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基于改进TPDS长阵列的车辆超偏载检测研究

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计算机测量与控制 2024年第5期32卷 53-59页

作者：王萌苏玉东范帆国能铁路装备有限责任公司北京100010 天津哈威克科技有限公司天津301799

由于车辆超偏载检测过程中,受天气、路况等因素以及车辆行驶状态影响,导致信号组成的阵列过短,利用传统的TPDS车辆超偏载检测精度较低、耗时较长;提出基于改进TPDS长阵列的车辆超偏载检测研究;通过车辆运行品质轨边动态监测系统,利用测... 详细信息

由于车辆超偏载检测过程中,受天气、路况等因素以及车辆行驶状态影响,导致信号组成的阵列过短,利用传统的TPDS车辆超偏载检测精度较低、耗时较长;提出基于改进TPDS长阵列的车辆超偏载检测研究;通过车辆运行品质轨边动态监测系统,利用测距传感器与数据采集仪将力学信号转换成电压信号,将其组合为长阵列输入到系统的测距传感器中;采用EDM算法对长阵列中的噪声点实施消除处理;将4个测距传感器安置到货运车辆底部,采用货运车辆动态称重方法,计算车辆上各弹簧组承载力的总和,并结合车辆有用信号,对车辆的载重情况展开测量,实现对车辆的超偏载检测;实验结果表明,利用长阵列改进TPDS系统后,其去噪效果好,在载重测量时,测量误差在5%以内,且平均耗时低、称重合格概率高,表明所提方法的测量精度、检测效率以及检测稳定性高。

关键词： TPDS 长阵列 EDM 测距传感器车辆超偏载检测系统

益气化痰活血法治疗心血管代谢性疾病的Meta分析

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中西医结合心脑血管病杂志 2024年第18期22卷 3265-3274页

作者：董敏田丁阳粟裕冬李慧歆董波山东中医药大学济南250014 山东第一医科大学附属省立医院济南250021

目的:系统评价益气化痰活血法治疗心血管代谢性疾病的疗效和安全性。方法:计算机检索中英文数据库内收录的关于益气化痰活血法治疗心血管代谢性疾病的随机对照研究(RCTs),采用RevMan 5.4软件进行资料提取和质量评价,并进行Meta分析。结... 详细信息

目的:系统评价益气化痰活血法治疗心血管代谢性疾病的疗效和安全性。方法:计算机检索中英文数据库内收录的关于益气化痰活血法治疗心血管代谢性疾病的随机对照研究(RCTs),采用RevMan 5.4软件进行资料提取和质量评价,并进行Meta分析。结果:共纳入24篇文献,涉及1951例病人,其中观察组980例,对照组971例。Meta分析结果显示,与对照组比较,观察组临床总有效率升高[OR=5.09,95%CI(3.67,7.07),P<0.00001];观察组空腹血糖[MD=-0.68,95%CI(-1.06,-0.30),P=0.0004]、餐后2 h血糖[MD=-1.37,95%CI(-1.62,-1.12),P<0.00001]、糖化血红蛋白[MD=-0.56,95%CI(-0.72,-0.41),P<0.00001]、总胆固醇[MD=-0.69,95%CI(-1.29,-0.08),P=0.03]、三酰甘油[MD=-0.47,95%CI(-0.58,-0.36),P<0.00001]、低密度脂蛋白胆固醇[MD=-0.61,95%CI(-0.72,-0.51),P<0.00001]、白细胞介素-6[SMD=-0.36,95%CI(-0.59,-0.13),P=0.002]、肿瘤坏死因子-α[SMD=-1.16,95%CI(-2.13,-0.19),P=0.02]、C反应蛋白[SMD=-0.83,95%CI(-1.63,-0.04),P=0.04]、体质指数[MD=-0.92,95%CI(-1.33,-0.52),P<0.00001]、中医证候积分[MD=-2.79,95%CI(-3.96,-1.62),P<0.00001]降低,差异均有统计学意义。观察组左室射血分数高于对照组,差异有统计学意义[SMD=1.15,95%CI(0.62,1.69),P<0.0001]。结论:现有证据表明,益气化痰活血法治疗心血管代谢性疾病疗效显著,且不良反应较少。

关键词：心血管代谢性疾病益气化痰活血法疗效安全性 Meta分析

毛壳素对卵巢癌细胞侵袭和迁移的调控机制研究

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中国计划生育和妇产科 2024年第4期16卷 47-51,58,F0004页

