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Research on feed-pulse collaborative control method in micro-electrical discharge machining

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Advances in Manufacturing 2024年第2期12卷 270-287页

作者： Qiang Gao Ya-Ou Zhang Xue-Cheng Xi yuan-Ding Wang Xiao-Fei Chen Wan-Sheng Zhao School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240People’s Republic of China State Key Laboratory of Mechanical System and Vibration Shanghai200240People’s Republic of China Shanghai Institute of Space Propulsion Shanghai201112People’s Republic of China

Reducing the short-circuit rate and increasing the effective discharge rate are important targets for improving the servo control effect of micro-electrical discharge machining(micro-EDM),as these two indicators are closely related to the machining efficiency and *** this study,a feed-pulse collaborative control(FPCC)method is proposed for micro-EDM based on two dimensions(space and time).In the spatial dimension,a feed control strategy with a discharge holding process is ***,in the time dimension,a forward-looking pulse control strategy is adopted,in which the pulse interval is adjusted based on a sequence analysis of feed commands and discharge *** experiments are carried out to determine the key parameters used in this method,including the discharge holding threshold and pulse interval adjustment value(T_(off_(adj))).The feed smoothness and discharge sufficiency analyses of the experimental results show that compared to the traditional double threshold average voltage method,the FPCC method reduces the number of long-distance retreats by 64%and improves the effective discharge time by 40%.

关键词： Micro-electrical discharge machining(micro-EDM) Electrode feed control Discharge pulse control Machining surface quality

C—F Bond Insertion into Indoles with CHBr_(2)F:An Efficient Method to Synthesize Fluorinated Quinolines and Quinolones

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Chinese Journal of Chemistry 2024年第10期42卷 1128-1132页

作者： Chao Li Lei Chen Hongye Wang Zixi Yan Bin Lyu Weiping Lyu Changwei Jiang Dehua Lu Jiaxing Li Ning jiao Song Song State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityXue Yuan Rd.38Beijing 100191China

A mild and practical method for synthesizing fluorinated quinoline derivatives,which have a wide range of applications in pharmaceuticals,materials,and organic synthesis,was described through C—F bond insertion into indoles using CHBr_(2)*** simple conditions,readily availability of CHBr_(2)F,as well as the versatility of the transformations make this strategy very powerful in synthesizing 3-fluoroquinoline and *** mechanistic studies reveal that bromofluorocarbene generated in-situ under basic condition was the key intermediate.

关键词： Skeleton edit Fluorocarbene Ring expansion Quinoline Quinolone

艾司奥美拉唑UPLC-MS/MS测定方法建立及其在健康中国人中的生物等效性研究

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药物评价研究 2024年第3期47卷 573-580页

作者：张静熊雯袁宇琳岳娇郑萍成都市药品检验研究院四川成都610000

目的建立UPLC-MS/MS法测定人血浆中艾司奥美拉唑浓度,并应用于人体生物等效性研究。方法采用UPLCMS/MS法,以艾司奥美拉唑-d3为内标,ACE 3 C_(18)-AR(50 mm×2.1 mm,3μm)为分析柱,流动相A为5 mmol·L^(-1)乙酸铵水溶液,流动相B为乙腈,... 详细信息

目的建立UPLC-MS/MS法测定人血浆中艾司奥美拉唑浓度,并应用于人体生物等效性研究。方法采用UPLCMS/MS法,以艾司奥美拉唑-d3为内标,ACE 3 C_(18)-AR(50 mm×2.1 mm,3μm)为分析柱,流动相A为5 mmol·L^(-1)乙酸铵水溶液,流动相B为乙腈,体积流量为0.6 mL·min^(-1)进行梯度洗脱;采用电喷雾离子源,以多反应监测(MRM)正离子模式进行检测,用于定量分析的离子对为m/z 346.1→198.1(艾司奥美拉唑)、m/z 349.1→198.1(艾司奥美拉唑-d3)。应用建立的方法测定人血浆中艾司奥美拉唑浓度,并计算生物等效性。结果艾司奥美拉唑在3~3000 ng·mL^(-1)范围线性关系良好(r≥0.9994),批内、批间精密度和准确度、回收率、基质效应及稳定性均符合生物样品测定要求。应用该方法进行人体生物等效性样品测定,证明受试制剂和参比制剂生物等效。结论建立的人血浆中艾司奥美拉唑浓度测定方法准确、灵敏、选择性好、重现性高,可用于受试者单次口服40 mg艾司奥美拉唑镁肠溶干混悬剂的生物等效性研究,受试制剂和参比制剂生物等效。

关键词：超高效液相色谱-串联质谱法艾司奥美拉唑生物等效性消化性溃疡生物样品

一种C_(3)N_(4)光催化剂的制备及其对四环素类抗生素的降解

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中国环境科学 2024年第4期44卷 2073-2082页

