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High Magnetic Property and Toxicity of Particulate Matter Generated during Welding and Cutting Processes

Environment & Health 2024年第6期2卷 381-389页

作者： Wei Cui Zizhen Ma Yuanzheng Chen Shuya Li Di Wu Xiu Chen yuankai Shao Yuzhe Liu Qing Li Jianmin Chen Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266520China Shanghai Institute of Eco-Chongming(SIEC) Shanghai 200062China National Engineering Laboratory for Mobile Source Emission Control Technology China Automotive Technology&Research Center Co.LtdTianjin 300300China

Magnetic particulate matter(PM)has raised increasing concern due to its abundant presence in ambient air and negative health ***,there is still a lack of comprehensive understanding of their emission sources and *** here report the observation of high magnetic property and toxicity of PM generated during typical welding and cutting ***,formed during high-temperature operation with less oxygen pressure,was revealed to be the major magnetic *** averaged saturation magnetization and magnetic susceptibility values of fine PM(PM_(2.5))from welding processes are 1.4−4.2 times greater than those of PM emitted from other unintended emission sources,including iron and steel plants and brake wear,while they are 2.0−5.7 times greater for the cutting ***,PM_(2.5)from welding and cutting processes are nearly 3.5−4.5 times more neurovirulent and 2.1−7.0 times more likely to induce oxidative stress than those from other magnetic sources in the nerve cells ***,all of these magnetic PM_(2.5)exhibit greater negative health effects than typical atmospheric PM_(2.5)collected in Shanghai urban *** new findings suggest that appropriate occupational protection measures should be implemented for the welding and cutting process to reduce adverse health impacts.

关键词： pollutant emission magnetic property particulate matters magnetite welding and cutting

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Efficacy and safety of utidelone for the treatment of patients with locally advanced or metastatic non-small-cell lung cancer who have failed standard second-line treatment:A phase 2 clinical trial(BG01-1801)

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Cancer Pathogenesis and Therapy 2024年第2期2卷 103-111页

作者： yuankai Shi Gongyan Chen Yanqiu Zhao jing Zhao Lin Lin Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study On Anticancer Molecular Targeted DrugsBeijing 100021China Department of Respiration Harbin Medical University Cancer HospitalHarbinHeilongjiang 150040China Respiratory Department of Internal Medicine Henan Provincial Cancer HospitalZhengzhouHenan 450003China Department of Pulmonary and Critcal Care Medicine Peking Union Medical College HospitaChinese Academy of Medical Sciences&Peking Union Medical College Beijing100021China

Background:Chemotherapy remains the standard-of-care for many patients with locally advanced or metastatic non-small-cell lung cancer(NSCLC),but acquired resistance presents *** aim of this open-label,multicenter phase 2 clinical trial was to determine the efficacy and safety of utidelone,a novel genetically engineered epothilone analog and microtubule-stabilizing agent,as a third-or later-line treatment for locally advanced ormetastatic ***:Patients who had failed standard second-line treatment(including platinum-containing chemotherapy or targeted therapy)received utidelone(40 mg/m?via intravenous injection daily,day 1-5)every 21 *** primary endpoint was the objective response rate(ORR).Secondary endpoints were the duration of response(DoR),progression-free survival(PFS),overall survival(OS),and ***:From March 12,2019 to January 18,2021,26 pretreated patients with locally advanced or metastatic NSCLC(100%of patients had received prior platinum and 65.4%patients had received prior taxane treatment)were enrolled(80.8%of patients had adenocarcinoma).At baseline,nine(34.6%)patients had received secondline treatment,10(38.5%)patients had received third-line treatment,and seven(26.9%)patients had received fourth-or later-line *** the data cut-off date of August 10,2021,the median follow-up was 7.49 months(range,1.4-26.7 months).The ORR was 15.4%(95%confidence interval[CI],4.4%-34.9%)in the intention-totreat(ITT)cohort(N=26)and 19.0%(95%CI,5.4%-41.9%)in the per-protocol(PP)cohort(N=21).The disease control rate was 69.2%(95%CI,48.2%-85.7%)and 81.0%(95%CI,58.1%-94.6%)in the ITT and PP cohorts,*** median DoR was 4.1 months(95%CI,3.1-5.1 months)in the ITT *** median PFS was 4.37 months(95%CI,2.50-5.29 months)in the ITT cohort and 4.37 months(95%CI,2.50-9.76 months)in the PP *** median OS was not reached,and the 12-month OS rate was 69%(95%CI,45.1%-84.1%).Grade 3/4 treatment-emergent adverse events occur

