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THE PERSISTENCE OF SOLUTIONS IN A NONLOCAL PREDATOR-PREY SYSTEM WITH A SHIFTING HABITAT

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Acta Mathematica Scientia 2024年第3期44卷 1096-1114页

作者：赵敏袁荣 School of Science Tianjin Chengjian UniversityTianjin300384China Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing100875China

In this paper,we mainly study the propagation properties of a nonlocal dispersal predator-prey system in a shifting *** is known that Choi et al.[J Differ Equ,2021,302:807-853]studied the persistence or extinction of the prey and of the predator separately in various moving *** particular,they achieved a complete picture in the local diffusion ***,the question of the persistence of the prey and of the predator in some intermediate moving frames in the nonlocal diffusion case was left open in Choi et al.'s *** using some a prior estimates,the Arzelà-Ascoli theorem and a diagonal extraction process,we can extend and improve the main results of Choi et *** achieve a complete picture in the nonlocal diffusion case.

关键词： predator-prey system persistence nonlocal dispersal shifting environment

Tetramethylpyrazine and paeoniflorin combination(TMP-PF)inhibits angiogenesis in atherosclerosis via miR-126/VEGF/VEGFR2 signaling pathway

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未来食品学报(英文) 2024年第3期4卷 280-287页

作者： Yahui yuan rong yuan Qiqi Xin Yu Miao Ying Chen Rui Gao Weihong Cong Laboratory of Cardiovascular Diseases Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China School of Health Economics and Management Nanjing University of Chinese MedicineNanjing 210023China Institution of Clinical Pharmacology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China Key Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine National Medical Products AdministrationBeijing 100091China

Angiogenesis in atherosclerosis(AS)promotes plaque ***-126 has a significant role in ***(TMP)and paeoniflorin(PF)have anti-atherosclerotic ***,the miR-126-related mechanisms of TMP and PF combination(TMP-PF)on angiogenesis in AS have not been *** explore the mechanism of TMP-PF on angiogenesis in AS targeting *** umbilical vein endothelial cells(HUVECs)were assigned into the control,model,TMP-PF,TMP-PF+miR-126 inhibitor,and simvastatin *** were transfected with miR-126 inhibitor or negative control,incubated with oxidized low-density lipoprotein(ox-LDL)to establish AS model,and then treated with TMP-PF or *** proliferation,migration,and tube formation assays are conducted,and the expression of angiogenesis-related factors were detected by enzyme-linked immunosorbent assay(ELISA)and Western *** expression level of miR-126 was confirmed by polymerase chain reaction(PCR).0x-LDL promoted HUVECs proliferation,migration,and tube formation,downregulated miR-126 expression,and increased the expression of VEGF,VEGFR2,bFGF,and ***-PF inhibited proliferation,migration,and tube formation,upregulated miR-126 expression and decreased the expression of VEGF,VEGFR2,bFGF,and FGFR1 in ox-LDL-induced ***,the effects of TMP-PF on angiogenesis and the expression of miR-126,VEGF,VEGFR2,and FGFR1 were abolished by miR-126 ***-PF suppressed angiogenesis in AS by regulating miR-126/VEGF/VEGFR2 pathway,which might elucidate the underlying mechanism of TMP-PF in alleviating AS.

关键词： Atherosclerosis Angiogenesis Tetramethylpyrazine Paeoniflorin miR-126/VEGF/VEGFR2 signaling pathway

Protective effects of oleic acid and polyphenols in extra virgin olive oil on cardiovascular diseases

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Food Science and Human Wellness 2024年第2期13卷 529-540页

作者： Yan Lu Jun Zhao Qiqi Xin rong yuan Yu Miao Manli Yang Hui Mo Keji Chen Weihong Cong Laboratory of Cardiovascular Diseases Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China National Clinical Research Center for Chinese Medicine Cardiology Beijing 100091China Traditional Chinese Medicine Department The Aff iliated Hospital of Qingdao UniversityQingdao 266000China Nanjing University of Chinese Medicine Nanjing 210023China Health Bureau of the Government of the Macao Special Administrative Region Macao 999078China

The Mediterranean diet has long been recognized as one of the most effective ways to prevent and improve cardiovascular *** virgin olive oil(EVOO)is the typical sources of fat in the Mediterranean diet which have been shown to have noteworthy nutritional value and positive impact on human *** is worth noting that EVOO owes its superior nutritional value to its bioactive *** main component of EVOO is monounsaturated fatty acids(MUFAs)in the form of oleic *** acid accounts for up to 70%-80%of ***,EVOO contains approximately more than 30 phenolic compounds,of which HT is essential for the protection against cardiovascular *** this review,we focused on the potential mechanisms of oleic acid and polyphenols combat cardiovascular diseases risk in terms of oxidative stress,inflammation,blood pressure,endothelial function and *** review might provide a reference for the studies on cardiovascular protective effects of EVOO.