作者：高艺芳郭瑞焦媛刘晓娜钱天伟太原理工大学环境科学与工程学院山西晋中030606

以单一尿素为前驱体,通过热聚合制备了C_(3)N_(4),并通过SEM、XRD、XPS、FT-IR、UV-Vis等分析表征了所制备的C_(3)N_(4)材料的结构、成分、光学性能和光催化活性.结果发现制备的C_(3)N_(4)具有花状的多孔纳米片结构和大的比表面积.制备... 详细信息

以单一尿素为前驱体,通过热聚合制备了C_(3)N_(4),并通过SEM、XRD、XPS、FT-IR、UV-Vis等分析表征了所制备的C_(3)N_(4)材料的结构、成分、光学性能和光催化活性.结果发现制备的C_(3)N_(4)具有花状的多孔纳米片结构和大的比表面积.制备的C_(3)N_(4)在氙灯320~780nm的照射下,对盐酸四环素(TCH)的降解表现出良好的光催化活性,60min内降解率达到99.60%.自由基淬灭实验的结果表明,·O_(2)^(-)、^(1)O_(2)和h^(+)是TCH降解的主要原因.对比试验和DFT理论计算分析发现,以尿素为原料制备的C_(3)N_(4)比三聚氰胺为原料制备的M-C_(3)N_(4)光催化效果优异是归因于C_(3)N_(4)具有花状的多孔结构,更大比表面积以更多的活性位点和氧空位.此外,制备的催化剂C_(3)N_(4)对四环素类的抗生素(盐酸金霉素(CTC)和土霉素(OTC))具有类似的催化效果.进一步通过分析光催化氧化中间产物,提出了TCH可能的降解路径.

关键词：光催化 C_(3)N_(4) 四环素理论计算

儿童药物反应伴嗜酸性粒细胞增多和全身性症状诊疗进展

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中国小儿急救医学 2024年第7期31卷 487-492页

作者：焦磊梁源国家儿童医学中心、首都医科大学附属北京儿童医院皮肤科 100045

药物反应伴嗜酸性粒细胞增多和全身性症状(DRESS),即药物超敏反应综合征,是一种少见但严重的、具有潜在致命风险的、全身性的药物不良反应。任何年龄均可发病,儿童发病率及病死率低于成人。抗生素及抗惊厥药物是儿童DRESS常见的致敏药... 详细信息

药物反应伴嗜酸性粒细胞增多和全身性症状(DRESS),即药物超敏反应综合征,是一种少见但严重的、具有潜在致命风险的、全身性的药物不良反应。任何年龄均可发病,儿童发病率及病死率低于成人。抗生素及抗惊厥药物是儿童DRESS常见的致敏药物。与成人相比,抗生素比例更高,潜伏期可小于2周。肝脏是最常见的受累器官。早期识别致敏药物并停用、早期诊断后立即治疗非常关键。系统应用糖皮质激素是中重度DRESS的一线治疗方法,生物制剂及小分子靶向药物应用前景广阔,但儿童应用的有效性及安全性仍需进一步研究支持。

关键词：药物反应伴嗜酸性粒细胞增多和全身性症状药物超敏反应综合征儿童靶向治疗生物制剂

基于零序信号全波形识别的小电流接地系统故障选线方法

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电网技术 2024年第2期48卷 839-850页

作者：袁嘉玮焦在滨西安交通大学电气工程学院陕西省西安市710049

小电流接地系统发生单相接地故障时,故障电流微弱,暂态特征复杂,导致现有选线方法正确率偏低,可靠性较差。该文提出了一种基于零序信号全波形识别的选线方法。首先,介绍了基于故障信号全波形识别的通用方法,指出从波形的角度认识并识别... 详细信息

小电流接地系统发生单相接地故障时,故障电流微弱,暂态特征复杂,导致现有选线方法正确率偏低,可靠性较差。该文提出了一种基于零序信号全波形识别的选线方法。首先,介绍了基于故障信号全波形识别的通用方法,指出从波形的角度认识并识别信号,可以充分利用信号的全部故障信息;其次,选取母线电压和所有馈线电流波形作为待识别信号,并根据电流波形分布特征自适应捕捉信号中特征差异最明显的波形进行故障识别,提出了基于故障信号全波形识别的选线方法;然后,利用改进后的全卷积神经网络来识别不同信号波形,并基于Dice系数对识别出的故障信号波形进行可信赖性评价。最后,PSCAD仿真和真型实验测试结果表明该方法具有很高的选线正确率和可靠性。

关键词：波形长度自适应技术可信度评价故障选线语义分割波形识别

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基于博弈竞价的区域综合能源系统运营弹性增强策略

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控制理论与应用 2024年第7期41卷 1216-1224页

