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PagMYB128 regulates secondary cell wall formation by direct activation of cell wall biosynthetic genes during wood formation in poplar

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Journal of Integrative Plant Biology 2024年第8期66卷 1658-1674页

作者： yuanyuan hao Fachuang Lu Seung-Won Pyo Min-Ha Kim Jae-Heung Ko Xiaojing Yan John Ralph Quanzi Li State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100091China Department of Biochemistry and DOE Great Lakes Bioenergy Research Center Wisconsin Energy InstituteUniversity of Wisconsin-MadisonWisconsin 53726USA Department of Plant&Environmental New Resources Kyung Hee UniversityYongin 17104Korea

The biosynthesis of cellulose,lignin,and hemicelluloses in plant secondary cell walls(SCWs)is regulated by a hierarchical transcriptional regulatory *** network features orthologous transcription factors shared between poplar and Arabidopsis,highlighting a foundational similarity in their genetic ***,knowledge on the discrepant behavior of the transcriptional-level molecular regulatory mechanisms between poplar and Arabidopsis remains *** this study,we investigated the function of PagMYB128 during wood formation and found it had broader impacts on SCW formation compared to its Arabidopsis ortholog,*** poplar trees overexpressing PagMYB128 exhibited significantly enhanced xylem development,with fiber cells and vessels displaying thicker walls,and an increase in the levels of cellulose,lignin,and hemicelluloses in the *** contrast,plants with dominant repression of PagMYB128 demonstrated the opposite *** sequencing and reverse transcription–quantitative polymerase chain reaction showed that PagMYB128 could activate SCW biosynthetic gene expression,and chromatin immunoprecipitation along with yeast one-hybrid,and effector–reporter assays showed this regulation was *** analysis revealed that PagSND1(SECONDARY WALL-ASSOCIATED NAC-DOMAIN PROTEIN1)directly regulates PagMYB128 but not cell wall metabolic genes,highlighting the pivotal role of PagMYB128 in the SND1-driven regulatory network for wood development,thereby creating a feedforward loop in SCW biosynthesis.

关键词： cellulose hemicellulose lignin PagMYB128 Populus transcription factor wood formation

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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-βsignaling

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Frontiers of Medicine 2024年第1期18卷 128-146页

作者： yuanyuan hao Panpan Chen Shanshan Guo Mengyuan Li Xueli Jin Minghuan Zhang Wenhai Deng Ping Li Wen Lei Aibin Liang Wenbin Qian Department of Hematology The Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou310009China Department of Hematology Henan Provincial People’s HospitalZhengzhou University People’s HospitalZhengzhou450003China Key Laboratory of Laboratory Medicine Ministry of EducationSchool of Laboratory Medicine and Life SciencesWenzhou Medical UniversityWenzhou325000China Department of Hematology Tongji Hospital of Tongji UniversityShanghai200065China

Tumor-derived exosomes (TEXs) enriched in immune suppressive molecules predominantly drive T-cell dysfunction and impair antitumor immunity. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising treatment for refractory and relapsed hematological malignancies, but whether lymphoma TEXs have the same impact on CAR T-cell remains unclear. Here, we demonstrated that B-cell lymphoma-derived exosomes induce the initial activation of CD19-CAR T-cells upon stimulation with exosomal CD19. However, lymphoma TEXs might subsequently induce CAR T-cell apoptosis and impair the tumor cytotoxicity of the cells because of the upregulated expression of the inhibitory receptors PD-1, TIM3, and LAG3 upon prolonged exposure. Similar results were observed in the CAR T-cells exposed to plasma exosomes from patients with lymphoma. More importantly, single-cell RNA sequencing revealed that CAR T-cells typically showed differentiated phenotypes and regulatory T-cell (Treg) phenotype conversion. By blocking transforming growth factor β (TGF-β)-Smad3 signaling with TGF-β inhibitor LY2109761, the negative effects of TEXs on Treg conversion, terminal differentiation, and immune checkpoint expression were rescued. Collectively, although TEXs lead to the initial activation of CAR T-cells, the effect of TEXs suppressed CAR T-cells, which can be rescued by LY2109761. A treatment regimen combining CAR T-cell therapy and TGF-β inhibitors might be a novel therapeutic strategy for refractory and relapsed B-cell lymphoma.

