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Plexin domain-containing 1 may be a biomarker of poor prognosis in hepatocellular carcinoma patients,may mediate immune evasion

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2091-2112页

作者： Ming-yue Tang Xue Shen Run-Sheng Yuan Hui-Yuan Li Xin-Wei Li Yi-Ming Jing yue zhang Hong-Hong Shen Zi-Shu Wang Lei Zhou Yun-Chuan Yang He-Xin Wen Fang Su Department of Medical Oncology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Otolaryngology and Head and Neck Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Neurology The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

BACKGROUND For the first time,we investigated the oncological role of plexin domain-containing 1(PLXDC1),also known as tumor endothelial marker 7(TEM7),in hepatocellular carcinoma(HCC).AIM To investigate the oncological profile of PLXDC1 in *** Based on The Cancer Genome Atlas database,we analyzed the expression of PLXDC1 in *** immunohistochemistry,quantitative real-time polymerase chain reaction(qRT-PCR),and Western blotting,we validated our *** prognostic value of PLXDC1 in HCC was analyzed by assessing its correlation with clinicopathological features,such as patient survival,methylation level,tumor immune microenvironment features,and immune cell surface checkpoint ***,to assess the immune evasion potential of PLXDC1 in HCC,we used the tumor immune dysfunction and exclusion(TIDE)website and immunohistochemical staining *** Based on immunohistochemistry,qRT-PCR,and Western blot assays,overexpression of PLXDC1 in HCC was associated with poor *** and multivariate Cox analyses indicated that PLXDC1 might be an independent prognostic *** HCC patients with high methylation levels,the prognosis was worse than in patients with low methylation *** enrichment analysis of HCC tissues indicated that genes upregulated in the high-PLXDC1 subgroup were enriched in mesenchymal and immune activation signaling,and TIDE assessment showed that the risk of immune evasion was significantly higher in the high-PLXDC1 subgroup compared to the low-PLXDC1 *** high-risk group had a significantly lower immune evasion rate as well as a poor prognosis,and PLXDC1-related risk scores were also associated with a poor *** As a result of this study analyzing PLXDC1 from multiple biological perspectives,it was revealed that it is a biomarker of poor prognosis for HCC patients,and that it plays a role in determining immune evasion status.

关键词： Plexin domain-containing 1 Biomarker Immune evasion Prognosis Immunotherapy Hepatocellular carcinoma

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Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions

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World Journal of Gastroenterology 2024年第14期30卷 1968-1981页

作者： Hong-Ju Sun Bo Jiao Yan Wang yue-Hua zhang Ge Chen Zi-Xuan Wang Hong Zhao Qing Xie Xiao-Hua Song Department of General Medicine Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Gastroenterology Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Department of Medical Administration Qingdao Central HospitalUniversity of Health and Rehabilitation Sciences(Qingdao Central Medical Group)Qingdao 266042Shandong ProvinceChina Qingdao Medical College Qingdao UniversityQingdao 266042Shandong ProvinceChina Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Nonalcoholic fatty liver disease(NAFLD)is the most prevalent type of chronic liver ***,the disease is underappreciated as a remarkable chronic disorder as there are rare managing *** studies have focused on determining NAFLD-caused hepatocyte death to elucidate the disease pathoe-tiology and suggest functional therapeutic and diagnostic ***,ferroptosis,and necroptosis are the main subtypes of non-apoptotic regulated cell deaths(RCDs),each of which represents particular *** the complexity of the findings,the present study aimed to review these types of RCDs and their contribution to NAFLD progression,and subsequently discuss in detail the role of necroptosis in the pathoetiology,diagnosis,and treatment of the *** study revealed that necroptosis is involved in the occurrence of NAFLD and its progression towards steatohepatitis and cancer,hence it has potential in diagnostic and therapeutic ***,further studies are necessary.

