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无锡市Omicron毒株引起的新型冠状病毒感染者相关持续症状的特征及其影响因素

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中华疾病控制杂志 2024年第2期28卷 221-227页

作者：詹星雅刘娟冀斌沈元南京医科大学公共卫生学院流行病学系南京211166 南京医科大学附属无锡疾病预防控制中心急性传染病防制科无锡214023

目的探究Omicron毒株引起的新型冠状病毒感染(新冠感染)者康复后3~4个月存在相关持续症状的特征及其影响因素,为制定随访计划、减少感染后相关持续症状提供依据。方法采用自编的躯体与精神神经症状量表、患者健康问卷(patient health qu... 详细信息

目的探究Omicron毒株引起的新型冠状病毒感染(新冠感染)者康复后3~4个月存在相关持续症状的特征及其影响因素,为制定随访计划、减少感染后相关持续症状提供依据。方法采用自编的躯体与精神神经症状量表、患者健康问卷(patient health questionnaire,PHQ-9)、压力知觉量表(Chinese perceived stress scale,CPSS)、焦虑量表(generalised anxiety disorder scale,GAD-7)和自编的疾病污名化量表进行调查。采用Mann-Whitney U检验、Kruskal-Wallis H检验、χ^(2)检验和二元logistic回归分析模型分析。结果有50.7%的受访者在康复后3~4个月存在相关持续症状,共报告躯体与精神神经症状47种,疲劳乏力是最常见的躯体症状(50.5%),失眠是最常见的精神神经症状(24.3%),抑郁和焦虑均与躯体或精神神经症状伴随出现。女性(β=0.70,OR=2.01,95%CI:1.04~3.86,P=0.037)、隔离期间存在临床症状(β=0.78,OR=2.17,95%CI:1.13~4.20,P=0.021)、中高压力(β=1.68,OR=5.35,95%CI:2.14~13.38,P<0.001)、严重污名化(β=1.03,OR=2.79,95%CI:1.33~5.83,P=0.006)是新冠感染者出院3~4个月后存在持续症状的危险因素。结论部分新冠感染者康复后3~4个月时仍存在相关持续症状。重点关注可能出现相关持续症状的高风险人群,并同时在医疗保健和精神心理卫生方面给予支持。

关键词：新型冠状病毒感染 Omicron毒株持续症状影响因素

水稻SPL家族转录因子的生物学功能研究进展

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中国水稻科学 2024年第3期38卷 223-232页

作者：胡丽杨范敏陈薇兰袁华四川开放大学农林卫生学院成都610073 四川农业大学水稻研究所/西南作物基因资源挖掘与利用国家重点实验室成都611130

SPL(SQUAMOSAPROMOTER-BINDINGPROTEIN-LIKE)家族蛋白是植物特有的一类多功能转录因子。水稻中有19个OsSPL基因,所编码蛋白均含有一个高度保守的SBP结构域,该结构域负责与下游靶基因的核心基序GTAC结合,调控靶基因表达。OsSPL的表达会受... 详细信息

SPL(SQUAMOSAPROMOTER-BINDINGPROTEIN-LIKE)家族蛋白是植物特有的一类多功能转录因子。水稻中有19个OsSPL基因,所编码蛋白均含有一个高度保守的SBP结构域,该结构域负责与下游靶基因的核心基序GTAC结合,调控靶基因表达。OsSPL的表达会受到OsmiR156/529/535和多种因子调控。研究表明OsSPL在水稻根系发育、叶舌叶耳发育、株型和穗型形成、籽粒发育和胁迫响应等多个生物学过程中发挥重要作用,是水稻生长发育的调控枢纽。本文综述了水稻OsSPL家族的系统进化与结构特征、表达调控及生物学功能研究进展,并对其研究前景进行了展望。

关键词： OsSPL 转录因子 OsmiR156 表达调控生物学功能

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由超拍电子伏特加速器产生的超高能伽马射线气泡

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Science Bulletin 2024年第4期69卷 449-457页

作者： LHAASO Collaboration Zhen Cao Chuandong Gao Cong Li Ruo-yu Liu Ruizhi yang 不详 Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China TIANFU Cosmic Ray Research Center ChengduChina Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China University of Science and Technology of China Hefei 230026China

We report the detection of aγ-ray bubble spanning at least 100deg2 in ultra-high energy(UHE)up to a few PeV in the direction of the star-forming region Cygnus X,implying the presence super PeVatron(s)accelerating protons to at least 10 PeV.A log-parabola form with the photon indexΓ(E)=(2.71±0.02)+(0.11±0.02)×log10(E/10 TeV)is found fitting the gamma-ray energy spectrum of the bubble *** sources,“hot spots”correlated with very massive molecular clouds,and a quasi-spherical amorphousγ-ray emitter with a sharp central brightening are observed in the *** the core of~0.5°,spatially associating with a region containing massive OB association(Cygnus OB2)and a microquasar(Cygnus X-3),as well as previously reported multi-TeV sources,an enhanced concentration of UHEγ-rays is observed with 2 photons at energies above 1 *** general feature of the bubble,the morphology,and the energy spectrum,are reasonably reproduced by the assumption of a particle accelerator in the core,continuously injecting protons into the ambient medium.

