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Neural stem cell activation and glial proliferation in the hippocampal CA3 region of posttraumatic epileptic rats

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Neural Regeneration Research 2011年第16期6卷 1232-1237页

作者： yuanxiang lin Kun lin Dezhi Kang Feng Wang Department of Neurosurgery First Affiliated Hospital of Fujian Medical University Fuzhou 350005 Fujian Province China

The present study observed the dynamic expression of CD133, nuclear factor-κB and glial fibrUlary acidic protein in the hippocampal CA3 area of the experimental posttraumatic epilepsy rats to investigate whether gliosis occurs after posttraumatic epilepsy. CD133 and nuclear factor-κB expression was increased at 1 day after posttraumatic epilepsy, peaked at 7 days, and gradually decreased up to 14 days, as seen by double-irnmunohistochemical staining. Glial fibrillary acidic protein/nuclear factor-EB double-labeled cells increased with time and peaked at 14 days after posttraumatic epilepsy. Results show that activation of hippocampal neural stem cells and glial proliferation after posttraumatic epilepsy-induced oxidative stress increases hippocampal glial cell density.

关键词： posttraumatic epilepsy neural stem cell glial cell CD133 nuclear factor-κB glialfibrillary acidic protein neural regeneration

Cognitive disorder and changes in cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor following brain injury

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Neural Regeneration Research 2008年第3期3卷 305-308页

作者： Weiliang Zhao Dezhi Kang yuanxiang lin Department of Neurosurgery First Hospital Affiliated to Fujian Medical University Fuzhou 350005 Fujian Province China

BACKGROUND： Learning and memory damage is one of the most permanent and the severest symptoms of traumatic brain injury; it can seriously influence the normal life and work of patients. Some research has demonstrated that cognitive disorder is closely related to nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor. OBJECTIVE： To summarize the cognitive disorder and changes in nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor following brain injury. RETRIEVAL STRATEGY： A computer-based online search was conducted in PUBMED for English language publications containing the key words ＂brain injured, cognitive handicap, acetylcholine, N-methyl-D aspartate receptors, neural cell adhesion molecule, brain-derived neurotrophic factor＂ from January 2000 to December 2007. There were 44 papers in total. Inclusion criteria： ① articles about changes in nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor following brain injury; ② articles in the same researching circle published in authoritative journals or recently published. Exclusion criteria： duplicated articles. LITERATURE EVALUATION： References were mainly derived from research on changes in these four factors following brain injury. The 20 included papers were clinical or basic experimental studies. DATA SYNTHESIS： After craniocerebral injury, changes in these four factors in brain were similar to those during recovery from cognitive disorder, to a certain degree. Some data have indicated that activation of nicotine cholinergic receptors, N-methyl-D aspartate receptors, neural cell adhesion molecule, and brain-derived neurotrophic factor could greatly improve cognitive disorder following brain injury. However, there are still a lot of questions remaining; for example, how do these fac

关键词： brain injured cognitive handicap acetylcholine N-methyl-D aspartate receptors neural cell adhesion molecule brain-derived neurotrophic factor

Solitary Langerhans cell histiocytosis of frontal lobe: a case report and literature review

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Chinese Journal of Cancer Research 2014年第2期26卷 211-214页

作者： Shanshan Cai Sheng Zhang Xueyong Liu yuanxiang lin Chunlin Wu Yupeng Chen Jianping Hu Xingfu Wang Department of Pathology the Second Affiliated Hospital of Fujian Medical University Department of Pathology the First Affiliated Hospital of Fujian Medical University Department of Neurosurgery the First Affiliated Hospital of Fujian Medical University Department of Radiology the First Affiliated Hospital of Fujian Medical University

The brain parenchymal Langerhans cell histiocytosis （LCH） without systemic disease or lytic skull lesions is extremely rare. We report a 23-year-old male presenting with new onset 1 hour seizure with loss of consciousness 20 days prior to admission, and recurrent seizure 2 weeks later. Brain magnetic resonance imaging （MRI） showed an irregularly mass with enhancement involving the right frontal lobe. Microscopically, the lesion was characterized by sheets of Langerhans cells in addition to reactive inflammatory elements. Immunohistochemically, Langerhans cells were positive for Langerin, CDla and S-100 protein. The patient received no chemotherapy or radiotherapy after surgery. After 24 months of follow-up, no recurrence or other systemic lesions were observed. Although there is no standard treatment for solitary cerebral LCH, the prognosis generally appears to be good.

