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Human umbilical cord mesenchymal stem cells derivedexosomes on VEGF-A in hypoxic-induced mice retinal astrocytes and mice model of retinopathy of prematurity

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1238-1247页

作者： Xiao-Tian Zhang Bo-Wen Zhao yuan-long Zhang Song Chen Tianjin Eye Hospital Tianjin 300020China Tianjin Key Lab of Ophthalmology and Visual Science Tianjin 300020China

AIM:To observe the effect of human umbilical cord mesenchymal stem cells(hUCMSCs)secretions on the relevant factors in mouse retinal astrocytes,and to investigate the effect of hUCMSCs on the expression of vascular endothelial growth factor-A(VEGF-A)and to observe the therapeutic effect on the mouse model of retinopathy of prematurity(ROP).METHODS:Cultured hUCMSCs and extracted exosomes from them and then retinal astrocytes were divided into control group and hypoxia *** assay,flow cytometry,reverse transcription-polymerase chain reaction(RT-PCR)and Western blot were used to detect related *** mechanisms by which hUCMSCs exosomes affect VEGF-A expression in hypoxia-induced mouse retinal astrocytes were *** last,the efficacy of exosomes of UCMSCs in a mouse ROP model was ***6 was used to comprehensively process data ***:The secretion was successfully extracted from the culture supernatant of hUCMSCs by gradient *** oxygen species(ROS)and hypoxia inducible factor-1α(HIF-1α)of mice retinal astrocytes under different hypoxia time and the expression level of VEGF-A protein and VEGF-A mRNA increased,and the ROP cell model was established after 6h of *** secretions of medium and high concentrations of hUCMSCs can reduce ROS and HIF-1α,the expression levels of VEGF-A protein and VEGF-A mRNA are statistically significant and concentration *** with the ROP cell model group,the expression of phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)signal pathway related factors in the hUCMSCs exocrine group is significantly *** intravitreal injection of the secretions of medium and high concentrations of hUCMSCs can reduce VEGF-A and HIF-1αin ROP model *** staining shows that the number of retinal neovascularization in ROP mice decreases with the increase of the dose of hUCMSCs ***:In a hypoxia induced

关键词： human umbilical cord mesenchymal stem cells retinal astrocytes retinopathy of prematurity vascular endothelial growth factor hypoxia inducible factor

The role of intestinal flora on tumorigenesis,progression,and the efficacy of PD-1/PD-L1 antibodies in colorectal cancer

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Cancer Biology & Medicine 2024年第1期21卷 65-82页

作者： Sen Wang Benling Xu Yangyang Zhang Guangyu Chen Peng Zhao Quanli Gao long yuan Department of Gastrointestinal Surgery Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China Department of Immunotherapy Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China

Intestinal flora affects the maturation of the host immune system,serves as a biomarker and efficacy predictor in the immunotherapy of several cancers,and has an important role in the development of colorectal cancer(CRC).Anti-PD-1/PD-L1 antibodies have shown satisfactory results in MSI-H/d MMR CRC but performed poorly in patients with MSS/p MMR *** recent years an increasing number of studies have shown that intestinal flora has an important impact on anti-PD-1/PD-L1 antibody efficacy in CRC *** and clinical evidence have suggested that anti-PD-1/PD-L1 antibody efficacy can be improved by altering the composition of the intestinal flora in ***,we summarize the studies related to the influence of intestinal flora on anti-PD-1/PD-L1 antibody efficacy in CRC and discuss the potential underlying mechanism(s).We have focused on the impact of the intestinal flora on the efficacy and safety of anti-PD-1/PD-L1 antibodies in CRC and how to better utilize the intestinal flora as an adjuvant to improve the efficacy of anti-PD-1/PD-L1 *** addition,we have provided a basis for the potential of the intestinal flora as a new treatment modality and indicator for determining patient prognosis.

