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Examination of wnt signaling mediated melanin transport and shell color formation in Pacific oyster(Crassostrea gigas)

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Marine Life Science & Technology 2024年第3期6卷 488-501页

作者： yue min Qi Li Hong Yu Shaojun Du Key Laboratory of Mariculture Ministry of Educationand College of FisheriesOcean University of ChinaQingdao 266003China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Institute of Marine and Environmental Technology Department of Biochemistry and Molecular BiologyUniversity of Maryland School of MedicineBaltimore 21240USA

Mollusca exhibit remarkable diversity in shell coloration,attributed to the presence of melanin,a widely distributed pigment with various essential roles,such as mechanical strengthening,antioxidation and ***,the regulatory network governing melanogenesis and melanin transport in molluscs remains poorly *** this study,we conducted a systematic analysis of melanin distribution and transport in the Pacific oyster,utilizing light microscopy and high-resolution transmission electron *** addition,we characterized CgWnt1 and CgWnt2b-a in Crassostrea gigas,and analyzed Wnt signaling in melanocyte *** analysis revealed that these genes were predominantly expressed in the mantle of black-shelled individuals,particularly in the outer fold of the ***,we employed RNA interference and inhibitors to specifically inhibit Wnt signaling in both in vivo and in *** results revealed impaired melanogenesis and diminished tyrosinase activity upon Wnt signaling *** findings suggest the crucial role of Wnt ligands and downstream factors in *** summary,our study provides valuable insights into the regulatory mechanism of shell pigmentation in *** demonstrating the promotion of melanogenesis through Wnt signaling modulation,we contribute to a better understanding of the complex processes underlying molluscan melanin production and shell coloration.

关键词： Melanogenesis Melanosome trafficking WIF-1

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Polyolefin vitrimers bearing acetoacetate functionality

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Science China Chemistry 2024年第11期67卷 3861-3867页

作者： Zihao Wang yue Liu Wenmin Pang Ao Chen min Chen Chinese Academy of Sciences (CAS) Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China Institutes of Physical Science and Information Technology Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education Anhui University

Polyolefin vitrimers are polymer networks bearing reversible covalent crosslinking points, enabling them to be reprocessed and recycled. In this contribution, a series of polyolefin vitrimers were designed based on the acetoacetate-functionalized polyolefin copolymers, which were produced through the direct copolymerization of ethylene with polar comonomers using a phosphinesulfonate palladium catalyst. The pendant acetoacetate group could mediate several characteristic reactions, such as the Michael addition reaction, ketone-amine condensation and metal coordination reaction. As such, structurally adjustable polyolefin vitrimers can be accessed by introducing various dynamic crosslinking bonds, including disulfide exchange, transamination of vinylogous urethane and labile metal coordination bond. The utilization of different crosslinking reactions and the mole ratio of crosslinkers significantly impact the material properties of the resultant polymers. Specifically, the generated polyolefin vitrimers demonstrated excellent reprocessability and closed-loop recycling properties. The study in this work provides an efficient strategy to access various polyolefin vitrimers.

关键词： polyolefin vitrimers acetoacetate group polar monomer olefin copolymerization

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Synergistic effect of Co and Co_(6)Mo_(6)C for electroreduction of nitrate to ammonia on Co-MOF derived Co_(6)Mo_(6)C/Co/NC

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Nano Research 2024年第7期17卷 5807-5816页

作者： Xinyan Wang yue Cao Yan Hai Xiaoman Li min Luo State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering School of Chemistry and Chemical EngineeringNingxia UniversityYinchuan 750021China

Electrocatalytic nitrate reduction reaction(e-NO_(3)RR)offers a promising alternative method for nitrogen cycling and ammonia(NH3)production under ambient ***,the method is still in the dilemma of lowering the reaction overpotential and increasing the reaction *** successfully developed the composition-adjustable Co_(6)Mo_(6)C/Co/N-doped carbon(NC)catalysts by in situ carbonization of Co-based metal-organic framework(MOF)with the constrained phosphomolybdic *** adjusting the ratio of Co0 and Co_(6)Mo_(6)C,Co_(6)Mo_(6)C/Co/NC-3 could satisfy both NO_(3)−conversion at low potential and NH_(x)hydrogenation,and synthesize ammonia efficiently through the synergistic effect of Co0 and Co_(6)Mo_(6)*** achieved an ammonia yield rate as 1233.2μg·h^(−1)·mgcat^(−1)and Faradaic efficiency of NH4+93.6%at−0.33 V *** hydrogen electrode(RHE).Importantly,density functional theory(DFT)calculations and experimental results have demonstrated for the first time the excellent adsorption of nitrite(NO_(2)^(−))by the Mo sites of Co_(6)Mo_(6)C during e-NO_(3)RR,avoiding the undesirable accumulation of NO_(2)^(−).