关键词： Langerhans cell histiocytosis (LCH) histiocytosis immunohistochemistry pathology

Synaptic plasticity effects on FeCl_2-induced post-traumatic epilepsy onset in the rat

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Neural Regeneration Research 2010年第18期5卷 1373-1377页

作者： yuanxiang lin Feng Wang Ruxiang Xu Xiaodan Jiang Dezhi Kang Yiquan Ke Mouxuan Du Lishuang Xu Department of Neurosurgery First Affiliated Hospital Fujian Medical University Fuzhou 350005 Fujian Province China Department of Neurosurgery Zhujiang Hospital Southern Medical University Guangzhou 510282 Guangdong Province China

Studies have confirmed that iron induces epilepsy onset, and iron ion-induced epilepsy in anima models closely resembles the clinical situation. Models of post-traumatic epilepsy （PTE） were established by intracortical injection of FeCl2 using stereotactic techniques. Electron microscopy revealed neuronal degeneration, with shrinkage of the neuronal soma, hyperplasia of rough endoplasmic reticulum, ribosomal detachment from the endoplasmic reticulum, and vacuolar degeneration of glial cells in the right frontal lobe of FeCl2-induced PTE rats. With prolonged time injuries became more severe and neuronal apoptosis was observed. Synapses in the hippocampal neuropil significantly increased （primarily type I/excitatory synapses） at day 14 following injury. Type II synapses （inhibitory synapse） were observed in the rat hippocampus at day 30. Cortical neuronal degeneration, apoptosis, glial cell proliferation, and ultrastructural hippocampal changes, in particular changes in type of neuronal synapse, play an important role in PTE onset.

关键词： post-traumatic epilepsy animal model ferrous chloride synapse synaptic plasticity electron microscope electric wire neurodegenerative diseases neural regeneration

Electrical tree degradation of MgO/epoxy resin composites at different voltage frequencies

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High Voltage 2024年第3期9卷 581-590页

作者： Yunxiao Zhang Wenxin lin yuanxiang Zhou Weiwei Xing Jiayu Cheng Chenyuan Teng College of Electrical Engineering and Automation Fuzhou UniversityFujian Key Laboratory of New Energy Generation and Power ConversionFuzhouChina State Key Laboratory of Control and Simulation of Power Systems and Generation Equipment Department of Electrical EngineeringTsinghua UniversityBeijingChina

Electrical tree degradation is one of the main causes of insulation failure in high-frequency *** tree degradation is studied on pure epoxy resin(EP)and MgO/EP composites at frequencies ranging from 50 Hz to 130 *** results show that the tree initiation voltage of EP decreases,while the growth rate and the expansion coefficient increase with ***,the bubble phenomenon at high frequencies in EP composites is *** with trap distribution character-istics within the material,the intrinsic mechanism of epoxy composites to inhibit the growth of the electrical tree at different frequencies is *** can be concluded that more deep traps and blocking effect are introduced by doping nano-MgO into EP bulks,which can improve the electrical tree resistance performance of EP composites in a wide frequency range.

关键词： composites tree Electrical

Glioblastoma vaccine tumor therapy research progress

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Chinese Neurosurgical Journal 2022年第2期8卷 128-132页

作者： Tong Zhao Chunwang Li Hongliang Ge yuanxiang lin Dezhi Kang Department of Neurosurgery Neurosurgery Research Institutethe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvincePeople’s Republic of China Fujian Key Laboratory of Precision Medicine for Cancer the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvincePeople’s Republic of China Key Laboratory of Radiation Biology of Fujian higher education institutions the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvincePeople’s Republic of China Clinical Research and Translation Center the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvincePeople’s Republic of China Fujian Institute for brain disorders and brain science the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvincePeople’s Republic of China

Glioblastoma(GBM)is the most common primary malignancy of the central nervous system in *** prognosis for late-stage glioblastoma(World Health Organization grade IV astrocytic glioma)is very *** treatment options are sought after and evaluated by clinicians and researchers,and remarkable advances have been made in surgical techniques,radiotherapy,and ***,the treatment of glioblastoma remains extremely difficult and it can extend the lives of patients by only a few *** has been notable progress in the field of immunotherapy,particularly with the use of tumor vaccines,for treating glioblastoma;especially peptide vaccines and cell-based vaccines such as dendritic cell vaccines and tumor cell ***,the results of the current clinical trials for vaccination are not *** article reviews the progress in the development of vaccines for glioblastoma.

