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The Kite Produced in Tianjin

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China's Foreign Trade 1997年第5期 62-63页

作者： yue xi

The kite-making in China has a long history of more than 2,000 years. It is said that Gong Shuban of Lu State of the Spring and Autumn and Warring Period made a wood magpie. Also at that time, Mu Zhai made a wood eagle to fly in the sky. These were the prototype of kites in China. During the end of Qin Dynasty and the beginning of Han Dynasty, a man named Hah xin made a paper kite using bomboo sticks as its framework, which was covered with paper and drawn by a string of thread to fly in the sky. During the period of the Five Dynasties, Li

关键词： The Kite Produced in Tianjin time

Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

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Frontiers of Medicine 2024年第2期18卷 375-393页

作者： Fu’an xie Yujia Niu Lanlan Lian yue Wang Aobo Zhuang Guangting Yan Yantao Ren xiaobing Chen Mengmeng xiao xi Li Zhe xi Gen Zhang Dongmei Qin Kunrong Yang Zhigang Zheng Quan Zhang xiaogang xia Peng Li Lingwei Gu Ting Wu Chenghua Luo Shu-Hai Lin Wengang Li Cancer Research Center Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102China xiamen University Research Center of Retroperitoneal Tumor Committee of Oncology Society of Chinese Medical Association Xiamen UniversityXiamen361102China Department of Laboratory Medicine Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing102206China School of Public Health Harvard UniversityBostonMA02115USA Laboratory of Biochemistry and Molecular Biology Research Department of Clinical LaboratoryFujian Medical University Cancer HospitalFuzhou350014China Surgery Department Affiliated Fuzhou First Hospital of Fujian Medical UniversityFuzhou350009China National Institute for Data Science in Health and Medicine Xiamen UniversityXiamen361102China Department of Hepatobiliary Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China

Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for *** proteomic and metabolic profiles of RLPS have remained *** aim of our study was to reveal the metabolic profile of ***,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during *** analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were *** particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor *** study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.

关键词： RLPS proteomics metabolomics lipidomics metabolism

Analytical Expression for the Atomic Friction of a Single Asperity Based on the Prandtl-Tomlinson Model

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Acta Mechanica Solida Sinica 2024年第3期37卷 416-422页

作者： Weike Yuan yue Ding Gangfeng Wang xinrui Niu Department of Engineering Mechanics SVLMMLXi’an Jiaotong UniversityXi’an710049China Department of Mechanical Engineering City University of Hong KongHong Kong SAR999077China

The Prandtl-Tomlinson(PT)model has been widely applied to interpret the atomic friction mechanism of a single *** this study,we present an approximate explicit expression for the friction force in the one-dimensional PT model under quasi-static ***‘stick-slip’friction curves are first approximated properly by sawtooth-like lines,where the critical points before and after the‘slip’motion are described analytically in terms of a dimensionless parameterη.Following this,the average friction force is expressed in a closed form that remains continuous and valid forη>***,an analytical expression for the load dependence of atomic friction of a single asperity is derived by connecting the parameterηwith the normal *** the parameters reported in experiments,our prediction shows good agreement with relevant experimental results.

关键词： Atomic friction Stick-slip friction Prandtl-Tomlinson model Friction force microscope

Self-powered and self-sensing devices based on piezoelectric energy harvesting

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Science China(Technological Sciences) 2024年第6期67卷 1631-1667页

作者： CHEN GanTong ZHU yue HUANG DongMei ZHOU Shengxi School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China School of Mathematics and Statistics Xidian UniversityXi’an710071China

Wearable devices,interactive human-machine interface equipment,wireless sensors,and small-scale cleaning devices play crucial roles in biomedical implantation,disease treatment,health monitoring,environmental purification,*** devices require a sustainable energy source to work *** the consideration of the global energy crisis and environmental pollution,researchers are exploring new,stable,and environmentally friendly methods to power these low-powered *** energy is one of the most abundant natural energy *** mechanical energy from the ambient environment or host structures into electrical energy via the direct piezoelectric effect is an efficient energy harvesting *** paper reviews the application of advanced piezoelectric materials,and small-scale self-powered and self-sensing piezoelectric devices at the cubic centimeter scale in energy harvesting and health monitoring of human,animal,machinery,roads,bridges,as well as the pollutant degradation of the *** of these devices have the capability to not only harvest mechanical energy but also enable real-time monitoring and analysis of the electrical signals generated by the direct piezoelectric effect,facilitating prompt decision-making and appropriate *** addition,potential challenges and future prospects of small-scale self-powered and self-sensing piezoelectric devices are discussed.