关键词： synergistic effect nitrate electroreduction Co_(6)Mo_(6)C ammonia synthesis

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Enhancing corn stalk-based anaerobic digestion with different types of zero-valent iron added during the acidification stage:Performance and mechanism

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Journal of Environmental Sciences 2024年第11期145卷 64-74页

作者： Xiang Liu yue Liu min Wang Qianzhen Deng Hao Yang College of Agricultural Science and Engineering Hohai UniversityNanjing 210098China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution Wenzhou UniversityWenzhou 325035China Anhui Provincial Key Laboratory of Environmental Pollution Control and Resource Reuse Anhui Jianzhu UniversityHefei 230009China

Anaerobic digestion has been defined as a competitive approach to facilitate the recycling of corn ***,few studies have focused on the role of direct interspecies electron transfer(DIET)pathway in the acidification stage under the addition of different particle sizes of zero-valent iron(ZVI).In this study,three types of ZVI,namely iron filings,iron powder and nanoscale iron,were investigated,respectively,to enhance its high-value *** in volatile fatty acids(VFAs)and methane(CH4)production associated with the underlyingmechanisms were emphatically *** indicated that the addition of ZVI could increase the concentration of VFAs,with the most outstanding performance observed with the use of nanoscale ***,the conversion of propionic acid to acetic acid was driven by adding ZVI with no between-group differences in acidizing ***,the substrate was more fully utilized when supplied with iron powder compared with other groups in methanogenic phase,thereby displaying the maximumCH4 yield with a value of 263.1 mL/(g total solids(TS)).However,adding nanoscale iron could signally shorten the digestion time(T80),saving 7 days in comparison to the group of iron powder.

关键词： Zero-valent iron Corn stalk Anaerobic digestion Volatile fatty acids Methane

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FA-assistant Iodide Coordination in Organic-Inorganic Wide-Bandgap Perovskite with Mixed Halides

FA-assistant Iodide Coordination in Organic-Inorganic Wide-B...

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第七届新型太阳能电池材料科学与技术学术研讨会

作者： yue-min xie Qifan Xue Hin-Lap Yip Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of Technology

Mixed-halide wide-bandgap perovskites are key components for the development of high-efficiency tandem structured ***,mixed-halide perovskites are usually suffered from phase-impurity and high defect density issues,where the causes are still *** using in-situ photoluminescence(PL) spectroscopy,it is found that in methylammonium(MA) based mixed-halide perovskites,MAPb(IBr),the halide composition of the spin-coated perovskite films is preferentially dominated by the bromide ions(Br).Additional thermal energy is required to initiate the insertion of iodide ions(I) to achieve the stoichiometric ***,by incorporating a small amount of formamidinium ions(FA) in the precursor solution,it can effectively facilitate the Icoordination in the perovskite framework during the spin-coating and improve the composition homogeneity of the initial small *** aggregation of these homogenous small particles is found to be essential to achieve uniform and high-crystallinity perovskite film with high *** a result,high-quality MAFAPb(IBr) perovskite film with a bandgap(E) of 1.81 eV has been achieved,along with an encouraging power conversion efficiency of 17.1% and open-circuit voltage(V) of 1.21 *** work also demonstrates the in-situ PL can provide a direct observation of the dynamic of ion coordination during the perovskite crystallization.

关键词： Mixed-halide perovskites wide-bandgap perovskites halide coordination

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Rapid profiling rock mass quality underneath tunnel face for Sichuan-Xizang Railway

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Underground Space 2024年第6期19卷 138-152页

作者： Siyuan Wu min Qiu Zhao Yang Fuquan Ji Zhongqi Quentin yue Department of Civil Engineering The University of Hong KongHong Kong 999077China CCCC Second Harbor Engineering Company Ltd. Wuhan 430000China Research and Development Center of Transport Industry of Intelligent Manufacturing Technologies of Transport Infrastructure Wuhan 430000China

The Sichuan-Xizang Railway is a global challenge,surpassing other known railway projects in terms of geological and topographical *** paper presents an approach for rapidly profiling rock mass quality underneath tunnel face for the ongoing construction of the Sichuan-Xizang *** adopts the time-series method and carries out the quantitative analysis of the rock mass quality using the depth-series measurement-while-drilling(MWD)data associated with drilling of blastholes.A tunnel face with 15 blastholes is examined for *** results include identification of the boundary of homogeneous geomaterial by plotting the blasthole depth against the net drilling time,as well as quantification of rock mass quality through the recalculation of the new specific *** new specific energy profile is compared and highly consistent with laboratory test,manual logging and tunnel seismic prediction *** consistency can enhance the blasthole pattern design and facilitate the dynamic determination of charge placement and *** paper highlights the importance of digital monitoring during blasthole drilling for rapidly profiling rock mass quality underneath and ahead of tunnel *** upgrades the MWD technique for rapid profiling rock mass quality in drilling and blasting tunnels.

