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A NEW ADAPTIVE CONTROLLER OF NONLINEAR SYSTEMS USING NEURAL NETWORKS

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A NEW ADAPTIVE CONTROLLER OF NONLINEAR SYSTEMS USING NEURAL ...

The dopaminergic system and Alzheimer's disease

IJCNN International Joint Conference on Neural Networks

作者： Cun Wu HAN Jing Xin ZHANG xing yuan gu Dept.of Automatic Control Northeast Univ.of Technology

＜正＞This paper is concerned with adaptive control of the affine nonlinear systems with unknown nonlinear *** neural networks are used to "learn" to approxinate the *** introducing a new cost function,we present a new adaptive controller which can limit the excessively large control *** stability of the closedloop system is analyzed based on the Lyapunov technique,and the tracking performance of the controller is also *** results show that the proposed controller has good control performance.

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang yuan Liang Yixue gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Exploration of Gas-Dependent Self-Adaptive Reconstruction Behavior of Cu₂O for Electrochemical CO₂ Conversion to Multi-Carbon Products

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NANO-MICRO LETTERS 2025年第1期17卷 1-17页

作者： Zhang, Chaoran gu, Yichuan Jiang, Qu Sheng, Ziyang Feng, Ruohan Wang, Sihong Zhang, Haoyue Xu, Qianqing yuan, Zijian Song, Fang Shanghai Jiao Tong Univ Sch Mat Sci & Engn State Key Lab Met Matrix Composites Shanghai 200240 Peoples R China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO2 reduction reaction (CO2RR), whereas the behavior is by far superficially understood. Here, we report that CO2 accessibility results in a universal self-adaptive structural reconstruction from Cu2O to Cu@CuxO composites, ending with feeding gas-dependent microstructures and catalytic performances. The CO2-rich atmosphere favors reconstruction for CO2RR, whereas the CO2-deficient one prefers that for hydrogen evolution reaction. With the assistance of spectroscopic analysis and theoretical calculations, we uncover a CO2-induced passivation behavior by identifying a reduction-resistant but catalytic active Cu(I)-rich amorphous layer stabilized by *CO intermediates. Additionally, we find extra CO production is indispensable for the robust production of C2H4. An inverse correlation between durability and FECO/FEC2H4 is disclosed, suggesting that the self-stabilization process involving the absorption of *CO intermediates on Cu(I) sites is essential for durable electrolysis. guided by this insight, we design hollow Cu2O nanospheres for durable and selective CO2RR electrolysis in producing C2H4. Our work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO2 reduction reaction Electrocatalysts Cu2O Reconstruction Self-adaptive electrocatalysis

Low-Temperature Fabrication of Stable Black-Phase CsPbI₃ Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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NANO-MICRO LETTERS 2025年第1期17卷 1-14页

作者： Zhao, Yingjie Sun, Yicheng Pei, Chaoxin Yin, xing Li, Xinyi Hao, Yi Zhang, Mengru yuan, Meng Zhou, Jinglin Chen, Yu Song, Yanlin Zhengzhou Univ Coll Chem Zhengzhou 450001 Peoples R China Zhengzhou Univ Pingyuan Lab Zhengzhou 450001 Peoples R China Chinese Acad Sci Inst Chem Key Lab Green Printing Beijing 100190 Peoples R China Chinese Acad Sci Tech Inst Phys & Chem Key Lab Bioinspired Mat & Interfacial Sci Beijing 100190 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China

Low-temperature fabrication of black-phase CsPbI3 perovskite films is first demonstrated by using diphenylphosphinic chloride additive under 30-50 degrees C, arising from the steric effect and chloride insertion ***-area high-quality all-inorganic perovskite films with fewer defects enhanced crystallographic orientation, and excellent environmental stability is *** record performances are demonstrated for flexible wearable photodetectors with a responsivity of 42.1 A W-1, a detectivity of 1.3 x 1014 Jones, high-fidelity image, photoplethysmography sensor functions, and high mechanical stability. Flexible wearable optoelectronic devices fabricated from organic-inorganic hybrid perovskites significantly accelerate the development of portable energy, biomedicine, and sensing fields, but their poor thermal stability hinders further applications. Conversely, all-inorganic perovskites possess excellent thermal stability, but black-phase all-inorganic perovskite film usually requires high-temperature annealing steps, which increases energy consumption and is not conducive to the fabrication of flexible wearable devices. In this work, an unprecedented low-temperature fabrication of stable black-phase CsPbI3 perovskite films is demonstrated by the in situ hydrolysis reaction of diphenylphosphinic chloride additive. The released diphenyl phosphate and chloride ions during the hydrolysis reaction significantly lower the phase transition temperature and effectively passivate the defects in the perovskite films, yielding high-performance photodetectors with a responsivity of 42.1 A W-1 and a detectivity of 1.3 x 1014 Jones. Furthermore, high-fidelity image and photoplethysmography sensors are demonstrated based on the fabricated flexible wearable photodetectors. This work provides a new perspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