关键词： Nonalcoholic fatty liver disease Apoptosis Necroptosis Cell death Diagnosis Treatment

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Recent advances in glycerol valorization through electrocatalytic methods

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Tungsten 2024年第4期6卷 696-710页

作者： Hao-Hai Dong Yu-Xin Zhu Yi-Gu Li Jia-Yan Liang Ya Tan Xin-yue zhang Hao-Min Jiang Liu Lin Ze-Min Sun Center for Advanced Materials Research & College of Arts and Sciences Beijing Normal University Department of Chemistry University College London

The recent tremendous growth of biodiesel production from vegetable oils or waste fats has led to increased glycerol accumulation as a by-product of this *** sparked attention towards glycerol use and valorization of this largely available and cheap *** several methods for glycerol valorization,electrochemical glycerol oxidation reaction(EGOR)is an attractive alternative anodic reaction to oxygen evolution reaction for a variety of electrolytic synthesis,due to the low thermodynamic ***,the EGOR at the anode can be coupled with a cathodic hydrogen evolution reaction to achieve efficient energy conversion in an aqueous electrolytic *** review provides a comprehensive summary and critical analysis of glycerol electrochemical oxidation research during the last 5 *** review focuses on the recent development and prospects of electrochemical pathways(indirect or direct routes) for application in the *** particular,the recent development and prospects of using noble and non-noble group metal catalysts for glycerol electro-oxidation are ***,reaction product selectivity analysis and conversion efficiency are also highlighted.

关键词： Active oxygen species Electrocatalytic methods Glycerol Noble metal catalysts Non-noble metal catalysts

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“媒介面具”代身的主体审视与文化反思

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上海交通大学学报（哲学社会科学版） 2024年第4期32卷 106-116页

作者：张玥广东外语外贸大学新闻与传播学院广州510006

“面具”既是一种装饰之物,又可以象征人们在社交和心理层面上的表达和适应。以“媒介面具”为分析框架理解当下可穿戴VR/AR技术,发现这类媒介技术物提供“技术眼睛”观看,协领身体行动组织,代身人格进行数字展演。“媒介面具”将主体... 详细信息

“面具”既是一种装饰之物,又可以象征人们在社交和心理层面上的表达和适应。以“媒介面具”为分析框架理解当下可穿戴VR/AR技术,发现这类媒介技术物提供“技术眼睛”观看,协领身体行动组织,代身人格进行数字展演。“媒介面具”将主体与精神“剥离”,又将碎片化的“自我”聚合进数字场景中,书写数字化身的新构型。“媒介面具”在改变数字化生活方式的同时,也会引发身体支配错觉、行动依赖和情感茧房等一系列文化后果。面对这些问题,重拾人类作为主体的多样性是应对“媒介面具”困境的有效路径。

关键词：媒介面具代身景观 “技术眼睛” 主体性

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人工智能算法重塑社会结构:挑战与启示

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哲学分析 2024年第4期15卷 32-42,196页

作者：张钺北京科技大学

人工智能算法技术不断改变着人们的生活方式和工作模式,使得人们越发重视算法技术在价值观、公平公正和权力关系中的影响。现有讨论主要集中在两条路径下:一是技术发展路径下认知能力的提升,二是社会干预路径下法律和道德的约束。然而... 详细信息

人工智能算法技术不断改变着人们的生活方式和工作模式,使得人们越发重视算法技术在价值观、公平公正和权力关系中的影响。现有讨论主要集中在两条路径下:一是技术发展路径下认知能力的提升,二是社会干预路径下法律和道德的约束。然而这两条路径本质都是聚焦于算法的“自我”凝视,缺乏将算法视为“社会化”个体的思考。算法在话语权、社会交往和知识生产方面的影响,揭示出其融入社会结构中的价值。因此,发挥算法作为社会参与者的积极作用,需要挖掘算法促进社会协作的潜力,形成对社会多元性的维护。

关键词：数字话语权人机协作技术治理社会交往社会结构

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论江淹对左思《咏史》的模拟与接受

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北京大学学报（哲学社会科学版） 2024年第3期61卷 63-73页

