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广东化工 2014年第16期41卷 89-89,84页

作者：许元刚唐伟强刘威李冬雪王建龙中北大学化工与环境学院山西太原030051

综述了墙面泛碱的现象、主要原因以及具有抗泛碱、抗盐析性能的建筑涂料在国内外的研究现状,并且指出了耐盐碱建筑涂料的发展方向。

关键词：建筑涂料抗盐析抗泛碱

The in vitro and in vivo anti-tumor effects of MTX-Fe_3O_4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO_2

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Science China(Life Sciences) 2014年第9期57卷 698-709页

作者： CHEN AiZheng DANG TingTing WANG ShiBin TANG Na LIU yuangang WU WenGuo College of Chemical Engineering Huaqiao University Institute of Biomaterials and Tissue Engineering Huaqiao University

The in vitro and in vivo anti-tumor efficacy of methotrexate-loaded Fe3O4-poly-L-lactide-poly(ethylene glycol)-poly-L-lactide magnetic composite microspheres(MTX-Fe3O4-PLLA-PEG-PLLA MCMs,MMCMs),which were produced by co-precipitation(C)and microencapsulation(M)in a supercritical process,was evaluated at various levels:cellular,molecular,and *** results at the cellular level indicate that MMCMs(M)show a better anti-proliferation activity than raw MTX and could induce morphological changes of cells undergoing *** the molecular level,MMCMs(M)lead to a significantly higher relative mRNA expression of bax/bcl-2 and caspase-3 than MMCMs(C)at 10μg mL-1(P<0.01);and the pro-caspase-3protein expression measured by Western blot analysis also demonstrates that MMCMs(M)can effectively activate *** the integrated level,mice bearing a sarcoma-180 tumor are used;in vivo anti-tumor activity tests reveal that MMCMs(M)with magnetic induction display a much higher tumor suppression rate and lower toxicity than raw *** studies show that MMCMs(M)with magnetic induction significantly increase the accumulation of MTX in the tumor tissue compared with the other *** results suggest that the MMCMs(M)prepared by the SpEDS process have great potential to play a positive role in the magnetic targeted therapy field.

关键词： methotrexate magnetic microsphere anti-tumor biological effectiveness

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沉积模拟实验信息系统的设计与实现

长江大学学报（自然科学版） 2024年第2期21卷 13-22页

作者：刘远刚张明望李少华于金彪龙颖波喻思羽长江大学地球科学学院湖北武汉430100 中国石化胜利油田分公司勘探开发研究院山东东营257015 油气资源与勘探技术教育部重点实验室(长江大学) 湖北武汉430100

多年来,国内外地质学家在沉积模拟实验研究中积累了海量的实验数据和资料,但目前缺少对此类信息进行规范化管理和共享应用的软件系统。对此,提出浏览器/服务器(B/S)模式的沉积模拟实验信息系统,实现了沉积模拟实验的实验设计方案、实验... 详细信息

多年来,国内外地质学家在沉积模拟实验研究中积累了海量的实验数据和资料,但目前缺少对此类信息进行规范化管理和共享应用的软件系统。对此,提出浏览器/服务器(B/S)模式的沉积模拟实验信息系统,实现了沉积模拟实验的实验设计方案、实验观测数据、实验结果等信息的集成管理、高效检索和可视化分析等功能,从而为沉积模拟实验的网上信息化管理与分析应用提供可行方案。最后,以某油田辫状河储层沉积模拟实验为例,介绍了系统中实验项目检索、实验详情浏览、砂体测量数据的统计分析等功能的应用效果,说明了本系统的实用性。本系统的研发与应用可极大地方便沉积模拟实验数据的管理、分享及分析工作。

关键词：沉积模拟实验信息系统 *** MVC Web *** Entity Framework ECharts

Virtual reality-based rehabilitation in patients following total knee arthroplasty:a systematic review and meta-analysis of randomized controlled trials

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Chinese Medical Journal 2022年第2期135卷 153-163页

作者： Linbo Peng Yi Zeng yuangang Wu Haibo Si Bin Shen Department of Orthopedics Orthopedic Research InstituteWest China HospitalSichuan UniversityChengduSichuan 610041China

