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Maternally expressed gene 3 regulates retinal neovascularization in retinopathy of prematurity

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Neural Regeneration Research 2022年第6期17卷 1364-1368页

作者： Yu Di yue wang yue-xia wang Xue wang Yuan Ma Qing-Zhu Nie Department of Ophthalmology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

The mouse model of oxygen induced retinopathy is suitable for the study of various retinal neovascularization diseases,including retinopathy of *** maternally expressed gene 3(MEG3)has been demonstrated to have an inhibitory effect on diabetic *** this study,we investigated the role of MEG3 overexpression in oxygen-induced retinopathy in *** results showed that MEG3 overexpression effectively inhibited the production of retinal neovascularization in oxygen-induced retinopathy *** acts by down-regulating the expression of phosphoinositide 3-kinase,serine/threonine kinase,and vascular endothelial growth factor and pro-inflammatory ***3 overexpression lentivirus has a future as a new method for the clinical treatment of retinopathy of *** animal experiments were approved by the Animal Ethics Committee of Shengjing Hospital of China Medical University,China(approval No.2016PS074K)on February 25,2016.

关键词： long noncoding RNA maternally expressed gene 3 neurodevelopment oxygen-induced retinopathy phos

Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei xia yue Ma Mingtong Gao Shuai Hou Shanshan Xu Yanqiang wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

Research progress and development tendency on storage mechanism of multi-principal element alloys for hydrogen/tritium storage

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Rare Metals 2024年第11期43卷 5549-5572页

作者： Yi-Jie Chen Jian-Wei Zhang Can-Hui Xu Mu-Hong Li Shuang-Lin Hu yue-xia wang xiao-Tao Zu Hai-Yan xiao xiao-Song Zhou Shu-Ming Peng Hua-Hai Shen Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Physics and Ion-Beam Application(MOE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghai 200433China School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China

Sustainable clean energy is gradually replacing traditional fossil energy sources in important industrial applications and is placing higher demands on the technologies of energy storage and *** development of multi-principal element alloys(MPEAs)offers a new idea for safe solid-state hydrogen storage *** to the unique characteristics of complex components and severe lattice distortion,MPEAs are predicted to have better hydrogen storage performance and more probability for modulation and enhancement,allowing them to meet the requirements of different hydrogen storage *** unique structure characteristic potentially devotes the improvement of thermodynamic and kinetic performance,such as the hydrogen storage capacity and hydrogen adsorption/desorption ***,several important modulation factors originating from components and structures facilitate the understanding of the correlation between hydrogen storage properties and ***,we highlight the correlations of hydrogen storage mechanism,with the degree of lattice distortion,the element variation or segregation and valence electron ***,the development tendency on the hydrogen storage mechanism based on the advanced microscopy and computational approach is ***,the chemically short-range ordered structure in MPEAs is predicted as a potential modification factor of the hydrogen/tritium storage properties.

关键词： Multi-principal element alloys(MPEAs) Hydrogen/Tritium storage Hydrogenation mechanism Development tendency Advanced microscopy

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OCT在弱视患者眼底研究中的应用

国际眼科杂志 2021年第12期21卷 2086-2089页

作者：马媛王雪王月王月霞底煜中国医科大学附属盛京医院眼科中国辽宁省沈阳市110000

弱视是一种常见的儿童眼部疾病,如未进行及时的矫正与治疗,将对儿童视力造成不可逆的损伤,导致单眼或双眼视力下降或丧失。弱视的发病原因复杂,目前具体发病机制尚不明确,主要集中于中枢学说与外周学说,既往传统观念认为弱视患者眼底无... 详细信息

弱视是一种常见的儿童眼部疾病,如未进行及时的矫正与治疗,将对儿童视力造成不可逆的损伤,导致单眼或双眼视力下降或丧失。弱视的发病原因复杂,目前具体发病机制尚不明确,主要集中于中枢学说与外周学说,既往传统观念认为弱视患者眼底无明显器质性改变。近年来光学相干断层扫描(OCT)技术迅速发展,作为一种便捷、直观的眼科检查手段,其安全无创、非接触性及快速清晰的优点,使OCT越来越多地应用于弱视患者的视网膜检查,弱视患者眼底结构存在的异常解剖学结构也逐渐被发现,为弱视的外周学说发病机制提供一定佐证和依据,对弱视的检查、治疗评估和预后也起到一定作用,本文对OCT技术对弱视患者视网膜厚度、脉络膜厚度及血管密度的研究情况进行综述。

关键词：弱视光学相干断层扫描(OCT) 视网膜厚度脉络膜厚度血管密度

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li Wen‑xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan yue‑Peng Cai Kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats

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World Journal of Gastroenterology 2010年第48期16卷 6111-6118页

作者： Ji-Wu Han,Department of Gastroenterology,The 4th Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China xiao-Rong Zhan,Xin-Yu Li,Bing xia,yue-Ying wang,Jing Zhang,Department of Endocrinology,First Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China Bao-Xin Li,Department of Pharmacology,State Key Laboratory of Biomedicine and Pharmacology,Harbin Medical University,Harbin 150001,Heilongjiang Province,China Department of Endocrinology First Hospital of Harbin Medical University Harbin 150001 Heilongjiang Province China.

