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Metformin promotes angiogenesis by enhancing VEGFa secretion by adipose-derived stem cells via the autophagy pathway

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Regenerative Biomaterials 2023年第1期10卷 990-1002页

作者： Zihan Tao Lei Liu Minliang Wu Qianqian wang yuchong wang Jiachao Xiong Chunyu Xue Department of Plastic Surgery Changhai HospitalNaval Medical UniversityShanghaiChina Department of Plastic and Reconstructive Surgery School of MedicineShanghai East HospitalTongji UniversityShanghaiChina Department of Marine Biomedicine and Polar Medicine Naval Special Medical CenterNaval Medical UniversityShanghaiChina School of Life Sciences and Technology Tongji UniversityShanghaiChina

Human adipose tissue-derived stem cell(ADSC)derivatives are cell-free,with low immunogenicity and no potential tumourigenicity,making them ideal for aiding wound ***,variable quality has impeded their clinical ***(MET)is a 5′adenosine monophosphate-activated protein kinase activator associated with autophagic *** this study,we assessed the potential applicability and underlying mechanisms of MET-treated ADSC derivatives in enhancing *** employed various scientific techniques to evaluate the influence of MET on ADSC,assess angiogenesis and autophagy in MET-treated ADSC in vitro,and examine whether MET-treated ADSC increase *** found that low MET concentrations exerted no appreciable effect on ADSC ***,MET was observed to enhance the angiogenic capacity and autophagy of ***-induced autophagy was associated with increased vascular endothelial growth factor A production and release,which contributed to promoting the therapeutic efficacy of *** vivo experiments confirmed that in contrast to untreated ADSC,MET-treated ADSC promoted *** findings thus indicate that the application of MET-treated ADSC would be an effective approach to accelerate wound healing by promoting angiogenesis at wound sites.

关键词： metformin stem cell angiogenesis wound healing human adipose tissue-derived stem cell

Is there a great unconformity between Xiamaling and Longshan formations in the North China Craton?

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Science China Earth Sciences 2023年第5期66卷 959-984页

作者： Hongwei KUANG Nan PENG Yongqing LIU yuchong wang Mingming CUI Xiaoshuai CHEN Dawei QIAO Keining QI Institute of Geology Chinese Academy of Geological SciencesBeijing100037China School of Earth Science and Mapping Engineering China University of Mining and Technology(Beijing)Beijing100083China School of Resource and Environmental Engineering Hefei University of TechnologyHefei230009China

The existence of a 0.3 Ga"great unconformity"between the Mesoproterozoic"Undefined System"Xiamaling Formation and the"Neoproterozoic"Longshan Formation has long been *** this study,stratigraphy,sedimentology,detrital zircon dating,lithium isotope,and major and trace elements were applied to systematically analyze their *** demonstrate that coarse to fine sandstone-mudstone normal cycles with different grades and thicknesses exist from the Xiamaling to the Longshan *** succession formed from a restricted platform with lagoon-shallow marine shelf-tidal flat-beach and tidal shoal developing in ascending *** pebbly sandstone at the bottom of the Long shan Formation does not have the properties of basal conglomerate with tectonic *** youngest detrital zircon is older than 1.6 Ga for the Long shan Formation and overlying Jing'eryu Formation *** addition,no(zircon)provenance has been found from the large igneous province of 1.32-1.2 Ga in Xiamaling ***δ^(7)Li isotope values exhibit a gradually increasing *** Li content and CIA(Chemical index of alteration)gradually decreases from the top of the Xiamaling Formation to the lower part of the Long shan ***,as K_(2)O/Al_(2)O_(3)and FeO/Fe_(2)O_(3)decreases,Na_(2)O/Al_(2)O_(3)increases,and Li/Al,V/Cr,and V/(V+Ni)fluctuates *** the boundary,the Ce/Ce^(*)and Eu/Eu^(*)show positive and negative anomalies,***,the Rb/Sr and Al/Si values decrease,and U/Th values *** indicates that the geochemistry of the weathering crust at the interface of the Xiamaling Formation-Long shan Formation is not ***,it indicates a weakening of continental weathering intensity from the bottom to the top of the *** results do not support the existence of a large unconformity between the Xiamaling and the Longshan ***,it is suggested that the Long shan Formation-Ji

关键词： North China Craton Mesoproterozoic Transition period Unconformity Continuous sedimentation

Transposition Flaps for Reconstruction of Perianal Skin Defects After Tumor Resection

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Chinese Journal of Plastic and Reconstructive Surgery 2020年第4期2卷 199-203页

