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Improved image filter based on SPCNN

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Science in China(Series F) 2008年第12期51卷 2115-2125页

作者： ZHANG yudong wu LeNan School of Information Science & Engineering Southeast University Nanjing 210096 China

By extraction of the thoughts of non-linear model and adaptive model match, an improved Nagao filter is brought. Meanwhile a technique based on simplified pulse coupled neural network and used for noise positioning, is put forward. Combining the two methods above, we acquire a new method that can restore images corrupted by salt and pepper noise. Experiments show that this method is more preferable than other popular ones, and still works well while noise density fluctuates severely.

关键词： Nagao filter pulse coupled neural network image smoothing image de-noising salt and pepper noise,edge preserving

Nanozyme-activating prodrug therapies:A review

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Chinese Chemical Letters 2024年第2期35卷 138-150页

作者： yudong wu wujun Chen Chao Wang Dongming Xing The Affiliated Hospital of Qingdao University Qingdao UniversityQingdao 266071China School of Life Sciences Tsinghua UniversityBeijing 100084China

Enzyme prodrug therapies(EPTs)have been intensively explored as attractive approaches to selective activation of systemically administered benign prodrugs by the exogenous enzymes or enzymes expressed at the desired target site,thus achieving localized,site-specific therapeutic *** effective strategies(e.g.,antibody-,viral-,gene-,as well as polymer-directed EPT)have been developed for enzyme localization to locally activate systemically administered benign ***,intrinsic limitations(e.g.,complex intracellular environment and catalyst instability)make the practical application of EPT strategies a task that presents itself as highly *** a promising alternative to natural enzyme,nanozyme has attracted substantial attention since its discovery in 2007,mainly due to the advantages of robust catalytic activity,high stability,low cost,and facile ***,nanozyme-activated prodrug strategies bring a new opportunity for targeted therapy,referred to as nanozyme-activating prodrug *** review focuses on recently reported nanozyme-activated prodrug strategies,aiming to provide some new insights into the potential applications in site-specific drug synthesis.

关键词： Enzyme prodrug therapy Nanozyme Prodrug activation Chemotherapy Drug synthesis

Surface terminals reconstruction:The way to widen the output voltage of MXene-based aqueous symmetrical microsupercapacitors

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Nano Research 2023年第5期16卷 6780-6788页

作者： yudong wu Jimin Fu Ningning He Jun Liu Tao Hua Chengbing Qin Haibo Hu School of Physics and Materials Science Key Laboratory of Structure and Functional Regulation of Hybrid MaterialsAnhui UniversityHefei 230601China Nanotechnology Centre Institute of Textiles&ClothingThe Hong Kong Polytechnic UniversityHung HomKowloon 999077Hong KongChina Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyCollaborative Innovation Center of Extreme OpticsShanxi UniversityTaiyuanShanxi 030006China

The low anodic oxidation potential severely suppresses the output voltage(≤0.6 V)of MXene-based symmetrical aqueous microsupercapacitors(MSA-MSCs)employing acidic ***,a surface terminals reconstruction mechanism on cathode of MSA-MSCs adopting aqueous neutral electrolyte(1 M Na_(2)SO_(4))is first revealed by systematical electrochemical experiments and in/ex-situ spectral analysis,which indicates that:the-O terminals on Ti3C2Tx flakes of cathode can combine with intercalated Na+cations during charging process to reconstruct into-ONa units to(i)inhibit the splitting reaction of adjacent water molecules,decreasing cathodic hydrogen evolution potential,more significantly,(ii)lower the potential of zero voltage(P0V)between the symmetrical electrodes to avoid anode oxidation,enabling full use of the unexploited potential range of ***,the output voltage of the MSA-MSCs tremendously expanded from 0.6 V in acidic polyacrylamide(PAM)/1 M H_(2)SO_(4)hydrogel electrolyte to 1.5 V in neutral polyacrylamide/1 M Na2SO4 hydrogel electrolyte,boosting the corresponding areal energy density from 9.9 to 34.6μW·h·cm^(-2).The demonstrated deep insight on the surface terminals reconstruction mechanism for synchronously modulating the P0V between symmetrical electrodes and hydrogen evolution potential on cathode provides critical guidance for widening the cell voltage of MSA-MSCs with safer and more inexpensive neutral electrolytes.

