189页

作者： Yi-hsing Chang Department of information management Southern Taiwan University the department No. 1 Nan-Tai Street Yongkang Dist. TainanCity 710 Taiwan

An effective domain ontology automatically constructed is proposed in this paper. The main concept is using the Formal Concept Analysis to automatically establish domain ontology. Finally, the ontology is acted as the base for the Naive Bayes classifier to approve the effectiveness of the domain ontology for document classification. The 1752 documents divided into 10 categories are used to assess the effectiveness of the ontology, where 1252 and 500 documents are the training and testing documents, respectively. The Fl-measure is as the assessment criteria and the following three results are obtained. The average recall of Naive Bayes classifier is 0.94. Therefore, in recall, the performance of Naive Bayes classifier is excellent based on the automatically constructed ontology. The average precision of Naive Bayes classifier is 0.81. Therefore, in precision, the performance of Naive Bayes classifier is gored based on the automatically constructed ontology. The average Fl-measure for 10 categories by Naive Bayes classifier is 0.86. Therefore, the performance of Naive Bayes classifier is effective based on the automatically constructed ontology in the point of F 1-measure. Thus, the domain ontology automatically constructed could indeed be acted as the document categories to reach the effectiveness for document classification.

关键词： Naive bayes classifier ontology formal concept analysis document classification.

基于单试验脑电图的n-back任务中的脑力负荷分类（英文）

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仪器仪表学报 2017年第6期38卷 1335-1344页

作者：代忠祥 Bezerianos Anastasios Chen Shen-hsing Annabel 孙煜新加坡国立大学生命科学中心新加坡神经科学研究所新加坡117456 南洋理工大学人文社会科学学院新加坡637332

近年来,脑力负荷估计已经经历了广泛的研究,因为监测认知负荷的能力能够防止认知超负荷并且改善工作场所安全。脑电图(EEG)信号已经被发现是一种客观和非侵入性的脑力负荷的测量方式。然而,作为实时脑力负荷监测和脑机接口研究的重要一... 详细信息

近年来,脑力负荷估计已经经历了广泛的研究,因为监测认知负荷的能力能够防止认知超负荷并且改善工作场所安全。脑电图(EEG)信号已经被发现是一种客观和非侵入性的脑力负荷的测量方式。然而,作为实时脑力负荷监测和脑机接口研究的重要一步,基于单试验EEG数据的认知负荷的评估一直是一个重大的挑战。最近,许多高级的特征提取方法和机器学习算法已经被采用于基于EEG的脑力负荷评估中。在本研究中,使用在具有2个难度水平的n-back任务的执行期间记录的EEG数据进行了单试验脑力负荷分类,测试了3种类型的特征提取的有效性(谱功率、离散小波变换和公共空间滤波),并评估了4种分类算法的性能(支持向量机、K-近邻、随机森林和梯度推进分类器)。研究结果表明,公共空间滤波是性能最好的基于单试验的脑力负荷分类的特征提取方法,而且最佳性能可以通过将来自谱功率或离散小波变换的特征与来自公共空间滤波的特征相结合,并采用随机森林分类器来实现。这项研究可能对基于单试验脑电图数据的脑力负荷评估中的特征提取方法以及机器学习算法的选择提供一些有用的指导。

关键词：脑电图单试精神工作量特征提取分类

Design of drug-like hepsin inhibitors against prostate cancer and kidney stones

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Acta Pharmaceutica Sinica B 2020年第7期10卷 1309-1320页

作者： Vincent Blay Mu-Chun Li Sunita P.Ho Mashall L.Stoller hsing-Pang Hsieh Douglas R.Houston Division of Biomaterials and Bioengineering School of DentistryUniversity of California San FranciscoSan FranciscoCA 94143USA Department of Urology School of MedicineUniversity of California San FranciscoSan FranciscoCA 94143USA Institute of Biotechnology and Pharmaceutical Research National Health Research InstitutesZhunanTaiwan 350China University of Edinburgh Institute of Quantitative BiologyBiochemistry and BiotechnologyEdinburghScotlandEH93BFUK

Hepsin,a transmembrane serine protease abundant in renal endothelial cells,is a promising therapeutic target against several cancers,particularly prostate *** is involved in the release and polymerization of uromodulin in the urine,which plays a role in kidney stone *** this work,we design new potential hepsin inhibitors for high activity,improved specificity towards hepsin,and promising ADMET *** ligands were developed in silico through a novel hierarchical *** pipeline explicitly accounts for off-target binding to the related serine proteases matriptase and HGFA(human hepatocyte growth factor activator).We completed the pipeline incorporating ADMET properties of the candidate inhibitors into custom multi-objective optimization *** ligands designed show excellent prospects for targeting hepsin via the blood stream and the urine and thus enable key experimental *** computational pipeline proposed is remarkably costefficient and can be easily adapted for designing inhibitors against new drug targets.

