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Combined chemo-endocrine therapy as a potential new option for HR+/HER2−advanced breast cancer:a prospective study of fulvestrant plus oral vinorelbine

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Cancer Biology & Medicine 2023年第4期20卷 287-296页

作者： Xue Wang jian yue Yikun Kang Zhong Dai Jie Ju Jiayu Wang Pin Zhang Fei Ma Binghe Xu Peng Yuan Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Comprehensive Oncology Huanxing Cancer HospitalBeijing 100026China Department of Medical Oncology and Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:Endocrine therapy with fulvestrant has shown synergistic antitumor effects with some chemotherapy drugs in *** study evaluated the efficacy and safety of fulvestrant with vinorelbine in patients with hormone receptor positive(HR+)/human epidermal growth factor receptor-2-negative(HER2−)recurrent or metastatic breast ***:Patients were intramuscularly administered fulvestrant 500 mg(day 1 per cycle for 28 days)and oral vinorelbine(60 mg/m2 on days 1,8,and 15 of each cycle).The primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival,objective response rate,disease control rate,duration of response,and ***:A total of 38 patients with HR+/HER2−advanced breast cancer included in the study were followed up for a median time of 25.1 *** overall median PFS was 9.86 months[95%confidence interval(CI)7.2-23.13],and the median PFS of the first-line and the second-line treatment population was 20.73 months(95%CI 9.82 to NR)and 4.27 months(95%CI 3.68 to NR),*** adverse events reported were of grade 1/2,and none were of grade 4/***:This is the first exploratory study of a fulvestrant and oral vinorelbine regimen in the treatment of HR+/HER2−recurrent and metastatic breast *** combination chemo-endocrine therapy was efficacious,safe,and promising for patients with HR+/HER2−advanced breast cancer.

关键词： HR+/HER2−breast cancer recurrence metastasis fulvestrant oral vinorelbine

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Research of the electrical anisotropic characteristics of water-conducting fractured zones in coal seams

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Applied Geophysics 2017年第2期14卷 216-224,322页

作者： Su Ben-Yu yue jian-Hua Institute of appliect geophysics The school resource and geosciences CUMT Xuzhou 221116 China.

Water flooding disasters are one of the five natural coal-mining disasters that threaten the lives of coal miners. The main causes of this flooding are water-conducting fractured zones within coal seams. However, when resistivity methods are used to detect water-conducting fractured zones in coal seams, incorrect conclusions can be drawn because of electrical anisotropy within the water-conducting fractured zones. We present, in this paper, a new geo-electrical model based on the geology of water-conducting fractured zones in coal seams. Factors that influence electrical anisotropy were analyzed, including formation water resistivity, porosity, fracture density, and fracture surface roughness, pressure, and dip angle. Numerical simulation was used to evaluate the proposed electrical method. The results demonstrate a closed relationship between the shape of apparent resistivity and the strike and dip of a fracture. Hence, the findings of this paper provide a practical resistivity method for coal-mining production.

关键词： water-conducting fractured zones in coal seams coalfield goaf electrical anisotropy surface roughness formation water resistivity formation pressure

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Knowledge Innovation of Great Tradition of Chinese Literary Anthropology

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Journal of Literature and Art Studies 2016年第6期6卷 597-602页

作者： HU jian-sheng yue jian-feng Shanghai Jiao Tong University Shanghai China

It is very innovative significance that Chinese Literary Anthropology invents the Great Tradition in the new century and puts forward series of theoretical propositions and academic points based on it. The new Great Tradition transforms the opposition between the Great and Little Tradition of American anthropology, and makes the new concepts gain the legitimacy of the cultural values transferred from the old terms. It dates the second coded significance of the written culture from the material narrative and the image narrative of the oral tradition, and highlights the generative and primary of the symbolic significance. It also questions the authenticity of the written representation, endows the truth and credibility to the material and image representation, and manifests the imaginative and expression of the early human culture. Though its theoretical innovation inverts the binary opposition structure, and it wants to jump out of knowledge limits of dual structure such as structure and destruction, objective and subjective, material and spiritual.