关键词： Cosmic rays γ-rays Interstellar medium Star cluster

Research on dual-command operation path optimization based on Flying-V warehouse layout

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High Technology Letters 2023年第4期29卷 388-396页

作者：刘建胜 yuan Bin yANG Zan ZHONG RAy y School of Advanced Manufacturing Nanchang UniversityNanchang 330031P.R.China Department of Industrial and Manufacturing Systems Engineering University of Hong KongHong Kong 999077P.R.China

To enhance the efficiency of warehouse order management,this study investigates a dual-com-mand operation mode in the Flying-V non-traditional warehouse *** dual-command opera-tion strategies are designed,and a dual-command operation path optimization model is established with the shortest path as the optimization ***,a genetic algorithm based on a dynamic decoding strategy is *** results demonstrate that the Flying-V layout warehouse management and access cooperation operation can reduce the operation time by an average of 25%-35%compared with the single access operation path,and by an average of 13%-23%compared with the‘deposit first and then pick’operation *** findings provide evidence for the effec-tiveness of the optimization model and algorithm.

关键词： Flying-V access collaboration path optimization dynamic decoding genetic al-gorithm

Islet separation and islet cell culture in vitro from human embryo-pancreas

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World Journal of Gastroenterology 1999年第5期5卷 458-460页

作者： yuan Z Wu Gy He yS Shao CM Zhan y Kunming Med Coll Dept Histol & Embryol Kunming 650031 Yunnan Province Peoples R China First Affiliated Hosp Kunming Med Coll Dept Nucl Med Kunming 650032 Yunnan Province Peoples R China Kunming Med Coll Dept Biol Kunming 650031 Yunnan Province Peoples R China

INTRODUCTIONDiabetes mellitus is the most common disease and its death rate ranks the 8th in the world. Up to now, its incidence has a tendency to increase[1]. Since disorder of sugar metabolism might result in microvascular degeneration and injury of important human organs, it will endanger human health seriously. In 1969, younszai first reported the method that could decrease diabetes symptoms by islet tissue transplantation. In 1981, our country began to treat diabetes type Ⅰ by transplanting cultured islet tissues. In our study, we digested the pieces of pancreas with collagenase and made morphological observation on islet cells cultured for 3d, 5d, 7d, 9d and 13d respectively, and the contents of insulin and C-peptide in the supernatant were detected by radioimmunoassay. The experimental model of rabbit diabetes was established, and certain curative effect was achieved in the treatment of experimental diabetes in rats.

关键词： cell culture islet cell islets of langerhans transplantetion pancreas/ embryology

Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients:An Open-Label,Multicenter,and Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第8期30卷 675-683页

作者： HE Qiu LIN Fu-xin SU Jin-ye ZHUO Ling-yunn ZHU Qing SUN Xiao-chuan JIANG Rong-cai yAO Zhi-gang WANG Lei DANG yan-wei LIU De-zhong LIU yang FANG Wen-hua WANG Fang-yu LIN yuan-xiang WANG An-xin WANG Deng-liang KANG De-zhi Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated HospitalFujian Medical UniversityFuzhou350209China Clinical Research and Translation Center The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou350004China Department of Neurosurgery The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu Province215000China Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing400000China Department of Neurosurgery Tianjin Medical University General HospitalTianjin300000China Department of Neurosurgery The Third Hospital of ShijiazhuangShijiazhuang050000China Department of Neurosurgery The First College of Clinical Medical ScienceChina Three Gorges UniversityYichangHubei Province443000China Department of Neurosurgery Yichang Central People’s HospitalYichangHubei Province443000China Department of Neurosurgery Xiangyang No.1 People’s Hospital Affiliated to Hubei University of MedicineXiangfanHubei Province441100China Department of Neurosurgery Zhoukou Central HospitalZhoukouHenan Province466000China Department of Neurosurgery The Third Hospital of MianyangMianyangSichuan Province621000China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing100000China Department of Clinical Epidemiology and Clinical Trial Capital Medical UniversityBeijing100000China Beijing Municipal Key Laboratory of Clinical