关键词： Utidelone Locally advanced or metastatic non-small-cell lung cancer Efficacy Platinum-and taxane-refractory

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A visual analysis approach for data imputation via multi-party tabular data correlation strategies

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Frontiers of Information Technology & Electronic Engineering 2024年第3期25卷 398-414页

作者： Haiyang ZHU Dongming HAN Jiacheng PAN Yating WEI Yingchaojie FENG Luoxuan WENG Ketian MAO yuankai XING Jianshu LV Qiucheng WAN Wei CHEN The State Key Lab of CAD&CG Zhejiang UniversityHangzhou 310058China Wuchan Zhongda Digital Technology Co. Ltd.Hangzhou 310020China Zhejiang Metals and Materials Co. Ltd.Hangzhou 310005China

Data imputation is an essential pre-processing task for data governance,aimed at filling in incomplete ***,conventional data imputation methods can only partly alleviate data incompleteness using isolated tabular data,and they fail to achieve the best balance between accuracy and *** this paper,we present a novel visual analysis approach for data *** develop a multi-party tabular data association strategy that uses intelligent algorithms to identify similar columns and establish column correlations across multiple ***,we perform the initial imputation of incomplete data using correlated data entries from other ***,we develop a visual analysis system to refine data imputation *** interactive system combines the multi-party data imputation approach with expert knowledge,allowing for a better understanding of the relational structure of the *** significantly enhances the accuracy and eficiency of data imputation,thereby enhancing the quality of data governance and the intrinsic value of data *** validation and user surveys demonstrate that this method supports users in verifying and judging the associated columns and similar rows using theirdomain knowledge.

关键词： Data governance Data incompleteness Data imputation Data visualization Interactive visual analysis

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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu Jie Gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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水肥一体化减量施肥对苹果果实挥发性物质的影响

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中国果树 2022年第2期 25-31页

作者：张天皓陶茹靳元凯李凤龙樊淼淼高华西北农林科技大学园艺学院陕西杨凌712100

为探究根域水肥一体化减量施肥对苹果果实挥发性成分的影响,同时筛选出渭北黄土高原地区苹果根域水肥一体化最佳施肥量,为水肥一体化施肥模式施肥量提供科学参考。采用顶空固相微萃取和气相色谱质谱联用技术,结合主成分分析法分析各处... 详细信息

为探究根域水肥一体化减量施肥对苹果果实挥发性成分的影响,同时筛选出渭北黄土高原地区苹果根域水肥一体化最佳施肥量,为水肥一体化施肥模式施肥量提供科学参考。采用顶空固相微萃取和气相色谱质谱联用技术,结合主成分分析法分析各处理的香气成分并进行比较。结果表明,不同施肥处理共检测出玉华早富苹果挥发性成分31种。主要挥发性成分分为酯类、醛类、醇类物质,此外还有少量的酸类和其他类物质,其中酯类24种,醛类3种,醇类2种,酸类1种,其他类1种。在苹果果实挥发性成分中,酯类物质相对含量各处理间无显著性差异。不同施肥处理下检测到苹果挥发性物质种类差异显著,其中水肥一体化施肥WF2处理果实挥发性物质种类最多,共检测到29种,水肥一体化施肥WF1最低,为21种。在香气物质总含量方面,其中常规施肥处理检测到的挥发性物质总含量最高,为2699.41μg/kg,WF1处理最低,为1328.10μg/kg。根据6个施肥处理中香气物质种类及其相对含量百分数为数据源进行主成分分析,得出WF4处理更接近于常规施肥处理,说明其挥发性物质成分与常规施肥处理的相似性更大。WF2处理在减施化肥37.07%的情况下,挥发性物质种类最多,种类及总含量均与常规施肥处理无显著性差异,因此推荐渭北地区水肥一体化施肥模式施肥量为N 0.27 kg/株、P_(2)O_(5)0.19 kg/株、K_(2)O 0.32 kg/株。

