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Journal of Iron and Steel Research International 2020年第2期27卷 228-237页

作者： Li-jing Yang Shao-peng Wang Pei Wang Huan Li Hai-yu Yang yuan-sheng ye Zheng-xian Li Northwest Institute for Non-ferrous Metal Research.Xi'an 710016 ShaanxiChina

WC7Co/Ti6Al4V composite coatings are deposited on the pure Ti substrate by pulse laser cladding(LC).During the laser melting process,the decomposition of WC7Co particles will lead to the evolution of microstructure and phases,which is directly related to the wear resistance and mechanism of composite *** microstructural evolution,phase compositions and interface reaction of WC7Co/Ti6Al4V composite coating were examined by scanning electron microscopy,energydispersive spectrum and X-ray diffraction(XRD).The hardness of different structures and abrasive resistance of composite coating were *** results show that the typical microstructure of LC WC7Co/Ti6Al4V composite coating can be classified into dissolved WC7Co composite structure and un-dissolved WC7Co *** to XRD results,there are Ti solid solution,W,TiC,VC,Co3W3C and secondary W2C in composite *** eutectic structure formed by the dissolved WC7Co particles consisted of W,W2C,TiC and P-Ti solid *** mean hardness of different structures exhibits a significant gradient distribution in composite coating.A reaction layer composed of TiC,W and W2C is also generated onto the interface between un-dissolved WC7Co particles and Ti6Al4V alloy *** abrasive mechanisms of WC7Co/Ti6Al4V composite coating are mainly adhesive wear and oxidation wear during the dry sliding process.

关键词： Laser cladding WC ceramic powder Titanium alloy Wear resistance Composite coating

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

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Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun yuan Li Tifei yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

Insight Into the Separation-of-Variable Methods for the Closed-Form Solutions of Free Vibration of Rectangular Thin Plates

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 329-355页

作者： Yufeng Xing ye yuan Gen Li Institute of Solid Mechanics Beihang University(BUAA)Beijing100191China

The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytical solutions for free vibration and eigenbuckling of rectangular plates and circular cylindrical *** taking the free vibration of rectangular thin plates as an example,this work presents the theoretical framework of the SOV methods in an instructive way,and the bisection–based solution procedures for a group of nonlinear eigenvalue ***,the explicit equations of nodal lines of the SOV methods are presented,and the relations of nodal line patterns and frequency orders are *** is concluded that the highly accurate SOV methods have the same accuracy for all frequencies,the mode shapes about repeated frequencies can also be precisely captured,and the SOV methods do not have the problem of missing roots as well.

关键词： Separation-of-variable method Rayleigh quotient nodal line eigenvalue equation bisection method

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

含有STATCOM的电力系统次同步谐振研究

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电力系统保护与控制 2008年第20期36卷 38-40,44页

作者：刘燕康积涛李晨霞何宗奎袁业升西南交通大学电气工程学院四川成都610031

在超高压远距离输电系统中采用串联电容补偿后,在某种运行方式或补偿度的情况下,会发生电力系统的次同步谐振(SSR)现象。柔性交流输电技术在电力系统中有着广阔的应用前景,是近年来电力系统研究的前沿课题之一。而静止同步无功补偿器(ST... 详细信息

在超高压远距离输电系统中采用串联电容补偿后,在某种运行方式或补偿度的情况下,会发生电力系统的次同步谐振(SSR)现象。柔性交流输电技术在电力系统中有着广阔的应用前景,是近年来电力系统研究的前沿课题之一。而静止同步无功补偿器(STATCOM)是FACTS家族的重要成员,是并联型补偿装置的代表。采用扫频-复转矩法分析系统的次同步谐振,摒弃传统的PID控制策略,设计多目标控制算法实现对STATCOM装置的系统级控制,使其在进行无功补偿的同时可以阻尼电力系统次同步谐振现象,这就显得既有理论又有现实意义。

关键词：次同步谐振静止同步无功补偿器柔性交流输电技术

Enhancing postoperative pain control by surgically-initiated rectus sheath block in abdominal aortic aneurysm open repair: A case report

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World Journal of Clinical Cases 2025年第6期13卷 41-47页

作者： Kuan-Hua Chen Ming-yuan Kang Yi-Ting Chang sheng-Yang Huang Yung-Szu Wu Center for Cardiovascular Disease Taichung Veterans General HospitalTaichung 407219TaiwanChina Department of Anesthesiology Taichung Veterans General HospitalTaichung 407219TaiwanChina Division of Pediatric Surgery Department of SurgeryTaichung Veterans General HospitalTaichung 407219TaiwanChina School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112304TaiwanChina Department of Post-Baccalaureate Medicine National Chung Hsing UniversityTaichung 402202TaiwanChina

BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side *** case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA *** SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain *** patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without *** preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular *** Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.

关键词： Abdominal aortic aneurysm Postoperative pain management Rectus sheath block Surgical anesthesia Opioid-sparing techniques Case report

Mixed Two-and Eight-level Fractional Factorial Split-plot Designs Containing Clear Effects

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Acta Mathematicae Applicatae Sinica 2016年第4期32卷 995-1004页

作者： ye yuan sheng-li ZHAO School of Statistics Qufu Normal University

Fractional factorial split-plot （FFSP） designs are useful in practical experiments. When the num- bers of levels of the factors are not all equal in an experiment, mixed-level design is selected. This paper investigates the conditions of a resolution III or IV FFSP design with both two-level and eight-level factors to have various clear effects, including two types of main effects and three types of two-factor interaction compo- nents.

关键词： split-plot design mixed-level design clear

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农民行为与农村社会保障制度建设

湘潭工学院学报（社会科学版） 2003年第1期5卷 6-9页

作者：谢圣远叶晨晖武汉大学社会保障研究中心湖北武汉430072

通过农民行为均衡及其转变的分析,认为,为了避免恶性社会冲突,必须建立与城镇社会保障制度相衔接、在农村范围内统一的多层次社会保障体系。

关键词：农民行为社会保障制度农村农村社会

Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu sheng Ni Xiong Zhao Meng Yan yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu Xian Qin Kun Zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

DOUBLE-PARAMETER PERTURBATION SOLUTION TO 3-D NONLINEAR PROBLEM OF OBLIQUE WATER EXIT

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Journal of Hydrodynamics 1991年第4期3卷 96-103页

作者： Qu-yuan, ye You-sheng, He Shanghai Jiao Tong Univ Shanghai China

With a new time-derivative operator, the nonlinear kinematic and dynamic free boundary conditions were modified to a convenient form for numerical computation. The original 3-D nonlinear problem of oblique water exit of an axisymmetric body at a large water exit-angle and a small angle of attack is reduced to a number of 2-D problems by means of the double-parameter-series expansion method and the Fourier-cosine-expansion method. Numerical results are presented of the free surface shapes and the forces exerted during the oblique water exit of a sphere at different Froude numbers.

关键词： Flow of Water Mathematical Models Mathematical Techniques Nonlinear Equations Mathematical Techniques Perturbation Techniques