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Role of penehyclidine in acute organophosphorus pesticide poisoning

World Journal of Emergency Medicine 2020年第1期11卷 37-47页

作者： Shi-yuan Yu Yan-xia Gao Joseph Walline Xin lu Li-na Zhao yuan-xu Huang Jiang Tao An-yong Yu Na Ta Ren-ju Xiao Yi Li Department of Emergency Medicine Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijingChina Department of Emergency Medicine the First Affi liated Hospital of Zhengzhou UniversityZhengzhouChina Accident and Emergency Medicine Academic Unit Prince of Wales Hospitalthe Chinese University of Hong KongHong KongChina Department of Emergency Medicine the Fourth Affi liated Hospital of Jishou UniversityHuaihuaChina Department of Emergency Medicine the First Affi liated Hospital of Zunyi Medical UniversityZunyiChina Department of Emergency Medicine Chifeng Municipal HospitalChifengChina Department of Emergency Medicine Xingyi People's HospitalXingyiChina

BACKGROUND:Penehyclidine is a newly developed anticholinergic *** aimed to investigate the role of penehyclidine in acute organophosphorus pesticide poisoning(OP)***:We searched the Pubmed,Cochrane library,EMBASE,Chinese National Knowledge Infrastructure(CNKI),Chinese Biomedical literature(CBM)and Wanfang *** controlled trials(RCTs)recruiting acute OP patients were identifi ed for *** outcomes included cure rate,mortality rate,time to atropinization,time to 60%normal acetylcholinesterase(AchE)level,rate of intermediate syndrome(IMS)and rate of adverse drug reactions(ADR).RESULTS:Sixteen RCTs involving 1,334 patients were identifi *** with the atropineor penehyclidine-alone groups,atropine combined with penehyclidine significantly increased the cure rate(penehyclidine+atropine ***,0.97 vs.0.86,RR 1.13,95%CI[1.07–1.19];penehyclidine+atropine ***,0.93 vs.0.80,RR 1.08,95%CI[1.01–1.15])and reduced the mortality rate(penehyclidine+atropine ***,0.015 vs.0.11,RR 0.17,95%CI[0.06–0.49];penehyclidine+atropine ***,0.13 vs.0.08,RR 0.23,95%CI[0.04–1.28]).Atropine combined with penehyclidine in OP patients also helped reduce the time to atropinization and AchE recovery,the rate of IMS and the rate of *** with a single dose of atropine,a single dose of penehyclidine also signifi cantly elevated the cure rate,reduced times to atropinization,AchE recovery,and rate of ***:Atropine combined with penehyclidine benefi ts OP patients by enhancing the cure rate,mortality rate,time to atropinization,AchE recovery,IMS rate,total ADR and duration of *** combined with atropine is likely a better initial therapy for OP patients than atropine alone.

关键词： Penehyclidine Organophosphorus pesticide poisoning Meta-analysis

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Influence of Gut Microbiota and its Metabolites on Progression of Metabolic Associated Fatty Liver Disease

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Chinese Medical Sciences Journal 2023年第4期38卷 286-296页

作者： yuan-yuan Wang Hai-Lian Lin Ke-Lang Wang Gen-xiang Que Ting Cao La-Mei Zhu Xia Yang Xue-Feng Yang Hunan Provincial Clinical Research Center for Metabolic Associated Fatty Liver Disease Affiliated Nanhua HospitalHengyang Medical School&University of South ChinaHengyangHunan 421002China Department of Gastroenterology Affiliated Nanhua HospitalHengyang Medical School&University of South ChinaHengyangHunan 421002China Department of Hepatobiliary Surgery Affiliated Nanhua HospitalHengyang Medical School&University of South ChinaHengyangHunan 421002China Department of General Practice Affiliated Nanhua HospitalHengyang Medical School&University of South ChinaHengyangHunan 421002China

Metabolic associated fatty liver disease(MAFLD)has become a prevalent chronic liver disease worldwide because of lifestyle and dietary *** microbiota and its metabolites have been shown to play a critical role in the pathogenesis of *** of the function of gut microbiota and its metabolites in MAFLD may help to elucidate pathological mechanisms,identify diagnostic markers,and develop drugs or probiotics for the treatment of *** we review the pathogenesis of MAFLD by gut microbiota and its metabolites and discuss the feasibility of treating MAFLD from the perspective of gut microbes.

