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Fundamentals and application in phytoremediation of an efficient arsenate reducing bacterium Pseudomonas putida ARS1

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Journal of Environmental Sciences 2024年第3期137卷 237-244页

作者： Ze-Wen Wang guang Yang Jian Chen Yaoyu Zhou Avelino Nunez Delgado hui-Ling Cui Gui-Lan Duan Barry P.Rosen Yong-guan Zhu Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450052China State Key Lab of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Cellular Biology and Pharmacology Florida International UniversityHerbert Wertheim College of MedicineMiamiFL33199USA University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China College of Resources and Environment Hunan Agricultural UniversityChangsha 410128China Department of Soil Science and Agricultura Chemistry Engineering Polytechnic SchoolUniversity of Santiago de CompostelaCampus Univ.s/n27002LugoSpain

Arsenic is a ubiquitous environmental ***-mediated arsenic biotransformations significantly infuence arsenic mobility and *** transformations by soil and aquatic organisms have been well documented,while little is known regarding effects due to endophytic *** endophyte Pseudomonas putida ARS1 was isolated from rice grown in arsenic contaminated *** ARS1 shows high tolerance to arsenite(As(Ⅲ))and arsenate(As(V)),and exhibits efficient As(V)reduction and As(Ⅲ)effux *** exposed to 0.6 mg/L As(V),As(V)in the medium was completely converted to As(Ⅲ)by *** ARS1 within 4 *** sequencing showed that *** ARS1 has two chromosomal arsenic resistance gene clusters(arsRCBH)that contribute to efficient As(V)reduction and As(Ⅲ)effux,and result in high resistance to *** globosa is a strong arsenic accumulator with high potential for arsenic phytoremediation,which takes up As(Ⅲ)more efficiently than As(V).Co-culture of *** ARS1 and *** enhanced arsenic accumulation in *** by 69%,and resulted in 91%removal of arsenic(at initial concentration of 0.6 mg/L As(V))from water within 3 *** study provides a promising strategy for in situ arsenic phytoremediation through the cooperation of plant and endophytic bacterium.

关键词： Arsenic Pseudomonas putida Arsenate reduction Endophyte Wolffia globosa Phytoremediation

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Effect and mechanism of Qingre Huashi decoction on drug-resistant Helicobacter pylori

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World Journal of Gastroenterology 2024年第24期30卷 3086-3105页

作者： Miao-Miao Lin Shan-Shan Yang Qiu-yue Huang guang-hui Cui Xiao-Fen Jia Yao Yang Zong-Ming Shi hui Ye Xue-Zhi Zhang Department of Integrated Traditional Chinese and Western Medicine Peking University First HospitalBeijing 100034China Institute of Integrated Traditional Chinese and Western Medicine Peking UniversityBeijing 100034China

BACKGROUND Helicobacter pylori(HP),the most common pathogenic microorganism in stomach,can induce inflammatory reactions in the gastric mucosa,causing chronic gastritis and even gastric *** infection affects over 4.4 billion people globally,with a worldwide infection rate of up to 50%.The multidrug resistance of HP poses a serious challenge to *** has been monstrated that compared to bismuth quadruple therapy,Qingre Huashi decoction(QHD)combined with triple therapy exhibits comparable eradication rates but with a lower incidence of adverse reactions;in addition,QHD directly inhibit and kill HP in *** In this study,12 HP strains were isolated in vitro after biopsy during gastroscopy of HP-infected *** vitro,the minimum inhibitory concentration(MIC)values for clinical HP strains and biofilm quantification were determined through the E-test method and crystal violet staining,*** most robust biofilm-forming strain of HP was selected,and QHD was evaluated for its inhibitory and bactericidal effects on the strain with strong biofilm *** assessment was performed using agar dilution,E-test,killing dynamics,and transmission electron microscopy(TEM).The study also explored the impact of QHD on antibiotic resistance in these HP strains with strong biofilm *** violet method,scanning electron microscopy,laser confocal scanning microscopy,and(p)ppGpp chromatographic identification were employed to evaluate the effect of QHD on biofilm in strong biofilm-forming HP *** effect of QHD on biofilm and efflux pump-related gene expression was evaluated by quantitative polymerase chain ***-targeted metabolomics with UHPLC-MS/MS was used to identify potential metabolic pathways and biomarkers which were different between the NC and QHD *** HP could form biofilms of different degrees in vitro,and the intensity of formation was associated with the drug resistance of the *** had str

关键词： Qingre Huashi decoction Helicobacter pylori Drug resistance Biofilm Metabolomics

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Research Progress on the Influencing Factors and Preventive Interventions of Iron Deficiency