关键词： Chinese Literary Anthropology Ye Shuxian Great Tradition Little Tradition theoretical innovation

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Association between homologous recombination deficiency and outcomes with platinum and platinum-free chemotherapy in patients with triple-negative breast cancer

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Cancer Biology & Medicine 2023年第2期20卷 155-168页

作者： Yimeng Chen Xue Wang Feng Du jian yue Yiran Si Xiaochen Zhao Lina Cui Bei Zhang Ting Bei Binghe Xu Peng Yuan Department of Medical Oncology and Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China The Medical Department 3D Medicines Inc.Shanghai 201114China

Objective:The choice of chemotherapeutic regimen for triple-negative breast cancer(TNBC)remains *** recombination deficiency(HRD)has attracted increasing attention in informing chemotherapy *** study was aimed at investigating the feasibility of HRD as a clinically actionable biomarker for platinum-containing and platinum-free ***:Chinese patients with TNBC who received chemotherapy between May 1,2008 and March 31,2020 were retrospectively analyzed with a customized 3D-HRD *** positivity was defined by an HRD score≥30 or deleterious BRCA1/2 mutation.A total of 386 chemotherapy-treated patients with TNBC were screened from a surgical cohort(NCT01150513)and a metastatic cohort,and 189 patients with available clinical and tumor sequencing data were ***:In the entire cohort,49.2%(93/189)of patients were identified as HRD positive(40 with deleterious BRCA1/2 mutations and 53 with BRCA1/2 intact with an HRD score of≥30).In the first-line metastatic setting,platinum therapy was associated with longer median progression-free survival(mPFS)than platinum-free therapy[9.1 vs.3.0 months;hazard ratio(HR),0.43;95%confidence interval 0.22–0.84;P=0.01].Among HRD-positive patients,the mPFS was significantly longer in those treated with platinum rather than platinum-free therapy(13.6 vs.2.0 months;HR,0.11;P=0.001).Among patients administered a platinum-free regimen,HRD-negative patients showed a PFS significantly superior to that of HRD-positive patients(P=0.02;treatment-biomarker P-interaction=0.001).Similar results were observed in the BRCA1/2-intact *** the adjuvant setting,HRD-positive patients tended to benefit more from platinum chemotherapy than from platinum-free chemotherapy(P=0.05,P-interaction=0.02).Conclusions:HRD characterization may guide decision-making regarding the use of platinum treatment in patients with TNBC in both adjuvant and metastatic settings.

关键词： Homologous recombination deficiency triple-negative breast cancer platinum survival BRCA

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碳化硅反射镜轻量化结构的改进与优化

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光子学报 2015年第8期44卷 34-39页

作者：袁健任建岳中国科学院长春光学精密机械与物理研究所长春130033 中国科学院大学北京100049

为了提高碳化硅反射镜的成像质量,针对反射镜传统的轻量化结构提出了改进形式及相应的优化方法.提出轻量化反射镜的变筋厚设计方案,分别基于几何位置与传力路径对轻量化筋进行分组,成像质量与传统结构相比明显提高,指出具有不同拓扑关... 详细信息

为了提高碳化硅反射镜的成像质量,针对反射镜传统的轻量化结构提出了改进形式及相应的优化方法.提出轻量化反射镜的变筋厚设计方案,分别基于几何位置与传力路径对轻量化筋进行分组,成像质量与传统结构相比明显提高,指出具有不同拓扑关系的轻量化筋在增强镜体刚度的过程中所起到的作用不同.对反射镜背部的筋板结构进行修剪,改善了远离支撑孔处面形的局部塌陷.针对改进后的反射镜建立集成优化模型,使用多岛遗传算法确定了反射镜中各结构参量的最佳组合.仿真结果表明,基于传力路径的分组改进方案经优化后的性能相比传统结构经优化所得的结果,面形准确度提高了33.2%,重量下降了11.7%.