关键词： piezoelectric energy harvesting self-powered self-sensing wearable devices implantable devices

Spatial association between landslides and environmental factors over Guizhou Karst Plateau,China

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Journal of Mountain Science 2018年第9期15卷 1987-2000页

作者： yue xi-liu WU Shao-hong HUANG Mei GAO Jiang-bo YIN Yun-he FENG Ai-qing GU xiao-ping Institute of Geographical Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 10010lChina Post-doctoral Workstation China Reinsurance GroupBeijing 100033China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China National Climate Center China Meteorological AdministrationBeijing 100081China Guizhou Key Laboratory of Mountainous Climate and Resource Guiyang 550002China

Guizhou Karst Plateau is located at the center of the karst region in Asia, where landslides are a typical disaster. Affected by the local karst environment, the landslides in this region have their own characteristics. In this study, 3975 landslide records from inventories of the Guizhou karst plateau are studied. The geographical detector method is used to detect the dominant casual factor and predominant multi-factor combinations for the local landslides. The results show that landslides are prone to areas on slopes between 10° and 35°, of clay rock, in close proximity to gullies, and especially in areas of moderate vegetation, dryland, and mild rocky desertification. Continuous precipitation over 10 days has a great effect on landslide occurrence. Compared with the individual factors, the impact of two-factor interaction has greater explanatory power for landslide volume. The volume of earthquake-induced landslides is predominantly controlled by the interactions of faults and slopes, while that of humaninduced landslides is affected by the interactions of land cover and hydrological conditions. For rainfallinduced landslides, the dominant interactions vary in different regions. In the central karst basin, the interactions between faults and precipitation can explain over 90% of the variations in landslide volumes. In the southern hilly karst region, the interactions between lithology and slope can explain over 71% of the variations in landslide volume and those between fault and land-use can explain 50% of the variations of the landslide volumes in the northeastern mountainous karst region.

关键词：石灰岩地区山崩地形环境因素高原贵州相互作用能协会

NOD2介导的信号通路及其与自身炎症性疾病关系以及抑制剂研究进展

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药学学报 2023年第4期58卷 899-908页

作者：杨熙玥叶菜英朱蕾中国医学科学院基础医学研究所北京协和医学院基础学院药理系北京100005

核苷酸结合寡聚化结构域蛋白2(nucleotide-binding oligomerization domain containing 2,NOD2)是一类胞浆内模式识别受体,其被激活后通过一系列信号级联转导,诱导炎症因子释放,从而在固有免疫应答中发挥重要作用。NOD2信号通路异常涉... 详细信息

核苷酸结合寡聚化结构域蛋白2(nucleotide-binding oligomerization domain containing 2,NOD2)是一类胞浆内模式识别受体,其被激活后通过一系列信号级联转导,诱导炎症因子释放,从而在固有免疫应答中发挥重要作用。NOD2信号通路异常涉及多种疾病的发生和发展,尤其是其基因的遗传多态性与自身炎症性疾病(autoinflammatory diseases,AIDs)密切相关。因此,靶向NOD2通路的抑制剂在炎症免疫性疾病治疗中具有巨大潜力。基于此,本文对NOD2受体介导的信号转导通路及其调节机制,NOD2与AIDs的关系以及NOD2通路抑制剂研究的最新进展进行综述。

关键词：核苷酸结合寡聚化结构域蛋白2 受体相互作用蛋白2 自身炎症性疾病抑制剂自噬内质网应激

Comparative Analysis of Hydrolytic Amino Acids in Human and Cow Milk of Different Lactation Periods

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Journal of Northeast Agricultural University(English Edition) 2022年第1期29卷 69-78页

作者： Zhang Juan Chen Jia-li Rayhnigul Abdlla Li Mo-han Yu Hai-kun Zhang xiu-min Zheng Yan yue xi-qing College of Food Science Shenyang Agricultural UniversityShenyang 110866China Beijing Academy of Food Sciences Beijing100068China

In this study,the hydrolytic amino acids of Chinese human and Holstein cow milk of different lactation periods were analyzed by the advanced isobaric tags for relative and absolute quantitation(iTRAQ)combined with the high performance liquid chromatography-mass spectrometry(HPLC-MS/MS)*** total contents of the hydrolytic amino acids in cow colostrum,cow mature milk,human colostrum and human mature milk were 5.00,4.38,2.12 and 2.48 g·L^(-1),*** these,the contents of the hydrolytic amino acids in cow milk were higher than those in human milk,indicating a decreasing trend with the prolongation of ***,principal component and hierarchical cluster analyses were used to further screen the differentially expressed amino *** results enhanced the understanding of the hydrolytic amino acids in cow and human milk across different lactation periods,which could provide potential directions for newborn dairy powder and nutritious supplementary.

