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Hoeffding's inequality for Markov processes via solution of Poisson's equation

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Frontiers of Mathematics in China 2021年第2期16卷 543-558页

作者： yuanyuan liu Jinpeng liu School of Mathematics and Statistics New CampusCentral South UniversityChangsha 410083China

We investigate Hoeffding's inequality for both discrete-time Markov chains and continuous-time Markov processes on a general state space. Our results relax the usual aperiodicity restriction in the literature, and the explicit upper bounds in the inequalities are obtained via the solution of Poisson's equation. The results are further illustrated with applications to queueing theory and reective diffusion processes.

关键词： Hoeffding's inequality Markov process Poisson's equation

Screening and evaluation of antioxidants from lees by micro-injector systems combined with a fluorescent probe,N-borylbenzyloxycarbonyl-3,7-dihydroxyphenoxazine,in living Drosophila

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Chinese Chemical Letters 2018年第10期29卷 1521-1527页

作者： Guangcui Chu Dandan Cheng Wenjuan liu Xuefeng Wang Xiaotao hou yuanyuan hou Hongjun Wei Jiagang Deng Gang Bai Tianjin University of Traditional Chinese Medidne Tianjin 300193 China State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin 300353 China Guangxi Collaborative Innovation Center of Study on Functional Ingredients of Agricultural Residues Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica Guangxi University of Chinese Medicine Nanning 530200 China JF-Pharmaceutical Technology Development Co. Ltd. Tianjin 300457 China

Over the past few decades, the determination of antioxidant activity by chemical probe has been widely reported, but in vivo evaluation via model organisms of Drosophila melanogaster and rapid discovery system has not been studied adequately. In this study, we determined the antioxidant activity of lees and demonstrated the ability of compounds in lees to scavenge H_2O_2 in vitro and in vivo by different chemical probes. Lees increased the ability of Drosophila against oxidative stress and antioxidant enzyme activity in vivo. Five ingredients of organic acids and flavones in lees extract that rapidly scavenged H_2O_2 were revealed by a post-column-derived HPLC-UV-FLD system based on 4-hydroxyphenylacetic acid（PHPAA）chemiluminescence. Additionally, another fluorescent probe,N-borylbenzyloxycarbonyl-3,7-dihydroxyphenoxazine（NBCD）, was selected to evaluate the reactive oxygen species（ROS） scavenging capacity of lees in living Drosophila melanogaster using a microfluidic injection test coupled with microscopic imaging analysis, and similar effects were observed in flies when they were treated with tartaric acid and caffeic acid. The results demonstrated that the novel integrated system was suitable for screening and evaluating antioxidant ingredients from natural products.

关键词： Lees Antioxidant Microinjection HPLC-UV-FLD NBCD PHPAA

Chemical proteomics combined with metabonomics reveals berberine targets NDUFV1 of complex Ⅰ in the respiratory chain to regulate energy metabolism

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Chinese Chemical Letters 2023年第3期34卷 419-423页

作者： Xiaoyao Ma Yiman Han Kaixin liu Yongping Bai He Gao yuanyuan hou Gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300381China

Berberine(BBR) is the primary alkaloid compound of the heat-clearing traditional Chinese medicine Huanglian(Coptis chinensis) and exerts regulatory effects on energy metabolism. However, the specific targets and molecular mechanisms are not clear. In this paper, the BBR-affected energy metabolism pathway was screened by nontargeted metabolomics, and a BBR-derived photoaffinity labeled(PAL) probe was designed to identify potential targets via a chemical proteomics approach. NDUFV1, a subunit of complex Ⅰ on mitochondria, was identified as a potential target of BBR. In the respiratory chain, BBR suppressed the activity of complex Ⅰ, reduced the electrochemical potential in the mitochondrial intermembrane and inhibited the generation of ATP and heat via competitive binding with NDUFV1. The results illustrated the underlying mechanism of BBR in the downregulation of energy metabolism.

关键词： Berberine Photoaffinity labeled Chemical proteomics NDUFV1 ComplexⅠ Energy metabolism

Reproductive aging:biological pathways and potential interventive strategies

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Journal of Genetics and Genomics 2023年第3期50卷 141-150页

作者： yuanyuan liu Jinmin Gao Center for Cell Structure and Function College of Life SciencesKey Laboratory of Animal Resistance Biology of Shandong ProvinceShandong Normal UniversityJinanShandong 250014China

Reproductive aging is a natural process conserved across species and is well-known in *** shows age-related follicle depletion and reduction of oocyte quality,eventually causing reproductive senescence and *** reproductive aging in males is not well noticed as in females,it also causes infertility and has deleterious consequences on the *** factors have been suggested to contribute to reproductive aging,including oxidative stress,mitochondrial defects,telomere shortening,meiotic chromosome segregation errors and genetic *** the increasing trend of pregnancy age,it is particularly crucial to find interventions to preserve or extend human *** in humans and model organisms have provided insights into the biological pathways associated with reproductive aging,and a series of potential interventive strategies have been ***,we review factors affecting reproductive aging in females and males and summarize interventive strategies that may help delay or rescue the aging phenotypes of reproduction.

关键词： Reproductive aging Infertility Oocytes Sperm Gamete quality

Design and regulation of the surface and interfacial behavior of protein molecules

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Chinese Journal of Chemical Engineering 2020年第11期28卷 2837-2847页

作者： Qianqian hou Nanxing Li yuanyuan Chao Shihao Li Lin Zhang Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China

Surface and interfacial behavior of protein molecules are crucial for the protein function involved in many biochemical processes and biomedical products such as enzyme design,bio-separation,drug design and *** article is devoted to an overview of design and regulation of the surface and interfacial behavior of protein *** improvement of enzyme surface such as the directed evolution and the rational design of enzymes is introduced at first,followed by the rational design of protein interface for the protein ***,the design of micro-environment and ligands are described as two examples for the design guided by protein *** the design of protein surface and interface with the help of artificial intelligence will be discussed.