关键词：苹果水肥一体化施肥量挥发性物质

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数智化时代大学生矛盾性内耗的表征、成因与应对

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中国电化教育 2024年第4期 59-65页

作者：杜源恺韩春红华东师范大学光华书院上海200062 华东师范大学教育学部上海200062

内耗是一种自我内部的心理矛盾样态,代入内耗一词的心理内耗、精神内耗成为当前网络热点话题,是青年群体普遍面临的心理样态。随着数智化时代的到来,大学生群体中逐渐呈现出“内卷焦虑”“自我至上”“社交狂欢”与“躺平颓丧”“身份... 详细信息

内耗是一种自我内部的心理矛盾样态,代入内耗一词的心理内耗、精神内耗成为当前网络热点话题,是青年群体普遍面临的心理样态。随着数智化时代的到来,大学生群体中逐渐呈现出“内卷焦虑”“自我至上”“社交狂欢”与“躺平颓丧”“身份困惑”“社交恐惧”并存的自我对抗、怀疑、冲突等矛盾性内耗表征。该样态的出现受到数智化时代社会评价异化、技术僭越失衡、网络亚文化渲染泛滥等多维影响。为应对和破解大学生矛盾性内耗,应在尊重其成长规律基础上,构建新型教育评价生态、强化大学生数智素养、供给优质网络文化资源,缓平纠结、治愈内耗,实现大学生的跃迁向上、主体回归和蓬勃生长。

关键词：数智化时代大学生心理内耗矛盾性

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陕西白水地区苹果花期低温危害调查及对策

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果树资源学报 2021年第3期2卷 33-35页

作者：姚奕君靳元凯王雷存西北农林科技大学园艺学院陕西杨凌712100

陕西省渭北地区作为苹果种植的优生区,是陕西省重要的鲜食苹果生产基地,同时也是花期冻害的高发区,花期冻害成为影响陕西苹果产量和品质最严重的自然灾害之一。大陆性季风气候决定了黄土高坡会发生非常频繁的气象灾害。为了避免气象灾害... 详细信息

陕西省渭北地区作为苹果种植的优生区,是陕西省重要的鲜食苹果生产基地,同时也是花期冻害的高发区,花期冻害成为影响陕西苹果产量和品质最严重的自然灾害之一。大陆性季风气候决定了黄土高坡会发生非常频繁的气象灾害。为了避免气象灾害,应及时采取有效的措施来预防低温霜冻产生的危害,从而不断提高果园的经济效益。本次通过在盛花期对白水苹果试验站的多个苹果品种进行冻害调查,分析了不同苹果品种花期所受到的冻害程度,并提出几项关键性防冻害措施,以最大限度的降低花期在低温时所受的冻害影响。

关键词：白水地区苹果花期低温调查对策

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不可切除肝内胆管癌的介入治疗研究进展

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介入放射学杂志 2024年第7期33卷 796-800页

作者：罗元凯李勇暨南大学附属珠海医院(珠海市人民医院)介入诊疗中心广东珠海519000

肝内胆管癌(i CCA)具有隐匿性强、恶性程度高的特点,外科切除是唯一可以根治的手段,但大部分患者确诊时已错过手术时机。针对不可手术切除的i CCA,降低肿瘤负荷、减少并发症和延长生存期是主要治疗目的。介入治疗在这方面有突出的优势,... 详细信息

肝内胆管癌(i CCA)具有隐匿性强、恶性程度高的特点,外科切除是唯一可以根治的手段,但大部分患者确诊时已错过手术时机。针对不可手术切除的i CCA,降低肿瘤负荷、减少并发症和延长生存期是主要治疗目的。介入治疗在这方面有突出的优势,可作为外科治疗的替代或补充,在国际各类指南中有着越来越重要的地位。现就目前临床上针对不可切除i CCA的消融治疗、经血管途径治疗及内照射放疗三大类介入治疗方法及其临床疗效作一综述。

关键词：肝内胆管癌不可切除介入治疗

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海带酶解物对生长育肥猪生长性能、肉品质和肠道形态的影响

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动物营养学报 2024年第3期36卷 1549-1561页