关键词： metabolic associated fatty liver disease intestinal microorganisms non-alcoholic fatty liver disease liver fibrosis hepatocellular carcinoma

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Dynamic Properties of Two-Dimensional Polydisperse Granular Gases

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Communications in Theoretical Physics 2007年第2X期48卷 343-347页

作者： LI Rui ZHANG Duan-Ming HUANG Ming-Tao SU xiang-Ying CHEN Zhi-yuan ZHU Hong-Ying ZHANG Lin Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

We propose a two-dimensional model of polydisperse granular mixtures with a power-law size distribution in the presence of stochastic driving. A fractal dimension D is introduced as a measurement of the inhomogeneity of the size distribution of particles. We define the global and partial granular temperatures of the multi-component mixture. By direct simulation Monte Carlo, we investigate how the inhomogeneity of the size distribution influences the dynamic properties of the mixture, focusing on the granular temperature, dissipated energy, velocity distribution, spatial clusterization, and collision time. We get the following results： a single granular temperature does not characterize a multi-component mixture and each species attains its own ＂granular temperature＂; The velocity deviation from Gaussian distribution becomes more and more pronounced and the partial density of the assembly is more inhomogeneous with the increasing value of the fractal dimension D; The global granular temperature decreases and average dissipated energy per particle increases as the value olD augments.

关键词： fractal fractal dimension polydisperse mixture

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Enhanced degradation of trichloroethene by calcium peroxide activated with Fe（III） in the presence of citric acid

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Frontiers of Environmental Science & Engineering 2016年第3期10卷 502-512页

作者： xiang ZHANG Xiaogang GU Shuguang lu Zhouwei MIAO Minhui XU Xiaori FU Muhammad DANISH Mark L. BRUSSEAU Zhaofu QIU Qian SUI State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and Technology Shanghai 200237 China Soil Water and Environmental Science Department School of Earth and Environmental Sciences The University of Arizona 429 Shantz Building Tucson AZ 85721 United States

Trichloroethene （TCE） degradation by Fe（III）- activated calcium peroxide （CP） in the presence of citric acid （CA） in aqueous solution was investigated. The results demonstrated that the presence of CA enhanced TCE degradation significantly by increasing the concen- tration of soluble Fe（III） and promoting H202 generation. The generation of HO· and O2^-· in both the CP/Fe（III） and CP/Fe（III）/CA systems was confirmed with chemical probes. The results of radical scavenging tests showed that TCE degradation was due predominantly to direct oxidation by HO·, while O2^-· strengthened the generation of HO· by promoting Fe（III） transformation in the CP/Fe （III）/CA system. Acidic pH conditions were favorable for TCE degradation, and the TCE degradation rate decreased with increasing pH. The presence of Cl·-, HCO3·-, and humic acid （HA） inhibited TCE degradation to different extents for the CP/Fe（III）/CA system. Analysis of Cl·- production suggested that TCE degradation in the CP/Fe （III）/CA system occurred through a dechlorination process. In summary, this study provided detailed information for the application of CA-enhanced Fe（III）-activated calcium peroxide for treating TCE contaminated groundwater.

关键词： calcium peroxide trichloroethene (TCE) citric acid ferric ion free radicals oxidation

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LiFePO_4/C via fluoride doping

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Rare Metals 2012年第6期31卷 573-577页

作者： Gu yuan Zhang xiangjun lu Shigang Zhao Ting Jiang Danping Yang Rong Wu Aide Gen Res Inst Nonferrous Met R&D Ctr Vehicle Battery & Energy Storage Beijing 100088 Peoples R China

Non-stoichiometric compound fluoride-doped LiFePO4/C cathode materials were synthesized via solid-state reaction using MgF2 and AlF3 as dopant. The fluoride-doped LiFePO4/C samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and electrochemical testing. The results show that the materials are well crystallized and fluoride doping cannot change the space structure of LiFePO4. Slight amounts of Fe2O3 with no fluoride impurity were detected. Charge-discharge curves show that fluoride-doped samples have higher capacity at low rates compared with undoped LiFePO4/C. AlF3-doped samples have highest capacity at high discharge current. Both doped samples have larger polarization voltage than undoped samples. All samples exhibit good cycle stability.

关键词： lithium-ion batteries cathode materials LiFePO4 fluoride doping

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多西他赛联合洛铂同步调强放疗对中晚期食管癌近远期疗效、肿瘤标志物和生存质量的影响

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现代生物医学进展 2024年第13期24卷 2573-2577,2600页

作者：刘涛林晓明李浩然杨翔峰陈正鲁广东医科大学附属医院乳腺食管肿瘤专科广东湛江524001

目的:评价多西他赛(DTX)联合洛铂(LBP)同步调强放疗(IMRT)对中晚期食管癌(EC)近远期疗效、肿瘤标志物和生存质量的影响。方法:选入我院2018年1月~2022年6月收治的中晚期EC患者276例,根据治疗方法不同分为对照组(IMRT治疗)和观察组(DTX联... 详细信息