关键词： Cardiovascular diseases Extra virgin olive oil Oleic acid Polyphenols

Advance on Chinese Medicine for Hypertensive Renal Damage:Focus on the Complex Molecular Mechanisms

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Chinese Journal of Integrative Medicine 2024年第10期30卷 938-948页

作者： LU Yan XIE Xue-na XIN Qi-qi yuan rong MIAO Yu CONG Wei-hong CHEN Ke-ji Laboratory of Cardiovascular Diseases Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing100091China School of Pharmacy Macao University of Science and TechnologyTaipaMacao999078China National Clinical Research Center for Chinese Medicine Cardiology Beijing100091China

Hypertensive renal damage(HRD)is a major cause of end-stage renal *** the causes of end-stage renal disease,HRD accounts for nearly 34%of the total number of *** treatment is primarily drug-based,but therapeutic efficacy is less effective and can have serious side *** medicine(CM)has significant advantages in the treatment of *** is rich in various active ingredients and has the property of targeting multiple targets and ***,the regulatory network of CM on disease is complex.A large number of CM have been employed to treat HRD,either as single applications or as part of compound *** key possible mechanisms of CM for HRD include regulation of the renin-angiotensin-aldosterone system,antioxidation,anti-inflammation,rescue of endothelial function,regulation of vasoactive substance secretion and obesity-related factors,*** review summarized and discussed the recent advance in the basic research mechanisms of CM interventions for HRD and pointed out the challenges and future prospects.

关键词： Chinese medicine hypertensive renal damage molecular mechanisms research progress

Generalized Newton-Busemann Law for Two-dimensional Steady Hypersonic-limit Euler Flows Passing Ramps with Skin-frictions

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Acta Mathematicae Applicatae Sinica 2024年

作者： Ai-fang QU Xue-ying SU Hai-rong yuan School of Mathematical Sciences Key Laboratory of Mathematics and Engineering Applications (Ministry of Education) & Shanghai Key Laboratory of PMMP East China Normal University School of Mathematics and Statistics Xi'an Jiaotong University Department of Mathematics Shanghai Normal University

By considering Radon measure solutions for boundary value problems of stationary non-isentropic compressible Euler equations on hypersonic-limit flows passing ramps with frictions on their boundaries, we construct solutions with density containing Dirac measures supported on the boundaries of the ramps, which represent the infinite-thin shock layers under different assumptions on the skin-frictions. We thus derive corresponding generalizations of the celebrated Newton-Busemann law in hypersonic aerodynamics for distributions of drags/lifts on ramps.

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Tetramethylpyrazine and paeoniflorin combination(TMP-PF)alleviates atherosclerosis progress by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway

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Food Science and Human Wellness 2024年第5期13卷 2642-2652页

作者： rong yuan Qiqi Xin Weili Shi Yu Miao Zhengchuan Zhu Yahui yuan Ying Chen Xiaoning Chen Sean Xiao Leng Keji Chen Weihong Cong Cardiovascular Diseases Laboratory Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing 100091China School of Health Economics and Management Nanjing University of Chinese MedicineNanjing 210023China Department of Otolaryngology Jiangsu Province Hospital of Chinese MedicineNanjing 210029China Division of Geriatric Medicine and Gerontology Department of MedicineJohns Hopkins University School of MedicineBaltimore 21224United States

Atherosclerosis remains a great threat to human health *** studies found that tetramethylpyrazine(TMP)and paeonifl orin(PF)combination(TMP-PF)exerts anti-atherosclerotic effects in ***,whether TMP-PF improves atherosclerosis in vivo needs further *** present study aims to assess the anti-atherosclerotic properties of TMP-PF in ApoE^(-/-)mice and explore the related molecule *** showed that TMP and high-dose TMP-PF decreased serum triglyceride and low-density lipoprotein cholesterol levels,suppressed vascular endothelial growth factor receptor 2(VEGFR2)and nuclear receptor subfamily 4 group A member 1(NR4A1)expression in aortic tissues,inhibited plaque angiogenesis,reduced plaque areas,and alleviated atherosclerosis in ApoE^(-/-)***,TMP-PF exhibited a better modulation effect than TMP or PF ***,NR4A1 agonist abolished the anti-atherosclerotic effects of *** conclusion,TMP-PF was first found to alleviate atherosclerosis progression by reducing hyperlipemia and inhibiting plaque angiogenesis via the NR4A1/VEGFR2 pathway,indicating that TMP-PF had a positive effect on reducing hyperlipemia and attenuating atherosclerosis development.

