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Clinical evaluation of endoscopic resection for treatment of large gastric stromal tumors

World Journal of Clinical Cases 2019年第7期7卷 830-838页

作者： yuan-yuan xiang yuan-yuan Li Ling Ye Yin Zhu Xiao-Jiang Zhou You-xiang Chen Guo-Hua Li Department of Digestive Diseases The First Affiliated Hospital of Nanchang University

BACKGROUND Gastric stromal tumor is a digestive tract mesenchymal tumor with malignant potential, and endoscopic techniques have been widely used in the treatment of gastric stromal tumors, but there is still controversy over their use for large gastric stromal tumors(≥ 3 cm).AIM To evaluate the clinical long-term efficacy and safety of endoscopic resection for large(≥ 3 cm) gastric stromal *** All patients who underwent endoscopic resection or surgery at our hospital from 2012 to 2017 for pathologically confirmed gastric stromal tumor with a maximum diameter of ≥ 3 cm were collected. The clinical data, histopathologic characteristics of the tumors, and long-term outcomes were *** A total of 261 patients were included, including 37 patients in the endoscopy group and 224 patients in the surgical group. In the endoscopy group, the maximum tumor diameter was 3-8 cm; the male: Female ratio was 21/16; 34 cases had low-risk tumors, 3 had intermediate-risk, and 0 had high-risk; the mean follow-up time was 30.29 ± 19.67 mo, no patient was lost to follow-up, and no patient received chemotherapy after operation; two patients with recurrence had low-risk stromal tumors, and neither had complete resection under endoscopy. In the surgical group, the maximum tumor diameter was 3-22 cm; the male: Female ratio was 121/103; 103 cases had low-risk tumors, 75 had intermediate-risk, and 46 had high-risk; the average follow-up time was 38.83 ± 21.50 mo, 53 patients were lost to follow-up, and 8 patients had recurrence after operation(6 cases had high-risk tumors, 1 had intermediate-risk, and 1 had low-risk). The average tumor volume of the endoscopy group was 26.67 ± 26.22 cm^3(3.75-120), all of which were less than 125 cm^3. The average volume of the surgical group was 273.03 ± 609.74 cm^3(7-4114). Among all patients with a tumor volume < 125 cm^3,7 with high-risk stromal tumors in the surgical group(37.625 cm^3 to 115.2 cm^3)accounted for 3.8%(7/183); of those

关键词： Endoscopic resection Surgery Gastric stromal tumor Clinical evaluation

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Mine disaster survivor’s pelvic floor hernia treated with laparoscopic surgery and a perineal approach:A case report

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World Journal of Clinical Cases 2020年第18期8卷 4228-4233页

作者： Kai Chen yuan-Zhi Lan Jing Li yuan-yuan xiang Dong-Zhu Zeng Department of General Surgery The Third Affiliated Hospital of Chongqing Medical UniversityChongqing 401120China

BACKGROUND A pelvic floor hernia is defined as a pelvic floor defect through which the intraabdominal viscera may *** is an infrequent complication following abdominoperineal *** type of hernia requires surgical repair by conventional or reconstructive *** main treatments could be transabdominal,transperineal or a *** SUMMARY In this article,we present the case of a recurrent perineal incisional hernia,postresection of the left side of the pelvis,testis and lower limbs resulting from a mine disaster 18 years *** laparoscopic surgery with a perineal approach was *** pelvic floor defect was repaired by a biological mesh and one pedicle skin *** signs of recurrence were indicated during the 2 years of *** The combination of laparoscopic surgery with a perineal approach was *** use of the biological mesh and pedicle skin flap to restructure the pelvic floor was effective.

关键词： Case report Pelvic floor hernia Hernioplasty Biological mesh Laparoscopic surgery Perineal approach

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Moyamoya syndrome may result from psoriasis: Four case reports

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World Journal of Clinical Cases 2024年第10期12卷 1830-1836页

作者： Zhi-Ying Chen Xiao-Qin Yu yuan-yuan xiang Ling-Hua Liu Xiao-Ping Yin Department of Neurology The Affiliated Hospital of Jiujiang UniversityJiujiang 332000Jiangxi ProvinceChina Department of Dermatology The Affiliated Hospital of Jiujiang UniversityJiujiang 332000Jiangxi ProvinceChina