Expert Review of Chinese Medical

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Expert Review of Chinese Medical 2024年第2期2卷 23-29页

作者： Zhen hui yue Lu Tianjin Medical University Qilu Medical College

Iron is an important element that maintains the normal operation of the *** not only participates in various physiological reactions as a component of various enzymes,but also is an indispensable component in the synthesis of hemoglobin(Hb)and myoglobin,which transport *** two-thirds of the iron in the body is stored in the Hb of red blood cells,with a small amount present in myoglobin in muscle tissue and enzymes required for various metabolic *** remaining amount is mostly in the form of ferritin as a mobilized iron *** dietary iron intake is limited and the stored iron in the body is insufficient or depleted,iron deficiency *** deficiency can be further divided into three stages based on their severity,namely iron deficiency(ID),iron deficiency erythropoiesis(IDE),and iron deficiency anemia(IDA).This study aims to explore the prevalence,diagnosis and differentiation,influencing factors,and preventive interventions of iron deficiency.

关键词： epidemic influencing factors research progress

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Oxygen vacancy promoting artificial atom(RuPd)by d-orbital coupling for efficient water dissociation

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Nano Research 2024年第8期17卷 7045-7052页

作者： Ruofan Shen Yanyan Liu Shuling Liu Shuyan guan Huanhuan Zhang Sehrish Mehdi Saima Ashraf Ting-hui Xiao Erjun Liang Jianchun Jiang Yongfeng Wang Baojun Li Laboratory of Zhongyuan Light School of PhysicsZhengzhou UniversityZhengzhou 450001China Key Laboratory of Materials Physics Ministry of EducationSchool of PhysicsZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China College of Science Henan Agricultural UniversityZhengzhou 450002China Department of Chemistry Tsinghua UniversityBeijing 100084China National Engineering Lab.for Biomass Chemical Utilization Institute of Chemical Industry of Forest ProductsCAFNanjing 210042China Center for Carbon-based Electronics and Key Laboratory for the Physics and Chemistry of Nanodevices Department of ElectronicsPeking UniversityBeijing 100871China

Rational design of highly active catalysts for breaking hydrogen-oxygen bonds is of great significance in energy chemical reactions involving ***,an efficient strategy for the artificial atom(RuPd)established by d-orbital coupling and adjusted by oxygen vacancy(V_(O))is verified for water *** an experimental verification,the turnover frequency of RuPd-TiO_(2)-VO(RuPdTVO)catalyst in ammonia borane hydrolysis reaches up to 2750 min^(−1)(26,190 min−1 based on metal dispersion)in the absence of alkali,exceeding the highest active catalysts(Rh-based catalysts).The d-orbital coupling effect between Ru and Pd simulates the outer electronic structure of *** transfer from V_(O) to(RuPd)constructs an electron-rich state of active sites that further enhances the ability of the artificial atom to dissociate *** work provides an effective electronic regulation strategy from V_(O) and artificial atom constructed by d-orbital coupling effect for efficient water dissociation.

关键词： ammonia borane hydrolysis d-orbital coupling oxygen vacancy artificial atom water dissociation

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Circ_0053943 complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of Epidermal growth factor receptor

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Oncology Research 2024年第5期32卷 983-998页

作者： ANDI ZHAO yue WANG ZIJIN WANG QING SHAO QI GONG hui ZHU SHIYA SHEN HU LIU XUEJUAN CHEN Department of Ophthalmology The First Affiliated Hospital with Nanjing Medical UniversityNanjing210029China The First Clinical Medical College Nanjing Medical UniversityNanjing211166China Department of Ophthalmology Nanjing First HospitalNanjing Medical UniversityNanjing210006China

Numerous studies have characterized the critical role of circular RNAs(circRNAs)as regulatory factors in the progression of multiple ***,the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma(UM)remain *** this study,we identified a novel circRNA,circ_0053943,through re-analysis of UM microarray data and quantitative ***_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo ***,circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like growth factor 2 mRNA-binding protein 3(IGF2BP3),thereby enhancing the function of IGF2BP3 by stabilizing its target *** sequencing assays identified epidermal growth factor receptor(EGFR)as a target gene of circ_0053943 and IGF2BP3 at the transcriptional *** assays demonstrated that circ_0053943 exerts its biological function by stabilizing EGFR mRNA and regulating the downstream mitogen-activated protein kinase/extracellular signal-regulated kinase(MAPK/ERK)signaling ***,circ_0053943 may promote UM progression by stabilizing EGFR mRNA and activating the MAPK/ERK signaling pathway through the formation of a circ_0053943/IGF2BP3/EGFR RNA-protein ternary complex,thus providing a potential biomarker and therapeutic target for UM.

