检索结果-南通市图书馆

Traditional Uses and Pharmacologically Active Constituents of Dendrobium Plants for Dermatological Disorders:A Review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2021年第5期11卷 465-487页

作者： yue-hu wang Key Laboratory of Economic Plants and Biotechnology The Yunnan Key Laboratory for Wild Plant Resourcesand Bio-Innovation Center of DR PLANTKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201People’s Republic of China

than 80 Dendrobium species have been reported in China.However,there are only six Dendrobium species,namely,D.bigibbum var.superbum(syn.D.phalaenopsis),D.chrysanthum,D.fimbriatum,D.loddigesii,D.nobile,and D.officinale(syn.D.candidum),listed in the New Inventory of Existing Cosmetic Ingredients in China Launched.Artificial planting of Dendrobium species has been a great success in China.To better utilize Dendrobium resources for medicinal and cosmetic purposes,we summarize their traditional uses and pharmacologically active compounds for treating dermatological disorders in this review.“Orchidaceae”,“Dendrobium”,“traditional use”,“ethnobotany”,“dermatological disorder”,and“skin disease”were used as search terms to screen the literature.Cited references were collected between 1970 and 2020 from the Web of Science,China National Knowledge Internet(CNKI),SciFinder,Google Scholar,and Chinese books.From the search,it was found that there are 22 Dendrobium species with traditional uses in dermatological disorders,and 131 compounds from Dendrobium plants have been reported to possess anti-inflammatory,antimicrobial,antioxidant,antiaging,anti-psoriasis,and tyrosinase-inhibitory activities,implying that Dendrobium plants are important resources for the discovery of active compounds and the development of new drugs and cosmetics.D.crepidatum,D.denneanum,D.loddigesii,D.nobile,and D.officinale have been extensively studied.More research on other Dendrobium species is needed.The major active compounds found in Dendrobium species are phenanthrenes,alkaloids,flavonoids,phenylpropanoids,and lignans.Several compounds,such as loddigesiinol A,(S)-5-methoxy-2,4,7,9-tetrahydroxy-9,10-dihydrophenanthrene,(S)-4-methoxy-2,5,7,9-tetrahydroxy-9,10-dihydrophenanthrene,2,5-dihydroxy-4-methoxy-phenanthrene 2-O-β-d-glucopyranoside,(9R)-1,2,5,9-tetrahydroxy-9,10-dihydrophenanthrene 5-O-β-d-glucopyranoside,(+)-homocrepidine A,and vicenin 2,have significant anti-inflammatory activities and inhibit nitric oxide(NO)production with IC_(50) values le

关键词： Orchidaceae Dendrobium Traditional uses Dermatological disorders Anti-inflammatory

Five new 2-(2-phenylethyl)chromone derivatives and three new sesquiterpenoids from the heartwood of Aquilaria sinensis, an aromatic medicine in China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2022年第1期12卷 12-25页

作者： Lu Zhang Ping Yi hui Yan Xiao-Nian Li Meng-Yuan Xia Jun Yang Ji-Feng Luo yue-Qiu He yue-hu wang Key Laboratory of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant Resourcesand State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Key Laboratory of Chemistry for Natural Products of Guizhou Province Chinese Academy of SciencesGuiyang 550014People’s Republic of China Faculty of Plant Protection Yunnan Agricultural UniversityKunming 650201People’s Republic of China

