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Journal of Thermal Science 2024年第6期33卷 2179-2189页

作者： LI Zeyu huang Caoxuheng YIN Jianhui School of Electric Power South China University of Technology Guangdong Province Key Laboratory of High Efficient and Clean Energy Utilization South China University of Technology Guangdong Province Engineering Research Center of High Efficient and Low Pollution Energy Conversion Ningbo Jetron Technology Co.Ltd.

The two-stage transcritical CO2refrigeration cycle with dedicated dual-subcooling and mechanical recooling is *** inter-stage pressure is critical for such cycle performances;however,it has not been studied ***,the research aim is to disclose the effect of inter-stage pressure on performances of the proposed *** main work consists of four ***,the comparative study is performed to display advantages of the proposed ***,the key temperatures,heat and power consumptions as well as performance indicators for different inter-stage pressures are analyzed in detail,based on the parametric ***,the optimal inter-stage pressure for different conditions is obtained by the nonlinear direct search ***,the economic performance is *** is found that the compressor power of the proposed cycle drops by 12%,and the working temperature lower limit is reduced by 11℃.Furthermore,it is considered that the optimal inter-stage pressure is insensitive to the heat source *** novelty lies in illustrating the effect of inter-stage pressure,obtaining trends of the optimal value,and pointing out the system *** paper is favorable for design and operation optimization of the proposed system.

关键词： CO2 refrigeration dedicated absorption subcooling recooling thermodynamics two-stage cycle

Single-atom catalysis:a promising avenue for precisely controlling reaction pathways

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 97-120页

作者： Xiaobo Yang Xuning Li Yanqiang huang State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Single-atom catalysts (SACs), characterized by exceptionally high atom efficiency, have garnered significant attention across various catalytic reactions. Recent studies have showcased SACs with robust capabilities for precise catalysis, specifically targeting reactions along designated pathways. This review focuses on the advances in the precise activation and reconstruction of chemical bonds on SACs, including precise activation of C–O and C–H bonds and selective couplings involving C–C and C–N bonds. Our discussion begins with a thorough exploration of the factors that render SACs skilled in precise catalytic processes, encompassing the narrow d-band electronic state of single atom site resulting in the adsorption tendency, isolate site resulting in unique adsorption structure, and synergy effect of a single atom site with its neighbors. Subsequently, we elaborate on the applications of SACs in electrocatalysis and thermocatalysis including four prominent reactions, namely, electrochemical CO_(2) reduction, urea electrochemical synthesis, CO_(2) hydrogenation, and CH4 activation. Then the concept of rational design of SACs for precisely controlling reaction pathways is discussed from the aspects of pore structure design, support-metal strong interaction, and support hydrophilic/hydrophobic. Finally, we summarize the challenges encountered by SACs in the field of precise catalytic processes and outline prospects for their further development in this domain.

关键词： single atom catalysts selective oxidation CO_(2)RR bond coupling

Gria:an efficient deterministic concurrency control protocol

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Frontiers of Computer Science 2024年第4期18卷 25-37页

作者： Xinyuan WANG Yun PENG Hejiao huang School of Computer Science and Technology Harbin Institute of TechnologyShenzhen 518055China Institute of Artificial Intelligence and Blockchain Guangzhou UniversityGuangzhou 510006China

Deterministic databases are able to reduce coordination costs in a *** property has fostered a significant interest in the design of efficient deterministic concurrency control ***,the state-of-the-art deterministic concurrency control protocol Aria has three ***,it is impractical to configure a suitable batch size when the read-write set is ***,Aria running in low-concurrency scenarios,e.g.,a single-thread scenario,suffers from the same conflicts as running in high-concurrency ***,the single-version schema brings write-after-write *** address these issues,we propose Gria,an efficient deterministic concurrency control *** has the following ***,the batch size of Gria is ***,Gria’s conflict probability in low-concurrency scenarios is lower than that in high-concurrency ***,Gria has no write-after-write conflicts by adopting a multi-version *** further reduce conflicts,we propose two optimizations:a reordering mechanism as well as a rechecking *** evaluation result on two popular benchmarks shows that Gria outperforms Aria by 13x.

关键词： deterministic concurrency control transaction processing

Robust AUC maximization for classification with pairwise confidence comparisons

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Frontiers of Computer Science 2024年第4期18卷 73-83页

作者： Haochen SHI Mingkun XIE Shengjun huang College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China MIIT Key Laboratory of Pattern Analysis and Machine Intelligence Nanjing 211106China

Supervised learning often requires a large number of labeled examples,which has become a critical bottleneck in the case that manual annotating the class labels is *** mitigate this issue,a new framework called pairwise comparison(Pcomp)classification is proposed to allow training examples only weakly annotated with pairwise comparison,i.e.,which one of two examples is more likely to be *** previous study solves Pcomp problems by minimizing the classification error,which may lead to less robust model due to its sensitivity to class *** this paper,we propose a robust learning framework for Pcomp data along with a pairwise surrogate loss called *** provides an unbiased estimator to equivalently maximize AUC without accessing the precise class ***,we prove the consistency with respect to AUC and further provide the estimation error bound for the proposed *** studies on multiple datasets validate the effectiveness of the proposed method.