关键词： Uveal melanoma Hsa_circ_0053943 IGF2BP3 EGFR MAPK/ERK signaling pathway

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Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1344-1362页

作者： Zi-Ling Hu Yu-Xuan Wang Zi-yue Lin Wen-Shuo Ren Bo Liu hui Zhao Qiong Qin Five Year Program of Ophthalmology and Optometry 2019 Beijing Tong Ren HospitalCapital Medical UniversityBeijing 100054China Four Year Program of Traditional Chinese Pharmacy 2020 School of Traditional Chinese MedicineCapital Medical UniversityBeijing 100069China School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Beijing Key Laboratory of TCM Collateral Disease Theory Research Beijing 100069China Five Year Program of Ophthalmology and Optometry 2021 School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Biochemistry&Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Age-related macular degeneration(AMD)is a complicated disease that causes irreversible visual *** evidences pointed retinal pigment epithelia(RPE)cells as the decisive cell involved in the progress of AMD,and the function of anti-oxidant capacity of PRE plays a fundamental physiological *** factor erythroid 2 related factor 2(Nrf2)is a significant transcription factor in the cellular anti-oxidant system as it regulates the expression of multiple anti-oxidative *** functions of protecting RPE cells against oxidative stress(OS)and ensuing physiological changes,including inflammation,mitochondrial damage and autophagy dysregulation,have already been *** the roles of upstream regulators of Nrf2 could provide further insight to the OS-mediated AMD *** the first time,this review summarized the reported upstream regulators of Nrf2 in AMD pathogenesis,including proteins and miRNAs,and their underlying molecular mechanisms,which may help to find potential targets via regulating the Nrf2 pathway in the future research and further discuss the existing Nrf2 regulators proved to be beneficial in preventing AMD.

关键词： Nrf2 upstream regulators retinal pigment epithelia age-related macular degeneration oxidative stress

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Microstructure and Mechanical Behavior of Mg-Based Bimetal Plates with High Formability Sleeve by Co-extrusion

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 499-512页

作者： yue-hui Dang Sheng-Lin Liu Xiao-Lei Ai Xiao-Wei Feng Bo Feng Zhuo Tian Ying-Fei Lin Huan-Tao Chen Kai-Hong Zheng School of Materials Science and Engineering Chang’an UniversityShaanxi 710064China guangdong Key Laboratory of Metal Toughening Technology and Application Institute of New MaterialsGuangdong Academy of SciencesGuangzhou 510650China

In this study,microstructure and mechanical behavior of two types of Mg-based bimetal plates with a high formability sleeve were systematically studied,with a great emphasis on the effect of the interface characteristic and the sleeve fraction on the plasticity of composite *** rule of mixtures(ROM)for elongation was also *** results show that when there is no or thin diffusion layer with thickness of about 3μm,Mg-based bimetal plates have a good plasticity with elongation of about 19-24%,and the ROM predicted elongations are very close to the experimental *** contrast,with a diffusion layer about 95-155μm thick,Mg-based bimetal plates exhibit a poor plasticity with elongation of about 11-17%,and the experimental elongations largely deviate from the ROM *** plasticity of Mg-based bimetal plates increases with increasing sleeve *** study provides new insights on the plastic deformation of Mg-based bimetal composites with a high formability sleeve.

关键词： Mg-based composites Co-extrusion Microstructure Mechanical behavior Plastic deformation

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Core-shell nanoparticle enhanced Raman spectroscopy in situ probing the composition and evolution of interfacial species on PtCo surfaces

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Nano Research 2024年第6期17卷 4687-4692页

作者： Jing Liu Han-Liang Zhong Xiangyu Li Mu-Fei yue Wei-Min Yang Xueqiu You Jing-Hua Tian Yao-hui Wang Jian-Feng Li Fujian Provincial Key Laboratory of Oceanic Information Perception and Intelligent Processing School of Ocean Information EngineeringJimei UniversityXiamen 361021China College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Physical Chemistry of Solid Surfaces MOE Key Laboratory of Spectrochemical Analysis and InstrumentationiChEMCollege of Chemistry and Chemical EngineeringCollege of MaterialsCollege of EnergyXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Shenzhen Research Institute of Xiamen University Shenzhen 518000China

The composition and evolution of interfacial species play a key role during electrocatalytic *** the structural evolution and intermediate during catalytic process by in situ characterization can shed new light on the electrocatalytic reaction mechanism and develop highly efficient ***,directly probing the interfacial species is extremely difficult for most spectroscopic techniques due to complicated interfacial environment and ultra-low surface ***,electrochemical core-shell nanoparticle enhanced Raman spectroscopy is utilized to probe the composition and evolution processes of interfacial species on Au@Pt,Au@Co,and Au@PtCo core-shell nanoparticle *** spectral evidences of interfacial intermediates including hydroxide radical(OH*),superoxide ion(O_(2)^(−)),as well as metal oxide species are directly captured by in situ Raman spectroscopy,which are further confirmed by the both isotopic experiment and density functional theory *** results provide a mechanistic guideline for the rational design of highly efficient electrocatalysts.