关键词： Protein Enzyme Surface Interface Design Artificial intelligence

Free Rotor Model or Rigid Rotor Model for CH3F-Ne Complex and Comparison with Other CH3F-Rare Gas Systems

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Chemical Research in Chinese Universities 2016年第5期32卷 818-826页

作者： MA Yongtao ZHAO yuanyuan hou Dan LI Hui Institute of Theoretical Chemistry Jilin University Changchun 130021 P. R. China

The assignment of the rovibrational spectra of molecule-Ne complexes is always a challenge to study van der Waals systems, since they usually exhibit behavior intermediate between free rotor and rigid rotor. In this paper, the microwave and infrared spectra of CH3F-Ne, a model system for symmetric-top-atom dimer, were firstly pre- dicted and analyzed based on the four-dimensional ab initio intermolecular potential energy surfaces（PESs）, which explicitly incorporate the v3（C--F） stretch normal model coordinate of the CH3F monomer. Analytic three-dimensional PESs were obtained by least-squares fitting vibrationally averaged interaction energies for v3（CH3F）=0 and 1 to the Morse/long-range（MLR） potential function for symmetry top impurity with atom model. These PESs fitting to 2340 points have root-mean-square（RMS） deviations of 0.07 cm1, and require only 167 parameters. Based on the analytical vibrationally averaged PESs, the rovibrational energy levels were calculated by employing Lanczos algorithm, with combined radial discrete variable representation and parity-adapted angular finite basis representation. Based on the wavefunction analysis and comparison of CH3F-Ne with CH3F-He and CH3F-Ar complexes, the bound states were assigned. Spectral parameters for CH3F-Rg（Rg： rare gas, Rg=He, Ne, Ar） complexes were fitted and discussed. Temperature dependent transition intensities for CH3F-Ne were also reported and analyzed. The complete microwave and infrared spectra information for CH3F-Ne made it possible to provide important guidance for future experimental spectroscopic assignments.

关键词： Morse/long-range model Rovibrational spectrum Symmetry-top molecule CH3F-Ne

Finite-Time H_(∞)Sampled-Data Reliable Control for a Class of Markovian Jump Systems with Randomly Occurring Uncertainty via T-S Fuzzy Model

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Journal of Systems Science & Complexity 2022年第3期35卷 860-887页

作者： liu yuanyuan ZHANG Yutong MA Yuechao School of Science Yanshan UniversityQinhuangdao 066004China

The paper analyzes finite-time H_(∞)sampled-data reliability control for nonlinear continuous time Markovian jump systems with randomly occurring uncertainty on account of T-S fuzzy *** particular,the transition rates of the Markovian jump systems have both the upper bound and lower ***,a new Lyapunov-Krasovskii functional(LKF)is considered,which fully captures the available characteristics of real sampling period,and a sampled-data controller with nonlinear actuator failures is *** on the integral inequality technique,some less conservative conditions are proposed such that the stochastic fuzzy system is reliable in the sense,which satisfies finite-time bounded and certain H_(∞)performance levelγ.Additionally,some numerical examples can illustrate the effectiveness of the results.

关键词： Actuator fault control finite-time H_(∞)bounded Markovian jump system sampled-data control T-S fuzzy model

Streptavidin-Biotin Complexes as Tools for Modulating an Important DNA Episgenetic Modification

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Chinese Journal of Chemistry 2024年第18期42卷 2166-2172页

作者： Yongjie liu Xinyan Xu Xingyu liu Wei Xiong Qianqian Qi yuanyuan Zhang Jinxuan hou Tian Tian Xiang Zhoua Key Laboratory of Biomedical Polymers of Ministry of Education College of Chemistry and Molecular SciencesHubei Province Key Laboratory of Allergyand ImmunologyWuhan UniversityWuhanHubei 430072China Department of Thyroid&Breast Surgery Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhanHubei 430072China

DNA 5-formylcytosine(5fC)is a prominent epigenetic modification within biological *** investigations have shed light on its pivotal role in governing cell fate,gene expression,and disease ***,our comprehension of the precise control of the 5f site structure to influence its functionality remains *** this study,we have successfully achieved precise control over 5fc activity by harnessing the interaction between streptavidin and *** research underscores the potential application of interactions between biomacromolecules and small molecules in advancing the field of DNA epigenetic functional regulation.

关键词： Epigenetic modification Biotin Streptavidin Selectivity Regulation

Integral-type functionals of first hitting times for continuous-time Markov chains

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Frontiers of Mathematics in China 2018年第3期13卷 619-632页

作者： yuanyuan liu Yanhong SONG School of Mathematics and Statistics Central South University Changsha 410083 China School of Statistics and Mathematics Zhongnan University of Economics and Law Wuhan 430073 China

We investigate integral-type functionals of the first hitting times for continuous-time Markov chains. Recursive formulas and drift conditions for calculating or bounding integral-type functionals are obtained. The connection between the subexponential integral-type functionals and the subexponential ergodicity is established. Moreover, these results are applied to the birth-death processes. Polynomial integral-type functionals and polynomial ergodicity are studied, and a sufficient criterion for a central limit theorem is also presented.

关键词： Integral-type functional continuous-time Markov chain (CTMC) subexponential ergodicity birth-death process central limit theorem (CLT)