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Progress on immuno-microenvironment and immune-related therapies in patients with pseudomyxoma peritonei

Cancer Biology & Medicine 2024年第7期21卷 586-605页

作者： Qidi Zhao Tian Wei Ru Ma yubin fu Rui Yang Yandong Su Yang Yu Bing Li Yan Li School of Clinical Medicine Tsinghua UniversityBeijing 100084China Department of Surgical Oncology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China Department of Peritoneal Cancer Surgery Bejing Shijitan HospitalCapital Medical UniversityBejing 100038China

Pseudomyxoma peritonei(PMP) is an indolent malignant syndrome. The standard treatment for PMP is cytoreductive surgery combined with intraperitoneal hyperthermic chemotherapy(CRS + HIPEC). However, the high recurrence rate and latent clinical symptoms and signs are major obstacles to further improving clinical outcomes. Moreover, patients in advanced stages receive little benefit from CRS + HIPEC due to widespread intraperitoneal metastases. Another challenge in PMP treatment involves the progressive sclerosis of PMP cell-secreted mucus, which is often increased due to activating mutations in the gene coding for guanine nucleotide-binding protein alpha subunit(GNAS). Consequently, the development of other PMP therapies is urgently needed. Several immune-related therapies have shown promise, including the use of bacterium-derived non-specific immunogenic agents, radioimmunotherapeutic agents, and tumor cell-derived neoantigens, but a well-recognized immunotherapy has not been established. In this review the roles of GNAS mutations in the promotion of mucin secretion and disease development are discussed. In addition, the immunologic features of the PMP microenvironment and immune-associated treatments are discussed to summarize the current understanding of key features of the disease and to facilitate the development of immunotherapies.

关键词： Pseudomyxoma peritonei tumor immuno-microenvironment immune-related therapy mucin 2 GNAS mutation

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我国青少年无偿献血科普工作实践研究——结合广州市近五年“献血健康”宣教项目的案例分析

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临床输血与检验 2024年第4期26卷 475-478页

作者：傅钰斌汤静儿张婷广州血液中心广东广州510095

无偿献血是中国公民的健康素养。本文通过对献血宣教和健康教育相关理论研究现状的文献综述,得出青少年时期作为人生发展的关键期,对其开展无偿献血健康教育工作,有利于18岁成人后参加无偿献血、保障社会面临床用血、促进全民健康,做好... 详细信息

无偿献血是中国公民的健康素养。本文通过对献血宣教和健康教育相关理论研究现状的文献综述,得出青少年时期作为人生发展的关键期,对其开展无偿献血健康教育工作,有利于18岁成人后参加无偿献血、保障社会面临床用血、促进全民健康,做好血源开发系统性基础性健康促进工作的结论。并回顾了广州血液中心2020—2024年“献血健康”青少年科普项目,总结了青少年献血科普若干“青”字号服务品牌的实践成果,提出了构建“市-区-社区”三级联动的青少年无偿献血宣教工作队的研究展望。

关键词：青少年无偿献血科普

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基于独立分类网络的开集识别研究

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华东交通大学学报 2024年第2期41卷 79-86页

作者：徐雪松付瑜彬于波华东交通大学电气与自动化工程学院江西南昌330013

【目的】为解决图像分类模型面对传统闭集训练方式出现的模型缺乏开集泛化性的问题,提出了一种分离式的独立分类网络结构。【方法】每个类别都包含独立的线性特征层,特征层中设计的神经元节点能够在有限的数据样本下更准确地捕获类别特... 详细信息

