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The protective effect of zeaxanthin on human limbal and conjunctival epithelial cells against UV-induced cell death and oxidative stress

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 369-374页

作者： yue Huang Chun Shi jing li Department of Ophthalmology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Ophthalmology Xinhua Hospital Chong Ming Branch Shanghai Jiao Tong University School of Medicine Department of Ophthalmology Jiangwan Hospital of Hongkou District

AIM: To explore the protective effect of zeaxanthin on human limbal and conjunctival epithelial cells against UVradiation and excessive oxidative ***: Human limbal and conjunctival epithelial cells were isolated from cadaver and cultured in vitro. They were challenged with UVB radiation and H2 O2 with and without zeaxanthin pretreatment. Cell viability, p38 and c-JUN NH(2)-terminal kinase(JNK) phosphorylation, IL-6, IL-8 and MCP-1 secretion and malondialdehyde(MDA) content were ***: Zeaxanthin had no measurable cytotoxicity on limbal or conjunctival epithelial cells when used at concentrations of 5 μg/mL and below. At 30 mJ/cm2 UVB, the pretreatment of zeaxanthin increased the percentage of live cells from 50% to 69%(P=0.01) and from 66% to 75%(P=0.05) for limbal and conjunctival epithelial cells, respectively. The concentrations of IL-6, IL-8 and MCP-1 in the culture medium reduced to 66%(for IL-6 and MCP-1)and 56%(for IL-8) of the levels without zeaxanthin. This was accompanied by reduced p38 and JNK protein phosphorylation. Pretreatment of zeaxanthin also reduced intracellular MDA content caused by H2 O2 stimulation from 0.86 μmol/L to 0.52 μmol/L(P=0.02) in limbal epithelial cells and from 0.96 μmol/L to 0.56 μmol/L in conjunctival epithelial cells(P=0.03). However, zeaxanthin did nothave significant effect on H2 O2-induced cell death in limbal or conjunctival epithelial ***: Zeaxanthin is an effective reagent in reducing the detrimental effect of UV-radiation and oxidative stress on ocular surface epithelial cells.

关键词： zeaxanthin UV-radiation oxidative stress malondialdehyde limbal epithelial cells conjunctival epithelial cells

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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong li yuewei Chen Nian liu jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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Studies on the Surface Properties of MCM-41

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Chemical Research in Chinese Universities 2002年第3期18卷 242-245页

作者： HE jing DUAN Xue EVANS DG li Cheng yue The Key Laboratory of Science and Technology of Controllable Chemical Reactions Ministry of EducationBeijing University of Chemical TechnologyBeijing 100029P.R.China

MCM 41 materials with a well ordered long range structure, a large pore size and a high surface area have been synthesized. Their surface properties including the number and the nature of the surface hydroxyl groups and surface hydrophobicity/hydrophilicity have been investigated by means of 29 Si MAS NMR and FT IR spectra and TPD of probe molecules. The results clearly show that the surface of MCM 41 has an abundance of acidic silanol groups, and that the hydrophobicity/hydrophilicity can be modified by the introduction of Al and transition metals Ti, Cr, Ni and Fe into it.

关键词： Hydroxyl group Hydrophobicity/Hydrophilicity MCM 41

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Catalytic Preparation of Methyl Formate from Methanol over Silver

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Chemical Research in Chinese Universities 2005年第5期21卷 573-576页

作者： YANG Zhi li jing YANG Xiang-guang WU yue Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China Graduate School Chinese Academy of Sciences Belting 100039 P. R. China

A catalytic reaction over a silver catalyst performed in an unregarded temperature region（473-873 K） with a long catalytic lifetime for the production of methyl formate from methanol was provided as a potential preparing route. The optimal yield of methyl formate（ca. 14. 8% ） with a selectivity 〉90% was obtained at about 573 K. Because α- oxygen species and bulk oxygen species coexist in the unregarded temperature region, a synergistic process concerning α-oxygen species and bulk oxygen species was proved over Oα -rich and Oγ-rich samples.