Background:Physical therapy is regarded as an essential aspect in achieving optimal outcomes following total knee arthroplasty(TKA).The coronavirus disease 2019(COVID-19)pandemic has made face-to-face rehabilitation *** reality(VR)is increasingly regarded as a potentially effective option for offering health care *** systematic review and meta-analysis investigate VR-based rehabilitation's effectiveness on outcomes following ***:From inception to May 22,2021,PubMed/Medline,Embase,Web of Science,the Cochrane Central Register of Controlled Trials,Scopus,PsycINFO,Physiotherapy Evidence Database,China National Knowledge Infrastructure,and Wanfang were comprehensively searched to identify randomized controlled trials(RCTs)evaluating the effect of VR-based rehabilitation on patients following TKA according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and the Cochrane Handbook for Systematic Reviews of ***:Eight studies were included in the systematic review,and seven studies were included in the ***-based rehabilitation significantly improved visual analog scale(VAS)scores within 1 month(standardized mean difference[SMD]:−0.44;95%confidence interval[CI]:−0.79 to−0.08,P=0.02),the Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)within 1 month(SMD:−0.71;95%CI:−1.03 to−0.40,P<0.01),and the Hospital for Special Surgery Knee Score(HSS)within 1 month and between 2 months and 3 months(MD:7.62;95%CI:5.77 to 9.47,P<0.01;MD:10.15;95%CI:8.03 to 12.27,P<0.01;respectively)following TKA compared to conventional *** significant difference was found in terms of the Timed Up and Go(TUG)***:VR-based rehabilitation improved pain and function but not postural control following TKA compared to conventional *** high-quality RCTs are needed to prove the advantage of VR-based *** the COVID-19 pandemic continues,

关键词： Arthroplasty,Replacement,Knee Virtual Reality Virtual Reality Exposure Therapy Rehabilitation Systematic review Meta-analysis

Neuro-fuzzy system modeling based on automatic fuzzy clustering

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控制理论与应用（英文版） 2005年第2期3卷 121-130页

作者： yuangang TANG Fuchun SUN Zengqi SUN Department of Computer Science and Technology Tsinghua University Beijing 100084 China

A neuro-fuzzy system model based on automatic fuzzy dustering is proposed. A hybrid model identification algorithm is also developed to decide the model structure and model parameters. The algorithm mainly includes three parts：1） Automatic fuzzy C-means （AFCM）, which is applied to generate fuzzy rttles automatically, and then fix on the size of the neuro-fuzzy network, by which the complexity of system design is reducesd greatly at the price of the fitting capability; 2） *** least square estimation （RLSE）. It is used to update the parameters of Takagi-Sugeno model, which is employed to describe the behavior of the system;3） Gradient descent algorithm is also proposed for the fuzzy values according to the back propagation algorithm of neural network. Finally,modeling the dynamical equation of the two-link manipulator with the proposed approach is illustrated to validate the feasibility of the method.

关键词： Neuro-fuzzy system Automatic fuzzy C-means Gradient descent Back propagation Recursive least square estimation Two-link manipulator

Reliable Facility Systems Design Subject to Edge Failures: Based on the Uncapacitated Fixed-Charge Location Problem

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American Journal of Operations Research 2014年第3期4卷 164-172页

作者： yuangang Pan Yali Du Zongtian Wei Department of Applied Mathematics Northwestern Polytechnical University Xi’an China Department of Mathematics Xi’an University of Architecture and Technology Xi’an China

The reliability of facility location problem has aroused wide concern recently. Many researchers focus on reliable and robust facility systems design under component failures and have obtained promising performance. However, the target and reliability of a facility system are to a large degree adversely affected by the edge failures in the network, which remains a deep study. In this paper, we focus on facility systems’ reliability subject to edge failures. For a facility location system, we formulate two models based on classical uncapacitated fixed-charge location problem under deterministic and stochastic cases. For a specific example, location decisions and the comparison of reliability under different location models are given. Extensive experiments verify that significant improvements in reliability can be attained simply by increasing the amount of operating cost.

关键词： Facility System Reliability Edge Failure Uncapacitated Fixed-Charge Location Problem

Source-field-plated Ga_2O_3 MOSFET with a breakdown voltage of 550 V

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Journal of Semiconductors 2019年第1期40卷 77-79页

作者： Yuanjie Lü xubo Song Zezhao He yuangang Wang Xin Tan Shixiong Liang Cui Wei Xingye Zhou Zhihong Feng National Key Laboratory of Application Specific Integrated Circuit (ASIC) Hebei Semiconductor Research Institute

Ga_2O_3 metal–oxide–semiconductor field-effect transistors(MOSFETs) with high-breakdown characteristics were fabricated on a homoepitaxial n-typed β-Ga_2O_3 film, which was grown by metal organic chemical vapor deposition(MOCVD) on an Fedoped semi-insulating(010) Ga_2O_3 substrate. The structure consisted of a 400 nm unintentionally doped(UID) Ga_2O_3 buffer layer and an 80 nm Si-doped channel layer. A high k HfO_2 gate dielectric film formed by atomic layer deposition was employed to reduce the gate leakage. Moreover, a source-connected field plate was introduced to enhance the breakdown characteristics. The drain saturation current density of the fabricated device reached 101 mA/mm at V_(gs) of 3 V. The off-state current was as low as 7.1 ×10^(-11) A/mm, and the drain current I_(ON)/I_(OFF) ratio reached 10~9. The transistors exhibited three-terminal off-state breakdown voltages of 450 and 550 V, corresponding to gate-to-drain spacing of 4 and 8 μm, respectively.