作者：陈翼邹媛媛李少远上海交通大学电子信息与电气工程学院自动化系上海200240

能源系统故障可能导致巨大的经济损失,因此,提升能源系统的运营弹性具有重要意义.为了提高区域综合能源系统在市场机制下的弹性,本文提出了一种基于博弈的能源竞标策略.首先,建立了区域综合能源系统模型,其中包括能源控制中心、能源枢... 详细信息

能源系统故障可能导致巨大的经济损失,因此,提升能源系统的运营弹性具有重要意义.为了提高区域综合能源系统在市场机制下的弹性,本文提出了一种基于博弈的能源竞标策略.首先,建立了区域综合能源系统模型,其中包括能源控制中心、能源枢纽、储能系统和用户聚合商.为了在市场环境下通过价格引导弹性增强,构建了基于Stackelberg博弈的能源竞标框架,通过调整能源零售价格和需求响应激励价格等策略,以减小能源缺口并降低价格波动.考虑到参与者间的隐私保护,设计了双层迭代定价算法.最后,通过仿真算例说明了所提策略在保证供需平衡的同时有效抑制价格波动,从而降低经济损失.

关键词：区域综合能源系统弹性增强 Stackelberg博弈

Clinical practice guidelines for nutritional assessment and monitoring of adult ICU patients in China

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Journal of Intensive Medicine 2024年第2期4卷 137-159页

作者： Xiangdong Guan Dechang Chen yuan Xu Chinese Society of Critical Care Medicine Department of Critical Care Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Critical Care Medicine Beijing Tsinghua Changgung HospitalBeijingChina 不详

The Chinese Society of Critical Care Medicine(CSCCM)has developed clinical practice guidelines for nutrition assessment and monitoring for patients in adult intensive care units(ICUs)in *** guideline focuses on nutrition evaluation and metabolic monitoring to achieve optimal and personalized nutrition therapy for critically ill *** guideline was developed by experts in critical care medicine and evidence-based medicine methodology and was developed after a thorough review of the system and a summary of relevant trials or studies published from 2000 to July 2023.A total of 18 recommendations were formed and consensus was reached through discussions and reviews by expert groups in critical care medicine,parenteral and enteral nutrition,and *** recommendations are based on currently available evidence and cover several key fields,including screening and assessment,evaluation and assessment of enteral feeding intolerance,metabolic and nutritional measurement and monitoring during nutrition therapy,and organ function evaluation related to nutrition *** question was analyzed according to the Population,Intervention,Comparison,and Outcome(PICO)*** addition,interpretations were provided for four questions that did not reach a consensus but may have potential clinical and research *** plan is to update this nutrition assessment and monitoring guideline using the international guideline update method within 3–5 years.

关键词： Adults Critical illness Intensive care unit Nutriti on Nutriti on assessment and monitoring Guideline Recommendations Chinese Society of Critical Care Medicine-Chinese Medical Association(CSCCM-CMA)

Design, performance and application of a line-imaging velocity interferometer system for any reflector coupled with a streaked optical pyrometer system at the Shenguang-Ⅱ upgrade laser facility

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High Power Laser Science and Engineering 2024年第1期12卷 52-59页

作者： Dawei yuan Shaojun Wang Huigang Wei Haochen Gu Yu Dai Jiayong Zhong Yutong Li Gang Zhao Jie Zhang Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijingChina Institute of Frontiers in Astronomy and Astrophysics of Beijing Normal University BeijingChina Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijingChina Key Laboratory for Laser Plasmas(MOE)and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Department of Astronomy Beijing Normal UniversityBeijingChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina School of Physical Sciences University of Chinese Academy of SciencesBeijingChina Songshan Lake Materials Laboratory DongguanChina

The velocity interferometer system for any reflector(VISAR) coupled with a streaked optical pyrometer(SOP) system is used as a diagnostic tool in inertial confinement fusion(ICF) experiments involving equations of state and shock *** validate the process of adiabatically compressing the fuel shell through precise tuning of shocks in experimental campaigns for the double-cone ignition(DCI) scheme of ICF, a compact line-imaging VISAR with an SOP system is designed and implemented at the Shenguang-II upgrade laser facility. The temporal and spatial resolutions of the system are better than 30 ps and 7 μm, respectively. An illumination lens is used to adjust the lighting spot size matching with the target size. A polarization beam splitter and λ/4 waveplate are used to increase the transmission efficiency of our system. The VISAR and SOP work at 660 and 450 nm, respectively, to differentiate the signals from the scattered lights of the drive lasers. The VISAR can measure the shock velocity. At the same time, the SOP system can give the shock timing and relative strength. This system has been used in different DCI campaigns, where the generation and propagation processes of multi-shock are carefully diagnosed.

关键词： double-cone ignition streaked optical pyrometer velocity interferometer system for any reflector