关键词： Virtual screening Docking Library Hepsin Tamm-Horsfall protein Biomineralization

China’s Stake In Europe

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Beijing Review 2011年第35期54卷 14-15页

作者： LOH SU hsing

China’s support of the debt-ridden euro zone shows its long-term commitment to Sino-EU ties The possibility of a major default continues to hover over the EU. Greece, Portugal and Ireland have already been bailed out.

关键词： In EU China’s Stake In Europe Greek

基于光纤布拉格光栅和压电转换器的电功率传感器(英文)

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光学精密工程 2011年第9期19卷 2255-2262页

作者： CHENG Chin-hsing CHANG Min-chih LIU Wen-fung Department of Electrical Engineering Feng Chia University

针对传统功率计测量电功率存在线圈电感、电容与金属部分的涡流感应等限制,本文基于布拉格光纤光栅与压电转换器设计了电功率传感器来测量实功率与虚功率。将布拉格光纤光栅粘贴于压电转换器上,构建了动态应变模拟装置。负载电压与负载... 详细信息

针对传统功率计测量电功率存在线圈电感、电容与金属部分的涡流感应等限制,本文基于布拉格光纤光栅与压电转换器设计了电功率传感器来测量实功率与虚功率。将布拉格光纤光栅粘贴于压电转换器上,构建了动态应变模拟装置。负载电压与负载电流的乘积形成的等效电压施加在压电转换器上使布拉格光纤光栅动态变化,由此测量光栅动态变化所造成的波长改变量即可得到等效负载功率。相位检测电路用于测量负载电压与负载电流的相位差,由该相位差即可求得功率因数。所研究的传感器可以取代传统功率计用于实功率和虚功率的测量。

关键词：电功率传感器实功率虚功率光纤布拉格光栅压电转换器

Cholecystoenteric fistula in a patient with advanced gallbladder cancer: A case report and review of literature

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World Journal of Clinical Cases 2023年第36期11卷 8519-8526页

作者： Chun-Yu Wang Sung-Hua Chiu Wei-Chou Chang Meng-hsing Ho Ping-Ying Chang Department of General Medicine Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Radiology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of General Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Hematology/Oncology Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Cholecystoenteric fistula(CEF)involves the formation of a spontaneous ano-malous tract between the gallbladder and the adjacent gastrointestinal *** gallbladder inflammation can lead to tissue necrosis,perforation,and *** most prevalent cause of CEF is chronic cholelithiasis,which rarely results from *** the symptoms and laboratory findings associated with CEF are nonspecific,the condition is often misdiagnosed,pre-senting a challenge to the surgeon when detected ***,a preoperative diagnosis of CEF is *** present the case of a 57-year-old male with advanced gallbladder cancer(GBC)who arrived at the emergency room with persistent vomiting,abdominal pain,and *** abdominopelvic computed tomography scan revealed a contracted gallbladder with bubbles in the fundus connected to the second por-tion of the duodenum and transverse *** suspected that GBC had invaded the adjacent gastrointestinal tract through a cholecystoduodenal fistula(CDF)or a cholecystocolonic fistula(CCF).He underwent multiple examinations,including esophagogastroduodenoscopy,an upper gastrointestinal series,colo-noscopy,and magnetic resonance cholangiopancreatography;the results of these tests con-firmed a diagnosis of synchronous CDF and *** patient underwent a Roux-en-Y gastrojejunostomy and loop ileostomy to address the severe adhesions that were previously observed to cover the second portion of the duodenum and hepatic flexure of the *** symptoms improved with supportive treatment while *** initiated oral targeted therapy with lenvatinib for further anticancer *** The combination of imaging and surgery can enhance preoperative diagnosis and alleviate symptoms in patients with GBC complicated by CEF.

关键词： Cholecystoenteric fistula Biliary enteric fistula Cholecystoduodenal fistula Cholecystocolonic fistula Gallbladder neoplasms Case report