BACKGROUND Moyamoya syndrome(MMS)is a group of diseases that involves more than one underlying disease and is accompanied by moyamoya vascular *** is a chronic immune skin disease closely linked to high blood pressure and heart ***,psoriasis-related MMS has not been *** SUMMARY We collected data on patients with stroke due to MMS between January 2017 and December 2019 and identified four cases of *** histories,imaging,and hematological data were *** average age of the initial stroke onset was 58.25±11.52 years;three cases of hemorrhagic and one case of ischemic stroke were *** average duration from psoriasis confirmation to the initial MMS-mediated stroke onset was 17±3.56 *** MMS-related stenoses involved the bilateral cerebral arteries:Suzuki grade III in one case,grade IV in two cases,and grade V in one *** elevated plasma interleukin-6 levels were observed in four *** patients had abnormally elevated immunoglobulin E levels,and two had *** four patients received medication instead of *** an average follow-up time of 2 years,two causing transient ischemic attacks occurred in two patients,and no hemorrhagic events *** Psoriasis may be a potential risk factor for *** with psoriasis should be screened for MMS when they present with neurological symptoms.

关键词： Moyamoya syndrome Psoriasis Stroke Interleukin-6 Immune Hypertension Case report

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New progress in roles of nitric oxide during hepatic ischemia reperfusion injury

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World Journal of Gastroenterology 2017年第14期23卷 2505-2510页

作者： Ya-Qi Zhang Ning Ding Yong-Fen Zeng yuan-yuan xiang Mei-Wen Yang Fen-Fang Hong Shu-Long Yang Department of Physiology Basic Medical CollegeNanchang University Medical Experimental Teaching Center Jiangxi Medical CollegeNanchang University

Hepatic ischemia reperfusion injury (HIRI) is a clinical condition which may lead to cellular injury and organ dysfunction. The role of nitric oxide (NO) in HIRI is complicated and inconclusive. NO produced by endothelial nitric oxide synthase (eNOS) activation plays a protective role during early HIRI. But eNOS overexpression and the resulting excessive NO bioavailability can aggravate liver injury. NO induced by inducible nitric oxide synthase (iNOS) may have either a protective or a deleterious effect during the early phase of HIRI, but it may protect the liver during late HIRI. Here, we reviewed the latest findings on the role of NO during HIRI: (1) NO exerts a protective effect against HIRI by increasing NO bioavailability, downregulating p53 gene expression, decreasing inflammatory chemokines, reducing ROS via inhibiting the mitochondrial respiratory chain, activating sGC-GTP-cGMP signal pathway to reduce liver cell apoptosis, and regulating hepatic immune functions; (2) eNOS protects against HIRI by increasing NO levels, several eNOS/NO signal pathways (such as Akt-eNOS/NO, AMPK-eNOS/NO and HIF-1 alpha-eNOS/NO) participating in the anti-HIRI process, and inhibiting over-expression of eNOS also protects against HIRI; and (3) the inhibition of iNOS prevents HIRI. Thus, the adverse effects of NO should be avoided, but its positive effect in the clinical treatment of diseases associated with HIRI should be recognized.

关键词： Liver Hepatic ischemia reperfusion injury Nitric oxide Nitric oxide synthase

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Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第1期68卷 329-336页

作者： Yuzhu Li Yumeng Gao Feng Tian Yu Wang yuan Yao Shaoliang Lin xiang Ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

关键词： self-assembly conformation ordering alternating copolymer phosphorescence emission

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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li Cui Chang xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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基于人口统计学的改进聚类模型协同过滤算法

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计算机科学 2017年第3期44卷 63-69页

作者：王媛媛李翔淮阴工学院计算机与软件工程学院淮安223003 河海大学计算机与信息学院南京211100

针对传统基于用户的协同过滤推荐算法在大数据环境下存在评分高维稀疏性、推荐精度低的问题,提出一种基于人口统计学数据与改进聚类模型相结合的协同过滤推荐算法,以提高推荐系统精度和泛化能力。该方法首先通过用户人口统计学数据属性... 详细信息

针对传统基于用户的协同过滤推荐算法在大数据环境下存在评分高维稀疏性、推荐精度低的问题,提出一种基于人口统计学数据与改进聚类模型相结合的协同过滤推荐算法,以提高推荐系统精度和泛化能力。该方法首先通过用户人口统计学数据属性,结合用户-项目评分矩阵计算各个用户间的相似度;然后对用户、项目进行分层近邻传播聚类,根据用户对项目的评分数据计算用户或项目之间的相似性,产生目标用户或项目的兴趣近邻;最后根据兴趣最近邻进行推荐。对Epinions,MovieLents等数据集进行仿真实验,仿真的结果表明,与传统的协同过滤算法相比,提出的算法提高了推荐精度,为传统的协同过滤推荐算法提供了参考。