作者： Haiying DAI Minliang WU yuchong wang Shuo FANG Zheng wang Yu XIA Jianguo XU Chunyu XUE Department of Plastic Surgery Changhai HospitalNaval Military Medical UniversityShanghai 200433China

Objective To investigate the application of transposition flaps in the reconstruction of perianal skin defects after tumor *** From September 2018 to December 2019,16 cases of perianal skin defects were repaired with unilateral or bilateral transposition *** wound size before closure ranged from 4 cm×8 cm to 7 cm×10 *** patients achieved primary *** dehiscence occurred in one patient at the flap tip,whereas a slight infection occurred in another patient,which healed after a dressing *** the follow-up period of 3–6 months,all patients were satisfied with the perianal area both aesthetically and *** Transposition flaps are a promising option for the repair of perianal skin defects after tumor *** to the simplicity of the flap design,the wide popularity of this flap type among surgeons is anticipated.

关键词： Transposition flaps Perianal wound repair Negative-pressure wound therapy

The Firstly Discovered Cosmic Spherules in Carbonaceous Siltstone from the Taizi Formation of the Mesoproterozoic Shennongjia Group,Central China

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Acta Geologica Sinica(English Edition) 2017年第3期91卷 1137-1138页

作者： KUANG Hongwei SONG Tianrui LIU Yongqing PENG Nan ZHU Zhicai FAN Zhengxiu wang yuchong XIA Xiaoxu SONG Huanxin TANG Yong Institute of Geology Chinese Academy of Geological Sciences China University of Geosciences Yangtze University

Objective Spherical micro-particles are often preserved in Precambrian sedimentary rocks. Finnish and Chinese scholars have previously discovered carbonaceous, siliceous or ferruginous spherules of out-space origin in the 1.6 Ga and 1.4 Ga sequence, respectively. The presence of spherules can record possible cosmic impact events. Also, cosmic spherules provide important information on the evolution of planets from outer space.

关键词： of on or is from The Firstly Discovered Cosmic Spherules in Carbonaceous Siltstone from the Taizi Formation of the Mesoproterozoic Shennongjia Group,Central China in

Discovery of Cosmic Spherules from the Mesoproterozoic Strata and its Significance——in Case of the Ming Tombs Area, Beijing

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Acta Geologica Sinica(English Edition) 2020年第1期94卷 38-56页

作者： SONG Tianrui ZHENG Ning LIU Yongqing KUANG Hongwei PENG Nan LI Chao TANG Jigang YAN Qinggao GAO Linzhi ZHU Zhicai XIA Xiaoxu wang yuchong Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China National Research Center of Geoanalysis Beijing 100037China Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093YunnanChina Beijing General Research Institute of Mining and Metallurgy Beijing 100044China

This study covers cosmic spherules derived from the Mesoproterozoic Dahongyu Formation in the Ming Tombs area, Beijing. The cosmic spherules include iron oxide cosmic spherules, carbonaceous chondrites, and atomic iron "steely bead"-shaped cosmic spherules. The mineral assemblage of silicon carbide, forsterite, zircon, and glass spherules and fragments were picked from melt-silicified carbonate of the Mesoproterozoic Dahongyu Formation(ca. 1625 Ma). Cosmic spherule assemblages are solely discovered from sedimentary rocks in China. Platinum group elements(PGE) were determined for the first time in cosmic spherules and associated minerals. PGE comparative observation between meteorite and cosmic spherules is presented in this study. It is recognized that an extraterrestrial meteorite impact event might have occurred in the Dahongyu Stage. The main evidence is a large number of iron cosmic spherules in silicified oncolitic limestone, and associated cosmic silicon carbide, glass spherules, and fragments, as well as the presence of forsterite. The impact-volcanic crater is characteristic of a big black shale block dropped into the bended silicified limestone.