【目的】为解决图像分类模型面对传统闭集训练方式出现的模型缺乏开集泛化性的问题,提出了一种分离式的独立分类网络结构。【方法】每个类别都包含独立的线性特征层,特征层中设计的神经元节点能够在有限的数据样本下更准确地捕获类别特征。同时,在模型训练时,文中引入了一类无需标注的负样本,使得模型在构建决策边界时不仅依赖于已知类别的特征差异,在不增加额外标注样本的情况下,增加模型决策边界的开集泛化性。【结果】结果表明:独立分类网络开集识别(ICOR)模型结构和开集自适应训练策略均能有效改善传统模型开放集识别(OSR)性能;随着开放度的增加,能表现出更好的鲁棒性,能更有效地降低模型的OSR风险。【结论】提出的独立分类网络并融合开集自适应训练的算法比现有开集识别算法具有更优的开集识别性能。

关键词：深度学习开集识别图像分类迁移学习

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电接枝双氰胺改性碳纤维海洋电场电极的制备及其电场响应性能研究

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西北工业大学学报 2024年第1期42卷 180-187页

作者：许嘉威胡承儒侯晓帆付玉彬中国海洋大学材料科学与工程学院山东青岛266100

碳纤维电极表面氨基改性可以显著提高其电化学性能和电场响应性能。通过控制接枝电压(3,5,7)V,在碳纤维表面接枝聚双氰胺薄膜调控电极/海水界面双电层结构和电化学性能。结果表明,接枝电位越高,碳纤维表面聚双氰胺薄膜越均匀,电极双电... 详细信息

碳纤维电极表面氨基改性可以显著提高其电化学性能和电场响应性能。通过控制接枝电压(3,5,7)V,在碳纤维表面接枝聚双氰胺薄膜调控电极/海水界面双电层结构和电化学性能。结果表明,接枝电位越高,碳纤维表面聚双氰胺薄膜越均匀,电极双电层结构越稳定。其中CF-7V的综合性能最佳,其比电容达到9.368 F·g^(-1),为空白组的31.6倍;电荷转移电阻和低频容抗显著降低;7天电位漂移量为1.68 mV,可以正常响应1×10^(-3)Hz,0.03 mV/m的低频弱电场信号,电极的响应灵敏度、准确度得到了显著提高。电接枝改性后碳纤维电极的电场响应性能与Ag/AgCl电极相当,这是一种新型高性能海洋电场传感器,可望提高海洋电场探测能力。

关键词：碳纤维电极双氰胺电化学接枝电化学性能电场响应特性

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边界内外:银行主承销商尽职调查机制建设

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金融市场研究 2024年第6期 1-8页

作者：马炼温婧付禹彬宋彦勇中国建设银行投资银行部中国建设银行投资银行部资本市场业务处中国建设银行投资银行部债券承销处

在强监管、严标准和投资者“索赔潮”叠加形势下,债券主承销商尽职调查被放到放大镜下检查考验,特别是近几年法院对债券虚假陈述的判例,提高了主承销商的履职尽责和责任承担要求。作为信用债承销主力的银行主承销商,自身也存在尽职调查... 详细信息

在强监管、严标准和投资者“索赔潮”叠加形势下,债券主承销商尽职调查被放到放大镜下检查考验,特别是近几年法院对债券虚假陈述的判例,提高了主承销商的履职尽责和责任承担要求。作为信用债承销主力的银行主承销商,自身也存在尽职调查机制不够完善,收益与付出不对等、手段与难度不适应、专业能力与岗位要求不匹配,以及特色发挥不足、精细化管理不足、系统智能化不足等问题。因此,银行主承销商应发挥特色优势,及时完善尽职调查机制体系,主动增强防范风险意识和风险应对能力,做实分层分类管理和差别化尽职调查安排,围绕涉及偿债能力的核心内容,对外持续推动职责边界的合理明确、对内整合综合金融业务视角,着眼长远提升队伍能力和打造智能机控,以高效可靠的尽职调查推动债券市场和承销业务高质量发展。

关键词：银行主承销商债券承销尽职调查高质量发展

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Oxidation Modification of Polyacrylonitrile-Based Carbon Fiber and Its Electro-Chemical Performance as Marine Electrode for Electric Field Test

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Journal of Ocean University of China 2020年第2期19卷 361-368页