目的:评价多西他赛(DTX)联合洛铂(LBP)同步调强放疗(IMRT)对中晚期食管癌(EC)近远期疗效、肿瘤标志物和生存质量的影响。方法:选入我院2018年1月~2022年6月收治的中晚期EC患者276例,根据治疗方法不同分为对照组(IMRT治疗)和观察组(DTX联合LBP同步IMRT治疗),各138例。比较两组的近期疗效、肿瘤标志物、生存质量和毒副反应;随访至2023年11月,记录两组患者生存状态并绘制Kaplan-Meier生存曲线。结果:观察组客观有效率、无进展生存期、总生存期和治疗后EORTC QLQ-C30评分分别为89.86%、10.100(95%CI:9.552~10.648)个月、14.300(95%CI:13.940~14.660)个月和(75.52±9.35)分,对照组分别为68.84%、7.800(95%CI:7.307~8.293)个月、12.500(95%CI:11.643~13.357)个月和(64.71±9.81)分,观察组显著高于对照组(P<0.05)。观察组治疗后血清癌胚抗原、糖类抗原19-9、细胞角蛋白19片段水平分别为(14.94±3.25)ng/mL、(14.36±3.74)U/m L和(9.29±1.34)ng/mL,对照组分别为(22.37±3.86)ng/mL、(14.36±3.74)U/m L和(9.29±1.34)ng/mL,观察组显著低于对照组(P<0.05)。观察组胃肠道反应发生严重程度显著高于对照组(P<0.05)。结论:与单纯IMRT相比,DTX联合LBP同步IMRT治疗中晚期EC的近期疗效显著,可有效降低血清肿瘤标志物水平,延长生存期,改善生活质量,且毒副反应可耐受。

关键词：中晚期食管癌多西他赛洛铂同步放化疗近远期疗效肿瘤标志物生存质量

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Effect of apolipoprotein E gene Hha Ⅰ restricting fragment length polymorphism on serum lipids in cholecystolithiasis

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World Journal of Gastroenterology 1999年第3期5卷 228-230页

作者： LIN Oi-yuan DU Jing-Ping ZHANG Ming-Yi YAO Yu-Gwei LI Lin CHENG Nan-Sheng YAN lu-Nan and XI-AO lu-Jia Department of General Surgery First Hospital West China University of Medical Sciences China Department of General Surgery First University Hospital West China University of Medical Sciences Chengdu 610041 Sichuan Province China

AIM To investigate the role of apolipoprotein E (apoE) polymorphism in the lithogenesis of gallstone and the hereditary pathogenesis of the *** Polymerase chain reaction (PCR)was used to study apoE phenotypes and allelefrequencies in patients with gallstones and control, and the fasting serum lipids of subjectswere also measured by enzymatic *** The levels of triglyceride (TG) andvery low density lipoprotein cholesterol (VLDLC) were much higher in Ez/, patients than that inE,/, control. E,/, patients were accompanied withremarkably low levels of high density lipoproteincholesterol (HDLC) and its subforms. But in E,/#patients there were only slight changes in levelsof VLDLC and low density lipoprotein cholesterol (LDL--C).CONCluSION Different apoE phenotype patientswith gallstones have different cheracteristics ofdyslipidemia and the average level of serum lipids in patients with gallstones are higher thansubjects without gallstones in the same apoEgene phenotype. EZ allele is possibly one of thedangerous factors in the lithogenesis of cholecystolithiasis.

关键词： LDL length Effect of apolipoprotein E gene Hha gene

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Three Zinc(Ⅱ) Complexes Based on 2-Carboxylic Acid-4-nitropyridine-1-oxide: Synthesis, Crystal Structure, and Fluorescence Properties

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Chinese Journal of Structural Chemistry 2020年第2期39卷 340-349,188页

作者： lu Sheng-Nan SHI Feng-xiang WU Wen-Shi QUAN Zhi-Long College of Materials Science and Engineering Huaqiao UniversityXiamen 361021China

