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Discovery potential of the Glashow resonance in an air shower neutrino telescope

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Chinese Physics C 2024年第8期48卷 266-275页

作者： Guo-yuan Huang School of Mathematics and Physics China University of GeosciencesWuhan 430074China Max-Planck-Institut für Kernphysik Saupfercheckweg 169117 HeidelbergGermany

The in-ice or in-water Cherenkov neutrino telescope,such as IceCube,has already proved its power in measuring the Glashow resonance by searching for the bump around E_(ν)=6.3PeV arising from the W-boson *** are many proposals for the next few decades for observations of cosmic tau neutrinos with extensive air showers,also known as tau neutrino *** air shower telescope is,in principle,sensitive to the Glashow resonance via the channel W→τν_(τ)followed by the tau decay in the air(e.g.,TAMBO,which has a geometric area of approximately 500km^(2)).Using a thorough numerical analysis,we find that the discovery significance can be up to 90%with a TAMBO-like setup if PeV neutrinos primarily originate from neutron decays,considering the flux parameters measured by IceCube as the *** presence of new physics affecting the neutrino flavor composition can also increase the ***,if ultrahigh-energy neutrinos are dominantly produced from meson decays,it will be statistically difficult for an advanced proposal such as TAMBO to discriminate the Glashow resonance induced byν¯e from the intrinsicντ/ν¯_(τ)*** have identified several limitations for such advanced telescopes,in comparison with the in-ice or in-water telescope,when measuring resonances:(i)a suppressed branching ratio of 11%for the decay W→τν_(τ);(ii)the smearing effect and reduced acceptance because the daughter neutrino takes away(y)∼75%of the energy from the W decay;and(iii)a large attenuation effect for Earth-skimming neutrinos with the resonance.

关键词： Ultrahigh-energy neutrinos Neutrino telescopes Glashow resonance

Macrocyclic trichothecenes from Myrothecium verrucaria PA 57 and their cytotoxic activity

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Chinese Journal of Natural Medicines 2024年第9期22卷 854-863页

作者： MO J. TAN y. AI W. LI y. yuan y. JIANG y. XU K. TAN G. WANG W. LI J. LIU S. Department of Pharmacy National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha 410008 China Xiangya School of Pharmaceutical Sciences Central South University Changsha 410008 China

Four novel macrocyclic trichothecenes, termed mytoxins D−G (1−4), along with four known analogs (5−8), were isolated from the ethyl acetate extract of fermented rice inoculated with the fungus Myrothecium verrucaria PA57. Each compound features a tricyclic 12,13-epoxytrichothec-9-ene (EPT) core. Notably, mytoxin G (4) represents the first instance of a macrocyclic trichothecene incorporating a glucosyl unit within the trichothecene structure. The structures of the newly identified compounds were elucidated through comprehensive spectroscopic analysis combined with quantum chemical calculations. All isolated compounds demonstrated cytotoxic activity against the CAL27 and HCT116 cell lines, which are models for human oral squamous cell carcinoma and colorectal cancer, respectively. Specifically, mytoxin D (1) and mytoxin F (3) exhibited pronounced cytotoxic effects against both cancer cell lines, with IC50 values ranging from 3 to 6 nmol·L−1. Moreover, compounds 1 and 3 were found to induce apoptosis in HCT116 cells by activating caspase-3. © 2024 China Pharmaceutical University

关键词： Cytotoxicity Macrocyclic trichothecenes Myrothecium verrucaria Secondary metabolite Soil fungi

Interface structure of α-Mg/14H-LPSO:First-principles prediction and experimental study

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Journal of Rare Earths 2024年第9期42卷 1792-1799,I0006页

作者： yuan Shi Xiaohua Zhang Hongyan yue Chao Li School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin150040China

The interfacial structure of the α-Mg/14H-LPSO phase in rare earth-including magnesium alloy was investigated via high-angle annular dark-field scanning transmission electron microscopy(HAADFSTEM) imaging and first-principles calculations of density-functional *** possible interfacial models were constructed according to the different terminations of the LPSO phase,and the corresponding interfacial energies were calculated,from which the four most stable structures(Terl-Mgy-hollow,Ter2-Zn-hollow,Ter3-MgyII-hollow and Ter4-Mg-bridge) were *** interfacial phase diagrams related to the y chemical potentials were obtained from the calculations,and the most stable interfacial structure was ***-Mgy-hollow and Ter2-Zn-hollow have the lowest interfacial energies in the range of-0.7 eV <Δμγ<-0.6 eV,where fluctuating change of state is the minimized and the interface is the most *** separation work of the two models was calculated to predict the bonding strength of the structures at both ends of the *** calculation results show that the maximum interfacial separation work is 1.45 J/m^(2) for the interface model of α-Mg and 14H-LPSO phase structure with Ter2-Zn-hollow termination.

