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先天性巨结肠患儿术后肠道组织中CAD、SOX2的表达水平及其临床意义

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海南医学 2024年第7期35卷 939-943页

作者：张宁岳铭袁宇航郑州大学第一附属医院小儿外科河南郑州450000

目的探讨先天性巨结肠(HD)患儿术后肠道组织蛋白酶D(CAD)、性别决定区Y框蛋白2(SOX2)的表达水平及其临床意义。方法选取2015年5月至2019年3月郑州大学第一附属医院收治的56例HD患儿结肠组织(HD组)和23例因肠道梗阻或穿孔实施造瘘手术获... 详细信息

目的探讨先天性巨结肠(HD)患儿术后肠道组织蛋白酶D(CAD)、性别决定区Y框蛋白2(SOX2)的表达水平及其临床意义。方法选取2015年5月至2019年3月郑州大学第一附属医院收治的56例HD患儿结肠组织(HD组)和23例因肠道梗阻或穿孔实施造瘘手术获取的结肠组织标本(对照组)。采用免疫组化、Western-blot技术检测结肠组织中CAD、SOX2的表达水平,并采用Pearson线性相关分析法分析CAD、SOX2表达与病变肠段肌间神经丛直径、神经节细胞数的关系。结果HD患儿的狭窄段组织中CAD蛋白、SOX2蛋白阳性表达率分别为7.14%、12.50%,移行段肠组织中CAD蛋白、SOX2蛋白阳性表达率分别为32.14%、35.71%,明显低于对照组的78.26%、82.61%,而狭窄段组织中CAD蛋白、SOX2蛋白阳性表达率明显低于移行段,差异均有统计学意义(P<0.05);HD患儿的狭窄段肠组织中肌间神经丛直径、神经节细胞数目分别为(30.66±5.14)μm、(0.83±0.24)个/视野,移行段肠组织中肌间神经丛直径、神经节细胞数目分别为(31.20±5.83)μm、(1.94±0.56)个/视野,明显短(少)于对照组的(54.29±8.50)μm、(5.40±1.84)个/视野,狭窄段肠组织中肌间神经丛直径、神经节细胞数目明显短(少)于移行段,差异均有统计学意义(P<0.05);Pearson相关分析结果显示,HD患儿狭窄段、移行段肠组织中肌间神经丛直径、神经节细胞数目与CAD蛋白、SOX2蛋白表达强度均呈显著正相关(P<0.05)。结论HD患儿病变结肠组织中CAD蛋白、SOX2蛋白的表达强度下调,可能与肌间神经丛直径、神经节细胞数目的减少有关。

关键词：先天性巨结肠组织蛋白酶D 性别决定区Y框蛋白2 相关性

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腹腔镜辅助经肛改良Soave术治疗先天性巨结肠的疗效分析

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中国肛肠病杂志 2024年第2期44卷 54-56页

作者：张宁岳铭袁宇航郑州大学第一附属医院小儿外科河南郑州450000

目的:探讨腹腔镜辅助经肛改良Soave术治疗先天性巨结肠的疗效。方法:回顾2020年1月至2023年3月我院收治的62例先天性巨结肠患儿资料,按不同手术治疗方式分为腹腔镜组(腹腔镜辅助经肛改良Soave术,32例)和常规组(常规经肛改良Soave术,30... 详细信息

目的:探讨腹腔镜辅助经肛改良Soave术治疗先天性巨结肠的疗效。方法:回顾2020年1月至2023年3月我院收治的62例先天性巨结肠患儿资料,按不同手术治疗方式分为腹腔镜组(腹腔镜辅助经肛改良Soave术,32例)和常规组(常规经肛改良Soave术,30例),比较2组围术期相关指标、术后并发症及术后6个月肛门功能。结果:62例患儿均顺利完成手术。腹腔镜组手术时间、术后下床活动时间、住院时间均短于常规组,术中出血量少于常规组,P<0.05。腹腔镜组术后并发症发生率低于常规组,患儿术后6个月肛门功能优于常规组,P<0.05。结论:腹腔镜辅助经肛改良Soave术治疗先天性巨结肠效果优于常规经肛改良Soave术,不仅可缩短手术时间、下床活动及住院时间,减少术中出血量,降低术后并发症发生率,而且可提高肛门功能状况。

关键词：先天性巨结肠腹腔镜手术经肛改良Soave术疗效

薄膜固相微萃取/气相色谱-质谱法同时分析电子烟中香精和违禁药物

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分析测试学报 2024年第6期43卷 848-857页

作者：牛可歆赵霞聂洪港廉洁李冬梅袁育航王绘超李艋中国人民公安大学侦查学院北京100038 国家毒品实验室北京分中心北京100164 北京大学分析测试中心北京100871

利用浸涂法制备了沉积聚苯乙烯-二乙烯基苯(PS-DVB)颗粒的PDMS薄膜,通过优化萃取条件,建立基于自制固相微萃取薄膜的电子烟中低沸点香精和高沸点违禁药物的顶空气相色谱-质谱分析方法,确定最佳萃取温度和萃取时间分别为180℃和30 min。... 详细信息