关键词： Atherosclerosis Hyperlipemia Angiogenesis Plaque stability Chinese medicine Tetramethylpyrazine Paeoniflorin

基于后悔理论的图模糊LINMAP多属性决策方法及应用

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控制与决策 2024年第8期39卷 2810-2816页

作者：王磊苑博荣辽宁工程技术大学基础教学部辽宁葫芦岛125105 辽宁工程技术大学理学院辽宁阜新123000

针对图模糊多属性决策方法基于未知属性权重且往往只考虑客观属性信息的不足,提出一种基于后悔理论的图模糊LINMAP多属性决策方法.首先,依据后悔理论的思想,定义图模糊后悔-欣喜函数,给出方案感知效用值的计算方法;然后,设计图模糊偏好... 详细信息

针对图模糊多属性决策方法基于未知属性权重且往往只考虑客观属性信息的不足,提出一种基于后悔理论的图模糊LINMAP多属性决策方法.首先,依据后悔理论的思想,定义图模糊后悔-欣喜函数,给出方案感知效用值的计算方法;然后,设计图模糊偏好信息集,用其表示属性间的相互影响关系,并提出方案对序列和决策者事先给定偏好信息的图模糊一致性程度和非一致性程度;接着,通过图模糊得分函数和精确度函数构建含有参数的目标函数,并设置图模糊阈值,使得非一致性程度最小化且一致性程度与非一致性程度差别至少不小于该图模糊阈值,据此建立新的优化模型,获得备选方案的属性权重向量和模糊理想点,进而利用感知效用值对备选方案进行排序择优;最后,通过算例分析验证所提出方法的合理性,并通过灵敏度分析和对比分析表明所提出方法的灵活性和优点.

关键词：图模糊集后悔理论图模糊偏好图模糊LINMAP方法感知效用值多属性决策

生态危机时代环境史研究的共生物种志探索与实践

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贵州民族研究 2024年第1期45卷 77-85页

作者：耿中耀杨沅蓉贵州大学历史与民族文化学院贵州贵阳550025

“人类世”概念的提出和推广运用,预示着全球生态危机时代的到来,学术界对此展开了激烈的讨论。在人文、社会科学界,研究者们跨越了此前将人与自然割裂的二元对立认识藩篱,试图进入跨界物种的共生关系探讨中,以寻求重建人与自然和谐关... 详细信息

“人类世”概念的提出和推广运用,预示着全球生态危机时代的到来,学术界对此展开了激烈的讨论。在人文、社会科学界,研究者们跨越了此前将人与自然割裂的二元对立认识藩篱,试图进入跨界物种的共生关系探讨中,以寻求重建人与自然和谐关系的理论依据。在环境史的文化转向和人类学的历史转向两条进路下,“多物种民族志”的写作范式可为环境史摆脱“整体史”困境提供一个新的思路。在环境史研究中,探索“共生物种志”的学理依据和实践方案,可服务于全球生态危机时代学科建设之急需。

关键词：全球生态危机环境史共生物种志

基于主题意义探究的高中英语单元写作教学实践

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教育参考 2024年第7期 63-68页

作者：袁蓉上海市闵行中学上海200240

《普通高中英语课程标准(2017年版)》指出,学生对主题意义的探究应是学生学习语言的最重要内容,直接影响学生语篇理解的程度、思维发展的水平和语言学习的成效。当前高中英语单元写作教学存在机械模仿范文、脱离主题意义、忽视学生核心... 详细信息

《普通高中英语课程标准(2017年版)》指出,学生对主题意义的探究应是学生学习语言的最重要内容,直接影响学生语篇理解的程度、思维发展的水平和语言学习的成效。当前高中英语单元写作教学存在机械模仿范文、脱离主题意义、忽视学生核心素养培养等问题。教师应围绕主题意义,创设主题情境,引导学生在写作活动过程中完成对主题意义的理解和内化,培养学生的英语核心素养。

关键词：主题意义高中英语单元写作英语核心素养