关键词： in situ Raman core-shell nanoparticle PtCo interfacial species composition and evolution

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Thymic carcinoid with multiple bone metastases:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2275-2280页

作者： Chun-Qiao Chen Ming-yue Huang Min Pan Qiu-Qiu Chen Fei-Fei Wei hui Huang Department of Oncology People’s Hospital of GuilinGuilin 541000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Thymic carcinoid(TC)is a rare entity among anterior mediastinal *** are neuroendocrine carcinomas that constitute approximately 2%–5%of all thymic epithelial *** SUMMARY The study reported a rare TC with multiple bone metastases.A 77-year-old man presented with a 2-month history of lower back pain and weight loss of 5 *** resonance imaging scans revealed damage to the lumbar spine,sacrocaudal vertebrae and iliac crest,suggesting bone metastasis;computed tomography(CT)scan of the thorax showed a calcified anterior mediastinal mass;positron emission tomography-CT demonstrated multiple abnormal bone signals;and laboratory work-up showed no endocrine ***-needle aspiration biopsy revealed predominantly single small,round to oval cells with scant cytoplasm and some loose clusters,suggesting endocrine *** pathological diagnosis was atypical carcinoid,which tend to originate from the thymus and was classified as intermediate-highly *** patient underwent anlotinib-targeted ***(12 mg)was administered daily for 2 wk,after which the patient was allowed to rest for 21 ***-up CT after one year demonstrated that the tumor had shrunk by approximately 29%after *** has a long stable disease benefit of more than 2.5 *** These findings demonstrated that anlotinib is a promising treatment regimen for patients with TC and multiple bone metastases.

关键词： Thymic carcinoid Anlotinib Multitargeted tyrosine kinase inhibitor Bone metastasis Case report

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Characteristics of geological structures in Shiling and Zhuanshanhu areas of Yehe Uplift,NE China

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Global Geology 2024年第2期27卷 105-120页

作者： guan yue YU Yinghua ZHANG Yaxiong YUAN Hongqi Key Laboratory of Oil and Gas Reservoir Formation Mechanism and Resource Evaluation in Heilongjiang Province Daqing 163318HeilongjiangChina Sinopec Petroleum Exploration and Production Research Institute Beijing 100083China

The basin marginal fault system is the key to understand the formation and evolution of Songliao *** order to investigate the influence of marginal fault system on the structural evolution of Songliao Basin,a comprehensive study was conducted on Shiling Town and Zhuanshanhu area of Yehe Town in Siping City of Jilin Province,where is the southeastern margin of the Songliao Basin and there are a series of well-exposed fault,fold and intrusive bodies belonging to the main marginal fault system of the Songliao Basin known as the Jiamusi-Yitong(Jia-Yi)fault *** profile measurement and field investigation,samples with various lithologies and distinctive features were *** field and laboratory works include component and microstructure analysis of these samples,rock-rock contact analysis,main strike measurement and statistics *** data reveal the structural characteristics of the fold,fault and intrusive bodies in the study *** research results show that the folds are distributed in the Mesozoic strata near the main fault of the eastern branch of the Jia-Yi fault zone,and the folded strata involve the Cretaceous Denglouku and Quantou *** addition,the section is dominated by high-angle strikeslip thrust ***-colored veins and dark-colored veins are extensively distributed in the exposed *** analysis of joint and fault attitudes in the study area reveals a right-lateral strike-sliping along the main *** large-scale right-lateral strike-slip and thrust fault system in Shiling Town occurred in right-lateral transpressive stage in Late *** on the results above,tectonic evolution sequence in Shiling section of the Jia-Yi fault zone during the Mesozoic can be divided into five stages:Middle Jurassic left-lateral ductile strike-slip stage,Late Jurassic compression stage,Early Cretaceous tension stage,Early Cretaceous extension stage and Late Cretaceous right-lateral transpressive stage

关键词： Jia-Yi fault structural characteristics evolution sequence Shiling Zhuanshanhu northern segment Tanlu fault

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