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Cholangiocarcinoma presenting with acquired thrombotic thrombocytopenic purpura confirmed by positive autoantibodies of a disintegrin and metalloproteinase with a thrombospondin type 1 motif,member 13

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Chinese Medical Journal 2020年第12期133卷 1495-1496页

作者： yue-ting li Han-Ze Du Chun-Yao Wang Tie-Nan Zhu Bo-Ju Pan Lu Zhang Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Medical Intensive Care Unit Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Hematology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China

To the Editor:Thrombotic thrombocytopenic purpura(TTP)is a type of life-threatening thrombotic microangiopathy(TMA)clinically characterized by severe thrombocytopenia,microangiopathic hemolytic anemia,and symptoms of ... 详细信息

关键词： thrombotic insufficiency anemia

Transcriptional regulation of Rat GalR1 gene expression

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Transcriptional regulation of Rat GalR1 gene expression

中国神经科学学会第十二届全国学术会议

作者： yue-ting li Han-Jiang LUO Xiao-Xiao li Yu-Tao YANG Zhi-Qing David XU Department of Neurobiology Beijing Key Laboratory of Neural Regeneration and RepairKey Laboratory of Brain Disorders Beijing Institute for Brain Disorders Capital Medical University

Objective Galanin is an important neuropeptide in the brain, and widely distributed in the central nervous system. Up to date, three galanin receptors, GalR1, Gal R2 and Gal R3, have been cloned and identified. GalR1 is highly expressed in many brain areas including the amygdala, hypothalamus, cortex, spinal cord and dorsal root ganglia. GalR1 has been demonstrated to be involved in appetite, mood, learning and memory, pain, intestinal secretion, neural growth and depression. It has been shown that the expression of GalR1 is increased in ventral periaqueductal gray（v PAG） in chronic mild stress rat. However, the regulation mechanisms underlying GalR1 expression is still unknown. Methods Amplify the rat GalR1 promoter with PCR and constructed a series of deletion mutant *** luciferase assay to analyse the transcription activities and find putative cic-elements in the key regulatory region. Carry out a site-directed mutagenesis experiment to determine the functional core sequence. Results The region between-250 bp and-220 bp upstream of the translational start site played a negative roles in regulation of the rat GalR1 gene *** the E-box sequence which can bind to Snail family in this 30 bp can reverse this decrese. Conclusion The regions between-250 to-220 play an important role in regulation of the rat GalR1 gene expression and Snail family transcription factors may be the putative cic-elements.

关键词： GalR1 Gene expression Transcription

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一种侵染鳢肠的双生病毒基因组特征

植物病理学报 2017年第4期47卷 479-486页

作者：钟静赵丽玲尹跃艳李婷婷丁铭李凡云南农业大学云南农业大学农业生物多样性应用技术国家工程中心昆明650201 云南省农业科学院生物技术与种质资源研究所云南省农业生物技术重点实验室昆明650223

菜豆金色花叶病毒属病毒是热带及亚热带地区经济作物的重要病原病毒,该类病毒在田间的杂草寄主范围较为广泛。本研究从云南红河流域采集到叶脉黄化的鳢肠植株,经克隆获得了菜豆金色花叶病毒属病毒分离物YN3306,该分离物核苷酸序列全长27... 详细信息

菜豆金色花叶病毒属病毒是热带及亚热带地区经济作物的重要病原病毒,该类病毒在田间的杂草寄主范围较为广泛。本研究从云南红河流域采集到叶脉黄化的鳢肠植株,经克隆获得了菜豆金色花叶病毒属病毒分离物YN3306,该分离物核苷酸序列全长2749 nt,具有典型的双生病毒基因组结构特征。进一步分析发现,分离物属于金腰剑曲叶病毒(Synedrella leaf curl virus,SyLCV),RDP软件分析表明,该分离物是由烟草曲茎病毒(Tobacco curly shoot virus,Tb CSV)、云南烟草曲叶病毒(Tobacco leaf curl Yunnan virus,TbLCYnV)和金腰剑曲叶病毒重组产生的病毒。本研究首次报道了GenBank中在印度注册的SyLCV可以侵染鳢肠植株。

关键词：鳢肠菜豆金色花叶病毒属病毒基因组重组

Targets capture by distributed active swarms via bio-inspired reinforcement learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 210-221页