关键词：空间光学变筋厚设计集成优化设计拓扑关系多岛遗传算法

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三角波比较法的幅值和相位补偿原理

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电力系统自动化 2010年第16期34卷 69-72页

作者：刘剑谭甜源乐健武汉大学电气工程学院湖北省武汉市430072

对引入系统电压前馈并采用P控制器的静止坐标系下三角波比较法的幅频特性和相频特性进行了详细的理论研究。首先用微分方程定量地推导出了该算法所带来的幅值差和相位差,然后用相量图推导出数字化实现时控制器的延时对算法所固有的幅值... 详细信息

对引入系统电压前馈并采用P控制器的静止坐标系下三角波比较法的幅频特性和相频特性进行了详细的理论研究。首先用微分方程定量地推导出了该算法所带来的幅值差和相位差,然后用相量图推导出数字化实现时控制器的延时对算法所固有的幅值差和相位差的影响。在实际装置中,以上述理论为指导对三角波比较法进行了幅值和相位补偿。实验结果验证了文中理论分析的正确性。

关键词：三角波比较法电压型变流器数字控制器

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Distribution and Selective Effects of Vrn-A1,Vrn-B1,and Vrn-D1 Genes in Derivative Varieties from Four Cornerstone Breeding Parents of Wheat in China

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Agricultural Sciences in China 2010年第10期9卷 1389-1399页

作者： ZHANG Yang LIU Wan-chen LI Jun WEI Hui-ting HU Xiao-rong LI yue-jian LU Bao-rong YANG Wu-yun Crop Research Institution Sichuan Academy of Agricultural Scienee Chengdu 610066 P.R. China School of Life Science Sichuan University Chengdu 610064 P.R.China Institution of Biodiversity Science Fudan University Shanghai 200433 P.R.China

Vernalization, the process of a long exposure to low temperature to induce flowering in plants, is essential for plants to adapt to cold winters. The presence of vernalization genes Vrn-A1, -B1, and -D1 in four cornerstone breeding parents of wheat in China （Funo, Mentana, Yanda 1817, and Bima 4） and 322 derivative varieties （mostly winter wheat） from these parents were determined using PCR based molecular method. The frequencies of the VRN-1 genes in these derivative varieties were in order of Vrn-Dl（67.1%）〉 Vrn-Bl（19.6%）〉 Vrn-Al（5.3%）, which are similar as the former conclusion that Vrn-D1 is associated with the latest heading time, Vrn-A1 the earliest, and Vrn-B1 intermediate values. The frequencies of Vrn-Al and Vrn-B1 loci in the derivative varieties from winter wheat zones were higher than that from spring winter zones. Based on the wheat breeding history in China and the fact of non-random distribution of Vrn-A1 and Vrn-B1 in the derivative varieties from the four parents, there could be a strong selective effect on VRN-1 genes in different regions where the derivative varieties were cultivated.

关键词： vernalization cornerstone breeding parents of wheat derivative varieties

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Simultaneous determination of metronidazole and tinidazole in plasma by using HPLC-DAD coupled with second-order calibration

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Chinese Chemical Letters 2010年第10期21卷 1223-1226页

作者： Li Qun Ouyang Hai Long Wu Ya Juan Liu jian yue Wang Yong Jie Yu Hong Yan Zou Ru Qin Yu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Zhoushan Municipal Center for Disease Control & Prevention Zhoushan 310062 China

A method using HPLC-DAD coupled with second-order calibration was developed to simultaneously determine metronidazole and tinidazole in plasma samples in this paper. The second-order calibration method based on APTLD （alternating penalty trilinear decomposition） algorithm was proposed to analyze the three-way HPLC-DAD data from both standard and prediction samples, which makes it possible that calibration can be performed even in the presence of unknown interferences with a simple and green chromatographic condition and short analysis time. The results showed that good recoveries were obtained although the chromatographic and spectral profiles of the analytes of interest as well as background were partially overlapped with each other in plasma samples.