关键词： tumor-derived exosome chimeric antigen receptor T-cell lymphoma TGF-β

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An Improved Thermal Conductivity Measurement Scheme for Macroscopic Graphitic Films Using the Laser Flash Method

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Journal of Thermal Science 2024年第4期33卷 1480-1490页

作者： ZHANG Peijuan MING Xin LIU Yingjun WANG Xuelong SHI Hang hao yuanyuan LU Jiahao LIU Zheng LAI Haiwen ZHANG Ying GAO Weiwei XU Zhen GAO Chao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials&Technologies of Zhejiang ProvinceZhejiang UniversityHangzhou310027China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan030032China Special Equipment Safety Supervision and Inspection Institute of Jiangsu Province National Graphene Products Quality Inspection and Testing Center(Jiangsu)Wuxi214174China Hangzhou Gaoxi Technol Co. LtdHangzhou311113China China Academy of Aerospace Aerodynamics Beijing100074China

Achieving efficient thermal management urges to exploit high-thermal-conductivity materials to satisfy the boosted demand of heat *** is critical to adopt standardized characterization protocols to evaluate the intrinsic thermal conductivity of thermal management ***,for the most representative laser flash method,the lack of standard measurement methodology and systematic description on the thermal diffusivity and influencing factors has led to significant deviations and confusion of the thermal conduction performance in the emerging thermal management ***,the measurement error factors of thermal diffusivity by the common laser flash analyzer(LFA)are *** high-thermal-conductivity graphitic film(GF)as a typical case,the key factors are analyzed to guide the measurement protocol of related carbon-based thermal management *** basic principle of the LFA measurement,actual pre-processing conditions,instrument parameters setting,and data analysis are elaborated for accurate ***,the graphene thick films and common isotropic materials are also extended to meet various thermal measurement *** on the existing practical problems,we propose a feasible test flow to achieve a unified and standardized thermal conductivity measurement,which is beneficial to the rapid development of carbon-based thermal management materials.

关键词： thermal management graphitic film laser flash method thermal conductivity thermal diffusivity

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Melatonin mitigates cold-induced damage to pepper seedlings by promoting redox homeostasis and regulating antioxidant profiling

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Horticultural Plant Journal 2024年第2期10卷 532-544页

作者： Muhammad Ahsan Altaf yuanyuan hao Huangying Shu Weiheng Jin Chuhao Chen Lin Li Yu Zhang Muhammad Ali Mumtaz Huizhen Fu Shanhan Cheng Guopeng Zhu Zhiwei Wang Key Laboratory for Quality Regulation of Tropical Horticultural Crops of Hainan Province Sanya Nanfan Research InstituteHainan UniversitySanyaHainan 572025China Key Laboratory for Quality Regulation of Tropical Horticultural Crops of Hainan Province School of HorticultureHainan UniversityHaikouHainan 570228China Hainan Yazhou Bay Seed Laboratory SanyaHainan 572025China

This study assessed the influence of exogenous ME in the mitigation of cold damage in pepper seedlings. Melatonin(ME) is a dynamic molecule that helps plants cope with stress in several ways. Cold stress(CS) is one of the most important environmental factors that restrict plant growth and yield. Pepper(Capsicum annuum L.) is a valuable commercial crop, highly sensitive to CS. Thus, identifying an efficient strategy to mitigate cold damage is critical for long-term pepper production. For this purpose, the roots of pepper seedlings were pretreated with ME(5 μmol · L^(-1)) and exposed to CS for 7 d. The results indicated that CS suppressed pepper growth, hampered photosynthetic capacity, and damaged root architecture in pepper plants. In contrast, the production of reactive oxygen species(ROS), malondialdehyde(MDA), electrolyte leakage(EL), proline, and soluble sugars were enhanced in plants under CS. ME(5 μmol · L^(-1)) pretreatment reduced the negative effects of CS by recovering plant growth, root traits, gas exchange elements, and pigment molecules compared to CS control treatment. Furthermore, ME application efficiently reduced oxidative stress markers [hydrogen peroxide(H_(2)O_(2)), superoxide ion(O_(2)^(·-)), EL, and MDA] while increasing proline and soluble sugar content in pepper leaves. ME application combined with CS further increased antioxidant enzymes and related gene expression. Collectively, our results confirmed the mitigating potential of ME supplementation for CS by maintaining pepper seedling growth,improving the photosynthesis apparatus, regulating pigments, and osmolyte content.