作者： ZAI Xuerong LIU Ang TIAN Yuhua CHAI Fanggang fu yubin College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China

A novel sensor for ocean electric field testing has been fabricated by polyacrylonitrile-based on carbon fibers with electro-chemical *** surface profile characteristics of the carbon fibers were characterized by scanning electron microscope,Fourier transform infrared spectra and contact *** voltammetry and Tafel curves have been used to study its electro-chemical *** identical electrodes in sea water as the electric field sensor will swiftly respond to applied electric field which causes positive and negative ions to move in opposite direction,resulting in a electric potential difference(ΔE).Test result indicates that the offset potential is typically below 1 m V with a drift of 60-170μVd^-*** self noise level is 1.07 nV√Hz^(1/2)@1 *** electric field response indicates that the modified electrode pair shows better response to AC sine signal of amplitude and frequency(5 mV and 1 mHz)respectively than its *** electric field response model of the modified electrodes is creatively presented according to its electric double layer capacitance and Faraday *** advantages of the carbon fiber electric field electrode will make it have potential application prospect.

关键词： carbon fiber electrode electro-chemical oxidation modification electro-chemical performance electric field response electric field test

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Carbon Foam Anode Modified by Urea and Its Higher Electrochemical Performance in Marine Benthic Microbial fuel Cell

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Journal of Ocean University of China 2015年第4期14卷 663-668页

作者： fu yubin LU Zhikai ZAI Xuerong WANG Jian Institute of Materials Science and Engineering Ocean University of China China Lucky Group Corporation College of Chemistry and Chemical Engineering Ocean University of China

Electrode materials have an important effect on the property of microbial fuel cell(MFC). Carbon foam is utilized as an anode and further modified by urea to improve its performance in marine benthic microbial fuel cell(BMFC) with higher voltage and output power. The electrochemical properties of plain carbon foam(PC) and urea-modified carbon foam(UC) are measured respectively. Results show that the UC obtains better wettability after its modification and higher anti-polarization ability than the PC. A novel phenomenon has been found that the electrical potential of the modified UC anode is nearly 100 m V lower than that of the PC, reaching-570 ±10 m V(vs. SCE), and that it also has a much higher electron transfer kinetic activity, reaching 9399.4 m W m-2, which is 566.2-fold higher than that from plain graphite anode(PG). The fuel cell containing the UC anode has the maximum power density(256.0 m W m-2) among the three different BMFCs. Urea would enhance the bacteria biofilm formation with a more diverse microbial community and maintain more electrons, leading to a lower anodic redox potential and higher power output. The paper primarily analyzes why the electrical potential of the modified anode becomes much lower than that of others after urea modification. These results can be utilized to construct a novel BMFC with higher output power and to design the conditioner of voltage booster with a higher conversion ratio. Finally, the carbon foam with a bigger pore size would be a potential anodic material in conventional MFC.

关键词： marine benthic microbial fuel cell carbon foam anode urea modification low anode potential high kinetic activity high output voltage

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Pyrolyzed Iron Phthalocyanine-Modified Multi-Walled Carbon Nanotubes as Composite Anode in Marine Sediment Microbial fuel Cells and Its Electrochemical Performance

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Journal of Ocean University of China 2019年第6期18卷 1395-1401页

作者： ZAI Xuerong DUAN Zhiwei CHEN Wei YU Jian fu yubin College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China School of Materials Science and Engineering Ocean University of ChinaQingdao 266100China