作者：张月澳门大学中文系中国澳门

学者对江淹《杂体诗三十首》的总体评价历来较高,但是对其中模拟左思《咏史》八首的《左记室思咏史》评价较低。在前贤研究的基础上,江淹拟诗还可以从文本细读、互文性与接受史的视角来进行重新解读,从而考察其与左思《咏史》八首之间... 详细信息

学者对江淹《杂体诗三十首》的总体评价历来较高,但是对其中模拟左思《咏史》八首的《左记室思咏史》评价较低。在前贤研究的基础上,江淹拟诗还可以从文本细读、互文性与接受史的视角来进行重新解读,从而考察其与左思《咏史》八首之间的异同点,探讨江淹在表达方式、主题、思想等方面对左思诗歌精神内核的把握。另外,对拟诗与原作的互文性分析还可用以阐释江淹拟诗所涉六朝咏史诗之间的关系,进而揭示该诗对左思《咏史》流传所产生的重要意义,为江淹拟诗的研究提供新的视角和思考维度。

关键词：江淹左思咏史拟诗接受

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Ambient electrosynthesis of urea from carbon dioxide and nitrate over Mo_(2)C nanosheet

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Chinese Chemical Letters 2024年第8期35卷 319-323页

作者： yue zhang Xiaoya Fan Xun He Tingyu Yan Yongchao Yao Dongdong Zheng Jingxiang Zhao Qinghai Cai Qian Liu Luming Li Wei Chu Shengjun Sun Xuping Sun College of Chemistry and Chemical Engineering and Key Laboratory of Photonic and Electronic Bandgap MaterialsMinistry of EducationHarbin Normal UniversityHarbin 150025China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Institute for Advanced Study Chengdu UniversityChengdu 610106China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJi’nan 250014China

Electrocatalytic synthesis of urea through C-N bond formation,converting carbon dioxide(CO_(2))and ni-trate(NO_(3)^(-)),presents a promising,less energy-intensive alternative to industrial urea production *** this communication,we report the application of Mo_(2)C nanosheets-decorated carbon sheets(Mo_(2)C/C)as a highly efficient electrocatalyst for facilitating C-N coupling in ambient urea *** CO_(2)-saturated 0.2 mol/L Na_(2)SO_(4)solution containing 0.05 mol/L NO_(3)^(-),the Mo_(2)C/C catalyst achieves an impres-sive urea yield of 579.13μg h^(-1)mg^(-1)with high Faradaic efficiency of 44.80%at-0.5 V versus the reversible hydrogen *** theoretical calculations reveal that the multiple Mo active sites enhance the formation of^(∗)CO and^(∗)NH_(2)intermediates and facilitate their C-N *** research propels the use of Mo_(2)C-based electrodes in electrocatalysis and accentuates the capabilities of binary metal-based catalysts in C-N coupling reactions.

关键词： Mo_(2)C Multiple active sites C-N coupling Electrocatalysis Urea synthesis Density functional theory calculation

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Changes in macrophage infiltration and podocyte injury in lupus nephritis patients with repeated renal biopsy: Report of three cases

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World Journal of Clinical Cases 2024年第1期12卷 188-195页

作者： Shi-Yuan Liu Hao Chen Li-Jia He Chun-Kai Huang Pu Wang zhang-Ru Rui Jue Wu Yang Yuan yue zhang Wen-Ju Wang Xiao-Dan Wang Central Laboratory Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan ProvinceYan'an Hospital Affiliated to Kunming Medical UniversityKunming 650051Yunnan ProvinceChina Department of Nephropathy Yan'an Hospital Affiliated to Kunming Medical UniversityKunming 650051Yunnan ProvinceChina