关键词： Measurement-while-drilling Drilling and blasting Rock mass quality New specific energy Constant penetration rate Sichuan-Xizang railway Tunnelling

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A condition-based maintenance policy for reconfigurable multi-device systems

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Advances in Manufacturing 2024年第2期12卷 252-269页

作者： Shu-Lian xie Feng Xue Wei-min Zhang Jia-Wei Zhu School of Mechanical Engineering Tongji UniversityShanghai201804People’s Republic of China

The exploration of component states for optimizing maintenance schedules in complex systems has garnered significant interest from ***,current literature usually overlooks the critical aspects of system flexibility and *** implementation of system reconfiguration can effectively mitigate system downtime and enhance production *** study proposes a dynamic condition-based maintenance policy considering reconfiguration for reconfigurable systems.A double-layer decision rule was constructed for the devices and *** achieve the best overall maintenance effect of the system,the remaining useful life probability distribution and recommended maintenance time of each device were used to optimize the concurrent maintenance time window of the devices and determine whether to reconfigure them.A comprehensive maintenance efficiency index was introduced that simultaneously considered the maintenance cost rate,reliability,and availability of the system to characterize the overall maintenance *** reconfiguration cost was included in the maintenance *** proposed policy was tested through numerical experiments and compared with different-level *** results show that the proposed policy can significantly reduce the downtime and maintenance costs and improve the overall system reliability and availability.

关键词： Condition-based maintenance(CBM) Reconfigurable system Remaining useful life Maintenance cost System reliability

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Natural products inspired[3+2]cycloaddition enables efficient construction of hydroxylated tetrahydrofuran acetals and concise syntheses of lignans

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Science China Chemistry 2024年第7期67卷 2306-2313页

作者： Dong-yue Cai Weiming Shi Zhao-Hui Jin Zhi-Xiang Yu Jin-Xin Zhao Jian-min yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom *** studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol *** the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and *** the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

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Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2992-3008页

作者： Shicheng Fan yue Gao Pengfei Zhao Guomin xie Yanying Zhou Xiao Yang Xuan Li Shuaishuai Zhang Frank JGonzalez Aijuan Qu min Huangb Huichang Bi NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao Joint Laboratory for New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Department of Physiology and Pathophysiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA The State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyShenzhen Graduate School of Peking UniversityShenzhen 518055China

Fenofibrate,a peroxisome proliferator-activated receptor α(PPARα)agonist,is widely prescribed for hyperlipidemia *** studies also showed that it has therapeutic potential in various liver ***,its effects on hepatomegaly and liver regeneration and the involved mechanisms remain ***,the study showed that fenofibrate significantly promoted liver enlargement and regeneration post-partial hepatectomy in mice,which was dependent on hepatocyteexpressed PPARα.Yes-associated protein(YAP)is pivotal in manipulating liver growth and *** further identified that fenofibrate activated YAP signaling by suppressing its K48-linked ubiquitination,promoting its K63-linked ubiquitination,and enhancing the interaction and transcriptional activity of the YAP-TEAD *** inhibition of YAP-TEAD interaction using verteporfin or suppression of YAP using AAV Yap shRNA in mice significantly attenuated fenofibrate-induced *** factors,such as MYC,KRT23,RAS,and RHOA,might also participate in fenofibrate-promoted hepatomegaly and liver *** studies demonstrate that fenofibratepromoted liver enlargement and regeneration are PPARα-dependent and partially through activating the YAP signaling,with clinical implications of fenofibrate as a novel therapeutic agent for promoting liver regeneration.

关键词： Fenofibrate PPARa Hepatomegaly Partial hepatectomy Liver regeneration YAP TEAD Ubiquitination

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A small organic molecule strategy for remedying oxygen vacancies by bismuth defects in BiOBr nanosheet with excellent photocatalytic CO_(2)reduction

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Nano Research 2024年第1期17卷 297-306页

作者： Jing xie Zhenjiang Lu yue Feng Jianguo Huang Jindou Hu Aize Hao Yali Cao State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of ChemistryXinjiang UniversityUrumqi 830046China

Defect modulation currently plays a decisive role in addressing the poor photoabsorption,sluggish electron hole separation,and high CO_(2)activation barrier in photocatalytic CO_(2)***,hunting for a straightforward strategy to balance the concentration of oxygen vacancy and metal cation defect in one photocatalyst is still a great ***,a bismuth vacancies BiOBr nanosheets(BiOBr-1)on the exposed[001]facets were constructed via an acetic acid molecule modification strategy,which can repair oxygen defect by bismuth vacancy in low-temperature solid-state chemical *** from the formed bismuth defects that can not only broaden light absorption and elevate charge separation efficiency,but also enhance adsorption and activation of CO_(2)molecules,the evolution rates of photocatalytic CO_(2)conversion into CO(71.23μmol·g^(-1)·h^(-1))and CH4(8.90μmol·g^(-1)·h^(-1))attained by BiOBr-1 are superior 7.1 and 11 times to that of plate-like *** photocatalytic mechanisms including adsorption concentration and activation process of CO_(2)are further revealed by the in situ diffuse reflectance infrared flourier transform spectra(DRIFTS).This finding of the existence of distinct defects in ultrathin nanosheets undoubtedly leads to new possibilities for photocatalyst design using two-dimensional materials with high solar-driven photocatalytic activity.

关键词： solid-state synthesis BiOBr metal vacancies photocatalysis carbon dioxide reduction

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