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Journal of Geriatric Cardiology 2014年第3期11卷 206-211页

作者： li-Xia YANG Yu-Jie ZHOU Zhi-Jian WANG yue-ping li Meng CHAI Department of Cardiology Beijing Anzhen Hospital Capital Medical University N0. 2 Anzhen Avenue Chaoyang District Beijing 100029 China

BackgroundFew studies have compared change in the health-related quality of life （HRQL） following treatment of non-ST-elevation acute coronary syndrome （NSTE-ACS） with either percutaneous coronary intervention （PCI） or coronary artery bypass grafting （CABG）. This study is tocompare changes in HRQL six months after hospital discharge between NSTE-ACS pa-tients who underwent either PCI or *** HRQL was assessed using the Seattle angina questionnaire at admission and six months after discharge in 1012 consecutive patients with NSTE-ACS. To assess associations of PCI and CABG with HRQL changes, logistic regression models were constructed treating changes in the score of each dimension of the Seattle angina question-naire as dependent *** Although both the PCI and CABG groups experienced angina relief and other improvements at 6-month follow-up （P〈0.001）, the CABG relative to PCI group showed more significant improvements in angina frequency （P= 0.044） and quality of life （P= 0.028）. In multivariable logistic analysis, CABG also was an independent predictor for both im-provement of angina frequency （OR： 1.62, 95%CI： 1.09-4.63,P= 0.042） and quality of life （OR： 2.04, 95%CI： 1.26-6.92,P= 0.038） relative to *** In patients with NSTE-ACS, both PCI and CABG provide great improvement in disease-specific health status at six months, with that of CABG being more prominent in terms of angina frequency and quality of life.

关键词： Non-ST elevation acute coronary syndrome Quality of life Therapeutic strategy

NT4(Si)-p53(N15)-antennapedia induces cell death in a human hepatocellular carcinoma cell line

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World Journal of Gastroenterology 2009年第46期15卷 5813-5820页

作者： li-ping Song yue-ping li Ning Wang Wei-Wei li Juan Ren Shu-Dong Qiu Quan-Ying wang Guang-Xiao Yang Department of Radiotherapy Oncology First Hospital MedicalSchool of Xi'an Jiao Tong University Xi'an 710061 ShaanxiProvince China Center for Reproductive Medicine AffiliatedHospital of Hainan Medical College Haikou 570102 HainanProvince China Department of Anatomy and Histology &Embryology Medical school of Xi'an Jiao Tong UniversityXi'an 710061 Shaanxi Province China Xi'an HuaguangBioengineering Co Xi'an 710061 Shaanxi Province China

AIM： To construct the recombinant lentivirus expression plasmid, pLenti6/V5-NT4 p53（N 15）-antennapedia （Ant）, and study its effect on HepG2 cells. METHODS： Plasmid pLenti6/V5-NT4 p53（N15）-Ant was constructed incorporating the following functional regions, including signal peptide sequence and proregion of neurotrophin 4, N-terminal residues 12-26 of p53 and 17 amino acid drosophila carrier protein, Ant. Hepatocellular carcinoma （HepG2） cells were used for transfection. 3-[4,5-climethyl-thiazol-2yl]-2,5 diphenyl tetrazolium bromide （MI-I） assay, lactate dehydrogenase （LDH） release assay, transmission electron microscopy （TEM） and flow cytometric analysis （FCM） were employed to investigate the effects of LV-NT4（Si）- p53（N15）-Ant in vitro on HepG2 cells. In vivo experiment was also performed to investigate the inhibitory effect of LV-NT4（Si）-p53（N15）-Ant on tumor growth in nude ***： LV-NT4（Si）-p53（N15）-Ant significantly suppressed the growth of HepG2 cells. MTT assay showed that the growth of HepG2 cells was mucj more significantly inhibited by LV-NT4（Si）-p53（N15）-Ant than by LV-EGFP. The inhibition rate for HepG2 cell growth in the two groups was 46.9% and 94.5%, respectively, 48 h after infection with LV-NT4（Si）-p53（N15）-Ant, and was 33.9% and 95.8%, respectively, 72 h after infection with LV-NT4（Si）-p53（N15）-Ant （P 〈 0.01）. light microscopy and TEM showed morphological changes in HepG2 cells infected with LV-NT4（Si）-p53（N15）-Ant, but no significant changes in HepG2 cells infected with LV-EGFR Changes were observed in ultra-structure of HepG2 cells infected with LV-NT4（Si）-p53（N15）-Ant, with degraded membranes, resulting in necrosis. LDH release from HepG2 cells was analyzed at 24, 48, 72 and 96 h after infection with LV-NT4（Si）-p53（N15）-Ant and LV-EGFP, which showed that LDH release was significantly higher in LV-NT4（Si）-p53（N15）-Ant treatment group （682 IU/L） than in control group （45 IU/L, P 〈 0.01）. The longer the time was after infection, the bigger the