关键词： Silver Methanol Methyl formate Oxygen species Svnergistic effect

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CSLabel： An Approach for Labelling Mobile App Reviews

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Journal of Computer Science & Technology 2017年第6期32卷 1076-1089页

作者： li Zhang Xin-yue Huang jing Jiang Ya-Kun Hu State Key Laboratory of Software Development Environment Beihang University Beijing 100191 China

Mobile apps （applications） have become a popular form of software, and the app reviews by users have become an important feedback resource. Users may raise some issues in their reviews when they use apps, such as a functional bug, a network lag, or a request for a feature. Understanding these issues can help developers to focus on users＇ concerns, and help users to evaluate similar apps for download or purchase. However, we do not know which types of issues are raised in a review. Moreover, the amount of user reviews is huge and the nature of the reviews＇ text is unstructured and informal. In this paper, we analyze 3 902 user reviews from 11 mobile apps in a Chinese app store -- 360 Mobile Assistant, and uncover 17 issue types. Then, we propose an approach CSLabel that can label user reviews based on the raised issue types. CSLabel uses a cost-sensitive learning method to mitigate the effects of the imbalanced data, and optimizes the setting of the support vector machine （SVM） classifier＇s kernel function. Results show that CSLabel can correctly label reviews with the precision of 66.5%, the recall of 69.8%, and the F1 measure of 69.8%. In comparison with the state-of-the-art approach, CSLabel improves the precision by 14%, the recall by 30%, the F1 measure by 22%. Finally, we apply our approach to two real scenarios： 1） we provide an overview of 1 076 786 user reviews from 1 100 apps in the 360 Mobile Assistant and 2） we find that some issue types have a negative correlation with users＇ evaluation of apps.

关键词： mobile app user review classification

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Single-cell transcriptomics of murine mural cells reveals cellular heterogeneity

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Science China(life Sciences) 2021年第7期64卷 1077-1086页

作者： Ya-Na Guan yue li Moom Roosan Qing jing Shanghai Jiao Tong University School of Medicine(SJTUSM)&CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of Sciences(CAS)Shanghai 200031China Chapman University IrvineCA 92618USA

Mural cells(MCs)wrap around the endothelium,and participate in the development and homeostasis of *** have been reported as heterogeneous population morphologically and ***,the transcriptional heterogeneity of MCs was rarely *** this study,we illustrated the transcriptional heterogeneity of MCs with different perspectives by using publicly available single-cell dataset ***,MCs are transcriptionally different from other cell types,and ligand-receptor interactions of different cells with MCs ***-clustering of MCs identified five distinct *** heterogeneity of MCs in tissues was reflected by MC coverage,various distribution of MC subclusters,and ligand-receptor interactions of MCs and parenchymal *** transcriptomic diversity of MCs revealed in this article will help facilitate further research into MCs.

关键词： mural cells single-cell analysis heterogeneity

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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu Wen-Chang Jia jing Wen Xue-lin Cheng Yan Han Ming-Hui Peng jing Zhou Yao liu Sun-Fang Jiang Xiao-Pan li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

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Effective source rock selection and oil–source correlation in the Western Slope of the northern Songliao Basin,China

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Petroleum Science 2021年第2期18卷 398-415页

作者： He Bi Peng li Yun Jiang jing-jing Fan Xiao-yue Chen Research Institute of Petroleum Exploration and Development PetroChinaBeijing100083China Petroleum Exploration and Production Research Institute SINOPECBeijing100083China China National Oil and Gas Exploration and Development Co.Ltd. Beijing100034China

