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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin wu Xiaowu Lin Yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Visualization of collision and aggregation behavior of particles simulating movement of inclusions in molten steel

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Journal of Iron and Steel Research International 2018年第2期25卷 173-180页

作者： Qiang yue Zeng Hu Zhao-yang wu Hong-ming Long Qing-min Meng Key Laboratory of Metallurgical Emission Reductionand Resources Recycling (Anhui University of Technology) Ministry of Education Ma'anshan 243002 Anhui China The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081 Hubei China School of Metallurgical Engineering Anhui Universityof Technology Ma'anshan 243002 Anhui China

Inclusions with sizes less than 1 μm in molten steel are difficult to float up to the molten steel and slag interface owing to their slow terminal velocity. Thus, increasing the size of inclusion is essential for accelerating the removal of inclusions. Polystyrene particles simulating inclusions in molten steel were quantified by direct observation of the particle collision behavior in a turbulent flow in a water model. The box-counting fractal dimension of particles was calculated by processing the binary images of aggregated particles. The fractal dimension of the outer contours of the single plastic particles was smaller than that of the aggregated particles. The fractal dimension was varied from 1.14 to 1.35. When two or more monomer particles collide, the aggregates are separated more easily, as the temperature increases from 40 to 80 ℃. The aggregated particles were loose and easy to separate in the high-temperature aqueous solution. The effect of temperature on the surface tension of liquid and the interracial tension of solid and liquid is obvious. The particles are wetting in the water solution at a temperature more than 60 ℃. The relationship between the velocity of the particles and the fractal dimension of the solid particles with the equivalent diameter was discussed.

关键词： Non-metallic inclusion Fractal Box-counting dimension Visualization Collision. Aggregation

Structure and intrinsic magnetic properties of Sm_(1-x)Pr_xCo_5(x=0–0.6) compounds

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Rare Metals 2016年第8期35卷 627-631页

作者： Miao-Ling Xu ming yue Yu-Qing Li Qiong wu Yun Gao College of Materials Science and Engineering Beijing University of TechnologyBeijing 100124China Samsung Advanced Institute of Technology Beijing 100028China

In this work, the effects of Pr content on the structure and intrinsic magnetic properties of Sml-xPrxCO5 （x = 0-0.6） compounds prepared by induction melting were systematically investigated by scanning electron microscopy （SEM）, X-ray diffraction （XRD）, and magnetic measurements. Microstructural observation and chemical composition analysis show that Sml xPrxCos compounds are composed of （Sin, Pr）Co （1：5） phase and （Sm, Pr）-rich grain boundary phase. XRD results show that all the Sml-xPrxCO5 compounds have a （Sm, Pr）lCo main phase with the hexagonal CaCus-type crystal structure and the （Sm, Pr）2 Co7 impurity phase. In addition, the detailed research shows that the lattice constants （a, c） and unit volume （V） are all enlarged with the increases in Pr con- tent. According to the magnetic measurements, as the Pr content increases to larger than 0.4, both the Curie tem- perature （Tc） and the anisotropy field （HA） of all the Pr- doped compounds decrease rapidly. Meanwhile, the mag- netization of Sml_***5 compounds at applied field of 14 T （MI4 T） are observably improved with Pr doping content of x 〉 0.3. Among them, Smo.6Pro.4Co5 compound exhibits slightly lower HA and Tc, but much higher M14 T than those of the binary SmCos, indicating that doping of proper Pr content into SmCo5 compound can optimize the intrinsic magnetic properties. As a result, the optimal intrinsic magnetic properties of HA = 29.11 T,Tc = 989 K, and M14 T = 102.31 mA.m2.g-1 are obtained in Smo.6Pro.4C05 compound.

关键词： Sml-xPrxCo5 compounds Microstructure Crystal structure Intrinsic magnetic property

Stress corrosion cracking behavior of buried oil and gas pipeline steel under the coexistence of magnetic field and sulfate-reducing bacteria

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Petroleum Science 2024年第2期21卷 1320-1332页

作者： Jian-Yu He Fei Xie Dan Wang Guang-Xin Liu ming wu yue Qin College of Petroleum Engineering Liaoning Petrochemical UniversityFushun113001LiaoningChina Key Laboratory of Oil and Gas Storage and Transportation Technology in Liaoning Province Fushun113001LiaoningChina State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing100084China PipeChina West East Gas Pipeline Company Shanghai200120China

Magnetic field and microorganisms are important factors influencing the stress corrosion cracking(SCC)of buried oil and gas pipelines. Once SCC occurs in buried pipelines, it will cause serious hazards to the soil environment. The SCC behavior of X80 pipeline steel under the magnetic field and sulfate-reducing bacteria(SRB) environment was investigated by immersion tests, electrochemical tests, and slow strain rate tensile(SSRT) tests. The results showed that the corrosion and SCC sensitivity of X80 steel decreased with increasing the magnetic field strength in the sterile environment. The SCC sensitivity was higher in the biotic environment inoculated with SRB, but it also decreased with increasing magnetic field strength, which was due to the magnetic field reduces microbial activity and promotes the formation of dense film layer. This work provided theoretical guidance on the prevention of SCC in pipeline steel under magnetic field and SRB coexistence.