关键词： Rare earths Magnesium alloy HAADF-STEM LPSO First-principles Interface

Biological soil crusts and their potential applications in the sand land over Qinghai-Tibet Plateau

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Research in Cold and Arid Regions 2024年第1期16卷 20-29页

作者： yuan Zhang BenLi Liu Key Laboratory of Desert and Desertification/Research Station of Gobi Desert Ecology and Environment in Dunhuang of Gansu Province(Dunhuang) Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouGansu 730000China University of Chinese Academy of Sciences Beijing 100049China Academy of Plateau Science and Sustainability Qinghai Normal UniversityXiningQinghai 810008China

The Qinghai-Tibet Plateau is now experiencing ecological degradation risks as a result of climate change and human *** alpine grassland ecology in permafrost zones is fragile and susceptible to deterioration due to its high altitude,low temperature,and limited oxygen,which complicates the repair of damaged *** soil crusts(BSCs)are crucial for land restoration in plateau regions because they can thrive in harsh conditions and have environmentally beneficial *** biological soil crust(IBSC)has shown success in low-altitude desert regions,but may not be easily duplicated to the plateau ***,it is essential to do a comprehensive and multifaceted analysis of the basic theoretical comprehension and practical application of BSCs on the Tibetan *** review article aims to provide a brief summary of the ecological significance and the mechanisms related to the creation,growth,and progression of *** discusses the techniques used for cultivating BSCs in laboratories and using them in the field,focusing on the Qinghai-Tibet Plateau *** thoroughly discussed the potential and the required paths for further *** study may be used as a basis for selecting suitable microbial strains and accompanying supplemental actions for implementing IBSCs in the Qinghai-Tibet Plateau.

关键词： Biological soil crusts Qinghai-Tibet Plateau Alpine sand areas Inoculated biological soil crusts technology Algae Cyanobacteria

Fractal Characteristics and Main Controlling Factors of High-Quality Tight Sandstone Reservoirs in the Southeastern Ordos Basin

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Journal of Earth Science 2024年第2期35卷 631-641页

作者： Ruilin Hao Wenhui Huang Jiu Bo Li yuan Key Laboratory for Marine Reservoir Evolution and Hydrocarbon Abundance Mechanism School of Energy ResourcesChina University of GeosciencesMinistry of EducationBeijing100083China

Due to the complex conditions and strong heterogeneity of tight sandstone reservoirs,the reservoirs should be classified and the controlling factors of physical properties should be *** thin section observations,cathodoluminescence,scanning electron microscopy(SEM),X-ray diffraction(XRD),and high-pressure mercury injection(HPMI)were used to classify and optimize the *** Brooks-Corey model and stepwise regression were used to study the fractal dimension and main controlling factors of the physical properties of the high-quality *** results show that the reservoirs in the study area can be divided into four types,and the high-quality reservoir has the best physical properties and pore-throat *** the high-quality reservoir,the homogeneity of transitional pores was the best,followed by that of micropores,and the worst was *** porosity was controlled by depth and *** model with standardized coefficients is y=12.454−0.778×(Depth)+0.395×(Kaolinite).The permeability was controlled by depth,illite/montmorillonite,and siliceous cement,and the model with standardized coefficients is y=1.689−0.683×(Depth)−0.395×(Illite/Montmorillonite)−0.337×(Siliceous Cement).The pore-throat evolutionary model shows that the early-middle diagenetic period was when the reservoir physical properties were at their best,and the kaolinite intercrystalline pores and residual intergranular pores were the most important.

关键词： fractal dimension main controlling factors stepwise regression high-quality tight sandstone reservoir Ordos Basin petroleum geolgoy

Stabilization or degradation?Post-translational modifications of JAZ proteins in plants

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Molecular Plant 2024年第7期17卷 1002-1004页

作者： Xiaoyan Xu Jianping Hu Zheng yuan Joint International Research Laboratory of Metabolic&Developmental Sciences School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai200240China Department of Energy Plant Research Laboratory and Plant Biology Department Michigan State UniversityEast LansingMI 48824USA

Jasmonates(JAs)are essential hormones that regulate plant responses to biotic and abiotic stresses and are involved in various developmental processes,including flowering time control,floral organ development,and fertility of male and female gametes(Howe et al.,2018).However,our understanding of the mechanisms by which JAs integrate multiple signals to regulate diverse physiological processes remains *** the canonical JA signaling pathway,activated JAs are perceived by the F-box protein receptor CORONATINE INSENSITIVE 1(COl1),which induces the interaction between COl1 and the Jas domain of the repressor proteins JASMONATE-ZIM DOMAIN PROTEINs(JAZs),leading to the ubiquitination and degradation of JAZ *** proteolytic destruction of the JAZ repressors is a crucial step that releases the inhibition of JAZs on the JA response transcription factor MyC2,allowing MyC2 to activate the expression of downstream genes(Howe et al.,2018).Therefore,the stability and specific spatiotemporal expression pattern of the JAZ proteins are critical for the regulation of JA signaling output,as they determine the activation and repression of JA responses.