利用浸涂法制备了沉积聚苯乙烯-二乙烯基苯(PS-DVB)颗粒的PDMS薄膜,通过优化萃取条件,建立基于自制固相微萃取薄膜的电子烟中低沸点香精和高沸点违禁药物的顶空气相色谱-质谱分析方法,确定最佳萃取温度和萃取时间分别为180℃和30 min。对比了热脱附与液液萃取两种薄膜脱附方式,结果显示二者在分析电子烟香精和违禁药物方面相互补充,但考虑方法的适用性,建立了基于液液萃取脱附方式的电子烟特征成分检验技术。通过与传统的样品处理方式直接稀释进样和商品化固相微萃取纤维对比,凸显基于自制PS-DVB/PDMS薄膜顶空分析电子烟特征成分的灵敏度与普适性,所建方法具有去除丙二醇和丙三醇基质干扰、满足高温萃取需求、吸附容量大、成本低的优势。将所建方法应用于实际案件中电子烟样品的检测,检测结果与案情相符,证实方法的准确性与实用性。该研究为电子烟液顶空气体中的香精和违禁药物提供了一种高效、准确的微全分析方案,对生命健康、法庭科学和和公共环境领域具有重要意义。

关键词：电子烟顶空分析违禁药物薄膜固相微萃取(TFME) 气相色谱-质谱微全分析

A Metabolic-associated Nomogram Predicts Recurrence Survival of Thyroid Cancer

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Current Medical Science 2021年第5期41卷 1004-1011页

作者： Zi-han XI Xian-xiong MA Heng-yu CHEN yuan-hang yu Lei LI Tao HUANG department of Breast and Thyroid Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Depcirtment of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Pancreatic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China NHC Key Laboratory of Hormones and Development Tianjin Institute of EndocrinologyTianjin Medical University Chu Hsien-I Memorial HospitalTianjin 300134China

Objective:Various studies have suggested that metabolic genes play a significant role in papillary thyroid cancer(PTC).The current study aimed to identify a metabolic signature related biomarker to predict the prognosis of patients with ***:We conducted a comprehensive analysis on the data obtained from the Cancer Genome Atlas(TCGA)*** correlation between survival result and metabolic genes was evaluated based on the univariate Cox analyses,least absolute shrinkage and selection operator(LASSO)and multivariate Cox *** performance of a 7-gene signature was assessed according to Kaplan-Meier and receiver operating characteristic(ROC)*** Cox regression analysis was adopted to unearth clinical factors related to the recurrence free survival(RFS)of patients with ***,a prognostic nomogram was developed based on risk score,cancer status and cancer width to improve the prediction for RFS of PTC ***:Seven metabolic genes were used to establish the prognostic *** ROC curve and C-index exhibited high value in training,testing and the whole TCGA *** established nomogram,incorporating the 7-metabolic gene signature and clinical factors,was able to predict the RFS with high *** 7-metabolic gene signature-based nomogram had a good performance to predict the RFS of patients with ***:Our study identified a 7-metabolic gene signature and established a prognostic nomogram,which were useful in predicting the RPS of PTC.

关键词： signature metabolism papillary thyroid cancer recurrence free survival nomogram

Effect of Al content on modification behavior of non-metallic inclusions in high-strength steel treated with rare earth

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Journal of Iron and Steel Research International 2024年第8期31卷 1886-1899页

作者： Zhan-peng Tie Xue-yuan Jiang Hai-yan Tang ·Gen Li yu-hang Wang Jia-quan Zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Continuous Casting Business Section CISDI Engineering Co.Ltd.Chongqing 401122China Special Steel Institute Central Iron and Steel Research Institute Co.Ltd.Beijing 100081China

The influence of Al content(0.0053,0.0171,and 0.0578 wt.%)on the modification behavior of non-metallic inclusions in 20CrMoVTiB steel treated with rare earth elements was studied through high-temperature experiments and thermodynamic *** results showed that the modification products varied with the Al content in steel under 0.01 wt.%of Ce *** formation sequence of typical rare earth inclusions in steel with the increase in Al content was Ce_(2)O_(3)→CeAlO_(3)→CeAl_(11)O_(18),and the final stable products were highly Al content *** the Al content was 0.0053 wt.%,the stable phase in steel was Ce2O3;while the[Al]reached 0.0171 wt.%,the stable phase became CeA1O_(3).As the A1 content reached 0.0578 wt.%,CeAl_(11)O_(18) became the stable *** a result,increasing the Al content could inhibit the precipitation of Ce_(2)O_(3) inclusions in steel while promote the formation of CeAIO3 and CeAl_(11)O_(18) *** addition,both Ca treatment and Ce treatment could effectively refine the size of inclusions in steel by changing their ***,the feeding amount of Ca wire into molten steel should be appropriately reduced under the condition of adding Ce simultaneously,which is expected to be beneficial for an improved Ce treatment effect.

