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Recovery of Flavor Perception and Umami Taste Sensitivity in Young Chinese Adults Following SARS-CoV-2.Omicron Infection: A Case-Control Series

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Food Science and Human Wellness 2024年

作者： Yiwen Zhu Xiaoxiao Feng Yuxia Fan yin Zhang Ye Liu yuan Liu Department of Food Science & Technology， School of Agriculture & Biology， Shanghai Jiao Tong university Key Laboratory of Meat Processing of Sichuan， Chengdu university Beijing Engineering and Technology Research Center of Food Additives， School of Food and Health， Beijing Technology and Business university School of Food and Health， Beijing Technology and Business university

SARS-CoV-2. particularly the Omicron variant， often leads to flavor perception dysfunction in infected individuals， making a comprehensive understanding of its duration and recovery patterns a critical part of disease management. This study surveyed a cohort of 199 mildly-to-moderately affected SARS-CoV-2.Omicron-infected patients， focusing on the alterations in their olfaction， taste， and chemesthesis perception. Further， a subset of 36 participants (18 healthy and 18 infected) underwent sensory evaluations to check the variation of umami taste sensitivity. The results demonstrated that most of the infected cohort experienced chemosensory disorders， with the recovery period var{2.g between one week and over a month. Intriguingly， the severity of flavor perception changes during infection significantly correlated with the length of the recovery period. Furthermore， this study explored the specific manifestations of flavor perception dysfunction， potential contributing factors， and potential mechanistic explanations for chemosensory disorders. These include local damage， inflammatory responses， and virus-induced neural damage. However， this study revealed no significant change (P > 0.05) in umami taste sensitivity among infected patients 55 days post-infection. While this research faces limitations related to its self-reported， cross-sectional design， and regional focus， it offers valuable insights into the multifaceted impact of COVID-19， particularly the Omicron variant， on chemosensory perception.

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Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid

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Acta Pharmacologica Sinica 2006年第8期27卷 1078-1084页

作者： Jing-jing LI~2.Qiang TANG~2.{2. LI Ben-rong HU Zhang-yin MING Qin FU~3 Jia-qing QIAN Ji-zhou XIANG~3 Department of Pharmacology,Tongji Medical College,Huazhong {2. of Science and Technology,{2. 430030,china Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:The present study was designed to determine the possible pathway under-lying the enhancement of apoptosis induced by the combined use of arsenictrioxide(As2.3)and ascorbic acid(AA).Methods:The level of intracellular reac-tive oxygen species(ROS)was detected by means of flow cytometry analysis withan oxidation-sensitive fuorescent probe(6-carboxy-2.,7′dichlorodihydrofluoresceindiacetate)*** activity of glutathione(GSH),glutathione peroxidase(GPx),and superoxide dismutase(SOD)were detected by biochemical *** mitochondrial membrane potential was measured by flow cytometry analysiswith rhodamine 12. ***-2.Bax,and p17 subunit of caspase-3 were ana-lyzed using the Western blot *** apoptosis rate was determined by flowcytometry with annexin-V/propidium iodide ***:Compared withAs2.3(2.0 μmol/L)treated alone,As2.3(2.0 μmol/L)in combination with AA(100μmol/L)decreased intracellular GSH content from 101.30+5.76 to 81.91+3.12.mg/gprotein,and increased ROS level from 12..61+5.12.to 152.60+5.88,which was rep-resented by the 2.7-dichlorofluorescein *** loss of mitochondria mem-brane potential was increased from 12.9.97±36.11 to 1540.52.52.63,which waspresented by fluorescence *** p17 subunit of caspase-3 expressionwas increased approximately ***,SOD and GPx depletion and theratio of Bcl-2.to Bax were equal to that of As2.3treated alone(P>0.05).When theROS scavenger,N-acetyl-L-cysteine,was added to As2.3and AA combined treat-ment group,the apoptosis rate decreased from 15.60%±1.14% to 9.48%±0.67%,and the ROS level decreased from 152.60±5.88 to 102.77±***:AApotentiated As2.3-induced apoptosis through the oxidative pathway by increas-ing the ROS *** may be the result of depleting intracellular *** mayinfluence the downstream cascade following ROS,including mitochondria depo-larization and caspase-3 ***,SOD and GPx depletion and theratio of Bcl-2.to Bax influenced by

关键词： arsenic trioxide ascorbic acid hepatocellular carcinoma apoptosis glutathione reactive oxygen species

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Synthesis of Chiral Amino Cyclic Phosphoric Acids

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wuhan university Journal of Natural Sciences 2000年第4期5卷 497-499页