关键词：协同过滤人口统计学聚类推荐系统

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Insight into the particle shape on the impact of dry granular flow against a rigid barrier: A DEM study

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Journal of Earth Science 2025年

作者： Rui-Xiao Zhan Dong Su xiang-Sheng Chen yuan-Jun Jiang Guo-Ping Lei Jing-Jing Yu Key Laboratory for Resilient Infrastructures of Coastal Cities (MOE)， Shenzhen University College of Civil and Transportation Engineering， Shenzhen University School of Architecture and Urban Planning， Shenzhen University Shenzhen Key Laboratory of Green， Efficient and Intelligent Construction of Underground Metro Station， Shenzhen University Institute of Mountain Hazards and Environment， Chinese Academy of Sciences School of Transportation， Civil Engineering & Architecture， Foshan University

The effect of particle shape on the impact of dry granular flow remains an open area for further investigation. Five distinct particle shapes were examined in this study using discrete element simulations after calibrating the numerical model using a published work. The findings indicated that the particle shape had a significant influence on granular mobility. With negligible variations in normalized kinetic energy between particles of different shapes， the effect of particle shape on the increasing rate of kinetic energy became more obvious. All irregular particle scenarios had longer accumulated particle lengths down the channel than spherical particles. Variations in particle shape led to adjustments in the distribution of impact forces on the barrier. These findings substantially enhance our understanding of the distinctive effects of particle shapes on the impact mechanism of dry granular flow.

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Fischer-Tropsch合成烃生成机理研究进展

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燃料化学学报 2002年第2期30卷 186-192页

作者：吉媛媛相宏伟李永旺徐元源钟炳中国科学院山西煤炭化学研究所煤转化国家重点实验室太原030001

Fischer Tropsch合成烃生成机理研究经历本体碳化物机理、烯醇机理和CO插入机理后 ,重新回到碳化物机理。但后者不同于早期的本体碳化物机理。新碳化物机理认为 ,催化剂表面亚甲基的生成与催化剂本体金属碳化物的生成无关。由于F T反应... 详细信息

Fischer Tropsch合成烃生成机理研究经历本体碳化物机理、烯醇机理和CO插入机理后 ,重新回到碳化物机理。但后者不同于早期的本体碳化物机理。新碳化物机理认为 ,催化剂表面亚甲基的生成与催化剂本体金属碳化物的生成无关。由于F T反应生成的烯烃在催化剂上发生烯烃再吸附并引起二次反应 ,所以F T合成产物选择性由一次和二次反应共同决定。由于现有的机理仅考虑了一次反应过程 ,为弥补其缺陷 ,本文在综述前人的F T反应机理基础上 ,补充了包括二次反应的F T反应机理。

关键词： Fischer-Tropsch合成 CO加氢反应反应机理二次反应

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Strategy for Enhancing the Available Capacity of Distribution Networks Considering Electric Vehicle Charging Modes

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Dianwang Jishu/Power System Technology 2025年第1期49卷 177-186页

作者： Chen, Peng Liu, Youbo yuan, Chuan Tang, Donglai xiang, Yue Liu, Junyong College of Electrical Engineering Sichuan University Sichuan Province Chengdu 610065 China State Grid Sichuan Electric Power Company Sichuan Province Chengdu 610041 China Aostar Information Technology Co. Ltd. Sichuan Province Chengdu 610067 China

The available capacity of distribution networks represents the maximum load capacity that can be accommodated under the existing conditions of the distribution network. It is an essential indicator for evaluating distribution networks' planning and operational effectiveness. This paper proposes a grid transformation method for distribution networks considering electric vehicle charging modes to address the significant decrease in available capacity caused by the large-scale disorderly charging of electric vehicles. By optimizing the grid topology and the optimal number, location, and type of line expansion and energy storage investment within the limited investment., the optimal enhancement of available capacity is achieved. Firstly, the Monte Carlo method is employed to generate scenarios of disorderly charging of electric vehicles, and an orderly electric vehicle charging model based on optimizing charging schedules is constructed. Secondly, a transformation model for enhancing the available capacity of distribution networks is developed based on the coordination of network reconfiguration, line expansion, and energy storage investment. Then, the complexity of the model is reduced using the Benders decomposition algorithm, and a commercial solver is employed for the solution. Finally, a case study based on a city's actual distribution network grid is conducted to validate the effectiveness of the proposed strategies for enhancing the available capacity. © 2025 Power System Technology Press. All rights reserved.

关键词： Monte Carlo methods

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