关键词： Magnetic field Sulfate-reducing bacteria Film layer Stress corrosion cracking Oil and gas pipelines

Recent progress of ultrasound-responsive titanium dioxide sonosensitizers in cancer treatment

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Chinese Chemical Letters 2024年第10期35卷 63-72页

作者： Hajing Cui Weihao Zhu Chuning yue ming Yang Wenzhi Ren Aiguo wu Cixi Biomedical Research Institute Wenzhou Medical UniversityNingbo 315300China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of Sciences Ningbo315201China C Advanced Energy Science and Technology Guangdong LaboratoryHuizhou 516000China

Sonodynamic therapy(SDT)exhibits promising clinical applications in cancer treatment owing to its ad-vantages,including ultrasonic cavitation effect,mechanical effect,and deep tissue *** dioxide(TiO_(2))nanomaterials,recognized as excellent sonosensitizers,have been extensively studied in cancer *** review first outlines the mechanism of TiO_(2)-based SDT,then systematically discusses the regulation of TiO_(2) sonosensitivity,covering aspects such as morphology,particle size,element doping,defect engineering,heterojunction structure,and interactions with the tumor ***-more,the review generalizes ultrasound-responsive TiO_(2)-based therapeutic modalities for tumor treat-ment,including SDT,SDT combined with chemotherapy,chemodynamic therapy,photothermal therapy,immunotherapy,and treatment ***,the review navigates the ongoing challenges and prospects in TiO_(2)-based cancer SDT.

关键词： Titanium dioxide Sonodynamic therapy Reactive oxygen species Cavitation effects Combined therapy

UHPLC-MS/MS analysis of cAMP and cGMP in rat plasma as potential biomarkers of Yin-Yang disharmony in traditional Chinese medicine

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Journal of Pharmaceutical Analysis 2021年第4期11卷 458-464页

作者： Xin Wang yue Du Cuiting wu ming Xu Youping Liu Xin Di Laboratory of Drug Metabolism and Pharmacokinetics School of PharmacyShenyang Pharmaceutical University103 Wenhua RoadShenyang110016PR China Shenyang Analytical Application Center Shimadzu(China)Co.Ltd.Shenyang167 Qingnian StreetShenyang110016PR China

Cyclic 3’,5’-adenosine monophosphate(cAMP)and cyclic 3’,5’-guanosine monophosphate(cGMP)are considered as potential biomarkers for Yin-Yang disharmony in traditional Chinese ***,phosphodiesterase-mediated ex vivo degradation of these molecules in biological samples may result in their *** the present study,a ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS)method was developed for determination of cAMP and cGMP in rat plasma,with special consideration of their stability ex *** precipitation of proteins from plasma samples with 0.4 M perchloric acid,the analytes were chromatographed on a Shimadzu Shimpack-XR-ODS II column with 2.5 mM ammonium acetate and methanol in gradient *** MS/MS detection was performed using multiple reaction monitoring in the positive electrospray ionization *** lower limit of quantification was 0.27 ng/mL for cAMP and 0.37 ng/mL for *** method was used to determine the plasma cAMP and cGMP levels in normal and Yin deficiency diabetic rats treated with or without Rehmannia *** developed method may be useful for evaluating the regulatory effects of Chinese herbal medicine on the levels of cAMP and cGMP in the body.

关键词： cAMP cGMP Plasma UHPLC-MS/MS Yin-Yang disharmony

Constructing of highly porous thermoelectric structures with improved thermoelectric performance

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Nano Research 2021年第10期14卷 3608-3615页

作者： Peilei He yue wu Department of Chemical and Biological Engineering Iowa State UniversityAmesIowa 50011USA

As more than 60%of worldwide consumed energy is unused and becomes waste heat every year,high-efficiency waste heat to power technologies are highly demanded for the conversion of wasted heat to *** which can convert the wasted heat directly into electricity represent a promising approach for energy *** technology has existed for several decades,but its usage has been limited due to low *** advances in nanotechnology have enabled the improving of thermoelectric properties which open up the thermoelectrics’feasibility in *** this paper,we present an overview of recent progress in increasing the porosity of thermoelectric materials from atomic scale to microscale,leading to the enhancement of figure of merit.

关键词： thermoelectrics semiconductors porous structures thermal conductivity

A Simple Approach for Synthesis of TAPO-11 Molecular Sieve with Controllable Space Group

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Chinese Chemical Letters 2006年第10期17卷 1409-1412页

作者： yue ming LIU Huan Yan ZHANG Hai Jiao ZHANG Hai Hong wu Peng wu ming Yuan HE Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of Chemistry East China Normal University Shanghai 200062

A TAPO-11 molecular sieve with the space group lcm2 was synthesized successfully. The samples with different space group were controlled simply only by adjusting the crystallization temperature （CT） in the hydrothermal system. In the system of gel with a molar composition of 0.7R- xTiO2： P2O5： Al2O3： 30H2O, where x is 0.01-0.10 and the R is a mixture of di-n-propylamine and diisopropylamine as templates. When CT was between 150-160℃, the calcined sample showed the space group of Icm^2, while it showed Pna21 at CT larger than 190℃. The characterizations of UV-Vis and FT-IR confirmed that Ti was incorporated into the AEL framework successfully.

关键词： TAPO-11 molecular sieve space group synthesis titanosilicate

The Role of Renewable Protocatechol Acid in Epoxy Coating Modification: Significantly Improved Antibacterial and Adhesive Properties

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Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： ming-Xuan Chen Jin-yue Dai Li-yue Zhang Shuai-Peng Wang Jing-Kai Liu Yong-Gang wu Xin-wu Ba Xiao-Qing Liu School of Chemistry and Materials Science Hebei UniversityBaoding 071000China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials and Related Technologies Chinese Academy of SciencesNingbo 315201China

It is of great significance to design epoxy coatings with superior antibacterial properties and high adhesive properties, as well as excellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antibacterial properties was introduced into the flexible alkane segment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was cured with isophorone diamine(IPDA) to prepare corresponding thermosets. The cured resins exhibited excellent allaround qualities, particularly in bonding and antibacterial. When 30% PCA was added to pure epoxy resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of bacterial cell membranes. The architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex synthesis techniques.

关键词： Epoxy coatings Thermosets Catechol structure Antibacterial High adhesion