Five new 2-(2-phenylethyl)chromone derivatives,(5S,6R,7R,8S,7ʹR)-7ʹ-hydroxyagarotetrol(1),(5S,6R,7R,8S,7ʹS)-7ʹ-hydroxyagarotetrol(2),(6S,7S,8R)-2-[2-(4-methoxyphenyl)ethyl]-6,7,8-trihydroxy-5,6,7,8-tetrahydrochromone(3),(6S,7S,8R)-2-(2-phenylethyl)-6,7,8-trihydroxy-5,6,7,8-tetrahydrochromone(4),(5S,6R,7S,8R)-2-(2-phenylethyl)-5,6,7-trihydroxy-5,6,7,8-tetrahydro-8-[2-(2-phenylethyl)-7-methoxychromonyl-6-oxy]chromone(5),three new sesquiterpenoids,(4S,5S,7S,8S,10S,13R)-7,8,13-trihydroxyrotunda-1,11-dien-3-one(6),(4S,5S,7S,8S,10S,13S)-7,8,13-trihydroxyrotunda-1,11-dien-3-one(7),and(4R,5S,7S,8S,10S,13S)-7,8,13-trihydroxyrotunda-1,11-dien-3-one(8),along with 14 known compounds were isolated from the resinous heartwood of Aquilaria sinensis(Thymelaeaceae).The chemical structures of these new compounds were elucidated by 1D and 2D NMR and MS data,single-crystal X-ray diffraction analysis,and electronic circular dichroism(ECD)calculations.The neuroprotective activities of these isolates were evaluated using an in vitro model of rat adrenal pheochromocytoma(PC12)cell injury induced by corticosterone.At concentrations from 5 to 40μM,compounds 4 and 6,agarotetrol(9),and 6-hydroxy-2-(2-phenylethyl)chromone(17)showed significant protective activities against corticosterone-induced PC12 cell injury(P<0.001).

关键词： Thymelaeaceae Aquilaria sinensis Sesquiterpenoids 2-(2-Phenylethyl)chromones Neuroprotective

Sesquiterpenoids and 2-(2-Phenylethyl)chromone Derivatives from the Resinous Heartwood of Aquilaria sinensis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2021年第5期11卷 545-555页

作者： Shu‑Ya Wei Dong‑Bao hu Meng‑Yuan Xia Ji‑Feng Luo hui Yan Jing‑hua Yang Yun‑Song wang yue‑hu wang Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationSchool of Chemical Science and TechnologySchool of PharmacyYunnan UniversityKunming 650091People’s Republic of China Key Laboratory of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant Resourcesand State Key Laboratory of Phytochemistry and Plant Resources in West ChinaChinese Academy of SciencesKunming 650201People’s Republic of China School of Chemical Biology and Environment Yuxi Normal UniversityYuxi 653100People’s Republic of China

One novel spirolactone,aquilarisinolide(1),three new sesquiterpenoids,(2R,4S,5R,7R)-2-hydroxyeremophila-9,11-dien-8-one(2),(1R,4S,5S,7R,11R)-13-hydroxyepidaphnauran-9-en-8-one(3),and(4R,5S,7R,8S,10S,13R)-8,13-dihydroxyrotunda-1,11-dien-3-one(4),together with 13 known compounds(5-17)were isolated from the resinous heartwood of Aquilaria sinensis(Thymelaeaceae).The structures of the new compounds were elucidated based on the analysis of NMR and MS data and theoretical calculations their ECD spectra.The isolated compounds were evaluated for their protective activities against PC12 cell injury induced by corticosterone(CORT)and 1-methyl-4-phenylpyridine ion(MPP+),as well as inhibitory activities against BACE1.Compound 4,5,6-dihydroxy-2-(2-phenylethyl)chromone(5),daphnauranol B(7),6-methoxy-2-[2-(3-methyoxyphenyl)ethyl]chromone(10),isoagarotetrol(14),and 1-hydroxy-1,5-diphenylpentan-3-one(16)showed significant protective effects on CORT-induced injury in PC12 cells at a concentration of 20μM(P<0.001).Isoagarotetrol(14)showed a significant protective effect on MPP+-induced injury in PC12 cells at a concentration of 20μM(P<0.001),while compound 4 showed a moderate activity(P<0.01).The BACE1-inhibitory activities of all tested compounds were very weak with less than 30%inhibition at a concentration of 20μM.