This study considers the Upper Cretaceous Qingshankou Formation,Yaojia Formation,and the first member of the Nenjiang Formation in the Western Slope of the northern Songliao *** mudstone with high abundances of organic matter of Gulong and Qijia sags are considered to be significant source rocks in the study *** evaluate their development characteristics,differences and effectiveness,geochemical parameters are ***-dimensional basin modeling and hydrocarbon evolution are also applied to discuss the effectiveness of source *** the biomarker characteristics,the source–source,oil–oil,and oil–source correlations are assessed and the sources of crude oils in different rock units are *** on the results,Gulong and Qijia source rocks have different organic matter primarily detrived from mixed sources and plankton,*** source rock has higher thermal evolution degree than Qijia source *** biomarker parameters of the source rocks are compared with 31 crude oil *** studied crude oils can be divided into two *** oil–source correlations show that group I oils from Qing II–III,Yao I,and Yao II–III members were probably derived from Gulong source rock and that only group II oils from Nen I member were derived from Qijia source rock.

关键词： Songliao basin Western slope Source rock distinction Crude oils Biomarker Oil-source correlation

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Ultrathin CeO_(2) nanosheets as bifunctional sensing materials for humidity and formaldehyde detection

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Rare Metals 2021年第6期40卷 1614-1621页

作者： Peng Zhang Le-Xi Zhang Heng Xu yue Xing jing-jing Chen li-Jian Bie School of Materials Science and Engineering Tianjin University of TechnologyTianjin 300384China Tianjin Key Laboratory for Photoelectric Materials and Devices Tianjin 300384China Key Laboratory of Display Materials and Photoelectric Devices(Ministry of Education) Tianjin 300384China National Demonstration Center for Experimental Function Materials Education Tianjin 300384China

Issues like morphology control and further multifunctional applications are of significant importance for rare earth nano-oxides,e.g.,cerium dioxide(CeO_(2))nanostructures,however,relevant results in this respect are rather limited up to *** the present work,ultrathin CeO_(2) nanosheets were synthesized through a facile lowtemperature hydrothermal *** structure,morphology and specific surface area of these CeO_(2) nanosheets were characterized by X-ray diffraction(XRD),field emission scanning electron microscope(FESEM)and N2 ***,CeO_(2) nanosheets have the potential as bifunctional sensing materials to detect both humidity and formaldehyde *** CeO_(2) nanosheet humidity sensor exhibited excellent sensing characteristics in the relative humidity range of 11%-97% with the response value as high as 3.1×10^(4).Meanwhile,the CeO_(2) nanosheet gas sensor showed superior sensitivity and repeatability with fast response/recovery speed toward formaldehyde vapor at 300℃.Finally,the humidity and formaldehyde sensing mechanism were discussed as well.

关键词： CeO_(2)nanosheets Humidity sensor Gas sensor Formaldehyde

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红树莓生物活性成分及功效研究进展

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食品科学 2025年第2期46卷 268-279页

作者：孙华军崔方正刘盈朱思静李跃黑龙江八一农垦大学食品学院黑龙江大庆163319

红树莓是蔷薇科悬钩子属果树,红树莓的果实、叶片、种子等部位富含多糖、黄酮类和酚类化合物等生物活性物质,具有提高免疫力、预防心血管疾病、抑制癌细胞生长等多种健康功效,是具有商业应用价值和药物研究价值的“黄金水果”。本文全... 详细信息

红树莓是蔷薇科悬钩子属果树,红树莓的果实、叶片、种子等部位富含多糖、黄酮类和酚类化合物等生物活性物质,具有提高免疫力、预防心血管疾病、抑制癌细胞生长等多种健康功效,是具有商业应用价值和药物研究价值的“黄金水果”。本文全面综述红树莓不同品种、采收期、组织部位的营养成分及含量,系统阐述红树莓不同部位在抗氧化、抗炎、抗菌、抗癌、改善代谢综合征等方面的功效和作用机制以及应用,以期为红树莓的功效研究、高值化利用和精深加工研究提供参考。

关键词：红树莓生物活性物质资源开发加工利用

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