一种用于数据库开发的UML类图的规格说明与C++源代码生成技术

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上海大学学报（自然科学版） 2004年第1期10卷 43-51页

作者：杨越冯远兴顾训穰上海大学计算机工程与科学学院上海200072

该文分析了信息系统软件开发的特点,并在UML静态结构模型中类图的基础上,提出了一种针对信息系统软件开发,特别是数据库系统开发的规格说明语言MISFRAME的语法原型,详细阐明了其在数据库开发中的语法定义,提供了相应的代码生成器,并说... 详细信息

该文分析了信息系统软件开发的特点,并在UML静态结构模型中类图的基础上,提出了一种针对信息系统软件开发,特别是数据库系统开发的规格说明语言MISFRAME的语法原型,详细阐明了其在数据库开发中的语法定义,提供了相应的代码生成器,并说明了其生成源代码的原理.

关键词： UML 类图规格说明 MISFRAME 代码生成器

Pingchan granule for depressive symptoms in parkinson’s disease:A randomized,double-blind,placebo-controlled trial

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Journal of Integrative Medicine 2021年第2期19卷 120-128页

作者： Si-chun gu Jie Zhou Qing Ye Can-xing yuan Department of Neurology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China

Background:Depression in Parkinson’s disease(dPD)is closely related to quality of *** studies have suggested that Pingchan Granule(PCG)might be effective for treating ***:This study determines the efficacy of PCG for depressive symptoms in Parkinson’s disease(PD).Design,setting,participants and interventions:This was a randomized,double-blind,placebo-controlled trial,conducted in Longhua Hospital,Shanghai,*** diagnosed with idiopathic PD and clinically significant depressive symptoms(defined by a 24-item Hamilton Rating Scale for Depression[HAM-D]score≥8)were included in this study,randomly assigned to PCG or placebo group in a 1:1 ratio and followed for 24 *** outcome measures:The primary outcome was the change from baseline to week 24 in HAM-D score among the set of patients who completed the study following the treatment protocol(per-protocol set).Secondary outcomes included changes in scores on the Unified Parkinson’s Disease Rating Scale(UPDRS)part 2(UPDRS-Ⅱ),UPDRS part 3(UPDRS-Ⅲ),Parkinson’s Disease Sleep Scale(PDSS)and Hamilton Rating Scale for Anxiety(HAM-A),between baseline and week ***:Eighty-six patients were enrolled,and 85 patients were included in the per-protocol ***-D scores decreased by an adjusted mean of 11.77(standard error SE 0.25)in the PCG group and 3.86(SE0.25)in the placebo group(between-group difference=7.91,95%confidence interval[7.22,8.80],P<0.001),in the multivariable linear *** in scores on the UPDRS-II,UPDRS-III,PDSS,and HAM-A scales were also ***:Treatment with PCG was well tolerated and improved depressive symptoms and motor and other non-motor symptoms in *** registration:Chinese Clinical Trial Register:ChiCTR-INR-17011949.