关键词： method pairwise weakly

Recent progress in side chain engineering of Y-series non-fullerene molecule and polymer acceptors

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Science China Chemistry 2024年第3期67卷 788-805页

作者： Li Tian Chunchen Liu Fei huang School of Materials Science and Engineering Henan University of TechnologyZhengzhou 450001China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Organic solar cells(OSCs) have drawn considerable attention in the last decade due to the great potential of light weight,flexibility, and low-cost solution processing. Particularly, Y-series non-fullerene acceptors(NFAs) including small molecular acceptors(SMAs) and polymerized small molecular acceptors(PSMAs) have become research hot spots due to their excellent power conversion efficiency. Side chain engineering is crucial to adjust the solubility and crystallinity of NFAs, which will significantly affect the morphology of active layers and the efficiency of OSCs. However, the understanding of side chain engineering on NFAs is still limited and lacks a systematic review. This review aims to provide a brief summary of the recent developments in side chain engineering of NFAs, with a special focus on the design and application of Y-series SMAs and PSMAs for high-efficiency non-fullerene organic solar cells(NF-OSCs). In addition, the review also points out challenges and provides useful guidance regarding side chain regulation for Y-series NFAs.

关键词： organic solar cell Y-series non-fullerene acceptors side chain engineering

WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling

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International Journal of Oral Science 2024年第1期16卷 85-96页

作者： Qingling huang Yi Xiao Ting Lan Youguang Lu Li huang Dali Zheng Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFujian Medical UniversityFuzhouChina Fujian Key Laboratory of Oral Diseases School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Preventive Dentistry School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Dentistry The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina

Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry. Unexpectedly, overexpression of WNT7A did not activate the canonical Wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that WNT7A potentially activated the FZD7/JAK1/STAT3 signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of WNT7A and phosphorylated STAT3 was observed, which positively correlated with tumor *** findings underscore the significance of WNT7A in HNSCC progression and propose the targeting of key molecules within the FZD7/JAK1/STAT3 pathway as a promising strategy for precise treatment of HNSCC.

关键词： WNT squamous tumorigenesis

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肺真菌病78例临床分析

中国感染与化疗杂志 2018年第3期18卷 252-257页

作者：梁嫄琦李鸿茹黄丽萍林晓红陈愉生福建医科大学省立临床医学院福建省立医院呼吸与危重症医学科福州350001 福建医科大学省立临床医学院福建省立医院呼吸四病研究室福州350001

目的比较不同菌种、不同免疫状态肺真菌病临床特点差异。方法回顾性分析福建省立医院2012年6月-2016年6月确诊的78例肺真菌病患者临床资料。结果确诊菌种包括隐球菌(61/78,78.2%);曲霉(14/78,17.9%);马尔尼菲篮状菌、毛霉、阿萨希毛孢子... 详细信息

目的比较不同菌种、不同免疫状态肺真菌病临床特点差异。方法回顾性分析福建省立医院2012年6月-2016年6月确诊的78例肺真菌病患者临床资料。结果确诊菌种包括隐球菌(61/78,78.2%);曲霉(14/78,17.9%);马尔尼菲篮状菌、毛霉、阿萨希毛孢子菌(各1例,3.8%)。肺隐球菌病主要感染无基础病人群,肺曲霉病主要感染有基础疾病者,基础疾病最常见为2型糖尿病。确诊方法包括CT引导下肺穿刺活检34例(34/78,43.6%),手术后病理32例(32/78,41.0%),经支气管肺活检(TBLB)11例(11/78,14.1%),血培养1例(1/78,1.3%)。肺隐球菌病以无症状为主(29/61,47.5%),仅在有基础疾病患者中出现咯血;而肺曲霉病咯血发生率(8/14,57.1%)高于其他菌种。气管镜下肺隐球菌病无异常表现(14/18,77.8%);肺曲霉病主要表现为炎性渗出(6/10),并仅在有基础疾病患者中出现管腔内坏死、新生物等情况。肺隐球菌病主要影像表现为结节肿块影(48/61,78.7%),肺曲霉病极少出现晕征、新月征。治疗采用单纯药物治疗45例(45/78,57.7%),手术治疗15例(15/78,19.2%),药物联合手术18例(18/78,23.1%)。最终死亡6例,失访25例,病情稳定47例。结论肺真菌病临床特征因菌种不同及宿主基础状态不同而有差异,临床诊断肺真菌病时应结合宿主免疫状态,根据不同症状推测可疑病原菌,尽早选择针对性方式确诊,以提高确诊率。

关键词：肺真菌病基础疾病临床特点

Mechanism of acupuncture in attenuating cerebral ischaemia-reperfusion injury based on nuclear receptor coactivator 4 mediated ferritinophagy

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Journal of Traditional Chinese Medicine 2024年第2期44卷 345-352页