作者：吴伟权苏裕东萧丽娟陈艳雅东莞市人民医院妇产科广东东莞523000

目的体外研究毛壳素(chaetocin)对卵巢癌细胞迁移和侵袭的影响,并通过探讨硫氧还蛋白还原酶-1(TrxR1)和NF-κB通路的作用机制以期发现并验证毛壳素可能的抗癌属性。方法培养卵巢癌细胞系SK-OV-3和OVCAR-3,用毛壳素处理卵巢癌细胞,用CCK-... 详细信息

目的体外研究毛壳素(chaetocin)对卵巢癌细胞迁移和侵袭的影响,并通过探讨硫氧还蛋白还原酶-1(TrxR1)和NF-κB通路的作用机制以期发现并验证毛壳素可能的抗癌属性。方法培养卵巢癌细胞系SK-OV-3和OVCAR-3,用毛壳素处理卵巢癌细胞,用CCK-8法分析毛壳素的细胞毒性和IC50,用EdU染色验证毛壳素的细胞毒性。将细胞分为6组,包括毛壳素0μm组、毛壳素8μm组、生理盐水+毛壳素0μm组、生理盐水+毛壳素8μm组、NF-κB激活剂1+毛壳素0μm组、NF-κB激活剂1+毛壳素8μm组。体外细胞伤口愈合实验检测细胞迁移率。Transwell细胞侵袭实验检测细胞侵袭率。qRT-PCR检测TrxR1 mRNA的表达。Western blot检测细胞质和细胞核中NF-κB的表达及检测全细胞中TrxR1、p-NF-κB、p-IKKα/β和p-IκBα的表达。结果毛壳素对卵巢癌细胞增殖有较强的抑制作用。毛壳素24 h对SK-OV-3和OVCAR-3细胞的IC50分别为(72.92±9.18)μm和(61.28±8.56)μm。8μm毛壳素为无细胞毒性的最大剂量。与毛壳素0μm组比,毛壳素8μm组抑制了SK-OV-3和OVCAR-3细胞的迁移和侵袭,并显著下调TrxR1、p-NF-κB、p-IKKα/β和p-IκBα的表达。与生理盐水+毛壳素8μm组比,NF-κB激活剂1+毛壳素8μm组显著促进了SK-OV-3和OVCAR-3细胞的迁移和侵袭,并显著上调了TrxR1、p-NF-κB、p-IKKα/β和p-IκBα的表达。结论毛壳素抑制卵巢癌细胞的增殖和TrxR1的表达,并通过抑制NF-κB通路的激活减少卵巢癌细胞的侵袭和迁移。

关键词：毛壳素硫氧还蛋白还原酶-1 核因子-κB 卵巢癌细胞侵袭迁移

苦豆碱抑制胃癌HGC-27细胞和AGS细胞增殖的作用机制

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中国高原医学与生物学杂志 2024年第4期45卷 235-245页

作者：锁丽娜马海秀易毅苏玉东翟少倩赵婧曹成珠苏占海青海大学医学部西宁810001 青海大学高原医学研究中心西宁810001

目的探讨苦豆碱(Aloperine,ALO)抑制胃癌HGC-27细胞、AGS细胞增殖的作用机制。方法用不同浓度ALO处理胃癌HGC-27细胞、AGS细胞。应用细胞毒性实验、细胞增殖实验和平板克隆实验评估增殖活性,应用划痕实验评估迁移与修复能力,应用侵袭实... 详细信息