Three new metal-organic complexes, namely [Zn(POA)2(H2O)2](1), [Zn(POA)2(H2O)2]·2H2O(2) and [Zn(POA)2]n(3), have been synthesized by organic ligand 2-carboxylic acid-4-nitropyridine-1-oxide(POA) and zinc(Ⅱ) ions. The structures of complexes 1~3 are characterized by single-crystal X-ray analysis, XRD powder diffraction analysis, infrared spectroscopy and thermal stability analysis method. Complex 1 belongs to monoclinic system, space group C2/c with a = 22.8215(15), b = 7.5613(16), c = 10.048(3) ?, β = 109.47°, V = 1634.7(6) ?~3, Z = 4, F(000) = 944, Dc = 1.900 g/cm^3, C(12)H(10)N4O(12)Zn, Mr = 467.61 and μ = 1.584 mm^(-1). The whole molecule presents "V" shape. Complex 2 is a centrosymmetric structure in triclinic system with space group P1: a = 7.4728(5), b = 7.6825(6), c = 8.5184(6) ?, α = 65.975(2), β = 79.87(2), γ = 89.855(2)°, V = 4384.1(5) ?~3, Z = 1, F(000) = 256, Dc = 1.908 g/cm^3, C(12)H(14)N4O(14)Zn, Mr = 503.64 and μ = 1.492 mm^(-1). Complex 3 is a one-dimensional chain structure belonging to monoclinic system and space group P21/c with a = 4.9456(6), b = 12.5322(14), c = 11.2514(13) ?, β = 97.313(11)°, V = 6916.8(14) ?~3, Z = 2, F(000) = 432, Dc = 2.072 g/cm^3, C(12)H6N4O(10)Zn, Mr = 431.58, and μ = 1.852 mm^(-1). In three complexes, six oxygen atoms from the surrounding coordination atoms form a ZnO6 distorted octahedral coordination geometry around the zinc ions. Meanwhile, fluorescent properties of the three complexes were investigated at room temperature. The fluorescence spectroscopic analysis demonstrated that the ligand POA shows red-shift after coordinating with the zinc(Ⅱ) ions.

关键词： 2-carboxylic acid-4-nitropyridine-1-oxide zinc complexes crystal structures fluorescence properties

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农林废物对畜粪堆肥有机质转化和酶活性的影响

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环境工程技术学报 2024年第5期14卷 1541-1549页

作者：戴启鹏向明灯常兆峰郭浩博陆智勇郑彤张六一于云江重庆三峡学院环境与化学工程学院生态环境部华南环境科学研究所国家环境保护环境污染健康风险评价重点实验室昆明理工大学环境科学与工程学院广东工业大学环境科学与工程学院

通过好氧堆肥技术利用农林废物对畜禽粪便进行堆肥,是实现农林废物资源化利用且减轻其对环境污染的有效途径。采用新鲜牛粪辅以农林废物进行堆肥中试试验,通过表征堆肥过程中堆体理化性质差异、有机质与腐殖质的物质结构演化和酶活性的... 详细信息

通过好氧堆肥技术利用农林废物对畜禽粪便进行堆肥,是实现农林废物资源化利用且减轻其对环境污染的有效途径。采用新鲜牛粪辅以农林废物进行堆肥中试试验,通过表征堆肥过程中堆体理化性质差异、有机质与腐殖质的物质结构演化和酶活性的变化,探究不同农林废物对牛粪堆肥过程的影响。结果显示:在堆肥初期,堆体中易降解的有机质被微生物降解,导致堆体温度上升,且铵态氮、腐殖酸和富里酸含量逐渐下降;随着高温期的持续,微生物开始加速降解堆体中较难降解的大分子有机物,导致纤维素、半纤维素含量减少,木质素含量迅速上升;当温度下降后,硝化细菌活性逐渐增大,大量铵态氮转化成硝态氮,且堆体中有机物含量的减少,降低了脲酶活性;在堆肥后期,难降解的木质素占比较高,有机质利用变慢,多酚氧化酶和过氧化氢酶活性下降。研究结果可为优化堆肥过程、提高堆肥质量提供科学依据。

关键词：农林废物好氧堆肥理化性质有机质酶活性

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Comparison of clinical and immunological profiles in coronavirus disease 2019 and influenza patients:a case control study

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World Journal of Emergency Medicine 2022年第4期13卷 309-312页

作者： Zhao-di Wang Cong-ying Song Da-gan Yang Yun-mei Yang yuan-qiang lu Department of Geriatric and Emergency the First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Department of Laboratory Medicine the First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003China

The pandemic caused by the SARS-CoV-2 coronavirus is still looming worldwide,and the pandemic has challenged health care delivery and health care systems internationally.[1]The epidemic of seasonal influenza would occur in the winter *** coronavirus disease 2019(COVID-19)and influenza share many clinical symptoms,[2]it is difficult to distinguish these two respiratory infections in the early stage.[3]Although nucleic acid testing was the gold standard to identify different virus infected diseases,false-negative nucleic acid results were reported frequently in COVID-19,[4]and its diagnostic sensitivity is less ***,the aim of our study is to explore and compare the clinical characteristics of COVID-19 and influenza,which could deepen the understanding of these two diseases and provide some guidance for clinicians to make a differential diagnosis.

关键词： influenza clinical diseases

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