关键词： terminals reconstruction MXene potential of zero voltage symmetrical micro-supercapacitor aqueous electrolyte

Migration and enrichment of trace elements of Lower Palaeozoic carbonate rock strata in Beijing

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Science China Earth Sciences 2008年第12期51卷 1759-1767页

作者： NI ShanQin HOU QuanLin JU YiWen XIAO LingLing wu yudong LIU Qing College of Earth Science Graduate University of Chinese Academy of SciencesBeijing 100049China

Analyses of trace elements of the Lower Palaeozoic carbonate rock strata in Beijing show that the contents of As, Hg, F increase from primary carbonate rocks to weathered carbonate rocks and from primary carbonate rocks to the soil coexisting with carbonate rocks, but the distribution regularity of S is not obvious. In the whole weathered stages, the sorption of As is mainly affected by Fe2O3. In soil Fe2O3 is also the main affecting factor of Hg enrichment. The main existing forms of Hg in primary carbonate rocks should simply be physical adsorption, coprecipitation and false isomorphous form between surface of carbonate rock and Hg. In soil the enrichment of F has little relationship with sul-fides and Fe2O3. In primary carbonate rocks, F is mainly absorbed by sulfides and clay minerals, etc. Weathered samples have closer genetic relationships with primary carbonate rocks. This also implies that weathered carbonate rocks have the close existing forms to that of primary carbonate rocks. In primary carbonate rocks FeS2 and FeS are the main forms of S, and sulfides have fixation effect on some heavy metals, whereas in weathered carbonate rocks and soil the fixation effect is weakened.

关键词： carbonate rocks trace elements Fe2O3 sulfide clay mineral enrichment

Comparison of coalbed gas generation between Huaibei-Huainan coalfields and Qinshui coal basin based on the tectono-thermal modeling

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Science China Earth Sciences 2011年第7期54卷 1069-1077页

作者： wu yudong JU YiWen HOU QuanLin HU ShengBiao PAN JieNan FAN JunJia College of Earth Science Graduate University of the Chinese Academy of Sciences Beijing 100049 China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Resources & Environment Henan Polytechnic University Henan 454000 China

The geothermal history and the tectonic subsidence history of the Huaibei-Huainan coalfields were reconstructed by using the vitrinite reflectance data, and their correlative restriction on coalbed gas generation of Huaibei-Huainan coalfields and Qinshui coal basin was discussed. The burial, thermal, and maturity histories of are similar between Huaibei coalfield and Huainan coalfield, obviously different from those of Qinshui coal basin. Based on the tectono-thermal evolution characters of Huaibei-Huainan coalfields and Qinshui basin, the process of coalbed gas generation can be divided into three stages：（1） Dur- ing Early Mesozoic, both in Huaibei-Huainan and Qinshui, the buried depth of Permian coal seams increased rapidly, which resulted in strong metamorphism and high burial temperature of coal seams. At this stage, the coal rank was mainly fat coal, and locally reached coking coal. These created an environment favoring the generation of thermogenic gas. （2） From Late Ju- rassic to Cretaceous, in the areas of Huaibei-Hualnan, the strata suffered from erosion and the crust became thinning, and the Permian coal-bearing strata were uplifted to surface. At this stage, the thermogenic gas mostly escaped. Conversely, in Qinshui basin, the cover strata of coal seams kept intact during this stage, and the thermogenic gas were mostly preserved. Furthermore, with the interaction of magmatism, the burial temperature of coal seams reached higher peak value, and it was suitable for the secondary generation of thermogenic gas. （3） From Paleogene onward, in area of Huainan-Huaibei, the maturity of coal and burial temperature were propitious to the generation of secondary biogenic gases. However, in Qinshui basin, the maturity of coal went against genesis of second biogenic gas or thermogenic gas. By comparison, Huaibei-Huainan coalfields are dominated by thermogenic gas with a significant biogenic gas and hydrodynamic overprint, whereas Qinshui basin is dominated mainly by t

关键词： HuaiBei coalfield Huainan coalfield Qinshui coal basin tectono-thermal modeling coalbed gas generation

Adaptive Multi-Feature Fusion for Vehicle Micro-Motor Noise Recognition Considering Auditory Perception

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Sound & Vibration 2023年第1期57卷 133-153页

作者： Ting Zhao Weiping Ding Haibo Huang yudong wu School of Mechanical Engineering Southwest Jiaotong UniversityChengdu610031China National Laboratory for Rail Transportation Southwest Jiaotong UniversityChengdu610031China

The deployment of vehicle micro-motors has witnessed an expansion owing to the progression in electrification and intelligent ***,some micro-motors may exhibit design deficiencies,component wear,assembly errors,and other imperfections that may arise during the design or manufacturing ***-quently,these micro-motors might generate anomalous noises during their operation,consequently exerting a substantial adverse influence on the overall comfort of drivers and *** micro-motors exhibit a diverse array of structural variations,consequently leading to the manifestation of a multitude of distinctive auditory *** address the identification of diverse forms of abnormal noise,this research presents a novel approach rooted in the utilization of vibro-acoustic fusion-convolutional neural network(VAF-CNN).This method entails the deployment of distinct network branches,each serving to capture disparate features from the multi-sensor data,all the while considering the auditory perception traits inherent in the human auditory *** intermediary layer integrates the concept of adaptive weighting of multi-sensor features,thus affording a calibration mechanism for the features hailing from multiple sensors,thereby enabling a further refinement of features within the branch *** optimal model efficacy,a feature fusion mechanism is implemented in the concluding *** substantiate the efficacy of the proposed approach,this paper initially employs an augmented data methodology inspired by modified SpecAugment,applied to the dataset of abnormal noise sam-ples,encompassing scenarios both with and without in-vehicle interior *** serves to mitigate the issue of limited sample *** comparative evaluations are executed,contrasting the performance of the model founded upon single-sensor data against other feature fusion models reliant on multi-sensor *** experimental results substantiate tha