关键词： cow milk human milk lactation period hydrolytic amino acid iTRAQ HPLC-MS/MS

Network Pharmacology-Based Dissection of the Bioactive Compounds and Pharmacological Mechanisms of Yiqi Fumai Lyophilized Injection for the Treatment of Heart Failure

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 75-82页

作者： Yu-xi Huang Jing-Jing Fan Lu-Lu Xu Rong Yu Yi Kuang yue Chai Rui Zheng xiao-Yu Zhang Hong-Cai Shang Xue Qiao Min Ye State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijingChina Key Laboratory of Chinese Internal Medicine of Ministry of Education Dongzhimen HospitalBeijing University of Chinese MedicineBeijingChina Yunnan Baiyao International Medical Research Center Peking UniversityBeijingChina Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Peking UniversityBeijingChina

Objective:Yiqi Fumai Lyophilized Injection(YQFM),a Chinese medicine injection,has been widely used for the treatment of cardiovascular diseases,especially heart failure(HF).However,bioactive compounds and underlying mechanisms of YQFM in treating HF remain poorly *** and Methods:Network pharmacology was employed to investigate the bioactive compounds and mechanisms of YQFM.A compound-target network was constructed to screen bioactive compounds based on contribution index ***,an adriamycin-induced HF rat model was established to evaluate the cardio-protective effects of YQFM by hematoxylin and eosin staining and enzyme-linked immunosorbent ***:Network pharmacology indicated that YQFM may alleviate HF through 36 compounds and 109 ***,ginsenosides Rb1,Rg1,Re,Rf,Rb2,Rh1,schisandrin,and ginsenoside Rc were indicated as the top contributors of YQFM in treating *** was predicted to act on multiple targets such as vascular endothelial growth factor A,interleukin-2(IL-2),IL-6,and IL-1β,as well as to regulate signaling pathways such as hypoxia-inducible factor 1,tumor necrosis factor,VEGF,and *** pharmacological study suggested that YQFM could attenuate cardiac injury and up-regulate plasma concentrations of VEGFR-1 and NO in HF *** Rb1,as the major contributor from network pharmacology analysis,also showed a cardioprotective effect and up-regulation of VEGFR-1 in ***:Ginsenosides and schisandrin were predicted as the most important contributors to the cardioprotective effect of *** Rb1 was proved to alleviate HF and increase the plasma concentration of VEGFR-1.

关键词： Contribution index heart failure network pharmacology traditional Chinese medicine yiqi fumai lyophilized injection

通过链脲佐菌素诱导建立糖尿病骨质疏松大鼠模型的实验研究进展

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中国实验动物学报 2022年第7期30卷 1003-1012页

作者：孙立亚刘北奚悦辽宁中医药大学沈阳110847 锦州医科大学附属第三医院辽宁锦州121001

糖尿病骨质疏松症(diabetic osteoporosis,DOP)是由糖尿病(diabetes mellitus,DM)诱发的慢性骨代谢疾病,其特征为骨量减少、骨脆性增加、强度降低以及易于发生骨折等。为更好地探索糖尿病骨质疏松发病机制,并为其治疗研究提供依据,建立... 详细信息

糖尿病骨质疏松症(diabetic osteoporosis,DOP)是由糖尿病(diabetes mellitus,DM)诱发的慢性骨代谢疾病,其特征为骨量减少、骨脆性增加、强度降低以及易于发生骨折等。为更好地探索糖尿病骨质疏松发病机制,并为其治疗研究提供依据,建立出能够模拟人类糖尿病骨质疏松病理学的动物模型具有重要价值。通过链脲佐菌素(streptozotocin,STZ)诱导建立糖尿病骨质疏松动物模型的方式具有操作简单、用时短、成模率高、稳定性相对较高等优势,本文从动物选择、饲料喂养、链脲佐菌素的应用、造模方法、成模标准及检测指标等方面进行综述,希望能够为更加深入研究糖尿病骨质疏松致病机制提供基础和依据。

关键词：链脲佐菌素糖尿病骨质疏松症大鼠模型研究进展