关键词： Rare earth Al content Steel Inclusion Thermodynamics Ca treatment

Unveiling the Contribution of Lactic Acid to the Passivation Behavior of Ti-6Al-4V Fabricated by Laser Powder Bed Fusion in Hank’s Solution

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 102-118页

作者： yu-hang Chu Liang-yu Chen Bo-yuan Qin Wenbin Gao Fanmin Shang Hong-yu Yang Lina Zhang Peng Qin Lai-Chang Zhang School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212100China Foshan(Southern China)Institute for New Materials Foshan528200China Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun130025China Centre for Advanced Materials and Manufacturing School of EngineeringEdith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

In actual physiological environments,bacteria can activate the immune system and release lactic ***,the detailed contribution of lactic acid to the passivation behavior of titanium(Ti)alloys is still *** current work investigated the in vitro passivation behavior of Ti-6Al-4V(TC4)alloys fabricated by laser powder bed fusion in Hank's solution with and without adding lactic *** methods,inductively coupled plasma atomic emission spectrometer,and X-ray photoelectron spectroscopy were jointly *** lactic acid decreases the corrosion resistance of samples by degrading the formed passive *** film formed in the(lactic acid)-containing solution exhibits a higher level of oxygen vacancies and a lower thickness,attributed to the suppressed formation of Ti^(4+)transformed from Ti^(3+)and Ti^(2+).Moreover,the presence of lactic acid would increase the open circuit potential,relieve the ions release,and hinder the deposition of calcium phosphates within 24 h immersion.

关键词： Titanium alloy Corrosion behavior Passive film Lactic acid Laser powder bed fusion

Suppression of the regrowth interface leakage current in AlGaN/GaN HEMTs by Fe doped GaN substrate

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Science China(Information Sciences) 2024年第6期67卷 461-462页

作者： Xiao WANG Zhi-yu LIN yuan-hang SUN Long yuE yu-Min Zhang Jian-Feng WANG Ke XU School of Nano-Tech and Nano-Bionics University of Science and Technology of China Suzhou Institute of Nano-tech and Nano-bionics Chinese Academy of Sciences Information Materials Research Department Suzhou laboratory Suzhou Nanowin Science and Technology Co. Ltd. Jiangsu Institute of Advanced Semiconductors

In the process of homoepitaxy AlGaN/GaN heterojunction by metal-organic chemical vapor deposition (MOCVD) on free-standing substrates,Si impurities from the air and reaction chamber accumulate at the regrowth interfac...

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A Coordinate-Free Approach to the Design of Generalized Griffis-Duffy Platforms

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 95-103页

作者： Chengwei Shen Xu Pei Lubin hang Jingjun yu College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityHangzhou 311300China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China

Architectural singularity belongs to the Type II singularity,in which a parallel manipulator(PM)gains one or more degrees of freedom and becomes *** remaining permanently in a singularity are beneficial for linearto-rotary motion ***-Duffy(GD)platform is a mobile structure admitting a Bricard *** this paper,we present a coordinate-free approach to the design of generalized GD platforms,which consists in determining the shape and attachment of both the moving platform and the fixed *** generalized GD platform is treated as a combination of six coaxial single-loop mechanisms under the same *** to the inversion,hidden in the geometric structure of these single-loop mechanisms,the mapping from a line to a circle establishes the geometric transformation between the fixed base and the moving platform based on the center of inversion,and describes the shape and attachment of the generalized GD ***,the center of inversion not only identifies the location of rotation axis,but also affects the shape of the platform mechanism.A graphical construction of generalized GD platforms using inversion,proposed in the paper,provides geometrically feasible solutions of the manipulator design for the requirement of the location of rotation axis.

关键词： Generalized Griffis-Duffy platforms Self-motion Inversion Coordinate-free determination Manipulator design

Effect of Cr_(2)O_(3) on properties of CaO-SiO_(2)-Fe_(t)O-MgO system and dissolution behavior of lime

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Journal of Iron and Steel Research International 2024年第4期31卷 870-881页

作者： Shan-nan Li Jian-li Li yue yu hang-yu Zhu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The productivity of the chrome-containing semi-steel converter smelting process is directly affected by the slag-forming speed during the converter preliminary *** effects of Cr_(2)O_(3) content on the physicochemical properties of the CaO-SiO_(2)-Fe_(t)O-MgO system,such as melting temperature,solidification behavior,mineral composition,and lime dissolution rate,were *** results showed that the slag was an amorphous phase at 1500℃.When Cr_(2)O_(3) was added,Ca(Fe,Mg)Si_(2)O_(6) and spinel were formed in the *** the increase in Cr_(2)O_(3) content,the amount of spinel precipitation increased,and the dendritic FegO_(4) crystal gradually changed into the granular(Fe,Mg)(Fe,Cr)2O_(4) *** the Cr_(2)O_(3) content increased from O to 2.91 wt.%,the melting temperature of the slag rose,and the melting range of the slag expanded slightly,but the lime dissolution rate did not *** the Cr_(2)O_(3) content further increased to 9.09 wt.%,the melting temperature continued to rise,the melting range rapidly expanded,and the lime dissolution rate decreased.

关键词： Cr_(2)O_(3) Vanadium-titanium magnetite Converter Slag Lime dissolution