关键词： Pepper Melatonin Cold stress Antioxidant enzyme Root trait

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Highly Thermally Conductive and Structurally Ultra‑Stable Graphitic Films with Seamless Heterointerfaces for Extreme Thermal Management

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Nano-Micro Letters 2024年第3期16卷 383-397页

作者： Peijuan Zhang yuanyuan hao Hang Shi Jiahao Lu Yingjun Liu Xin Ming Ya Wang Wenzhang Fang Yuxing Xia Yance Chen Peng Li Ziqiu Wang Qingyun Su Weidong Lv Ji Zhou Ying Zhang Haiwen Lai Weiwei Gao Zhen Xu Chao Gao MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang ProvinceZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032People’s Republic of China Beijing Spacecrafts Manufacturing Co. LtdBeijing Friendship Road 104Haidian DistrictBeijing 100094People’s Republic of China Beijing Institute of Space Mechanics and Electricity Beijing Friendship Road 104Haidian DistrictBeijing 100094People’s Republic of China China Academy of Aerospace Aerodynamics Beijing 100074People’s Republic of China Hangzhou Gaoxi Technol Co. LtdHangzhou 311113People’s Republic of China International Research Center for X Polymers International CampusZhejiang UniversityHaining 314400People’s Republic of China

Highly thermally conductive graphitic film(GF)materials have become a competitive solution for the thermal management of high-power electronic ***,their catastrophic structural failure under extreme alternating thermal/cold shock poses a significant challenge to reliability and ***,we present the first investigation into the structural failure mechanism of GF during cyclic liquid nitrogen shocks(LNS),which reveals a bubbling process characterized by“permeation-diffusion-deformation”*** overcome this long-standing structural weakness,a novel metal-nanoarmor strategy is proposed to construct a Cu-modified graphitic film(GF@Cu)with seamless *** well-designed interface ensures superior structural stability for GF@Cu after hundreds of LNS cycles from 77 to 300 ***,GF@Cu maintains high thermal conductivity up to 1088 W m^(−1)K^(−1)with degradation of less than 5%even after 150 LNS cycles,superior to that of pure GF(50%degradation).Our work not only offers an opportunity to improve the robustness of graphitic films by the rational structural design but also facilitates the applications of thermally conductive carbon-based materials for future extreme thermal management in complex aerospace electronics.

关键词： Highly thermally conductive Structurally ultra-stable Graphitic film Extreme thermal management Liquid nitrogen bubbling

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新世纪安徽黄梅戏文化资源开发利用研究

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四川戏剧 2024年第3期 107-110页

作者：邵敏郝圆圆安庆师范大学传媒学院江苏省昆山登云科技职业学院建筑与设计学院

20世纪末以来,安徽黄梅戏在院团改制、公共文化服务、剧目创作、文化产业、媒介传播和人才培养等文化资源开发利用方面均有上佳表现,但也存在黄梅戏文献资源挖掘整理不足、资源数字化程度不高、文化产业规模偏小、传播媒介运用不充分、... 详细信息

20世纪末以来,安徽黄梅戏在院团改制、公共文化服务、剧目创作、文化产业、媒介传播和人才培养等文化资源开发利用方面均有上佳表现,但也存在黄梅戏文献资源挖掘整理不足、资源数字化程度不高、文化产业规模偏小、传播媒介运用不充分、专业人才断层、新创剧目总体水准需要进一步提升等现象。实践中,通过加强文献资源挖掘收集整理、共建共享数字化资源、跨界融合打造文化产业集群、立体传播推广文化品牌、多措并举培育专业人才、守正创新创造新时代经典等途径,可以提升黄梅戏文化资源开发利用成效。

关键词：黄梅戏戏曲文化地方戏资源开发利用

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提升高职生学习参与度的护理学基础课程混合式教学设计与实践

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中华护理教育 2024年第6期21卷 695-700页

作者：周丽荣郝圆圆江苏联合职业技术学院南京卫生分院/南京卫生高等职业技术学校南京市210028

目的探讨护理学基础中的混合式教学活动设计对提升高职护理专业学生学习参与度的效果。方法基于探究社区理论设计一系列混合式教学活动,线上活动包括“案”“言”“赞”“图”;线下活动包括“境”“问”“比”“评”。在114名护理高职... 详细信息

目的探讨护理学基础中的混合式教学活动设计对提升高职护理专业学生学习参与度的效果。方法基于探究社区理论设计一系列混合式教学活动,线上活动包括“案”“言”“赞”“图”;线下活动包括“境”“问”“比”“评”。在114名护理高职生中开展护理学基础课程教学,并应用混合式教学活动。课程结束后评价学生线上、线下学习参与度,以及期末成绩的及格率和优秀率;应用中文版探究社区量表调查学生的学习体验,并进行教学改革前后比较。结果教学任务完成率为76.3%~100%;视频观看时长782.7~1028.7(851.6±100.7)min;发表讨论话题73个,回复4210个;图表作业发布32个,回复3019个;教师回复448个,点赞2430次。线下课堂记录显示,96%的学生主动提出了问题,小组汇报平均3~5次。教学改革后的线上参与度、线下参与度、期末成绩的及格率和优秀率均高于教学改革前(P<0.05)。教学改革后学生的探究社区量表总分及各维度得分均高于教学改革前(P<0.05)。结论本研究设计的混合式教学活动可以提高学生对护理学基础课程教学的学习参与度,加速个人知识建构,提高学生学习专注度。