Improving the performance of anode is a crucial step for increasing output power of marine sediment microbial fuel cells(MSMFCs)to drive marine monitor to work for a long term on the ocean floor.A pyrolyzed iron phthalocyanine modified multi-walled carbon nanotubes composite(FePc/MWCNTs)has been utilized as a novel nodified anode in the *** structure of the composite modified anode and electrochemical performance have been investigated respectively in the *** is a substantial improvement in electron-transfer efficiency from the bacteria biofilm to the modified anode via the pyrolyzed FePc/MWCNTs composite based on their cyclic voltammetry(CV)and Tafel *** electron transfer kinetic activity of the FePc/MWCNTs-modified anode is 1.86 times higher than of the unmodified *** maximum power density of the modified MSMFC was 572.3±14 m W m^-2,which is 2.6 times larger than the unmodified one(218.3±11 m W m^-2).The anodic structure and cell scale would be greatly minimized to obtain the same output power by the modified MSMFC,so that it will make the MSMFC to be easily deployed on the remote ocean ***,it would have a great significance for us to design a novel and renewable long term power ***,a novel molecular synergetic mechanism is proposed to elucidate its excellent electrochemical performance.

关键词： marine sediment microbial fuel cells iron phthalocyanine/multi-walled carbon nanotube composite modified anode electrochemical kinetics power density

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Sulfonated polyaniline/vanadate composite as anode material and its electrochemical property in microbial fuel cells on ocean floor

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Science China Chemistry 2011年第5期54卷 844-849页

作者： fu yubin ZHAO ZhongKai LIU Jia LI KuiZhong XU Qian ZHANG ShaoYun Institute of Materials Science and Engineering Ocean University of ChinaQingdao 266100China

A unique sulfonated polyaniline/vanadate composite was synthesized and utilized as a composite anode in microbial fuel cells on ocean floor (BMFCs). X-ray diffraction (XRD) and thermogravimetric analysis (TGA) were employed to characterize its chemical composition and morphology. Wettability of the composite anodes decreases due to the addition of polytetrafluoroethylene (PTFE). The electrochemical behavior of the composite anodes was investigated by means of linear sweep voltammetry and Tafel plot measurements. Compared with the plain graphite anode,the composite anode significantly improves the power density,5.5-fold higher,reaching 187.1 mW/m2 and gives a 27-fold higher exchange current density and a higher kinetic activity. A novel synergistic mechanism between sulfonated polyaniline and vanadate is proposed to explain the excellent electrochemical performance. This composite thus has great potential to be used as an anode material for a high-power BMFC.

关键词： sulfonated polyaniline/vanadate composite anode material microbial fuel cells on ocean floor power density electrochemical property

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无机酸掺杂聚苯胺/碳纤维复合海洋电场传感器电极

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上海交通大学学报 2024年第3期58卷 391-399,I0001,I0002页

作者：侯晓帆孙久哲许嘉威胡承儒付玉彬中国海洋大学材料科学与工程学院山东青岛266100

碳纤维电极具有成本低、化学稳定性好、性能可调控等优点,可用于开发高性能海洋电场传感器.利用电化学原位聚合法制备盐酸、硫酸、磷酸掺杂的聚苯胺/碳纤维(PANI/CF)复合电场电极,提高其电化学性能与电场响应性能.结果表明:碳纤维表面... 详细信息

碳纤维电极具有成本低、化学稳定性好、性能可调控等优点,可用于开发高性能海洋电场传感器.利用电化学原位聚合法制备盐酸、硫酸、磷酸掺杂的聚苯胺/碳纤维(PANI/CF)复合电场电极,提高其电化学性能与电场响应性能.结果表明:碳纤维表面生成致密的导电聚苯胺膜,并在循环伏安测试中出现特征氧化还原峰;电化学阻抗分析显示PANI/CF复合电极低频(0.01 Hz)阻抗值至少降低为空白电极的1/118,利于对水下微弱电场信号进行响应.在电场响应性能测试中,盐酸掺杂PANI/CF复合电极电位漂移量最低达1.77 mV/d;能够较好地响应1 mV/10 mHz的低频率低强度电场信号;误差线性度最小值为0.111%,在同类电极中具有最好响应灵敏度.该新型复合电场电极制备方法简单、成本低廉,有助开发新一代低成本、高性能海洋电场传感器.

关键词：碳纤维电极碳纤维/聚苯胺复合材料无机酸掺杂电化学性能电场响应性能

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