关键词： Auditory perception multi-sensor feature adaptive fusion abnormal noise recognition vehicle interior noise

Multi-Objective Prediction and Optimization of Vehicle Acoustic Package Based on ResNet Neural Network

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Sound & Vibration 2023年第1期57卷 73-95页

作者： Yunru wu Xiangbo Liu Haibo Huang yudong wu Weiping Ding Mingliang Yang School of Mechanical Engineering Southwest Jiaotong UniversityChengdu610031China Engineering Research Center of Advanced Driving Energy-Saving Technology Ministry of EducationChengdu610031China

Vehicle interior noise has emerged as a crucial assessment criterion for automotive NVH(Noise,Vibration,and Harshness).When analyzing the NVH performance of the vehicle body,the traditional SEA(Statistical Energy Analysis)simulation technology is usually limited by the accuracy of the material parameters obtained during the acoustic package modeling and the limitations of the application *** order to effectively solve these shortcomings,based on the analysis of the vehicle noise transmission path,a multi-level objective decomposition architecture of the interior noise at the driver’s right ear is *** with the data-driven method,the ResNet neural network model is *** stacked residual blocks avoid the problem of gradient dis-appearance caused by the increasing network level of the traditional CNN network,thus establishing a higher-precision prediction *** method alleviates the inherent limitations of traditional SEA simulation design,and enhances the prediction performance of the ResNet model by dynamically adjusting the learning ***,the proposed method is applied to a specific vehicle model and *** results show that the proposed meth-od has significant advantages in prediction accuracy and robustness.

关键词： NVH acoustic package performance prediction ResNet data-driven

Immune fluorescence test strips based on quantum dots for rapid and quantitative detection of carcino-embryonic antigen

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Chinese Chemical Letters 2017年第9期28卷 1881-1884页

作者： yudong wu Weipan Peng Qian Zhao Jiafang Piao Bo Zhang Xiaoli wu Hanjie Wang Zhihong Shi Xiaoqun Gong Jin Chang School of Life Sciences School of Materials Science and EngineeringTianjin University and Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology(Tianjin) Department of Neurology and Tianjin Neurosurgery InstituteTianjin Huanhu Hospital

At present,many researchers focused on the point-of-care testing（POCT）,a method of disease markers detection without large-scale instruments and specialized ***,most POCT diagnostic methods were suffered from poor detection sensitivity or inefficiency in quantitative ***,we developed a newly QD-immune fluorescence test strips（QD-IFTS） based on quantum dots（QDs） as the fluorescence nanocarrier to prepare the immune fluorescence probes in the classical immunochromatography detection system for sensing carcino-embryonic antigen（CEA）,a kind of glycoprotein produced by intestinal tissue and a broad spectrum of tumor marker for cancer *** we designed a homemade strips fluorescence reader for detection of fluorescence intensity of QDs on the *** the optimized reaction conditions,chromatographic time of the newly QD-IFTS was only25 min,sample volume of the newly QD-IFTS was only 40 m L and the LOD of the newly QD-IFTS was 0.72 ng/m *** addition,the efficiency and robustness of the newly QD-IFTS were confirmed by successfully application in 300 clinical serum samples,and the results revealed great potential in clinical POCT of other biomarkers.

关键词： Point-of-care testing Immunochromatography assay Quantum dots Carcinoembryonic antigen Quantitative detection

Color image enhancement based on HVS and PCNN

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Science China(Information Sciences) 2010年第10期53卷 1963-1976页

作者： ZHANG yudong, wu LeNan , WANG ShuiHua & WEI Geng School of Information Science & Engineering, Southeast University, Nanjing 210096, China School of Information Science & Engineering Southeast University Nanjing China

To enhance color images more effectively, a novel strategy is presented in this paper. We firstly translate the image to be enhanced from RGB space into HIS space, secondly keep its H component unchanged, and thirdly stretch its S component exponentially, and at last process its I component in the following manner: couple both the gray value and the spatial information into an inner activity item of corresponding neuron, integrate the human visual system into a dynamic component of corresponding neuron, and compare the inner activity item with dynamic component to obtain the enhanced image. Experiments demonstrate the effectiveness and validity of our strategy.

关键词： image enhancement human visual system (HVS) pulse coupled neural network (PCNN) color image