关键词： Gene therapy Lentivirus vector Anticancer Necrosis LV-NT4(Si)-p53(N15)-Ant Hepatocellularcarcinoma cell line

Spaceflight alters the gene expression profile of cervical cancer cells

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Chinese Journal of Cancer 2011年第12期30卷 842-852页

作者： Zhi-Jie Zhang Yong-Qing Tong Jia-Jia Wang Cheng Yang Guo-Hua Zhou yue-Hui li ping-li Xie Jin-yue Hu Guan-Cheng li Cancer Research Inst tute Xiangya Schoo of Med c neCentral South University Changsha Hunan 410078 P. R. China

Our previous study revealed that spaceflight induced biological changes in human cervical carcinoma Caski cells. Here, we report that 48A9 cells, which were subcloned from Caski cells, experienced significant growth suppression and exhibited low tumorigenic ability after spaceflight. To further understand the potential mechanism at the transcriptional level, we compared gene expression between 48A9 cells and ground control Caski cells with suppression subtractive hybridization (SSH) and reverse Northern blotting methods, and analyzed the relative gene network and molecular functions with the Ingenuity Pathways Analysis (IPA) program. We found 5 genes, SUB1, SGEF, MALAT-1, MYL6, and MT-CO2, to be up-regulated and identified 3 new cDNAs, termed B4, B5, and C4, in 48A9 cells. In addition, we also identified the two most significant gene networks to indicate the function of these genes using the IPA program. To our knowledge, our results show for the first time that spaceflight can reduce the growth of tumor cells, and we also provide a new model for oncogenesis study.

关键词：基因表达谱航天飞行癌细胞宫颈癌 Northern 抑制性消减杂交生长抑制基因网络

Diagnostic accuracy of a deep learning approach to calculate FFR from coronary CT angiography

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Journal of Geriatric Cardiology 2019年第1期16卷 42-48页

作者： Zhi-Qiang WANG Yu-Jie ZHOU Ying-Xin ZHAO Dong-Mei SHI Yu-Yang liU Wei liU Xiao-li liU yue-ping li Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Disease Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Clinical Center for Coronary Heart Disease Capital Medical University

Background The computational fluid dynamics(CFD)approach has been frequently applied to compute the fractional flow reserve(FFR)using computed tomography angiography(CTA).This technique is *** developed the DEEPVESSEL-FFR platform using the emerging deep learning technique to calculate the FFR value out of CTA images in five *** study is to evaluate the DEEPVESSEL-FFR platform using the emerging deep learning technique to calculate the FFR value from CTA images as an efficient *** A single-center,prospective study was conducted and 63 patients were enrolled for the evaluation of the diagnostic performance of *** quantification method for the three-dimensional coronary arterial geometry and the deep learning based prediction of FFR were developed to assess the ischemic risk of the stenotic coronary *** performance of the DEEPVESSEL-FFR was assessed by using wire-based FFR as reference *** primary evaluation factor was defined by using the area under receiver-operation characteristics curve(AUC)*** For per-patient level,taking the cut-off value<0.8 referring to the FFR measurement,DEEPVESSEL-FFR presented higher diagnostic performance in determining ischemia-related lesions with area under the curve of 0.928 compare to CTA stenotic severity ***-FFR correlated with FFR(R=0.686,P<0.001),with a mean di&ference of-0.006士0.0091(P=0.619).The secondary evaluation factors,indicating per vessel accuracy,sensitivity,specificity,positive predictive value,and negative predictive value were 87.3%,97.14%,75%,82.93%,and 95.45%,*** DEEPVESSEL-FFR is a novel method that allows efficient assessment of the functional significance of coronary stenosis.

关键词： Computed tomography angiography Coronary artery Deep learning Fractional flow reserve

Is it better to choose immediate dialysis treatment for renal transplant patients after PCI?

