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Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical cancer

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Frontiers of Medicine 2014年第1期8卷 106-112页

作者： Tian wang Yan Li Abidan Tuerhanjiang Wenwen wang Zhangying Wu ming yuan Shixuan wang Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan430030 China

Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasis. However, the molecular alterations that drive progression and metastasis of cervical cancer remain unclear. Cellular senescence has been proposed as the mechanism that protects an organism against cancer progression and metastasis. In addition, Twist, a basic helix-loop-helix transcription factor, has been suggested as an oncogene because it is overexpressed in many types of human cancer. This gene also exhibits a positive function in regulating invasion and metastasis. In this study, Twist was strongly and positively expressed in normal tissue, squamous cell carcinoma （SCC） IA-IIA, and SCC IIB-IIIB （4.3%, 44%, and 88.9%, respectively）. The strong positive expressions of the senescence marker CBX3 were 39.1%, 32%, and 15.6%, respectively. The strong positive expressions of Twist in the SCC groups with or without lymph node metastasis were 80.8% and 50%. For CBX3, such expressions were 7.7% and 29.5%, respectively. Results also showed that the expression of Twist was inversely correlated with that of CBX3. Moreover, the knockdown of Twist with target siRNA in SiHa triggered the induction of the chromatin marker of the cellular senescence CBX3 and senescence-associated p-galactosidase activity. Our results suggested that the expression of Twist increased during the progression and metastasis of cervical cancer. Furthermore, Twist-induced senescence bypass is important in this process.

关键词： cervical cancer senescence Twist CBX3 lymph node metastasis

Temporal characteristic analysis of single event effects in pulse width modulator

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Nuclear Science and Techniques 2017年第7期28卷 59-64页

作者： Wen Zhao Xiao-Qiang Guo Wei Chen Zu-Jun wang Hong-Xia Guo yuan-ming wang School of Nuclear Science and Technology Xi'an Jiaotong University State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear Technology

In this paper,the nature and origin of single event effects(SEE) are studied by injecting laser pulses into different circuit blocks,combining with analysis to map pulse width modulators circuitry in the microchip die.A time-domain error-identification method is used in the temporal characteristic analysis of *** signatures of different injection times are *** serious SEE are observed when the laser shot occurs on a rising edge of the device output for blocks of the error amplifier,current sense comparator,and T and SR latches.

关键词：单粒子效应脉宽调制器时间特性误差放大器电路模块激光脉冲时间特征注射次数

The control system for SSRF injection and extraction

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Nuclear Science and Techniques 2007年第6期18卷 326-329页

作者： yuan Qibing GU ming wang Ruiping CHENG Zhihao FAN Xuerong ZHU Haijun Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China

This paper introduces the injection and extraction control system design for SSRF,which is a distributed control system aimed at stability and reliability of the pulse power supplies,PPS(Personnel Protection System)and MPS(Machine Protection System).The hardware environment is mainly based on PLC(Programmable Logic Con- troller),and ARM(Advanced RISC Machine)is also applied for studying stability of the power *** and EPICS(Experimental Physics and Industrial Control System)have been selected as the platforms of SCADA(Super- visory Control and Data Acquisition).For unifying the interfacing to the control computer,all front-end equipments are connected via Industrial Ethemet.

关键词：控制系统 PPS MPS PLC

The First Ground-based White Light Lunar Polarization Imaging:A New Kind of FeO Observation on the Near Side of the Moon

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Research in Astronomy and Astrophysics 2024年第6期24卷 1-6页

作者： Wei-Nan wang Jin-Song Ping ming-yuan wang Wen-Zhao Zhang Han-Lin Ye Xing-Wei Han Song-Feng Kou Changchun Observatory National Astronomical ObservatoriesChinese Academy of SciencesChangchun 130117China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 101408China Astronomy Department Beijing Normal UniversityBeijing 100875China International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Nanjing Institute of Astronomical Optics and Technology Chinese Academy of SciencesNanjing 210042China

Lunar optical polarization is a fascinating phenomenon that occurs when sunlight reflects off the surface of the Moon and becomes *** study employs a novel split-focus plane polarimetric camera to conduct the initial white light polarimetric observations on the near side of the *** obtained the linear degree of polarization(DOP)parameters of white light by observation from the eastern and western hemispheres of the *** findings indicate that the white light polarization is lower in the lunar highland than in the lunar maria *** the analysis of lunar soil samples,we noticed and determined that the DOP parameters of white light demonstrate high consistency with iron oxide on the *** study may serve as a new diagnostic tool for the Moon.