作者： Zhang Zhan, Hu quan-yuan, Deng Fa-da, Shu Jia-you, He Jian-she, Hu Xian-ming College of Chemistry and Environmental Science,{{2., wuhan 430072 College of Chemistry and Environmental Science Wuhan UniversityWuhan 430072

Chiral amino cyclic phosphoric acids, 5-amino-2.hydroxy-4-(4-nitrophenyl)-1,3,2.dioxaphosphorinane 2.oxide and 2.hydroxy-4-(4-methylsulfonylphenyl)-5-phthalimido-1,3,2.dioxaphos phorinane 2.oxide are synthesized in good over yields (64.2.and 72.8%respectively) from 2.amino-1-aryl-1,3-propanediols. The different reaction conditions are necessary in hydrolysis reactions of amino cyclic phosphonyl chlorides.

关键词： chiral amino cyclic phosphoric acid amino diols synthesis

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Confirmation of a natural hybrid species in Petrocosmea(Gesneriaceae) based on molecular and morphological evidence

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Journal of Systematics and Evolution 2011年第5期49卷 449-463页

作者： 1,3~Zhi-Jing QIU 2.Zu-Li yuan 1~Zhen-Yu LI 1~{2.-Zheng WANG 1(State Key Laboratory of Systematic and Evolutionary Botany,Institute of Botany,Chinese Academy of Sciences,Beijing 100093,{2.) 2.Henan Agricultural {2.,Zhengzhou 45002.{2.) 3(Graduate School of the Chinese Academy of Sciences,Beijing 100049,{2.) (State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences Beijing 100093 China) (Graduate School of the Chinese Academy of Sciences Beijing 100049 China) (Henan Agricultural university Zhengzhou 45002 China)

A natural hybrid species in Petrocosmea named Longianthera in Yanshan County,Yunnan Province is confirmed for the first time based on molecular and morphological *** character count procedure of the variable characters show that Longianthera populations are characteristic of the intermediate morphological traits between its putative parents Yanshan and Petrocosmea *** nuclear ribosomal internal transcribed spacer region and three chloroplast regions of matK,trnL-F,and trnT-L are sequenced in the putative hybrid and the related *** alignment of DNA sequences and the phylogenetic trees could exclude all the other species in Petrocosmea as the parental species except for Yanshan and *** haplotypes in the 31 internal transcribed spacer sequences and six haplotypes in 42.cpDNA sequences were found from 14 individuals of Longianthera *** analyses of DNA sequences,haplotypes,and phylogenetic trees indicate that Longianthera is likely a hybrid species between its putative parents Yanshan and ***,in which Yanshan might be the most possible maternal *** factors may contribute to the natural hybridization between these two parental species in Petrocosmea,such as the overlapped geographic distribution,habitats,flowering periods,and shared ***,the new species of Yanshan and the natural hybrid species of Longianthera are described.

关键词： chloroplast DNA Gesneriaceae ITS morphology natural hybridization Petrocosmea.

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Crystal　Structure　of　Calix［4］（dioxo）　crown－6　Acetonitrile（1：3）　Inclusion　Complex

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Chinese Journal of Structural Chemistry 1996年第5期15卷 358-361页

作者： ZHONG Zhen-Lin CHEN yuan-yin LU Xue-Ran(Department of Chemistry,{{2. {2.,{{2. 430072.LUO Bao-Sheng CHEN Liao-Rong(Center of Analytical Science,{{2. {2., {{2. 430072. 武汉大学化学系湖北武汉武汉大学分析测试中心湖北武汉

The X-ray crystal structure of the inclusion complex of p-tert-butylcalix [4] crown-6 with actonitrile is reported. C54H70O10·3CH3CN, Mr=1002. 3 ,monoclinic, space group C2.c with cell dimensions of a=2..587(7),b=2..153(6),c=15.608(8) A,β=116.99(3)°,V=6939.2.A3,Z=4, F(000)=2.60,Dc=0.959 g/cm3,μ=1.114 cm-1; R=0.088 for 2.66 reflections with I>3σ(I).The calixarene subunit exists in a distorted cone conformation. One of the three acetonitrile molecules is located in the intracavity of the calixarene subunit and the other two in the intermolecular channels.

关键词： crystal structure calixarene calixcrown acetonitrile inclusion complex

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A lithium–tin fluoride anode enabled by ionic/electronic conductive paths for garnet-based solid-state lithium metal batteries

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Rare Metals 2024年第2期43卷 575-587页

作者： Lei Zhang Qian-Kun Meng Xiang-Ping Feng Ming Shen Yu-Qing Zhang quan-Chao Zhuang Run-Guo Zheng Zhi-yuan Wang Yan-Hua Cui Hong-Yu Sun Yan-Guo Liu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao066004China School of Materials and Physics China University of Mining&TechnologyXuzhou221116China Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang621900China

The high energy density and stability of solid-state lithium metal batteries(SSLMBs)have garnered great ***-type oxides,especially Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12.(LLZTO),with high ionic conductivity,wide electrochemical window,and stability to Li metal anode,are promising solid-state electrolyte(SSEs)materials for ***,Li/LLZTO interface issues including high interface resistance,inhomogeneous Li deposition,and Li dendrite growth have hindered the practical application of ***,a multi-functional Li–SnF_(2. composite anode with Li,LiF,and Li-Sn alloy was specifically designed and *** composite anode improves the wettability to LLZTO,constructing an intimate contact interface between it and ***,ionic/electronic conductive paths in situ formed at the interface can effectively uniform Li deposition and suppress Li *** solid-state symmetric cell exhibits low interface resistance(11Ω·cm^(2.) and high critical current density(1.3 mA·cm^(−2.)at 2.℃.The full SSLMB based on LiFePO_(4) or LiNi_(0.5)Co_(0.2.Mn_(0.3)O_(2. cathode also shows stable cycling performance and high rate *** work provides a new composite anode strategy for achieving high-energy density and high-safety SSLMBs.

关键词： Solid-state lithium metal batteries(SSLMBs) Lithium-tin fluoride anode Ionic/electronic conductive Interface resistance Lithium dendrite

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Structure,ligands,and roles of GPR12./ADGRG6 in the development and diseases

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Genes & Diseases 2024年第1期11卷 294-305页

作者： Qi Li Anran Huo Mengqi Li Jiali Wang Qiao yin Lumiao Chen Xin Chu yuan Qin Yuwan Qi Yang Li Hengxiang Cui Qifei Cong Institute of Neuroscience and Jiangsu Key Laboratory of Neuropsychiatric Diseases Soochow UniversitySuzhouJiangsu215123China Department of Neurology and Clinical Research Center of Neurological Disease The Second Affliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Nephrology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215004China Department of Emergency Center The Second Affiliated Hospital of Nantong UniversityNantongJiangsu226001China Department of Neurology Huzhou Central HospitalThe Affiliated Huzhou HospitalZhejiang University School of MedicineHuzhouZhejiang 313000China Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China

Adhesion G protein-coupled receptors(aGPCRs)are the second largest diverse group within the GPCR superfamily,which play critical roles in many physiological and patho-logical processes through cell-cell and cell-extracellular matrix *** adhesion GPCR Adgrg6,also known as GPR12.,is one of the better-characterized ***12. was previously found to have critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system in both zebrafish and *** studies have extended our understanding of GPR12.-mediated roles during develop-ment and in human *** this review,we highlighted these recent advances in GPR12. in expression profile,molecular structure,ligand-receptor interactions,and associated physiological and pathological functions in development and diseases.

关键词： Adhesion G protein-coupled receptor Function GPR12./Adgrg6 Ligand Structure

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I-DCGAN and TOPSIS-IFP:A simulation generation model for radiographic flaw detection images in light alloy castings and an algorithm for quality evaluation of generated images

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china Foundry 2024年第3期21卷 239-247页

作者： Ming-jun Hou Hao Dong Xiao-yuan Ji Wen-bing Zou Xiang-sheng Xia Meng Li Ya-jun yin Bao-hui Li Qiang Chen Jian-xin Zhou State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China Xinjiang Technology(Jiangsu)Co. Ltd.Nantong 226100JiangsuChina Southwest Technique and Engineering Research Institute Chongqing 400039China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy ***,the efficacy of deep learning models hinges upon a substantial abundance of flaw *** existing research on X-ray image augmentation for flaw detection suffers from shortcomings such as poor diversity of flaw samples and low reliability of quality *** this end,a novel approach was put forward,which involves the creation of the Interpolation-Deep Convolutional Generative Adversarial Network(I-DCGAN)for flaw detection image generation and a comprehensive evaluation algorithm named TOPSIS-IFP.I-DCGAN enables the generation of high-resolution,diverse simulated images with multiple appearances,achieving an improvement in sample diversity and quality while maintaining a relatively lower computational ***-IFP facilitates multi-dimensional quality evaluation,including aspects such as diversity,authenticity,image distribution difference,and image distortion *** results indicate that the X-ray radiographic images of magnesium and aluminum alloy castings achieve optimal performance when trained up to the 800th and 600th epochs,*** TOPSIS-IFP value reaches 78.7%and 73.8%similarity to the ideal solution,*** to single index evaluation,the TOPSIS-IFP algorithm achieves higher-quality simulated images at the optimal training *** approach successfully mitigates the issue of unreliable quality associated with single index *** image generation and comprehensive quality evaluation method developed in this paper provides a novel approach for image augmentation in flaw recognition,holding significant importance for enhancing the robustness of subsequent flaw recognition networks.

关键词： light alloy casting flaw detection image generator discriminator comprehensive evaluation index

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Efficacy of physiological seawater nasal irrigation for the treatment of children with SARS-CoV-2.Omicron BA.2.variant infection:a randomized controlled trial

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World Journal of Pediatrics 2024年第5期20卷 461-469页

作者： Ji-Lei Lin Fen Zhang Yan-Bo Li Shu-Hua yuan Jin-Hong Wu Jing Zhang Lei Zhang Yi He Jie Chen Yong yin Department of Respiratory Medicine Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang RoadPudong DistrictShanghaiChina university of British Columbia VancouverCanada Information Technology Department Shanghai Children’s Medical Center National Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang RoadPudong DistrictShanghaiChina Department of Otorhinolaryngology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang RoadPudong DistrictShanghaiChina Department of Respiratory Medicine Sanya Women and Children’s Hospital Affiliated to Hainan Medical CollegeHainan Branch of Shanghai Children’s Medical CenterSanyaChina Department of Respiratory Medicine Linyi Maternal and Child Healthcare HospitalLinyiChina Shanghai Children’s Medical Center Pediatric Medical Complex(Pudong) ShanghaiChina Pediatric AI Clinical Application and Research Center Shanghai Children’s Medical CenterShanghaiChina

Background Saline nasal irrigation is an effective therapy for relieving common cold *** study aimed to investigate and explore the efficacy of physiological seawater nasal irrigation(PSNI)on children with mild and asymptomatic infection with *** This randomized controlled trial was conducted in Shanghai,china,and 403 children with mild and asymptomatic infection with Omicron were *** children were allocated into the PSNI group and the control *** primary outcome was the duration of viral shedding(DVS),and the secondary outcome was the change in clinical *** The median age of all participants was 5.59(6.2.)years *** DVS was significantly shorter in the PSNI group[2.40(1.13)]than in the control group[3.09(2.14)](P=0.014).The multivariable Cox regression model also showed that patients in the PSNI group had an increased probability of shorter DVS compared with patients in the control group[hazard ratio(HR),1.2.;95%confidence interval(CI),1.04–1.55;P=0.017].Subgroup analysis suggested that the DVS of patients without full vaccination was significantly reduced in the PSNI *** proportions of runny nose and stuffy nose were apparently reduced in the first three days in the PSNI group or the control group,but there was no evidence showing that PSNI contributes to the benefit compared with the control *** PSNI can reduce the DVS of patients with mild and asymptomatic infection with SARS-CoV-2.Omicron BA.2.variant.

关键词： Children Duration of viral shedding Omicron Physiological seawater nasal irrigation

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Fibroblast-localized lncRNA CFIRL promotes cardiac fibrosis and dysfunction in dilated cardiomyopathy

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Science china(Life Sciences) 2024年第6期67卷 1155-1169页

作者： Shuai yuan Xudong Zhang Jiabing Zhan Rong Xie Jiahui Fan Beibei Dai Yanru Zhao Zhongwei yin Qian Liu Dao Wen Wang Huaping Li Chen Chen Division of Cardiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders Wuhan 430030China Department of Forensic Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

CFIRL is a long noncoding RNA(lnc RNA),we previously identified as the most significantly upregulated lnc RNA in the failing hearts of patients with dilated cardiomyopathy(DCM).In this study,we determined the function of CFIRL and its role in ***-time polymerase chain reaction and in situ hybridization assays revealed that CFIRL was primarily localized in the nucleus of cardiac fibroblasts and robustly increased in failing *** knockdown or fibroblast-specific knockout of CFIRL attenuated transverse aortic constriction(TAC)-induced cardiac dysfunction and fibrosis in *** of CFIRL in vitro promoted fibroblast proliferation and aggravated angiotensin II-induced differentiation to *** knockdown attenuated these ***,RNA pull-down assay and gene expression profiling revealed that CFIRL recruited ENO1,a newly identified noncanonical transcriptional factor,to activate ***-6 exerted a paracrine effect on cardiomyocytes to promote cardiac hypertrophy,which can be prevented by CFIRL *** findings uncover the critical role of CFIRL,a fibroblast-associated lnc RNA,in heart failure by facilitating crosstalk between fibroblasts and *** knockdown might be a potent strategy to prevent cardiac remodeling in heart failure,particularly in DCM.

关键词： lncRNA fibroblast fibrosis dilated cardiomyopathy heart failure

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