关键词： cosmic spherules carbonaceous chondrite meteorite PGE Proterozoic strata Beijing impact event

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预构皮瓣的研究与应用进展

中华烧伤杂志 2014年第5期30卷 437-440页

作者：王宇翀薛春雨第二军医大学长海医院整形外科上海200433

预构皮瓣（prefabricated flap）是将知名血管束或含有知名血管的筋膜、肌肉等组织移位于随意型皮瓣下方，或将游离皮片移植于含有血管束并有丰富血运的筋膜、大网膜等组织上，经过血管新生、吻接和沟通的血管化过程，将随意型皮瓣转化... 详细信息

预构皮瓣（prefabricated flap）是将知名血管束或含有知名血管的筋膜、肌肉等组织移位于随意型皮瓣下方，或将游离皮片移植于含有血管束并有丰富血运的筋膜、大网膜等组织上，经过血管新生、吻接和沟通的血管化过程，将随意型皮瓣转化为由知名血管供血的轴型组织瓣以供局部转移或游离移植。而将皮瓣中加入软骨、骨等组织再制作的皮瓣称为预制皮瓣（prelaminated flap），与预构皮瓣是不同的概念。

关键词：伤口愈合新生血管化,生理性扩张术预构皮瓣

相对论点耦合模型结合复动量表象方法研究^(74)Ca奇特结构

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中国科学：物理学、力学、天文学 2022年第6期52卷 42-49页

作者：王宇翀侯奎仕敏安徽建筑大学数理学院合肥230601 先进电子材料与器件重点实验室合肥230601 安徽省建筑声环境重点实验室合肥230601

本文介绍了奇特原子核的研究意义、研究方法及研究进展.给出了近期在相对论点耦合模型下结合复动量表象(CMR)方法和Bardeen-Cooper-Schrieffer(BCS)方法,发展的RMFPC-CMR-BCS方法的理论框架.本文重点是用此方法研究^(74)Ca的奇特结构.... 详细信息

本文介绍了奇特原子核的研究意义、研究方法及研究进展.给出了近期在相对论点耦合模型下结合复动量表象(CMR)方法和Bardeen-Cooper-Schrieffer(BCS)方法,发展的RMFPC-CMR-BCS方法的理论框架.本文重点是用此方法研究^(74)Ca的奇特结构.由于那些靠近连续谱阈值的单粒子态对奇特结构的形成有着重要作用,本文详细研究了对晕现象较为重要的单粒子态的波函数和密度分布,在用BCS方法考虑对关联作用后,低轨道角动量2d_(3/2)态因其是分布在最靠近连续谱阈值的共振态,最后一个核子将有很大概率弥散到2d_(3/2)共振态,从而使原子核半径增大,形成奇特晕现象.文中对这部分进行了详细研究,也展示出共振态对奇特结构形成的重要作用.

关键词：相对论点耦合模型复动量表象方法奇特核结构

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论汉武帝的治边方略

兰台世界 2018年第12期 144-146页

作者：王玉冲中国人民警察大学边防系

汉武帝初期,西汉的边防形势依然严峻。为破解安全困境,汉武帝在加强中央集权之后,开始了大规模经营边疆的活动。以战止战,维护边境稳定;凿通西域,完善统一格局;因险制塞,修筑防御工事;开发边疆,增强守御之备。汉武帝的治边举措促进了边... 详细信息

汉武帝初期,西汉的边防形势依然严峻。为破解安全困境,汉武帝在加强中央集权之后,开始了大规模经营边疆的活动。以战止战,维护边境稳定;凿通西域,完善统一格局;因险制塞,修筑防御工事;开发边疆,增强守御之备。汉武帝的治边举措促进了边疆地区的开发,增进了民族融合,维护了国家的统一,为西汉王朝提供了良好的发展环境,还促进了亚、欧、非之间的经济文化交流,对当今的边疆治理有着积极的启迪意义。

关键词：汉武帝边防治边方略

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论共生视域下中国与周边命运共同体建设

武警学院学报 2018年第5期34卷 14-18页

作者：王玉冲武警学院边防系河北廊坊065000

中国与周边国家在地缘环境、人文精神和经济利益等方面相互交织,紧密联系在一起。基于地缘共生环境的区域合作,使得中国与周边国家的联系愈加紧密,相互依赖程度日益加深。中国与周边国家的多元共生文化,有助于相互沟通和理解,更好地达... 详细信息

中国与周边国家在地缘环境、人文精神和经济利益等方面相互交织,紧密联系在一起。基于地缘共生环境的区域合作,使得中国与周边国家的联系愈加紧密,相互依赖程度日益加深。中国与周边国家的多元共生文化,有助于相互沟通和理解,更好地达成认同与共识。中国与周边国家的经济互融促进了跨境地缘经济区域的形成,推动了区域经济的协同发展。中国与周边国家地缘相近、文化相似、经济互融的共生格局,形成了"命运共同体"的雏形。若中国与周边国家能够排除域外国家的干扰,本着"道不同,互相为谋、为学、学鉴"的信念,共谋区域和平与发展,定能不断推进命运共同体的构建。

关键词：共生关系中国周边命运共同体