作者： Kun Xu yue li Jun Sun Shuyuan Du Xinpeng Di Yuguang Yang Bo li Institute of Biomechanics and Medical Engineering Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua University Institute of Nuclear and New Energy Technology Tsinghua University Shanghai Aerospace Control Technology Institute Shanghai Key Laboratory of Aerospace Intelligent Control Technology College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Natural swarms arranged from cells to herds are usually decentralized but display intriguing collective intelligence in coordinating individuals across large scales to efficiently achieve their common goals. Learning from nature may provide new strategies for controlling collective dynamics of synthetic swarms to accomplish specific functions. Here, we present a bioinspired computational framework that steers distributed active swarms to collectively capture and merge targets via reinforcement learning. We exploit collective milling structures of natural herds to cage the targets, and adopt a switching control policy inspired by sperms' chiral dynamics to optimize the trajectories of individuals, through which the active swarms can selforganize to enclose single or multiple distant targets in a dynamical, adaptive and scalable manner. There exists a critical swarm size, beyond which the excessive competition between agents would generate large mechanical forces, leading to capture instability but enabling the transition from short-distance to long-distance merging capture of multiple targets. This work provides physical insights into distributed active swarms and could offer a multilevel, decentralized strategy toward controlling swarm robotics in wide applications such as bio-medical devices, machine immunity, and target clearance.

关键词： swarm intelligence robotics multi-tasks artificial intelligence bionics

Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

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Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang Lu-Yu liu Sha-Sha Cui ting-ting li Xiao-Meng Yang Zhijuan liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

水溶性TiO_2离子液体纳米杂化材料的制备与应用（英文）

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无机材料学报 2018年第5期33卷 577-581页

作者：张娇霞易靖焦月婷李世云史鑫兰孙凯江苏科技大学材料科学与工程学院材料科学与工程国家级实验教学示范中心镇江212003

TiO_2纳米颗粒具有较强的氧化性,作为光催化剂,可以在阳光照射下减少或消除有机污染物。为提高TiO_2纳米颗粒分散性和溶解性,研究其在不同领域,特别是环境保护领域的应用,本实验室用两步法制备得到黄色透明的水溶性TiO_2离子液体纳米杂... 详细信息

TiO_2纳米颗粒具有较强的氧化性,作为光催化剂,可以在阳光照射下减少或消除有机污染物。为提高TiO_2纳米颗粒分散性和溶解性,研究其在不同领域,特别是环境保护领域的应用,本实验室用两步法制备得到黄色透明的水溶性TiO_2离子液体纳米杂化材料。在这个杂化体系中,有机磺酸基团作为冠层可以提供"自溶剂"成为TiO_2纳米粒子的分散体。分散实验表明:TiO_2离子液体纳米杂化材料表面的水溶性有机物在水中具有良好的溶解性,容易去除,可应用于家居装饰表面。光催化降解甲醛的研究表明:TiO_2离子液体纳米杂化流体具有良好的光催化性能。水溶性TiO_2离子液体纳米杂化材料有望成为未来环境保护的发展方向。

关键词： TiO2离子液体杂化材料水溶性光催化

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： Xiaoqin li Jian Xiang Lu Qiu Xiaohan Chen Yinkun Zhao Yujue Wang Qu yue Taotao Gao Wenlong liu Dan Xiao Zhaoyu Jin Panpan li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation

铁棍山药PPO的最适底物、热稳定性及褐变控制研究

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河南农业科学 2010年第12期39卷 95-98页

作者：刘莹赵喜亭赵月丽鲁梦娇成淑君赵雪蕾李明军刘亚丽 Xi-ting yue-li Meng-jiao Shu-jun Xue-lei Ming-jun Ya-li 河南师范大学生命科学学院河南新乡453007 河南省高校道地中药材保育及利用工程技术研究中心河南新乡453007

研究了铁棍山药多酚氧化酶(PPO)的最适底物、热稳定性及不同抑制剂对其活性的影响。结果表明:在试验范围内,铁棍山药PPO最适底物为邻苯二酚;在较低温度(20～40℃)下其PPO能保持较稳定的活性,较高温度(40～80℃)下其活性快速下降,80℃下... 详细信息

研究了铁棍山药多酚氧化酶(PPO)的最适底物、热稳定性及不同抑制剂对其活性的影响。结果表明:在试验范围内,铁棍山药PPO最适底物为邻苯二酚;在较低温度(20～40℃)下其PPO能保持较稳定的活性,较高温度(40～80℃)下其活性快速下降,80℃下保温10 min,PPO活性几乎为零;抑制剂对PPO活性的抑制效果依次为:L-抗坏血酸>L-半胱氨酸盐酸盐>植酸>柠檬酸。

关键词：铁棍山药 PPO活性底物热稳定性褐变控制研究 Studies Control Polyphenol Oxidase 半胱氨酸盐酸盐抑制剂多酚氧化酶抑制效果试验范围邻苯二酚抗坏血酸较低温度柠檬酸高温度植酸

Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai Hui Ma yue Zhang Jinfeng li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury