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Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin Zhang Guangyu Yang Lei Xiao Zhiyong Kan jing Guo Qiang li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang Peifeng li Hai Zhu Dong Wang jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

人工泪液配合雷火灸及耳穴贴压治疗儿童干眼的临床观察

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广州中医药大学学报 2020年第4期37卷 656-660页

作者：单婷婷岳丽菁广州中医药大学广东广州510405 广东省第二中医院眼科广东广州510095

【目的】观察人工泪液(聚乙烯醇滴眼液)配合雷火灸及耳穴贴压治疗儿童干眼的临床疗效。【方法】将116例干眼患儿随机分为治疗组和对照组,每组各58例。治疗组给予聚乙烯醇滴眼液滴眼配合雷火灸及耳穴贴压治疗,对照组单纯给予聚乙烯醇滴... 详细信息

【目的】观察人工泪液(聚乙烯醇滴眼液)配合雷火灸及耳穴贴压治疗儿童干眼的临床疗效。【方法】将116例干眼患儿随机分为治疗组和对照组,每组各58例。治疗组给予聚乙烯醇滴眼液滴眼配合雷火灸及耳穴贴压治疗,对照组单纯给予聚乙烯醇滴眼液滴眼治疗,疗程为2周。观察2组患儿治疗前后泪膜破裂时间(BUT)、泪液分泌试验(SIT)、泪河高度、裂隙灯下观察角膜荧光染色(FL)评分的变化情况,评价2组患儿的临床疗效。【结果】(1)治疗2周后,治疗组的总有效率为93.10%,对照组为56.90%;组间比较,治疗组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患儿的BUT、SIT、泪河高度、FL评分均较治疗前明显改善(P<0.01),且治疗组对BUT、SIT、泪河高度、FL评分的改善作用均明显优于对照组,差异均有统计学意义(P<0.01)。【结论】在人工泪液治疗儿童干眼的基础上配合雷火灸及耳穴贴压在临床上能够取得显著的治疗效果。

关键词：儿童干眼人工泪液雷火灸耳穴贴压临床疗效

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紫杉醇固体脂质纳米粒大鼠体内药动学

沈阳药科大学学报 2010年第3期27卷 240-243页

作者：孙铭韩静张多婷张玥杨静李智沈阳药科大学制药工程学院辽宁沈阳110016

目的研究紫杉醇固体脂质纳米粒在大鼠体内的药动学。方法10只健康大鼠,雌雄各半,分为2组,分别口服给药紫杉醇固体脂质纳米粒和紫杉醇乳剂30 ***-1,在设计的时间点从颈静脉取血,采用RP-HPLC测定紫杉醇在全血中的药物浓度,药动学参数用3P9... 详细信息

目的研究紫杉醇固体脂质纳米粒在大鼠体内的药动学。方法10只健康大鼠,雌雄各半,分为2组,分别口服给药紫杉醇固体脂质纳米粒和紫杉醇乳剂30 ***-1,在设计的时间点从颈静脉取血,采用RP-HPLC测定紫杉醇在全血中的药物浓度,药动学参数用3P97软件进行处理。结果大鼠口服给药后,紫杉醇固体脂质纳米粒和乳剂的tm ax分别为3.133 h和1.627 h,MRT分别为10.362 h和3.297 h,mρax分别为1.512 2 mg.L-1和0.718 9 mg.L-1。结论固体脂质纳米粒能够显著改善大鼠体内紫杉醇的药动学行为,有利于其更好地发挥抗肿瘤作用。

关键词：紫杉醇反相高效液相色谱法固体脂质纳米粒药动学

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑life lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang li Wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan yue‑Peng Cai Kang li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous li deposition and highly reversible li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous li+flux lithium metal battery

Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

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Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng Zhou Yang Dai Guoyao yue Yiman Zhang Lulu li Zhong-Zhen Yu Peng Min Hao-Bin Zhang 21 State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfaces,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability

基于熵权与集成学习的半监督小样本树种分类研究

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森林工程 2025年第1期41卷 151-161页

作者：王静李静河南机电职业学院信息工程学院郑州451191 河南科技大学信息工程学院河南洛阳471000

针对传统半监督自训练分类方法易导致数据集混乱,影响后续小样本树种分类精度这一问题,基于熵权法(en-tropy weight,EW)与集成学习(ensemble learning,EL)提出EW-EL的半监督小样本树种分类方法。EW-EL在传统半监督自训练分类方法的理论... 详细信息

针对传统半监督自训练分类方法易导致数据集混乱,影响后续小样本树种分类精度这一问题,基于熵权法(en-tropy weight,EW)与集成学习(ensemble learning,EL)提出EW-EL的半监督小样本树种分类方法。EW-EL在传统半监督自训练分类方法的理论上引入EL的思想,以熵权法作为基础理论设计按基分类器当前训练周期下的F1分数计算的信息熵作为计算权重因子,再依信息熵越大基分类器越不稳定思想设计权重,使集成分类器分类概率更集中,减少集成分类器偏向性。结果显示,EW-EL较传统半监督自训练方法能更有效地均衡数据分布,使新加入数据的伪标签样本类别更准确。EW-EL所得到的小样本树种分类总精度(OA)为0.97、召回率(Recall)为0.96及Kappa系数为0.97,3种指标均优于监督分类、传统半监督自训练方法及利用传统EL机制所构建的半监督自训练方法。其中,EW-EL方法较融合软投票机制的半监督自训练方法,OA与Recall均提升了1%。EW-EL联合简单线性迭代聚类所制成的树种图在所选测试区内达到了94%。此外,进一步分析证明,EW-EL能通过集成诸多分类器,来实现更佳的小样本树种分类结果,更适用于低成本下的相关部门进行林业资源统计的工作。

关键词：无人机影像熵权法深度学习集成学习半监督小样本分类树种分类树种制图 EW-EL

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中国女性性工作者生殖道沙眼衣原体感染率的Meta分析

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中国艾滋病性病 2017年第4期23卷 318-321页

作者：岳晓丽李婧门佩璇王建龚向东中国医学科学院北京协和医学院皮肤病研究所中国疾病预防控制中心性病控制中心南京210042 中国医学科学院北京协和医学院医学信息研究所/图书馆北京100005

目的了解近年中国女性性工作者(FSW)生殖道沙眼衣原体(CT)的感染现状。方法检索中英文电子文献数据库,2006年1月至2015年12月公开发表的中国大陆FSW人群CT感染的论著,根据文献入选标准纳入符合要求的文献,使用R3.2.5软件进行Meta分析。... 详细信息

目的了解近年中国女性性工作者(FSW)生殖道沙眼衣原体(CT)的感染现状。方法检索中英文电子文献数据库,2006年1月至2015年12月公开发表的中国大陆FSW人群CT感染的论著,根据文献入选标准纳入符合要求的文献,使用R3.2.5软件进行Meta分析。结果共纳入符合标准的14篇文献进行Meta分析。中国大陆FSW人群CT合并感染率为16.39%[95%可信区间(CI):12.78%~20.35%],高、中、低档FSW的合并感染率分别为15.98%(95%CI:14.12%~17.94%)、16.62%(95%CI:14.97%~18.33%)和20.85%(95%CI:18.78%~23.00%)。聚合酶链式反应方法检测阳性率高于抗原检测方法,两种检测方法合并感染率分别为20.84%(95%CI:17.48%~24.41%)和9.93%(95%CI:5.43%~15.56%)。结论中国FSW人群CT感染率高,尤其是低档FSW,应加强相关人群CT筛查,推行核酸检测方法,及时发现传染源,采取有效措施控制该病流行。

关键词：女性性工作者沙眼衣原体 Meta分析

Single-cell omics: experimental workflow, data analyses and applications

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Science China life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao jing-Dong J.Han Qi liu Xiaohui Fan Chen li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening