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Triclosan-conjugated,lipase-responsive Polymeric Micelles for Eradication of Staphylococcal Biofilms

Chinese Journal of Polymer Science 2024年第6期42卷 718-728页

作者： Yan-Qiang Huang yuan-feng li Yong liu lin-Qi Shi Guangxi Technology Innovation Cooperation Base of Prevention and Control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise533000China Translational Medicine Laboratory the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325035China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials of Ministry of Educationand Institute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin300071China

Bacterial biofilms present a significant challenge in treating drug-resistant infections,necessitating the development of innovative *** this study,we introduce triclosan-conjugated,lipase-responsive polymeric micelles designed to exploit biofilm properties and serve as a responsive drug delivery *** micelles were created using an amphiphilic block polymer synthesized via ring-opening polymerization ofε-caprolactone(CL)and triclosan-containing cyclic trimethylene carbonate(MTC-Tri).Poly(ethylene glycol)(PEG-OH)acted as the macro-initiator,resulting in micelles with a PEG shell that facilitated their penetration into bacterial *** important advantage of our micelles lies in their interaction with local bacterial lipases within *** lipases triggered rapid micelle degradation,releasing triclosan in a controlled *** liberated triclosan effectively eliminated bacteria embedded in the ***,the triclosan-conjugated micelles displayed minimal toxicity to murine fibroblasts,indicating their biocompatibility and *** finding emphasizes the potential application of these micelles in combatting drug resistance observed in bacterial *** triclosan-conjugated,lipase-responsive polymeric micelles exhibit promising characteristics for addressing drug resistance in bacterial *** harnessing biofilm properties and implementing a responsive drug delivery system,we seek to provide an effective solution in the fight against drug-resistant bacteria.

关键词： Self-assembly Polymer prodrug Ring-opening polymerization Biofilm eradication Cytotoxicity

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Effects of Guiding Angle on Plastic Metal Flow and Defects in Extrusion of Aluminum Alloy

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Journal of Materials Science & Technology 2008年第2期24卷 256-260页

作者： Shijian yuan feng li Zhubin HE School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

To reduce defects, such as the shrinkage cavity and the surface cracks caused by non-homogeneous metal flow in extrusion process, an extrusion method was proposed by using a die with the guiding angle. Numerical simulation and experiment were conducted to investigate the metal flow in this extrusion process. It is shown that the stress state at the bottom of the die is changed. The tendency to generate the dead zone is decreased by employing the guiding angle at the die entrance. The shrinkage cavity is reduced because the non-homogeneous metal flow at the final stage of extrusion is improved. The axial stress is decreased greatly so that the surface cracks caused by additional stress are avoided.

关键词： Guiding angle Extrusion Metal flow Defects

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Rise and Fall of the Peer-to-Peer Empire

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Tsinghua Science and Technology 2012年第1期17卷 1-16页

作者： Baochun li yuan feng, Bo li Department of Electrical and Computer Engineering University of Toronto Toronto M5S 3G4 Canada Department of Computer Science Hong Kong University of Science and Technology Hong Kong China

The essence of the peer-to-peer design philosophy is to design protocols for end hosts, or ＂peers＂, to work in collaboration to achieve a certain design objective, such as the sharing of a large file. From a theoretical perspective, it has been recognized that the peer-to-peer design paradigm resembles gossip protocols, and with appropriate algorithmic design, it maximizes the network flow rates in multicast sessions. Over the past ten years, research on peer-to-peer computing and systems, a unique and intriguing category of distributed systems, has received a tremendous amount of research attention from academia and indus-try alike. Peer-to-peer computing eventually culminated in a number of successful commercial systems, showing the viability of their design philosophy in the Internet. The peer-to-peer design paradigm has pushed all design choices of innovative protocols to the edge of the Internet, and in most cases to end hosts themselves. It represents one of the best incarnation of the end-to-end argument, one of the frequently dis-puted design philosophies that guided the design of the Internet. Yet, research on peer-to-peer computing has recently receded from the spotlight, and suffered from a precipitous fall that was as dramatic as its me-teoric rise to the culmination of its popularity. This article presents a cursory glimpse of existing results over the past ten years in peer-to-peer computing, with a particular focus on understanding what has stimulated its rise in popularity, what has contributed to its commercial success, and eventually, what has led to its pre-cipitous fall in research attention. Our insights in this article may be beneficial when we develop our thoughts on the design paradigm of cloud computing.

关键词： peer-to-peer gossip protocols network coding

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Responsive Polymeric Nanoparticles for Biofilm-infection Control

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Chinese Journal of Polymer Science 2021年第11期39卷 1376-1391页

作者： lin-Zhu Su Yong liu yuan-feng li Ying-li An lin-Qi Shi State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer MaterialsMinistry of EducationInstitute of Polymer ChemistryCollege of ChemistryNankai UniversityTianjin 300071China Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesOujiang LaboratoryWenzhou 325000China

With the emergence of multidrug resistance(MDR)in many pathogens,bacterial infections are becoming a growing threat to public *** frightening scenario is due largely to the formation of biofilms,in which the bacteria are extremely recalcitrant to the conventional antibiotic *** address the emergence of MDR and biofilm-associated infections,numerous polymer-based materials have been designed and prepared *** subject of this perspective is the recent development of polymer-based materials that have been applied to combat multidrug-resistant pathogens,to prevent the formation of biofilms,or enhance the eradication efficacy to mature biofilms via killing biofilm-bacteria or dispersing *** advantages and shortcomings of these polymer-based materials are discussed,as well as the challenges we are facing in the clinical translation of these systems.

关键词： Antibacterial Biofilm Multidrug resistance Polymeric nanoparticles Stimuli-responsive

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Preparation of Uniform Ni-B Amorphous Alloy Catalyst on CNTs and its Performance for Acetylene Selective Hydrogenation

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Chinese Chemical Letters 2006年第1期17卷 109-112页

作者： Chang yuan HU feng Yi li Rong Bin ZHANG li HUA Department of Chemistry Nanchang University Nanchang 330047

Uniform Ni-B amorphous alloys about 14 nm have been prepared on CNTs-A support,named Ni-B/CNTs-A. In comparison with the Ni-B/CNTs amorphous catalyst, Ni-B/CNTs-A showed higher nickel loading, determined by ICP and be... 详细信息

关键词： CNTs aniline Ni-B amorphous alloy catalyst acetylene selective hydrogenation.

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An efficient synthesis of 3-(guaiazulene-1-yl)succinimides by addition of guaiazulene to maleimides

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Chinese Chemical Letters 2011年第7期22卷 789-792页

作者： Dao lin Wang Shao Fei li Wei li yuan feng li li Nan lin Key Laboratory of Synthesis & Application of Functional Compound College of Chemistry & Chemical Engineering Bohai University Jinzhou 121001 China

A facile, efficient synthesis of 3-（guaiazulen-l-yl）succinimides was developed by Michael-type addition of guaiazulene to maleimides in the presence of p-toluenesulfonic acid under mild reaction conditions.

关键词： Guaiazulene Succinimidcs Michael-type addition p-Toluenesulfonic acid

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Uniaxial experimental study of the acoustic emission and deformation behavior of composite rock based on 3D digital image correlation(DIC)

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Acta Mechanica Sinica 2017年第6期33卷 999-1021页

作者： Jian-Long Cheng Sheng-Qi Yang Kui Chen Dan Ma feng-yuan li li-Ming Wang State Key Laboratory for Geomechanics and Deep Underground Engineering School of Mechanics and Civil Engineering China University of Mining and Technology State Key Laboratory of Shield Machine and Boring Technology China Railway Tunnel Group Co. Ltd.