关键词： techniques:photometric polarization methods:observational Moon

The alcoholysis of acetonitrile prompted by Brфnsted acidic ionic liquid [HSO_3-pmim]HSO_4

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Chinese Chemical Letters 2008年第8期19卷 889-892页

作者： Dong Jiang yuan yuan wang ming Tu Li Yi Dai Shanghai Key Laboratory of Green Chemistry and Chemical Processes Department of Chemistry East China Normal University Shanghai 200062 China

BrФnsted acidic ionic liquids based on imidazolium cation were employed as a series of environmentally benign catalysts and mediums in the alcoholysis of acetonitrile to synthesize ester. The results showed that BrФnsted acidic ionic liquid [HSO3- pmim]HSO4 was an efficient catalyst and medium for the alcoholysis of acetonitrile which could be recycled easily without obvious decline in catalytic activity, the highest yield could reach 85%.

关键词： BrФnsted acidic ionic liquid Alcoholysis Ester

Dependence of single event upsets sensitivity of low energy proton on test factors in 65 nm SRAM

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Chinese Physics B 2018年第7期27卷 566-571页

作者： Yin-Yong Luo Feng-Qi Zhang Xiao-Yu Pan Hong-Xia Guo yuan-ming wang State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi＇an 710024China

In order to accurately predict the single event upsets （SEU） rate of on-orbit proton, the influence of the proton energy distribution, incident angle, supply voltage, and test pattern on the height, width, and position of SEU peak of low energy protons （LEP） in 65 nm static random access memory （SRAM） are quantitatively evaluated and analyzed based on LEP testing data and Monte Carlo simulation. The results show that different initial proton energies used to degrade the beam energy will bring about the difference in the energy distribution of average proton energy at the surface and sensitive region of the device under test （DUT）, which further leads to significant differences including the height of SEU peak and the threshold energy of SEU. Using the lowest initial proton energy is extremely important for SEU testing with low energy protons. The proton energy corresponding to the SEU peak shifts to higher average proton energies with the increase of the tilt angle, and the SEU peaks also increase significantly. The reduction of supply voltage lowers the critical charge of SEU, leading to the increase of LEP SEU cross section. For standard 6-transitor SRAM with bit-interleaving technology, SEU peak does not show clear dependence on three test patterns of logical checkerboard 55H, all＂ 1＂, and all ＂0＂. It should be noted that all the SEUs in 65 nm SRAM are single cell upset in LEP testing due to proton＇s low linear energy transfer （LET） value.

关键词： low energy proton energy distribution tilt angle supply voltage test pattern

Preliminarily study of Saturn’s upper atmosphere density by observing Cassini plunging via China’s deep space station

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Research in Astronomy and Astrophysics 2020年第7期20卷 112-116页

作者： Lue Chen Jin-Song Ping Xiang Liu Na wang Jian-Feng Cao Guang-ming Chen ming-yuan wang Wen-Xiao Li Jian-Hui Zhang Yong-Qiang Chen Shi-Lei Yue Song-Tao Han Jing Sun Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Aerospace Control Center Beijing 100094China Xi’an Satellite Control Center Xi’an 710043China

When the Cassini spacecraft finally plunged into the Saturnian atmosphere on 2017 September15,China’s deep space telescope pointed to Saturn to observe Cassini and study the Saturnian upper neutral *** this first Chinese Saturnian radio science experiment,X band Doppler velocity radio science data between the deep space telescope and the Cassini spacecraft were *** removing Saturnian and solar gravity effects,Earth rotation effect,the remaining Saturnian atmosphere drag information was retrieved in the Cassini final plunge ***’s upper neutral atmosphere mass density profile is approximately estimated based on atmosphere mass density derived principally by real orbit measurement ***’s upper neutral atmosphere mass density from 76000 km to 1400 km is estimated from the orbit measurement data,the mass density results are about from 1.4×10^-15 kg cm^-3 to 2.5×10^-14 kg cm^-3.

关键词： Cassini Saturn Doppler velocity neutral atmosphere mass density

A Novel Low-frequency Radio Astronomical Observation Array(1~90 MHz)and its First Light

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Research in Astronomy and Astrophysics 2023年第12期23卷 96-104页

作者： Wen-Jun Yang Zhen wang ming-yuan wang Fa-Bao Yan Guang Lu Guan-Nan Gao Shao-Jie Guo Yu-Mei Shen Bing-Qiang Xu Yu Bai Yong Chen Jin-Song Ping Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Key Laboratory of the Solar Physics and Space Science Kunming 650216China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Weihai campus Shandong UniversityWeihai 264209China Yunnan Observatories Chinese Academy of SciencesKunming 650011China

The extremely low frequency(f<40 MHz)is a very important frequency band for modern radio astronomy *** is also a key frequency band for solar radio bursts,planetary radio bursts,fast radio bursts detected in the lunar space electromagnetic environment,and the Earth’s middle and upper atmosphere with low dispersion *** this frequency band,the solar stellar activity,the early state of the universe,and the radiation characteristics of the planetary magnetosphere and plasma layer can be *** there are few observations with effective spatial resolution in the extremely low frequency,it is highly possible to discover unknown astronomical phenomena on such a band in the *** conjunction with low frequency radio observation on the far side of the Moon,we initially set up a novel low-frequency radio array in the Qitai station of Xinjiang Astronomical Observatory deep in Tianshan Mountains,Xinjiang,China on 2021 August *** array covers an operating frequency range of 1~90 MHz with a sensitivity of-78 dBm/125kHz,a dynamic range of 72 dB,and a typical gain value of 6 dBi,which can realize unattended all-weather *** two antennas due south of the Qitai Low-Frequency Radio Array were put into trial observations on 2021 May 28,and the very quiet electromagnetic environment of the station has been *** far,many solar radio bursts and other foreign signals have been *** results show that this novel low frequency radio array has the advantages of good performance,strong direction,and high antenna *** can play a unique role in Solar Cycle 25,and has a potential value in prospective collaborative observation between the Earth and space for extremely low frequency radio astronomy.

关键词： The Sun-Astronomical Instrumentation-Methods and Techniques-Stars-Planetary Systems

Interactions Between Exogenous Bt Insecticidal Protein and Cotton Terpenoid Aldehydes

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Agricultural Sciences in China 2002年第6期1卷 642-647页

作者： ZHANG Yong-jun, GUO Yu-yuan, WU Kong-ming and wang Wu-gang(Institute of Plant Protection , Chinese Academy of-Agricultural Sciences , Beijing 100094 , P. R . China) Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100094 P. R. China

The contents of terpenoid aldehydes in Bt transgenic cotton and their non-Bt parental varieties were analyzed by the HPLC method. Statistical analysis of variance showed that Bt insecticidal protein Bt-ICP expression has no negative effect on the synthesis of gossypol, total heliocides and total resistant terpenoids. The results of the combined dosage test of Bt-ICP and gossypol in vitro showed that there is no interaction between gossypol and Bt-ICP on the mortality of cotton bollworm larvae Helicoverpa armigera (Hubnner). It is indicated that the actions of Bt-ICP and gossypol on cotton bollworm are additive. Therefore, it is advantageous to combine Bt-ICP with cotton terpenoid aldehydes in controlling cotton bollworm.

关键词： Bt-ICP Terpenoid aldehydes Interaction