关键词： Thymelaeaceae Aquilaria sinensis Sesquiterpenoids 2-(2-phenylethyl)chromones Neuroprotective

Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L.,a Traditional Folk Medicine of Myanmar

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2019年第3期9卷 243-249页

作者： Nay Lin Tun Dong-Bao hu Meng-Yuan Xia Dong-Dong Zhang Jun Yang Thaung Naing Oo yue-hu wang Xue-Fei Yang Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China College of Resources and Environment Yuxi Normal UniversityYuxi 653100People’s Republic of China Forest Research Institute YezinNay Pyi Taw 05282Myanmar

We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L.,a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases.A new neolignan,(7S,8R)-9′-O-acetylcedrusin(1),a new lactam,(3S,4S)-4-chloro-3-hydroxypiperidin-2-one(2),along with 21 known compounds,including fve lignans(3-7),four favonoid glycosides(8-11),and others(12-23),were isolated from the ethanoic extract of the aerial parts of L.aequata.The structures of the new compounds were determined by NMR,MS,and ECD spectra.For all the antimicrobial tests of the 23 compounds,only 3,4,5-trihydroxybenzoic acid ethyl ester(17)showed weak inhibitory activities against Escherichia coli and Salmonella enterica subsp.enterica.

关键词： Leea aequata Vitaceae Traditional medicines Lignans Flavonoids

New Amides and Phenylpropanoid Glucosides from the Fruits of Piper retrofractum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2019年第3期9卷 231-241页

作者： Rong Tang Ya-Qiong Zhang Dong-Bao hu Xue-Fei Yang Jun Yang Myint Myint San Thaung Naing Oo Yi Kong yue-hu wang Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China School of Life Science&Technology China Pharmaceutical UniversityNanjing 210009People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China School of Chemical Biology and Environment Yuxi Normal UniversityYuxi 653100People’s Republic of China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar Forest Research Institute YezinNay Pyi Taw 05282Myanmar

Two new amides(E)-N-cinnamoyl-2-methoxypiperidine(1)and(R)-1-(2-oxopyrrolidin-3-yl)-5,6-dihydropyridin-2(1H)-one(2),four new amide glucosides,retrofractosides A-D(3-6),and two new phenylpropanoid glucosides,retrofractosides E(7)and F(8),together with 24 known compounds(9-32)were isolated from the fruits of Piper retrofractum.The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis.All of these isolates(1-32)were evaluated for inhibitory activity against mouse platelet aggregation induced by the peptide AYPGKF-NH2.(E)-N-(Tetrahydro-2H-pyran-2-yl)cinnamamide(9)showed a weak inhibitory efect,with an inhibition ratio of 52.0%at a concentration of 150μM.

关键词： Piper retrofractum Piperaceae Antiplatelet Amides Phenylpropanoids

Neolignans from Selaginella moellendorffii

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2016年第3期6卷 161-166页

作者： Jing-Xian Zhuo yue-hu wang Xing-Li Su Ren-Qiang Mei Jun Yang Yi Kong Chun-Lin Long Key Laboratory of Economic Plants and Biotechnology and Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China School of Life Science&Technology China Pharmaceutical UniversityNanjing 210009China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China

Two new neolignans selaginellol(1)and selaginellol 4'-O-β-D-glucopyranoside(2),together with seven known compounds(3–9),were isolated from the whole plant of Selaginella moellendorffii.The structures of the new isolates were determined through spectroscopic data analysis.Compounds 1–9,as well as compounds 10–18 previously isolated from the species,were measured for the activity against platelet aggregation induced by ADP or collagen.Three neoligans(8,11,and 12),one flavanone(14),and one alkaloid(16)showed inhibitory activity against ADP-or collagen-induced platelet aggregation as compared with tirofiban.The dihydrobenzofuran neolignans(8,11,and 12)are more potent than the benzofuran neolignan(13)and other types of neolignans(1–7).Glucosidation of the dihydrobenzofuran neolignans(11 and 12)is helpful for the activity.Graphical Abstract Two new neolignans selaginellol(1)and selaginellol 40-O-b-D-glucopyranoside(2)were isolated from the whole plant of Selaginella moellendorffii.Several compounds from this plant showed the activity against platelet aggregation induced by ADP or collagen.

关键词： Selaginellaceae Selaginella moellendorffii Lignans Antiplatelet

Chemical Constituents from the Whole Plant of Cuscuta reflexa

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2020年第5期10卷 337-344页

作者： Tin Thu Thu Aung Meng-Yuan Xia Pyae Phyo Hein Rong Tang Dong-Dong Zhang Jun Yang Xue-Fei Yang Dong-Bao hu yue-hu wang Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China School of Chemical Biology and Environment Yuxi Normal UniversityYuxi 653100People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

Two new 2H-pyran-2-one glucosides,cuscutarosides A(1)and B(2),and one new steroidal glucoside,7β-methoxy-β-sitosterol 3-O-β-glucopyranoside(3),together with 12 known compounds(4-15)were isolated from the whole plant of Cuscuta reflexa(Convolvulaceae)collected from Myanmar.The chemical structures of these new compounds were elucidated based on extensive spectroscopic analysis.The antiobesity activity of these isolates was evaluated using porcine pancreatic lipase(PPL),and the antiplatelet aggregation activity was screened using rabbit platelets induced by thrombin,platelet-activating factor(PAF),arachidonate(AA),or collagen.7β-Methoxy-β-sitosterol 3-O-β-glucopyranoside(3)showed weak PPL inhibitory activity.Cuscutaroside A(1),its acetylated derivative(1a),and scrophenoside B(8)showed weak inhibitory activity against rabbit platelet aggregation induced by collagen.Compound 1a also showed inhibitory activity against rabbit platelet aggregation induced by AA.

关键词： Cuscuta reflexa Porcine pancreatic lipase Platelet aggregation 2H-pyran-2-one glucosides Steroidal glucosides

Amides,Isoquinoline Alkaloids and Dipeptides from the Aerial Parts of Piper mullesua

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural Products and Bioprospecting 2018年第6期8卷 419-430页

作者： Meng-Yuan Xia Jun Yang Pan-hua Zhang Xiao-Nian Li Ji-Feng Luo Chun-Lin Long yue-hu wang Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081People’s Republic of China Key Laboratory of Ethnomedicine(Minzu University of China) Ministry of EducationBeijing 100081People’s Republic of China

One undescribedamide,pipermullesine A,twoundescribed isoquinoline alkaloids,pipermullesinesBand C,and six undescribed dipeptides,pipermullamides A–F,along with 28 known compounds,were isolated from the aerial parts of Piper mullesua.The structures of the undescribed compounds were elucidated based on the analysis of 1D and 2D NMR and MS data.Furthermore,the structures of pipermullesines A–Cwere confirmed by single crystal X-ray diffraction analysis.All isolates were evaluated for inhibitory activity against platelet aggregation induced by thrombin(IIa)or platelet-activating factor(PAF).(-)-Mangochinine,pellitorine,and(2E,4E)-N-isobutyl-2,4-dodecadienamide showed weak inhibitory activity against rabbit platelet aggregation induced by PAF,with IC_(50)values of 470.3μg/mL,614.9μg/mL,and 579.7μg/mL,respectively.

关键词： Piper mullesua Piperaceae Antiplatelet Amides Isoquinoline alkaloids

A new isoflavonolignan from Pueraria alopecuroides Craib

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第3期18卷 297-299页

作者： Zhen Zhang Guang Ming Liu yue hu wang Chun Shun Li yan Li Ren huai Xiao XJao Jang Hao Hong Ping He State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Science Kunming 650204 China College of Pharmaceutical Sciences Dali University Dali 677100 China

A new isoflavonolignan has been isolated from the Pueraria alopecuroides Craib. The structure was elucidated by the combination of 1D, 2D NMR analysis and mass spectrometry.

关键词： Pueraria alopecuroides Craib Chemical constituents Isoflavonolignan