关键词： translational fertility release

Determination of global geodetic parameters using satellite laser ranging to Galileo,GLONASS,and BeiDou satellites

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Satellite Navigation 2024年第1期5卷 240-257页

作者： Xingxing Li Jiaqing Lou yongqiang yuan Jiaqi Wu Keke Zhang School of Geodesy and Geomatics Wuhan University129 Luoyu RoadWuhan430079HubeiChina

The new Global Navigation Satellite System(GNSS)satellites,including GLONASS,Galileo,and BeiDou system,are equipped with Laser Retroreflector Arrays(LRA)to support Satellite Laser Ranging(SLR)tracking,which contributes to the estimation of global geodetic *** this study,we estimate the global geodetic parameters using the SLR observations to GNSS satellites and also investigate the effects of different data processing strategies on the estimated Earth Rotation Parameters(ERP),geocenter motion,and terrestrial *** results indicate that setting range bias parameters for each satellite-station pair can effectively account for the satellite-specific biases induced by LRAs,leading to smaller Root Mean Square Errors(RMSE)of the post-fit SLR ***,estimating the range biases for each satellite-station pair improves the accuracy of the estimated station coordinates and *** also examine the impact of different arc lengths on the estimates of ERP,geocenter motion,and terrestrial *** results show that extending arc length can significantly reduce the formal error of *** 7-day strategy produces the smallest RMSEs of 473 microarcseconds and 495 microarcseconds for the estimated X-and y-component of pole coordinates,and 52 microseconds for length-of-day,***,the estimated geocenter motion is less affected by the arc length,even the shortest 1-day arc strategy can capture the seasonal variations of geocenter motion in Z *** scale estimation,extending the arc length notably improves the accuracy of the estimated station coordinates and scale,but this advantage becomes less noticeable in longer *** 7-day solution also obtains the closet scale results compared to ITRF2014,with the RMSE of 2.10×10^(–9).

关键词： Satellite laser ranging GNSS Geodetic parameters Earth rotation parameters Geocenter motion Terrestrial scale

Self-assembled all-oxides three-phase vertically aligned nanocomposite thin film with multifunctionality

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Nano Research 2024年第9期17卷 8226-8232页

作者： Jijie Huang yuan Fang Ping Lu Juanjuan Lu Haiyan Wang School of Materials Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China School of Materials Engineering Purdue UniversityWest LafayetteIN 47907USA Sandia National Laboratories AlbuquerqueNew Mexico 87185USA School of Electrical and Computer Engineering Purdue UniversityWest LafayetteIN 47907USA

Multi-phase vertically aligned nanocomposite(MP-VAN)thin films represent a promising avenue for achieving complex multifunctionality,exploring novel interfacial phenomena,and enabling complex metamaterial designs and *** this study,a novel self-assembled all-oxides three-phase VAN system was conceptualized and fabricated utilizing pulsed laser deposition(PLD)with a single composite *** microstructural analysis reveals the presence of three distinct phases:LiNbO_(3),CeO_(2-x),and LiNbCe_(1-x)O_(y)within the MP-VAN ***,ferroelectric,dielectric,optical anisotropy,and magnetic properties were systematically investigated to showcase the multifunctionality inherent in these *** work presents a pioneering approach to designing and realizing MP-VAN systems,and opens up opportunities for tailoring the complex three-dimensional(3D)physical properties and property coupling of VAN films towards diverse device applications.

关键词： thin film three-phase vertically aligned nanocomposite multifunctionality ferroelectricity optical anisotropy

CSCO guidelines for colorectal cancer version 2024:Updates and discussions

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Chinese Journal of Cancer Research 2024年第3期36卷 233-239页

作者： Liubo Chen Hanguang Hu ying yuan Shanshan Weng Department of Medical Oncology(Key Laboratory of Cancer Prevention and Intervention China National Ministry of EducationKey Laboratory of Molecular Biology in Medical SciencesZhejiang ProvinceChina)the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Zhejiang Provincial Clinical Research Center for CANCER Hangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China

According to the latest global cancer statistics,colorectal cancer(CRC)is the most common malignancy of the digestive system and the second most lethal among all cancer types(1).In China,CRC is the second most prevalent cancer,following only after lung cancer(2).The first version of the Chinese Society of Clinical Oncology(CSCO)guideline was launched in 2017 and has been updated annually based on the latest findings of clinical research,drug accessibility and expert consensus(3-8).Here,we present the main updates of the 2024 version compared to the 2023 version.

关键词： CSCO colorectal cancer