关键词： Pingchan granule Depression Parkinson’s disease Randomized controlled trial

黄斑颗粒含药血清预处理对人RPE细胞缺氧损伤的保护作用

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上海中医药大学学报 2010年第5期24卷 73-76页

作者：刘晓娟宫媛媛吴星伟顾青上海交通大学附属第一人民医院眼科上海200080

目的:观察中药黄斑颗粒含药血清预处理后对人视网膜色素上皮(hRPE)细胞缺氧损伤的保护作用。方法:制备不同剂量中药黄斑颗粒含药血清,用含药血清预处理hRPE细胞,分不同时间段建立化学缺氧损伤模型,培养24h后,用MTT法检测细胞活性,流式... 详细信息

目的:观察中药黄斑颗粒含药血清预处理后对人视网膜色素上皮(hRPE)细胞缺氧损伤的保护作用。方法:制备不同剂量中药黄斑颗粒含药血清,用含药血清预处理hRPE细胞,分不同时间段建立化学缺氧损伤模型,培养24h后,用MTT法检测细胞活性,流式细胞仪(FCM)检测细胞周期。结果:黄斑颗粒含药血清组细胞活力较空白血清组与模型组细胞活力显著提高,其中高剂量含药血清组细胞活力高于低剂量含药血清组,但仍低于正常对照组,有显著性差异;各含药血清组细胞活力抑制率均明显降低,其中高剂量组低于低剂量组。此外,含药血清能促进缺氧条件下RPE细胞由G0/G1期进入S期,促进RPE细胞的增殖。结论:中药黄斑颗粒含药血清预处理对人视网膜色素上皮细胞缺氧损伤具有一定的保护作用。

关键词： “黄斑颗粒” 人视网膜色素上皮细胞缺氧保护作用

不同荚色豇豆品种花青素和营养成分含量变化分析

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南方农业学报 2017年第6期48卷 1080-1085页

作者：张红梅许文静陈华涛刘晓庆张智民崔晓艳袁星星顾和平陈新江苏省农业科学院蔬菜研究所/江苏省高效园艺作物遗传改良重点实验室南京210014 南京农业大学生命科学学院南京210095

【目的】分析不同荚色品种豇豆花青素和营养成分含量的变化规律,为豇豆特色品种选育及其规模化生产提供参考依据。【方法】以白荚的苏豇1419、紫荚的苏紫41、青荚的苏青29和绿白荚的苏豇3号为材料,测定分析其不同发育时期嫩荚及商品荚... 详细信息

【目的】分析不同荚色品种豇豆花青素和营养成分含量的变化规律,为豇豆特色品种选育及其规模化生产提供参考依据。【方法】以白荚的苏豇1419、紫荚的苏紫41、青荚的苏青29和绿白荚的苏豇3号为材料,测定分析其不同发育时期嫩荚及商品荚的花青素、矿物质(钙、镁和铁)及常规营养成分(可溶性蛋白、可溶性总糖、纤维素、维生素C、淀粉、干物质和脂肪)含量。【结果】苏紫41商品荚的花青素含量为330.48 nmol/gFW,极显著高于其他3个不同荚色品种(P<0.01);苏豇1419的钙含量最高(1295.75 mg/kgDW),显著高于苏豇3号和苏紫41(P<0.05);4个不同荚色豇豆品种均有各自突出的常规营养成分。在豆荚发育过程中,苏豇1419、苏豇3号和苏青29的花青素含量(3.92~30.98nmol/gFW)均有明显变化,但变化范围明显小于苏紫41(花青素含量为174.33~644.52 nmol/gFW);苏豇1419、苏豇3号和苏紫41的可溶性蛋白含量呈先上升后下降的变化趋势,苏青29呈上升—下降—上升的变化趋势;苏豇1419、苏青29和苏豇3号的可溶性总糖含量总体上呈上升趋势,苏紫41呈上升—下降变化趋势;苏豇1419、苏豇3号和苏青29的维生素C含量最高值分别出现在前期荚(长30 cm)、后期荚(长40 cm)和前期荚(长30 cm),苏紫41的维生素C含量最高值出现在后期荚(长50 cm);4个不同荚色品种豇豆豆荚的纤维素含量总体上也呈上升趋势。不同荚色品种豇豆的花青素含量与营养成分含量间存在不同程度的协同或拮抗关系。【结论】紫荚的苏紫41花青素含量最高,青荚的苏青29纤维素含量较高、脂肪含量较低,白荚的苏豇1419钙和脂肪含量较高,绿白荚的苏豇3号营养成分含量一般,这些特征可供豇豆特色品种选育及其规模化生产参考利用。

关键词：豇豆花青素营养成分变化特性