目的探讨苦豆碱(Aloperine,ALO)抑制胃癌HGC-27细胞、AGS细胞增殖的作用机制。方法用不同浓度ALO处理胃癌HGC-27细胞、AGS细胞。应用细胞毒性实验、细胞增殖实验和平板克隆实验评估增殖活性,应用划痕实验评估迁移与修复能力,应用侵袭实验检测迁移和侵袭能力,使用流式细胞术分析细胞周期变化情况,应用实时荧光定量聚合酶链反应实验测定GSPT1、CDK4、Cyclin D1和Caspase-3、Caspase-9、Bax、Bcl-2的mRNA表达水平,应用蛋白印迹实验评估GSPT1和Caspase-3、Caspase-9、Bax及Bcl-2的蛋白表达水平。结果细胞毒性、细胞增殖以及平板克隆实验结果显示,ALO抑制胃癌HGC-27细胞、AGS细胞增殖并呈现浓度依赖性:与对照组相比,用0.1 mM和0.25 mM ALO处理的HGC-27细胞、AGS细胞的增殖能力下降。划痕实验结果显示,ALO抑制了HGC-27细胞、AGS细胞的迁移修复能力。细胞侵袭检测结果显示,经ALO处理后的HGC-27细胞、AGS细胞的迁移、侵袭能力受到抑制。流式细胞术结果显示,经ALO作用后的HGC-27细胞、AGS细胞的周期发生变化。实时荧光定量聚合酶链反应实验和蛋白印迹实验结果显示,与对照组相比,经药物处理后的HGC-27细胞、AGS细胞中的GSPT1、Bcl-2、CDK4、Cyclin D1表达水平降低,Caspase-3、Caspase-9、Bax表达水平升高。结论ALO可以通过调节GSPT1和Caspase-3、Caspase-9、Bax、Bcl-2的表达水平来抑制胃癌HGC-27细胞、AGS细胞的增殖。

关键词：苦豆碱抑制 HGC-27 AGS 增殖机制

Fiber cladding SPR bending sensor characterized by two parameters

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Chinese Physics B 2020年第12期29卷 205-211页

作者： Chunlan Liu Jiangxi Hu Yong Wei yudong su Ping Wu Lingling Li Xiaoling Zhao College of Electronic&Information Engineering Chongqing Three Gorges UniversityChongqing 404100China College of Electronic Engineering Heilongjiang UniversityHarbin 150080China

A fiber cladding surface plasmon resonance(SPR)bending sensor is realized by the cladding of the fiber *** employing coating film,the sensing zone is protected and the toughness of the sensor *** different sensing probes are tested,the experiment results indicate that the two parameters(wavelength sensitivity and light intensity sensitivity)sensing performances of the eccentric butt joint structures are superior to that of hetero-core structure,and the SPR bending sensor based on hetero-core structure is stable and uneasy to *** employing hetero-core fiber and silver film,a fiber cladding SPR bending sensor with better stabilization and sensing performance is *** proposed fabricating method of sensing probe with coating film provides a new approach for fiber SPR-distributed bending sensor.

关键词： surface plasmon resonance(SPR) bending sensor eccentric butt joint hetero-core fiber

Cascaded dual-channel fiber SPR temperature sensor based on liquid and solid encapsulations

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Chinese Physics B 2021年第10期30卷 252-260页

作者： Yong Wei Lingling Li Chunlan Liu Jiangxi Hu yudong su Ping Wu Xiaoling Zhao College of Electronic&Information Engineering Chongqing Three Gorges UniversityChongqing 404100China

In order to control the working wavelength range of the fiber surface plasmon resonance(SPR)temperature sensor and realize the wavelength division multiplexing type multi-channel fiber SPR temperature sensor,by comprehensively investigating the influence of liquids with different thermal-optical coefficients and solid packaging materials on the performance of fiber SPR temperature sensor,a dual-channel fiber SPR temperature sensor based on liquid-solid cascade encapsulation was designed and *** liquid temperature sensing stage encapsulated in capillary worked in 616.03 nm-639.05 nm band,the solid sensing stage coated with pouring sealant worked in 719.37 nm-825.27 nm band,and the two stages were cascaded to form a fiber dual-channel temperature *** testing results indicated that when the temperature range was 35℃-95℃,the sensitivity of two-stage temperature detection was−0.384 nm/℃and−1.765 nm/℃*** proposed fiber sensor has simple fabrication and excellent performance which can be widely used in various fields of dual-channel temperature measurement and temperature compensation.

关键词： surface plasmon resonance(SPR) temperature sensor liquid-solid cascade dual channel

EZH2 identifies the precursors of human natural killer cells with trained immunity

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Cancer Biology & Medicine 2021年第4期18卷 1021-1039页

作者： Chen Zhang Jie Yin Jian Zheng Jun Xiao Jiajian Hu yudong su Kaichen Zhou Yingchi Zhang Xuzhen Zhang Hong Zhang Qian sun Yang Wang Wenwen Yu Feng Wei Qiang Zhao Long Li Xiubao Ren Department of Immunology and Biotherapy Key Laboratory of Cancer Immunology and BiotherapyTianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Immunology Key Laboratory of Immune Microenvironment and Disease of the Ministry of EducationTianjin Medical UniversityTianjin 300070China Department of Pediatric Cancer Tianjin Medical University Cancer Institute and HospitalTianjin 300060China State Key Laboratory of Experimental Hematology and Division of Pediatric Blood Diseases Center Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300000China Center for Stem Cell Medicine Chinese Academy of Medical SciencesBeijing 100730China Research Center of Basic Medicine Science Tianjin Medical UniversityTianjin 300070China