关键词： Ga_2O_3 MOSFET breakdown voltage filed plate

The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo

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Acta Pharmaceutica Sinica B 2019年第2期9卷 316-323页

作者： Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang Department of Pharmaceutical Sciences College of Pharmacy and Health Sciences St.John's University Department of Pharmacy the First Affiliated Hospital of Guangxi Medical University Guangxi Colleges and Universities Key Laboratory of Biological Molecular Medicine Research Guangxi Medical University Department of Biochemistry and Molecular Biology School of Preclinical Medicine Guangxi Medical University Department of Hepatobiliary Surgery Zhujiang Hospital Southern Medical University Department of Biotechnology School of Preclinical Medicine Guangxi Medical University The Affiliated Tumor Hospital of Guangxi Medical University College of Pharmacy Guangxi Medical University

Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function.

关键词： Epigallocatechin gallate(EGCG) 5,3’,4’,3″,4″,5″-6-O-ethylEGCG(Y6) Drug resistance Resistance reversal ABCB1 P-gp

人工智能CT定量分析技术在评价不同时期肺挫伤支气管变化过程中的应用价值

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中国中西医结合影像学杂志 2024年第2期22卷 184-187,197页

作者：代永亮张宇哲张元刚苟杰程永涛段小艺郭佑民李艳西安电子科技大学医院影像科陕西西安710000 兵器工业五二一医院影像科陕西西安710065 西安交通大学第一附属医院医学影像科陕西西安710061

目的:探讨人工智能CT定量分析技术在肺挫伤病情进展中的应用价值。方法:回顾性分析90例肺挫伤患者108处病灶的CT资料,利用人工智能CT定量分析技术自动分割图像,并测量不同时期(急性期、渗出期及吸收好转期)肺挫伤3~7级支气管定量指标,... 详细信息

目的:探讨人工智能CT定量分析技术在肺挫伤病情进展中的应用价值。方法:回顾性分析90例肺挫伤患者108处病灶的CT资料,利用人工智能CT定量分析技术自动分割图像,并测量不同时期(急性期、渗出期及吸收好转期)肺挫伤3~7级支气管定量指标,行统计学分析。结果:渗出期3~7级支气管的最大壁厚、平均壁厚大于急性期和吸收好转期,渗出期4~7级支气管的管腔内外直径、管腔内外周长及5~7级支气管的内腔横截面积、管壁横截面积小于急性期和吸收好转期(均P<0.05)。急性期4~7级支气管的最大壁厚、平均壁厚大于吸收好转期而小于渗出期,急性期4~7级支气管的管腔内外直径、管腔内外周长及5~7级支气管的内腔横截面积、管壁横截面积小于吸收好转期而大于渗出期,差异均有统计学意义(均P<0.05)。急性期肺挫伤灶占两肺总容积的百分比为(4.26±1.81)%,渗出期为(7.91±2.70)%,吸收好转期为(1.63±0.91)%。急性期肺挫伤灶容积占比与7级支气管内腔横截面积、最大壁厚及平均壁厚相关,渗出期肺挫伤灶容积占比与5级支气管内腔横截面积、支气管内外直径及内周长相关,吸收好转期肺挫伤灶容积占比与6级支气管内腔横截面积、最大壁厚、平均壁厚及7级支气管最大壁厚相关。结论:人工智能CT定量分析技术可直观显示肺挫伤及支气管的形态学变化情况,为临床预估病情发展及干预治疗提供新方法。

关键词：肺挫伤人工智能体层摄影术,X线计算机定量分析技术

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利用Snake移位模型构建中心型地图

武汉大学学报（信息科学版） 2022年第12期47卷 2105-2112,2122页

作者：魏智威刘远刚许文嘉王洋中国科学院网络信息体系技术重点实验室北京100830 中国科学院空天信息创新研究院北京100830 长江大学地球科学学院湖北武汉430100 北京邮电大学信息与通信工程学院北京100876

中心型地图可表示空间各点到中心点的时间距离,能直观反映地理分布因交通系统影响而产生的相近性变化。其构建核心是依据控制点的位置移动确定非控制点的新位置,因此,将中心型地图的构建过程建模为地图目标的移位问题,以相对邻近图表示... 详细信息

中心型地图可表示空间各点到中心点的时间距离,能直观反映地理分布因交通系统影响而产生的相近性变化。其构建核心是依据控制点的位置移动确定非控制点的新位置,因此,将中心型地图的构建过程建模为地图目标的移位问题,以相对邻近图表示点之间的邻近关系,并基于控制点的位置移动计算点的初始受力,应用Snake移位方法迭代计算各点的新位置生成中心型地图,同时利用后处理解决潜在拓扑错误。利用所提方法和最小二乘方法可视化武汉市到其他各市的旅行时间,并定量、定性地进行对比分析。结果表明,所提方法能更好地避免拓扑错误,且局部形态保持更好。

关键词：中心型地图时空可视化时间地图空间变形移位算法