Objective To investigate whether Naoxueshu Oral Liquid(NXS)could promote hematoma absorption in post-craniotomy hematoma(PCH)*** This is an open-label,multicenter,and randomized controlled trial conducted at 9 hospitals in *** aged 18–80 years with post-craniotomy supratentorial hematoma volume ranging from 10 to 30 mL or post-craniotomy infratentorial hematoma volume less than 10 mL,or intraventricular hemorrhage following cranial surgery were *** were randomly assigned at a 1:1 ratio to the NXS(10 mL thrice daily for 15 days)or control groups using a randomization code *** medical care was administered in both *** primary outcome was the percentage reduction in hematoma volume from day 1 to day *** secondary outcomes included the percentage reduction in hematoma volume from day 1 to day 7,the absolute reduction in hematoma volume from day 1 to day 7 and 15,and the change in neurological function from day 1 to day 7 and *** safety was closely monitored throughout the ***,subgroup analysis was performed based on age,gender,history of diabetes,and etiology of intracerebral hemorrhage(ICH).Results A total of 120 patients were enrolled and randomly assigned between March 30,2018 and April 15,*** patient was lost to follow-up in the control ***,there were 119 patients(60 in the NXS group and 59 in the control group)included in the *** the full analysis set(FAS)analysis,the NXS group had a greater percentage reduction in hematoma volume from day 1 to day 15 than the control group[median(Q1,Q3):85%(71%,97%)vs.76%(53%,93%),Py outcomes showed no statistical significance between two groups,either in FAS or per-protocol set(P>0.05).Furthermore,no adverse events were reported during the *** the FAS analysis,the NXS group exhibited a higher percentage reduction in hematoma volume on day 15 in the following subgroups:male patients,patients younger than 65 yea

关键词： post-craniotomy hematoma Naoxueshu Oral Liquid hematoma absorption randomized controlled trial Chinese medicine

Timoshenko beam model for chiral materials

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Acta Mechanica Sinica 2018年第3期34卷 549-560页

作者： T.y.Ma y.N.Wang L.yuan J.S.Wang Q.H.Qin Department of Mechanics Tianjin University School of Engineering Deakin University Research School of Engineering Australian National University

Natural and artificial chiral materials such as deoxyribonucleic acid （DNA）, chromatin fibers, flagellar filaments, chiral nanotubes, and chiral lattice materials widely exist. Due to the chirality of intricately helical or twisted microstructures, such materials hold great promise for use in diverse applications in smart sensors and actuators, force probes in biomedical engineering, structural elements for absorption of microwaves and elastic waves, etc. In this paper, a Timoshenko beam model for chiral materials is developed based on noncentrosymmetric micropolar elasticity theory. The governing equations and boundary conditions for a chiral beam problem are derived using the variational method and Hamilton＇s principle. The static bending and free vibration problem of a chiral beam are investigated using the proposed model. It is found that chirality can significantly affect the mechanical behavior of beams, making materials more flexible compared with nonchiral counterparts, inducing coupled twisting deformation, relatively larger deflection, and lower natural frequency. This study is helpful not only for understanding the mechanical behavior of chiral materials such as DNA and chromatin fibers and characterizing their mechanical properties, but also for the design of hierarchically structured chiral materials.

关键词： Timoshenko beam model Chiral material Chirality Deflection Microrotation

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采空区瓦斯治理技术及治理效果分析

山西冶金 2024年第3期47卷 214-216页

作者：袁帅山西焦煤霍州煤电店坪煤矿山西吕梁033102

店坪煤矿204工作面回采期间架后采空区150 m范围内瓦斯浓度高达4.7%,导致工作面上隅角、架间间隙以及工作面内瓦斯严重超限现象,制约着工作面安全高效回采。店坪煤矿通过技术研究,对204工作面采空区瓦斯超限原因进行合理分析,布置采空... 详细信息

店坪煤矿204工作面回采期间架后采空区150 m范围内瓦斯浓度高达4.7%,导致工作面上隅角、架间间隙以及工作面内瓦斯严重超限现象,制约着工作面安全高效回采。店坪煤矿通过技术研究,对204工作面采空区瓦斯超限原因进行合理分析,布置采空区埋管+高位裂隙带钻孔+顺煤层长短孔,并采取y型通风等联合瓦斯治理技术。实际应用表明,采取联合瓦斯治理技术后,工作面在后期回采中架后采空区瓦斯浓度控制在1.0%以下,上隅角及工作面未出现瓦斯超限现象,取得了显著的应用成效。

关键词：综采工作面采空区瓦斯超限原因治理技术效果分析

基于学科评估指标体系和一流专业考核指标体系的学科专业一体化建设研究

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科教文汇 2024年第5期 6-9页

作者：陈媛河南科技大学外国语学院河南洛阳471000

学科建设与专业建设的协同是适应新一轮工业革命、培养高素质创新型人才的必然要求。该文以“双一流”高校建设目标为出发点,基于学科评估指标体系和一流专业指标观测点,从师资队伍、课程建设、科技创新、社会服务等方面分析专业建设与... 详细信息

学科建设与专业建设的协同是适应新一轮工业革命、培养高素质创新型人才的必然要求。该文以“双一流”高校建设目标为出发点,基于学科评估指标体系和一流专业指标观测点,从师资队伍、课程建设、科技创新、社会服务等方面分析专业建设与学科建设的关系,提出专业建设与学科建设相融合的建议,促进教师自觉承担学科建设与专业建设的双重责任,全面提升“双一流”建设的质量与效益。

关键词：学科建设专业一体化人才培养