作者：曲元凯李明潭臧建军威海市世代海洋生物科技股份有限公司威海264319 中国农业大学动物科学技术学院北京100193

本试验旨在研究海带酶解物对生长育肥猪生长性能、肉品质和肠道健康的影响。选取体重[(45.3±7.5)kg]相近的生长猪200头,随机分为5组(每组5个重复,每个重复8头猪):对照组饲喂基础饲粮,试验组分别饲喂在基础饲粮中添加5、10、15和25 kg/... 详细信息

本试验旨在研究海带酶解物对生长育肥猪生长性能、肉品质和肠道健康的影响。选取体重[(45.3±7.5)kg]相近的生长猪200头,随机分为5组(每组5个重复,每个重复8头猪):对照组饲喂基础饲粮,试验组分别饲喂在基础饲粮中添加5、10、15和25 kg/t海带酶解物的试验饲粮,试验期84 d。结果表明:与对照组相比,1)饲粮中添加10 kg/t的海带酶解物组试验全期料重比显著降低(P<0.05),第29~56天平均日增重显著提高(P<0.05);2)饲粮中添加15 kg/t的海带酶解物显著提高了育肥猪屠宰后背最长肌的红度(a∗)值(P<0.05);3)饲粮中添加15和25 kg/t海带酶解物组育肥猪空肠和回肠的绒毛高度显著增加(P<0.05)。由此可见,在饲粮中添加海带酶解物可以改善生长育肥猪生长性能、肉品质和肠道形态;基于本试验结果,生长育肥猪饲粮中海带酶解物的推荐添加量为10~15 kg/t。

关键词：海带酶解物生长育肥猪生长性能肉品质肠道形态

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Prediction of mechanical ventilation outcome by early abdominal-visceral-blood-flow-and-function score in critically ill patients after cardiopulmonary bypass in the ICU: A prospective observational study

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Journal of Intensive Medicine 2024年第1期4卷 101-107页

作者： Chaofu Yue Longxiang Su Jun Wang Na Cui yuankai Zhou Wei Cheng Bo Tang Xi Rui Huaiwu He Yun Long Department of Intensive Care Unit Peking Union Medical College HospitalBeijingChina Department of Intensive Care Unit Qujing First People’s HospitalQujingYunnanChina Department of Intensive Care Unit Shiyan People’s Hospital of Bao’an DistrictShenzhenGuangdongChina

Background:Abdominal organs are important organs that sense and respond to ischemia and hypoxia,but there are few evaluation *** use ultrasonography to evaluate abdominal organ function and blood flow in patients with mechanical ventilation(MV)after cardiopulmonary bypass and to obtain a semiquantitative score for abdominal organ function and blood ***:Patients with cardiopulmonary bypass in the Critical Care Department of Peking Union Medical College Hospital in China from March to July 2021 were enrolled in this prospective observational *** correlation of the abdominal-visceral-blood-flow-and-function score(AVBFS)with the duration of MV,number of days spent in the intensive care unit(ICU),acute physiology and chronic health evaluation II(APACHE-II),sequential organ failure assessment(SOFA),lactate,epinephrine,and norepinephrine use was analyzed,and the results were used to assess the predictive value of the receiver operating characteristic curve(ROC)regression analysis score for the duration of ***:Of the 92 patients who underwent cardiopulmonary bypass,41 were finally *** AVBFS were significantly correlated with the duration of MV,number of days spent in the ICU,APACHE-II score,SOFA score,and norepinephrine use *** AVBFS in a group of patients using ventilators≥36 h were significantly higher than those obtained for a group of patients using ventilators<36 h(P<0.05).The evaluation results for the AVBFS at 0-12 h after ICU admission were as follows:area under the ROC curve(AUC)=0.876(95%confidence interval[CI]:0.767 to 0.984),cut-off value=2.5,specificity=0.842,and sensitivity=***:Abdominal visceral organ function and blood perfusion can be used to evaluate gastrointestinal *** is related to early and late extubation after cardiac surgery.

关键词： Ultrasonic evaluation Abdominal-visceral-blood-flow-and-function score(AVBFS) Gastrointestinal dysfunction Mechanical ventilation Cardiopulmonary bypass

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