In this paper, uniaxial compression tests were carried out on a series of composite rock specimens with different dip angles, which were made from two types of rock-like material with different strength. The acoustic emission technique was used to monitor the acoustic signal characteristics of composite rock specimens during the entire loading process. At the same time, an optical non-contact 3 D digital image correlation technique was used to study the evolution of axial strain field and the maximal strain field before and after the peak strength at different stress levels during the loading process. The effect of bedding plane inclination on the deformation and strength during uniaxial loading was analyzed. The methods of solving the elastic constants of hard and weak rock were described. The damage evolution process, deformation and failure mechanism, and failure mode during uniaxial loading were fully determined. The experimental results show that the θ = 0?–45?specimens had obvious plastic deformation during loading, and the brittleness of the θ = 60?–90?specimens gradually increased during the loading process. When the anisotropic angle θincreased from 0?to 90?, the peak strength, peak strain,and apparent elastic modulus all decreased initially and then increased. The failure mode of the composite rock specimen during uniaxial loading can be divided into three categories:tensile fracture across the discontinuities(θ = 0?–30?), slid-ing failure along the discontinuities(θ = 45?–75?), and tensile-split along the discontinuities(θ = 90?). The axial strain of the weak and hard rock layers in the composite rock specimen during the loading process was significantly different from that of the θ = 0?–45?specimens and was almost the same as that of the θ = 60?–90?specimens. As for the strain localization highlighted in the maximum principal strain field, the θ = 0?–30?specimens appeared in the rock matrix approximately parallel to the loading direction,while in the θ =

关键词： Uniaxial compression tests on composite rock Anisotropy Elastic constant Failure mode 3D digital image correlation Acoustic emission Strain field

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Mathematical Model,Numerical Simulation and Convergence Analysis of a Semiconductor Device Problem with Heat and Magnetic Influences

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 302-319页

作者： Chang-feng li Yi-rang yuan Huai-ling SONG School of Economics Shandong UniversityJinan 250100China Institute of Mathematics Shandong UniversityJinan 250100China College of Mathematics and Econometrics Hunan UniversityChangsha 410082China

In this paper,the authors discuss a three-dimensional problem of the semiconductor device type involved its mathematical description,numerical simulation and theoretical *** important factors,heat and magnetic influences are *** mathematical model is formulated by four nonlinear partial differential equations(PDEs),determining four major physical *** influences of magnetic fields are supposed to be weak,and the strength is parallel to the *** elliptic equation is treated by a block-centered method,and the law of conservation is *** computational accuracy is improved one *** equations are convection-dominated,thus are approximated by upwind block-centered *** difference can eliminate numerical dispersion and nonphysical *** diffusion is approximated by the block-centered difference,while the convection term is treated by upwind ***,the unknowns and adjoint functions are computed at the same *** characters play important roles in numerical computations of conductor device *** the theories of priori analysis such as energy estimates,the principle of duality and mathematical inductions,an optimal estimates result is *** a composite numerical method is shown for solving this problem.

关键词： three-dimensional conductor device problem with heat and magnetic influences upwind blockcentered differences elemental conservation of mass numerical analysis

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NCAD v1.0: a database for non-coding variant annotation and interpretation

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Journal of Genetics and Genomics 2024年第2期51卷 230-242页

作者： Xiaoshu feng Sihan liu Ke li fengxiao Bu Huijun yuan Institute of Rare Diseases West China HospitalSichuan UniversityChengduSichuan 610044China

The application of whole genome sequencing is expanding in clinical diagnostics across various genetic disorders, and the significance of non-coding variants in penetrant diseases is increasingly being demonstrated. Therefore, it is urgent to improve the diagnostic yield by exploring the pathogenic mechanisms of variants in non-coding regions. However, the interpretation of non-coding variants remains a significant challenge, due to the complex functional regulatory mechanisms of non-coding regions and the current limitations of available databases and tools. Hence, we develop the non-coding variant annotation database (NCAD, http://***/), encompassing comprehensive insights into 665,679,194 variants, regulatory elements, and element interaction details. Integrating data from 96 sources, spanning both GRCh37 and GRCh38 versions, NCAD v1.0 provides vital information to support the genetic diagnosis of non-coding variants, including allele frequencies of 12 diverse populations, with a particular focus on the population frequency information for 230,235,698 variants in 20,964 Chinese individuals. Moreover, it offers prediction scores for variant functionality, five categories of regulatory elements, and four types of non-coding RNAs. With its rich data and comprehensive coverage, NCAD serves as a valuable platform, empowering researchers and clinicians with profound insights into non-coding regulatory mechanisms while facilitating the interpretation of non-coding variants.

关键词： Non-coding variants Annotation Variant interpretation Database

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Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： feng li yuan Yang Hua Yue Shuang Wang Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

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