关键词： HPLC-DAD Second-order calibration Alternating penalty trilinear decomposition (APTLD) Metronidazole Tinidazole Plasma

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轨下扣件支承失效对轨道结构动力性能的影响

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振动工程学报 2011年第2期24卷 158-163页

作者：朱剑月同济大学铁道与城市轨道交通研究院轮轨系统研究所上海200092

通过建立连续弹性离散点支承上Timoshenko梁的钢轨模型,运用车辆-轨道耦合动力学理论,模拟计算了室内模型轨道轨下支承失效状态下轮轨系统动力响应,分析了列车运行速度与扣件失效数量对轨道结构动力性能的影响,并进行了时域与频域内的... 详细信息

通过建立连续弹性离散点支承上Timoshenko梁的钢轨模型,运用车辆-轨道耦合动力学理论,模拟计算了室内模型轨道轨下支承失效状态下轮轨系统动力响应,分析了列车运行速度与扣件失效数量对轨道结构动力性能的影响,并进行了时域与频域内的试验分析与验证。结果表明:轨下扣件失效破坏了轨道结构支承的连续性,轮轨间相互作用增强,并随其失效数量的增加与列车运行速度的提高而显著增大;同时,扣件支承失效将影响其前后毗邻的正常轨道结构的动态特性,形成较长范围内线路不平顺,影响车辆运行平稳性与乘坐舒适度。钢轨频响函数测试表明,由于扣件支承失效改变了该区段轨枕间距与轨下支承刚度,削弱了道床对线路所提供的阻尼,轨道结构的动力性能也产生了显著变化。

关键词：轨道结构扣件支承失效轮轨相互作用试验验证频响函数测试

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Effects of Yogurt Supplementation on the Growth of Preschool Children in Beijing Suburbs

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Biomedical and Environmental Sciences 2005年第3期18卷 192-197页

作者： MEIHE yue-XINYANG HuIHAN jian-HUAMEN LI-HUABIAN GUO-DONGWANG InstituteofNutritionandFoodSafety ChineseCenterforDiseaseControlandPreventionBeijing100050China

Objective To investigate the effect of yogurt supplementation on the growth of preschool children in Beijing suburbs. Methods Four hundred and two preschool children (217 males, 185 females), aged 3-5 years, whose height for age and/or weight for age were less than the reference level, were selected as subjects from 7 kindergartens in Beijing Fangshan District. The subjects were divided randomly into control group (CG, 201) and yogurt supplemented group (YG, 201). Each subject in YG was given one serving of yogurt (125 g) for 5 days a week from March to December in 2001, while nothing additional was provided to CG. All subjects kept their usual diet during the study. Anthropometry (body height and weight and upper-arm circumference) and the bone mineral density (BMD) of forearm were measured every 3 months. Disease status and dietary intake were also recorded and assessed. Results The intake of calcium, zinc, and vitamin B2 in YG was significantly higher than that in CG. The incidence and duration of upper-respiratory infection and diarrhea of children in YG were significantly less than those in CG. The height gain of children in YG was significantly higher than that in CG after yogurt was supplemented for 3, 6, and 9 months (P<0.05) (1.90±0.49 cm vs 1.77±0.54 cm, 3.83±0.57cm vs 3.64±0.66 cm and 5.43±0.69 cm vs 5.24±0.76 cm, respectively). The weight gain of children in YG was significantly higher than that in CG after yogurt was supplemented for 3, 6, and 9 months (P<0.05) (0.70±0.43 kg vs 0.49±0.35 kg, 0.98±0.62 kg vs 0.80±0.60 kg and 1.42±0.76 kg vs 1.20±0.67 kg, respectively). The BMD of children in YG was significantly higher than that in CG after yogurt was supplemented for 9 months (P<0.05) (0.415±0.058 g/cm2 vs 0.400±0.065 g/cm2). Conclusion Yogurt is beneficial to the improvement of calcium, zinc, and vitamin B2 intake, the decreasing of the incidence and duration of upper-respiratory infection and diarrhea, and the promotion of the health and the growth an

关键词： Yogurt Preschool children Growth and development

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