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Journal of Geriatric Cardiology 2020年第2期17卷 116-119页

作者： Qian-Yun GUO Xun-Xun FENG Zhi-Jian WANG yue-ping li Jing QI Yu-Jie ZHOU Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical University

Administration of iodinated contrast agents can give rise to allergic/hypersensitivity reactions and contrast-induced *** extremely rare cases,intravascularly administered iodinated contrast agents can trigger contrast-induced encephalopathy(CIE)in patients undergoing percutaneous coronary intervention(PCI).[1]Here,we describe the case of a male patient diagnosed with CIE after undergoing PCI with a non-ionic contrast agent,*** is the first such case to be reported in a patient undergoing hemodialysis after kidney transplantation.

关键词： Contrast-induced encephalopathy Hemodialysis Kidney transplantation Percutaneous coronary intervention

Effects of therapeutic hypercapnia on inflammation and apoptosis after hepatic ischemia-reperfusion injury in rats

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Chinese Medical Journal 2010年第16期123卷 2254-2258页

作者： li Ai-min QUAN Yan GUO yue-ping li Wen-zhi CUI Xiao-guang Department of Anesthesiology second Affiliated Hospital Harbin Medical University Harbin Heilongjiang 150086 China

Background Therapeutic hypercapnia （TH） has been demonstrated to protect several organs ischemia-reperfusion *** study aimed to investigate the effects of therapeutic hypercapnia on hepatic ischemia-reperfusion injury （HIRI）.Methods Thirty adult male Wistar rats weighing （250 ± 20） g were randomized into 3 groups （n=10 in each）, group C （control group）, group A （hypercapnia group） and group B （CO2 preconditioning group）.A segmental ischemia of the liver was induced by interrupting the blood vessels including the bile duct to the median and left lateral lobes for 60 minutes and all the animals were sacrificed after 240 minutes observation period of *** arterial pressure （MAP）and the blood gases were measured before ischemia （baseline） and at 30, 60, 120, 180 and 240 minutes after *** blood samples were obtained for determination of serum levels of TNF-α, IL-10, serum aspartate aminotransferase （AST） and alanine aminotransferase （ALT）.The histopathology of liver tissues was evaluated by light *** NF-κB expression and apoptotic hepatocytes were respectively determined by immunohistochemistry and TUNEL *** The serum levels of liver enzymes and TNF-α were significantly decreased while the IL-10 level was significantly increased in groups A and B than in group C （P 〈0.05）, and group B surpassed group A （P 〈0.05）.The histopathological scores, the NF-κB immunohistochemical score （IHS） and apoptotic index were significantly lower in groups A and B than in group C （P 〈0.05）, and the decrease in group B was more obvious than in group A （P〈0.05）.Conclusion Therapeutic hypercapnia attenuates ischemia-reperfusion injury to the ***, the effects of CO2preconditioning are outstandingly notable.

关键词： hypercapnia CO2 preconditioning liver ischemia-reperfusion injury

Elevated Levels of Very Low？density lipoprotein Cholesterol Independently Associated with In？stent Restenosis in Diabetic Patients after Drug？eluting Stent Implantation

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Chinese Medical Journal 2017年第19期130卷 2326-2332页

作者： Zheng Qin Fang-Wu Zheng Chuang Zeng Kuo Zhou Yu Geng Jian-Long Wang yue-ping li Qing-Wei Ji Yu-Jie Zhou Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China Department of Cardiology Yuncheng Hospital of Traditional Chinese Medicine Yuncheng Shandong 274700 China Department of Cardiology Yunyang Hospital of Traditional Chinese Medicine Yunyang Chongqing 404500 China Beijing Institute of Heart Lung and Blood Vessel Disease The Key Laboratory of Remodeling-related Cardiovascular Disease Ministry of Education Beijing 100029 China

Background： High rate of in-stent restenosis （ISR） remained an unsolved clinical problem in clinical practice, especially among patients with diabetes mellitus （DM）. Diabetic patients often had hypertriglyceridemia with elevated levels of very low-density lipoprotein cholesterol （VLDL-C）. Increasing evidence suggested that VLDL-C was known as a significant risk factor for atherosclerosis and had been recommended as a treatment target by current dyslipidemia guidelines. However, the role of VLDL-C in the occurrence and development of ISR in coronary artery disease （CAD） patients with DM had not been studied. The aim of this study was to evaluate the association between the elevated levels of VLDL-C and the risk of ISR in CAD patients with DM. Methods： A total of 1390 diabetic patients, who underwent coronary drug-eluting stent （DES） implantation at Beijing Anzhen Hospital and followed up by angiography within 6–24 months, were consecutively enrolled. Patients＇ demographic and clinical characteristics, including age, gender, CAD risk factors, family history, life style, medical history, and coronary angiographic information, were collected carefully at baseline percutaneous coronary intervention and follow-up angiography. Multivariate Cox＆#39;s proportional hazards regression modeling using the step-wise method （entry, 0.05; removal, 0.05） was used to determine the independent risk associated with ISR in diabetic patients. Results： Finally, 1206 of patients were included in this study. ISR occurred in 132/1206 diabetic patients （10.9%） by follow-up angiography. Patients with ISR had elevated median serum VLDL-C levels compared with those without ISR （0.65 mmol/L vs. 0.52 mmol/L, P = 0.030）. The multivariate regression analysis showed that VLDL-C was significantly associated with the risk of ISR in diabetic CAD patients （hazard ratio [HR] = 1.15, 95% confidence interval [CI]： 1.03–1.29, P = 0.017）. The HR for the risk of ISR associated with VLDL-C level ≥0.52 mmol/L wa