AIM:To determine whether mitochondrial dysfunction resulting from high-fat diet is related to impairment of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt,also known as PKB) pathway. METHODS:Rat models of nonalcoholic fatty liver were established by high-fat diet feeding. The expression of total and phosphorylated P13K and Akt proteins in hepatocytes was determined by Western blotting. Degree of fat accumulation in liver was measured by hepatic triglyceride. Mitochondrial number and size were determined using quantitative morphometric analysis under transmission electron microscope. The permeability of the outer mitochondrial membrane was assessed by determining the potential gradient across this ***:After Wistar rats were fed with high-fat diet for 16 wk,their hepatocytes displayed an accumulation of fat (103.1 ± 12.6 vs 421.5 ± 19.7,P < 0.01),deformed mitochondria (9.0% ± 4.3% vs 83.0% ± 10.9%,P < 0.05),and a reduction in the mitochondrial membrane potential (389.385% ± 18.612% vs 249.121% ± 13.526%,P < 0.05). In addition,the expression of the phosphorylated P13K and Akt proteins in hepatocytes was reduced,as was the expression of the anti-apoptotic protein Bcl-2,while expression of the pro-apoptotic protein caspase-3 was increased. When animals were treated with pharmacological inhibitors of P13K or Akt,instead of high-fat diet,a similar pattern of hepatocellular fat accumulation,mitochondrial impairment,and change in the levels of PI3K,Akt,Bcl-2 was observed. CONCLUSION:High-fat diet appears to inhibit the PI3K/Akt signaling pathway,which may lead to hepa-tocellular injury through activation of the mitochondrial membrane pathway of apoptosis.

关键词： Nonalcoholic fatty liver Phosphatidylinositol 3-kinase/protein kinase B signaling pathway Mitochondria B-cell lymphoma gene 2 Caspase-3

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鸡全蛋粉中金属硫蛋白检测方法的研究

食品工业科技 2018年第19期39卷 214-219页

作者：张根生岳晓霞王芮常虹哈尔滨商业大学黑龙江省普通高等学校食品科学与工程重点实验室黑龙江哈尔滨150076

使用5,5'-二硫硝基苯甲酸(DTNB)比色法来测定鸡全蛋粉中的金属硫蛋白含量,采用酸水解的方法对样品进行前处理,通过单因素和正交试验确定最优条件为:水解时间24 h,盐酸浓度6 mol/L,质量体积比1∶20 g/m L,水解温度130℃,在此条件下,水解... 详细信息

使用5,5'-二硫硝基苯甲酸(DTNB)比色法来测定鸡全蛋粉中的金属硫蛋白含量,采用酸水解的方法对样品进行前处理,通过单因素和正交试验确定最优条件为:水解时间24 h,盐酸浓度6 mol/L,质量体积比1∶20 g/m L,水解温度130℃,在此条件下,水解度为55.28%,金属硫蛋白含量为0.4821 mg/g。在前处理后对检测方法的反应条件及试剂配制条件进行优化,最终选用pH为4.0的磷酸氢二钠-柠檬酸缓冲液配制Ellman试剂,反应最佳pH为7.2。得到的线性回归方程为Y=0.019x+0.027,R2=0.999,呈良好的线性关系。加标回收率在75.83%~88.15%,相对标准偏差为3.10%,该方法具有较好的重现性和准确度和精密度,方法检测限为7.57μg/g,本方法可以用于样品中金属硫蛋白(MTs)的快速检测。

关键词：比色法鸡全蛋粉金属硫蛋白快速检测

静脉用药调配中心配置护士分层管理的工作实践

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解放军药学学报 2016年第4期32卷 378-379页

作者：王丽萍岳红霞王书杰解放军251医院护理部河北张家口075000 解放军251医院药剂科河北张家口075000

目的对静脉用药调配中心的配置护士实行分层管理,提高服务质量和患者满意度。方法将配置护士按照老、中、青进行搭配,在质量、教育、绩效等方面分大、小组长和组员3层进行管理。结果通过对静配中心配置护士分层管理,极大地调动了全体配... 详细信息

目的对静脉用药调配中心的配置护士实行分层管理,提高服务质量和患者满意度。方法将配置护士按照老、中、青进行搭配,在质量、教育、绩效等方面分大、小组长和组员3层进行管理。结果通过对静配中心配置护士分层管理,极大地调动了全体配置护士的工作积极性和主动性,在提高输液质量、服务质量、患者满意度,减少差错事故和药物不良事件等方面都起到了积极推动作用。结论方法简单,效果满意,易于推广。

关键词：静脉用药调配中心配置护士分层管理综合效益

Accurate and Robust Eye Center Localization via Fully Convolutional Networks

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IEEE/CAA Journal of Automatica Sinica 2019年第5期6卷 1127-1138页

作者： Yifan xia Hui Yu Fei-yue wang the School of Creative Technologies University of PortsmouthPortsmouthPO1 2DJUK the State Key Laboratory of Management and Control for Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China

Eye center localization is one of the most crucial and basic requirements for some human-computer interaction applications such as eye gaze estimation and eye tracking. There is a large body of works on this topic in recent years, but the accuracy still needs to be improved due to challenges in appearance such as the high variability of shapes, lighting conditions, viewing angles and possible occlusions. To address these problems and limitations, we propose a novel approach in this paper for the eye center localization with a fully convolutional network(FCN),which is an end-to-end and pixels-to-pixels network and can locate the eye center accurately. The key idea is to apply the FCN from the object semantic segmentation task to the eye center localization task since the problem of eye center localization can be regarded as a special semantic segmentation problem. We adapt contemporary FCN into a shallow structure with a large kernel convolutional block and transfer their performance from semantic segmentation to the eye center localization task by *** experiments show that the proposed method outperforms the state-of-the-art methods in both accuracy and reliability of eye center localization. The proposed method has achieved a large performance improvement on the most challenging database and it thus provides a promising solution to some challenging applications.

关键词： Deep learning eye center localization eye gaze estimation eye tracking fully convolutional network (FCN) humancomputer interaction