BACKGROUND In this study,we retrospectively analysed macrophage infiltration and podocyte injury in three patients with diffuse proliferative lupus nephritis(LN)who un-derwent repeated renal *** SUMMARY Clinical data of three diffuse proliferative LN patients with different pathological characteristics(case 1 was LN IV-G(A),case 2 was LN IV-G(A)+V,and case 3 was LN IV-G(A)+thrombotic microangiopathy)were *** patients underwent repeated renal biopsies 6 mo later,and renal biopsy specimens were *** infiltration was assessed by CD68 expression detected by immunohistochemical staining,and an immunofluorescence assay was used to detect podocin expression to assess podocyte *** treatment,Case 1 changed to LN III-(A),Case 2 remained as type V LN lesions,and Case 3,which changed to LN IV-S(A),had the worst *** observed reduced macro-phage infiltration after ***,two of the patients with active lesions after treatment still showed macrophage infiltration in the renal *** treatment,the three patients showed discontinuous expression of ***,the integrity of podocin was restored after treatment in Case *** It may be possible to reverse podocyte damage and decrease the infiltrating ma-crophages in LN patients through effective treatment.

关键词： Lupus nephritis Macrophage Podocyte Repeat renal biopsy Thrombotic microangiopathy Case report

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分时电价下泊位岸桥联合调度研究

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计算机工程与应用 2024年第9期60卷 338-345页

作者：苟悦梁承姬张悦上海海事大学物流科学与工程研究院上海201306

基于全球各地推行分时电价政策以及大力发展港口岸电的背景下,将分时电价引入集装箱码头作业问题中,考虑岸电和分时电价对集装箱码头作业计划的影响,同时兼顾码头和船方的利益,在保证船舶可以按计划离港的前提下,构建以船舶在港时间、... 详细信息

基于全球各地推行分时电价政策以及大力发展港口岸电的背景下,将分时电价引入集装箱码头作业问题中,考虑岸电和分时电价对集装箱码头作业计划的影响,同时兼顾码头和船方的利益,在保证船舶可以按计划离港的前提下,构建以船舶在港时间、岸桥电力成本和船舶使用岸电的电力成本最小化为目标的多目标优化模型,根据所选取问题和模型目标函数的特点,选择带精英策略的非支配排序遗传算法(NSGA II)进行求解。通过不同规模的实例验证,与不考虑电力成本的传统泊位岸桥分配策略相比,所提出的模型算法均能够有效降低码头的电力成本,缓解高峰用电压力,尤其对集装箱吞吐量较少的码头优化效果更加显著。最后,通过对分时电价峰谷电价差的灵敏度分析,为码头相关部门针对不同的电价政策进行决策提供一定的依据。

关键词：分时电价泊位岸桥联合调度岸电非支配排序遗传算法(NSGA II)

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数字治理下农民收入增长与收入分配效应

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华南农业大学学报（社会科学版） 2024年第1期23卷 63-75页

作者：张岳张博河北大学管理学院河北保定071002 河北大学河北省乡村振兴研究院河北保定071002

实现共同富裕要求兼顾“发展”与“共享”的双重目标,数字技术为乡村治理转型提供支撑。以中国乡村振兴综合调查(CRRS)数据为样本进行实证分析,结论如下:农民参与数字治理具有收入增长效应,能有效提升其收入水平,实现共同富裕所要求的... 详细信息

实现共同富裕要求兼顾“发展”与“共享”的双重目标,数字技术为乡村治理转型提供支撑。以中国乡村振兴综合调查(CRRS)数据为样本进行实证分析,结论如下:农民参与数字治理具有收入增长效应,能有效提升其收入水平,实现共同富裕所要求的“发展”目标。分位数回归与再中心化影响函数回归结果均表明农民参与数字治理具有收入分配效应,能够缩小农民内部收入差距,实现共同富裕所要求的“共享”目标。影响机制检验表明,农民参与数字治理将显著提高其信息获取能力,同时,数字治理参与对具有较低社会资本群体的收入赋能作用更显著。

关键词：数字治理乡村数字化共同富裕收入差距

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