作者： ZHANG Xinchang huang Zheng huang Peiyan YANG Mengning ZHANG Zhihui NI Guangxia College of Acupuncture-Moxibustion and Tuina Nanjing University of Chinese MedicineNanjing 210023China Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE:To explore the effect of acupuncture treatment on cerebral ischaemia-reperfusion injury(CIRI)and reveal the underlying mechanism of the effect based on nuclear receptor coactivator 4(NCOA4)mediated ***:Sprague-Dawley male rats were divided into four groups:the sham group,model group,acupuncture group,and sham acupuncture *** 2 h of middle cerebral artery occlusion(MCAO),reperfusion was performed for 24 h to induce *** rats were treated with acupuncture at the Neiguan(PC6)and Shuigou(GV26)*** neurological function was evaluated by taking their Bederson scores at 2 h after ischaemia and 24 h after *** chloride staining was applied to assess the cerebral infarct volume at 24 h after *** malondialdehyde(MDA)and ferrous iron(Fe^(2+))levels were observed after 24 h of reperfusion using an assay *** blotting was performed to detect the expression of NCOA4 and ferritin heavy chain 1(FTH1)at 24 h after ***,the colocalization of ferritin with neurons,NCOA4 with microtubule-associated protein 1 light chain 3(LC3),and NCOA4 with ferritin was visualized using immunofluorescence ***:Acupuncture significantly improved neurological function and decreased cerebral infarct volume in the acupuncture *** CIRI,the expression of NCOA4,LC3 and FTH1 was increased,which enhanced ferritinophagy and induced an inappropriate accumulation of Fe^(2+)and MDA in the ischaemic ***,acupuncture dramatically downregulated the expression of NCOA4,LC3 and FTH1,inhibited the overactivation of ferritinophagy,and decreased the levels of MDA and Fe^(2+).CONCLUSIONS:Acupuncture can inhibit NCOA4-mediated ferritinophagy and protect neurons against CIRI in a rat model.

关键词： acupuncture ferritinophagy ferroptosis ferritin nuclear receptor coactivator 4 cerebral ischaemia-reperfusion injury

Triad-displaced ULAs configuration for non-circular sources with larger continuous virtual aperture and enhanced degrees of freedom

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Journal of Systems Engineering and Electronics 2024年第1期35卷 81-93页

作者： SHAIKH Abdul Hayee DANG Xiaoyu huang Daqing College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China

Non-uniform linear array(NULA)configurations are well renowned due to their structural ability for providing increased degrees of freedom(DOF)and wider array aperture than uniform linear arrays(ULAs).These characteristics play a significant role in improving the direction-of-arrival(DOA)estimation ***,most of the existing NULA geometries are primarily applicable to circular sources(CSs),while they limitedly improve the DOF and continuous virtual aperture for noncircular sources(NCSs).Toward this purpose,we present a triaddisplaced ULAs(Tdis-ULAs)configuration for *** TdisULAs structure generally consists of three ULAs,which are appropriately *** proposed antenna array approach fully exploits the non-circular characteristics of the *** the same number of elements,the Tdis-ULAs design achieves more DOF and larger hole-free co-array aperture than its sparse array ***,the number of uniform DOF,optimal distribution of elements among the ULAs,and precise element positions are uniquely determined by the closed-form ***,the proposed array also produces a filled resulting *** simulations are conducted to show the performance advantages of the proposed Tdis-ULAs configuration over its counterpart designs.

关键词： direction-of-arrival(DOA)estimation sparse array non-circular source(NCS) sum co-array difference co-array degrees of freedom(DOF)

Percarbonate activation catalyzed by nanoblocks of basic copper molybdate for antibiotics degradation: High performance, degradation pathways and mechanism

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Chinese Chemical Letters 2024年第10期35卷 375-378页

作者： Xiaotao Jin Yanlan Wang Yingping huang Di huang Xiang Liu Engineering Research Center of Eco-Environment in Three Gorges Reservoir Region of Ministry of Education College of Materials and Chemical EngineeringChina Three Gorges UniversityYichang 443002China Department of chemistry and chemical engineering Liaocheng UniversityLiaocheng 252059China

Sodium percarbonate(Na_(2)CO_(3)·1.5H_(2)O_(2),SPC)has been extensively employed as a solid substitute of H_(2)O_(2)for Fenton process in water treatment,because of its high stability during the production,transport,storage and *** addition,SPC can be applied in a wider range of work pH,it is also applied as a buffer in Fenton reaction for preventing a drop in ***,we have synthesized basic copper molybdate(BCM)nanoblocks with the molecular formula of Cu_(3)(MoO_(4))_(2)(OH)_(2)as an efficient and heterogeneous catalyst for antibiotics degradation via percarbonate ***,fully physical characterizations confirmed BCM nanocomposite exhibited a structure of *** also found that BCM/SPC system could work in a much wider pH range,compared with H_(2)O_(2).Then,BCM/SPC system presented a good anti-interference ability for natural organic matter in OTC *** results and Quenching tests confirmed that the co-presence of·CO_(3)-,·O_(2)-,1O_(2)and·OH in BCM/SPC system.

关键词： Sodium percarbonate Fenton process Water treatment Copper molybdate Nanoblocks