关键词：教育,护理课程探究社区理论护理学基础混合式教学

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癌症患者决策疲劳的研究进展及护理启示

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中华护理杂志 2024年第8期59卷 941-946页

作者：房钰郝媛媛张晨董莹吴赢鑫姜桂春辽宁省肿瘤医院临床技能培训中心沈阳市110000 辽宁省肿瘤医院妇科四病区沈阳市110000

癌症的治疗方案具有多样性,患者在选择时需要反复权衡利弊,考虑各种健康风险以及对家庭的影响,易出现决策疲劳,不仅影响其决策判断,还可能影响其身心健康。该文概述了决策疲劳的概念、理论模型、评估工具,总结了癌症患者决策疲劳的影响... 详细信息

癌症的治疗方案具有多样性,患者在选择时需要反复权衡利弊,考虑各种健康风险以及对家庭的影响,易出现决策疲劳,不仅影响其决策判断,还可能影响其身心健康。该文概述了决策疲劳的概念、理论模型、评估工具,总结了癌症患者决策疲劳的影响因素及应对策略,可为国内医护人员进一步制订个性化的决策辅助工具、开展相关临床实践和科学研究提供参考。

关键词：癌症决策疲劳自我损耗自我控制综述护理

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Pilot Contamination Elimination in Massive MIMO Systems with an Improved Time-Shifted Scheme

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Journal of Beijing Institute of Technology 2020年第1期29卷 16-22页

作者： yuanyuan hao Zhengyu Song Institute of Telecommunication Satellite China Academy of Space TechnologyBeijing 100094China School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China

Pilot contamination can bring up a grave impairment in the performance of massive multiple-input multiple-output(MIMO)*** this paper,an improved time-shifted pilot scheme is proposed to reduce the pilot contamination,where orthogonal pilots are employed in the same group to eliminate the residual intragroup interference existing in the original time-shifted pilot ***,the rigorous closed-form expressions of both downlink and uplink transmission rates with a finite number of antennas are derived,and it is shown that the intra-group interference can be completely eliminated by the proposed *** results demonstrate that both downlink and uplink transmission rates are significantly improved by employing the proposed scheme.

关键词： massive multiple-input multiple-output(MIMO) pilot contamination time-shifted pilot

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经直肠超声联合超声造影对前列腺低回声病灶良恶性诊断的价值

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临床荟萃 2024年第7期39卷 635-639页

作者：郝苑苑王君黄茜南阳医学高等专科学校第一附属医院超声诊断科河南南阳473058

目的探讨经直肠超声(transrectal ultrasonography,TRUS)联合超声造影(contrast-enhanced ultrasound,CEUS)对前列腺低回声病灶良恶性诊断的价值。方法选取2022年9月-2023年8月本院收治的54例疑似前列腺癌患者(共75个前列腺低回声病灶)... 详细信息

目的探讨经直肠超声(transrectal ultrasonography,TRUS)联合超声造影(contrast-enhanced ultrasound,CEUS)对前列腺低回声病灶良恶性诊断的价值。方法选取2022年9月-2023年8月本院收治的54例疑似前列腺癌患者(共75个前列腺低回声病灶),均接受TRUS联合CEUS检查,以病理检查结果作为金标准,统计病灶良恶性情况,并进行单因素分析与多因素logistic回归分析以明确对前列腺低回声病灶良恶性诊断的价值。结果75个前列腺低回声病灶中,经病理检查检出恶性病灶39个、良性病灶36个;恶性组病灶包膜不完整、病灶内有钙化、病灶形态不规则、造影峰值高增强的占比更高,两组声像图特征、造影模式差异有统计学意义(P<0.05);多因素logistic回归分析结果显示,病灶包膜不完整(OR=10.592)、“污渍”样低回声(OR=13.325)、快进快退(OR=12.960)、造影峰值高增强(OR=16.025)是前列腺低回声病灶恶性的独立危险因素(P<0.05);绘制受试者工作特征(receiver operating characteristic,ROC)曲线显示,TRUS、CEUS、二者联合诊断前列腺低回声病灶良恶性的曲线下面积(area under curve,AUC)分别为0.889、0.837、0.953,二者联合的AUC较TRUS、CEUS更高。结论采用TRUS联合CEUS诊断前列腺低回声病灶良恶性,具有较高的诊断价值,需要重点关注病灶包膜、声像图特征、造影模式、造影峰值强度等超声特征。

关键词：前列腺疾病超声检查超声造影低回声病灶诊断价值

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