关键词： Diabetes Mellitus Drug-eluting Stent Implantation ln-stent Restenosis Very Low-Density lipoprotein Cholesterol

新时代中国特色社会主义政治经济学人民中心论思想的渊源与创新

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西北大学学报（哲学社会科学版） 2018年第3期48卷 23-31页

作者：岳利萍毕冬一西北大学经济管理学院西北大学中国西部经济发展研究中心陕西西安710127

以人民为中心是习近平新时代中国特色社会主义政治经济学的特色和精神内核,是实现两个百年奋斗目标的理论指引,其与毛泽东思想以及中国特色社会主义理论体系一脉相承,共同发展和创新了马克思主义政治经济学的人本思想。以人民为中心的... 详细信息

以人民为中心是习近平新时代中国特色社会主义政治经济学的特色和精神内核,是实现两个百年奋斗目标的理论指引,其与毛泽东思想以及中国特色社会主义理论体系一脉相承,共同发展和创新了马克思主义政治经济学的人本思想。以人民为中心的中国特色社会主义政治经济学在研究主题、研究内容、理论体系和发展理念等方面对中国特色社会主义政治经济学进行了创新,集中回答了新时期"为什么人,依靠什么人实现发展""为什么要坚持公有制"以及"为什么要坚持和加强党的领导"这三大根本性问题。对这些问题的严肃回答,即是以人民为中心的新时代中国特色社会主义政治经济学在新时代的价值所在。

关键词：新时代中国特色社会主义人民中心论马克思主义政治经济学

我国区域经济差异变动的阶段性特征——基于区域经济政策演变的视角

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未来与发展 2011年第11期32卷 94-99页

作者：岳利萍严汉平李冀西北大学经济管理学院陕西西安710127

区域经济政策对区域经济差异的影响已经得到学术界的认可,但由于概念属性存在差异,因此如何通过定性或定量的方法对这一影响进行衡量尚无定论。本文通过考察建国以来我国区域经济差异的变动轨迹以及我国区域经济政策的演变过程,对二者... 详细信息

区域经济政策对区域经济差异的影响已经得到学术界的认可,但由于概念属性存在差异,因此如何通过定性或定量的方法对这一影响进行衡量尚无定论。本文通过考察建国以来我国区域经济差异的变动轨迹以及我国区域经济政策的演变过程,对二者分别进行阶段划分,划分结果表明二者均呈现阶段性变化,且在阶段划分上存在明显的一致性。由此可以认为我国区域经济政策的演变对区域经济差异的变化具有深远的影响。

关键词：区域经济差异绝对差距相对差距区域经济政策

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抑郁障碍患者配偶心理调查分析

中国民康医学 2010年第4期22卷 371-371,398页

作者：岳丽萍河南省洛阳荣康医院河南洛阳471000

目的:探索抑郁障碍患者配偶心理状态及干预方法。方法:采用SCL-90症状自评量表对136例抑郁症患者配偶进行心理调查,并将调查结果与常模对照分析研究。结果:研究组因子分分析中,SCL-90量表躯体化、人际关系、抑郁、焦虑、恐怖等因子分与... 详细信息

目的:探索抑郁障碍患者配偶心理状态及干预方法。方法:采用SCL-90症状自评量表对136例抑郁症患者配偶进行心理调查,并将调查结果与常模对照分析研究。结果:研究组因子分分析中,SCL-90量表躯体化、人际关系、抑郁、焦虑、恐怖等因子分与常模相应因子分比较差异具有统计学意义。结论:抑郁症患者配偶存在明显的情绪问题,应对其进行必要的心理干预。

关键词：抑郁障碍配偶心理调查心理干预