关键词： Glioblastoma Vaccine therapy Immunotherapy Tumor microenvironment Review

Endoscopically controlled surgery with open hemilaminectomy for the treatment of intradural extramedullary tumors:an operative technique and short-term outcomes of 20 consecutive cases

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Chinese Neurosurgical Journal 2021年第2期7卷 89-97页

作者： Xiaorong Yan Huiqing Wang Cai Li yuanxiang lin lin lin Shinong Zhu Chenyang Wang Zhangya lin Changzhen Jiang Dezhi Kang Neurosurgery Department The First Affiliated Hospital of Fujian Medical University20#Chazhong RoadFuzhou CityFujian ProvinceChina Neurosurgery Department The First Affiliated Hospital of University of South ChinaHengyang CityHunan ProvinceChina Operation Room The First Affiliated Hospital of Fujian Medical UniversityFuzhou CityFujian ProvinceChina Neurosurgery Department Jinjiang Hospital Jinnan Branch CourtsJinjiang CityFujian ProvinceChina

Background:To present a surgical technique for the treatment of intradural extramedullary(IDEM)tumors by using endoscopically controlled surgery with open hemilaminectomy ***:In this study,20 patients with 22 IDEM tumors were *** endoscopically controlled surgery with open hemilaminectomy was employed to remove the *** related to clinical symptoms and medical images before and after surgery were collected for perioperative evaluation and follow-up ***:All the tumors in 20 patients were well *** clinical symptoms were significantly reduced in all the patients as *** short-term follow-up data showed that there was no tumor recurrence or spinal ***:The endoscopically controlled surgery with open hemilaminectomy technique provided favorable exposure and satisfactory resection to the IDEM *** may be an effective surgical method for treating IDEM *** samples and longer follow-up data are needed to verify its long-term effectiveness.

关键词： Endoscopically controlled surgery Open hemilaminectomy Intradural extramedullary tumors

Anatomy and surgery of pure neuroendoscopic infratentorial supracerebellar approach for resection of pineal region tumor

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Chinese Neurosurgical Journal 2018年第3期4卷 133-138页

作者： Yuanlong Zhang Dezhi Kang Changzhen Jiang Xiaorong Yan Zhangya lin yuanxiang lin Xiyue Wu Chenyang Wang Department of Neurosurgery The First Affiliated Hospital Of Fujian Medical UniversityFuzhou 350004China

Background: The pineal region tumors are surrounded by important structures. Neuroendoscopy has been increasingly used at home and abroad. This study is to simulate pure neuroendoscopic infratentorial supracerebellar approach for resection of pineal region tumor from the cadaveric head, and discuss the advantages and safety through this corridor. Methods: The anatomical structure for resection of pineal region tumor was visualized through pure neuroendoscopic infratentorial supracerebellar approach in three cadaveric heads. Three cases with pineal region tumors were retrospectively analyzed and summarized between June 2017 and December 2017. All cases were operated through pure neuroendoscopic infratentorial supracerebellar approach in the first affiliated hospital of Fujian medical university. Results: The anatomical structures of pineal region can be completely visualized by pure neuroendoscopic infratentorial supracerebellar corridor in the cadaveric head. Among the three cases, the first case was total resection, the second case was subtotal resection and the last case was partial resection. The postoperative pathology revealed cavernous hemangioma, germinoma and yolk sac tumor, respectively. The patients were followed-up for 1-6 months and had normal *** KPS (karnofsky performance status) score was 100. Conclusion: The anatomical structure of the pineal region can be completely visualized and the tumor can be safely removed through pure neuroendoscopic infratentorial supracerebellar approach.

关键词： Neuroendoscopy Infratentorial supracerebellar approach Surgery Anatomy Pineal region tumor

Exosomal circular RNAs inglioma:coexistenceof opportunitiesand challenges forapplication

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Chinese Medical Journal 2022年第13期135卷 1528-1530页

作者： Xiaoyong Chen Jinyuan Chen Yue Chen Honghai You yuanxiang lin Zanyi Wu Dezhi Kang Chenyu Ding Department of Neurosurgery Neurosurgical Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Department of Ophthalmology The First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina The Graduate School of Fujian Medical University FuzhouFujianChina Fujian Provincial Key Laboratory of Precision Medicine for Cancer The First Affiliated HospitalFujan Medical UniversityFuzhouFujianChina Key Laboratory of Radiation Biology of Fujian Higher Education Instions The First Affiliated HospitalFujian Medical UniversitFuzhouFujianChina Fujian Provincial Insttutes of Brain Disorders and Brain Sciences FuzhouFujianChina Fujian Provincial Clinical Research Center for Neurological Diseases FuzhouFujianChina.

Glioma is the most common primary tumor in the central nervous *** the help of intercellular communication,glioma cells have the ability to survive in the tumor microenvironment(TME)and make it more suitable.

关键词： glioma tumor circular