Objective:Trained immunity of natural killer(NK)cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods after ***,the human NK cells responsible for the generation and maintenance of trained immunity are largely *** hypothesized that heterogeneous human NK cells would respond differentially to stimulation with a combination of IL-12,IL-15,and IL-18,and that an NK cell subset might exist that is mainly responsible for the induction of trained *** the basis of our hypothesis,we aimed to identify the subset from which cytokine-trained human NK cells originate and to explore possible regulatory targets for drug ***:Flow cytometry assays were performed to analyze the functions of cytokine-trained NK cells and examine cell division and protein expression in NK cell ***-cell RNA sequencing(scRNA-seq)plus TotalSeq™technology was used to track the heterogeneity of NK cells during the induction of trained ***:Traditional developmental markers for peripheral NK cells were unable to identify the precursors of human NK cells with trained ***,we used scRNA-seq plus TotalSeq™technology to track the heterogeneity of NK cells during the induction of trained immunity and identified a unique cluster of CD57−NKG2A+EZH2+IFNG+MKI67+IL12R+IL15R+IL18R+NK *** and pseudotime trajectory analyses suggested that this cluster of NK cells contained the precursor of trained NK *** then used flow cytometry to further investigate the role of EZH2 in trained NK precursors and found that CD57−NKG2A+EZH2+NK cells had faster cell cycles and an enhanced trained phenotype,and EZH2 inhibition significantly impaired the induction of trained immunity in NK *** results suggested that EZH2 is a unique epigenetic marker of precursors of human NK cells with trained ***:Ou

关键词： Natural killer cells trained immunity precursor EZH2 cell cycle

Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

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Oncology Research 2024年第7期32卷 1185-1195页

作者： XIAOBI HUANG CHUNYUAN CHEN YONGYANG CHEN HONGLIAN ZHOU YONGHUA CHEN ZHONG HUANG YULIU XIE BAIYANG LIU yudong GUO ZHIXIONG YANG GUANGHUA CHEN WENMEI su Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Thoracic surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China

Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as *** dysregulation has been closely associated with ***00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this ***,the mechanism underlying its function in cancer progression remains poorly ***:Here,the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines,clinical samples,and ***:We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients,whereas knockdown of LINC00265 inhibited proliferation of cancer cell lines and tumor growth in *** blot andﬂow cytometry analyses indicated that silencing of LINC00265 induced autophagy and ***,we showed that LINC00265 interacted with and stabilized the transcriptional co-repressor Switch-independent 3a(SIN3A),which is a scaffold protein functioning either as a tumor repressor or as an oncogene in a context-dependent *** of SIN3A also reduced proliferation of lung cancer cells,which was correlated with the induction of *** observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung ***:Ourﬁndings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.

关键词： LINC00265 Autophagy Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A)

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基于IPMC驱动的自主微型机器鱼

机器人 2010年第2期32卷 262-270页

作者：苏玉东叶秀芬郭书祥哈尔滨工程大学黑龙江哈尔滨150001 香川大学

本文从微小型鱼类的运动和受力分析入手,基于人工肌肉IPMC(离子聚合物金属复合材料)的特性,进行微型机器鱼的结构和控制系统的设计.在此基础上实现仿小型鱼类的各种运动模式,然后,讨论了IPMC驱动器推进效率的优化.实验结果证明,基于IPM... 详细信息

本文从微小型鱼类的运动和受力分析入手,基于人工肌肉IPMC(离子聚合物金属复合材料)的特性,进行微型机器鱼的结构和控制系统的设计.在此基础上实现仿小型鱼类的各种运动模式,然后,讨论了IPMC驱动器推进效率的优化.实验结果证明,基于IPMC的厘米级机器鱼是可行的:通过改变控制信号的频率和占空比,实现微型机器鱼的速度控制;通过控制胸鳍和尾鳍,实现上浮、下潜、转弯、巡游等运动模式.最后从尾鳍推进器的结构角度分析了如何提高推进效率.

关键词： IPMC 微型机器鱼运动模式避障