关键词： Intestinal flora anti-PD-1/PD-L1 therapy colorectal cancer immune checkpoint inhibitor CD8~+T cell

Malvidin Mitigates Sepsis-induced Cardiac Injury by Modulating the TLR4-iNOS-COX-2 Inflammatory Pathway and the Bax/Bcl-2/Cyto-C Mitochondrial Apoptosis Pathway in a p38 MAPK-dependent Manner

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Biomedical and Environmental Sciences 2024年第2期37卷 221-227页

作者： ZHANG Wei yuan Si long QIANG Jing Chao HUANG He LI Da SUN Ying ZHANG Hong Gang Department of Vascular Surgery The First People’s Hospital of LianyungangLianyungang 222005JiangsuChina Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening College of PharmacyJiangsu Ocean UniversityLianyungang 222005JiangsuChina Jinzhou Medical University postgraduate training base(Lianyungang First People’s Hospital) Lianyungang 222005JiangsuChina

In critical care medicine,sepsis is a dangerous systemic condition that is highly prevalent and is associated with high morbidity and mortality rates^([1]).The high mortality rate associated with sepsis is closely related to multi-organ dysfunction,with heart injury being particularly critical and considered the starting point of multi-organ injury^([2]).

关键词： mortality Apoptosis TLR4

Sum rate optimizing for multi-IRS-assisted UAV downlink transmission system using deep reinforcement learning

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The Journal of China Universities of Posts and Telecommunications 2024年

作者： long yuan He Xiaoli Ye Yang Zhang Bo School of Computer Science and Engineering， Sichuan University of Science and Engineering School of Resources， Sichuan Agricultural University

By leveraging the high maneuverability of the unmanned aerial vehicle (UAV) and the expansive coverage of the intelligent reflecting surface (IRS)， a multi-IRS-assisted UAV communication system aimed at maximizing the sum data rate of all users is investigated in this paper. This is achieved through the joint optimization of the trajectory and transmit beamforming of the UAV， as well as the passive phase shift of the IRS. Nevertheless， the initial problem exhibits a high degree of non-convexity， posing challenges for conventional mathematical optimization techniques in delivering solutions that are both quick and efficient while maintaining low complexity. To address this issue， a novel scheme called the deep reinforcement learning (DRL)-based enhanced cooperative reflection network (DCRN) is proposed. This scheme effectively identifies optimal strategies， with the long short-term memory (LSTM) network improving algorithm convergence by extracting hidden state information. Simulation results demonstrate that the proposed scheme outperforms the baseline scheme， manifesting substantial enhancements in sum rate and superior performance.

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Genetically modified pigs:Emerging animal models for hereditary hearing loss

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Zoological Research 2024年第2期45卷 284-291页

作者： Xiao Wang Tian-Xia Liu Ying Zhang Liang-Wei Xu Shuo-long yuan A-long Cui Wei-Wei Guo Yan-Fang Wang Shi-Ming Yang Jian-Guo Zhao State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Department of Otolaryngology-Head and Neck Surgery Institute of OtolaryngologyChinese PLA General HospitalBeijing 100853China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefeiAnhui 230022China State Key Laboratory of Animal Biotech Breeding Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China

Hereditary hearing loss(HHL),a genetic disorder that impairs auditory function,significantly affects quality of life and incurs substantial economic losses for *** investigate the underlying causes of HHL and evaluate therapeutic outcomes,appropriate animal models are *** have been extensively used as valuable large animal models in biomedical *** this review,we highlight the advantages of pig models in terms of ear anatomy,inner ear morphology,and electrophysiological characteristics,as well as recent advancements in the development of distinct genetically modified porcine models of hearing ***,we discuss the prospects,challenges,and recommendations regarding the use pig models in HHL ***,this review provides insights and perspectives for future studies on HHL using porcine models.

关键词： Pigs Animal models Hereditary hearing loss Genetic modification Inner ear

Bifurcations and Spatiotemporal Patterns in the Diffusive Nutrient-Microorganism Model

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Acta Mathematicae Applicatae Sinica 2024年

作者： Ya-di WANG Hai-long yuan Yan-ling LI School of Arts and Sciences Shaanxi University of Science and Technology School of Mathematics and Statistics Xi'an Jiaotong University School of Mathematics and Information Science Shaanxi Normal University

In this paper, the diffusive nutrient-microorganism model subject to Neumann boundary conditions is considered. The Hopf bifurcations and steady state bifurcations which bifurcate from the positive constant equilibrium of the system are investigated in details. In addition, the formulae to determine the direction of Hopf and steady state bifurcations are derived. Our results show the existence of spatially homogeneous/nonhomogeneous periodic orbits and steady state solutions, which indicates the spatiotemporal dynamics of the system. Some numerical simulations are also presented to support the analytical results.

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Analysis and Response of Steel Stacking Accidents in Hot Rolling Coilers

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Frontiers of Metallurgical Industry

Frontiers of Metallurgical Industry 2024年第2期2卷 10-14页

作者： Zhenyi Yu yuan long Shuqi Tang The Fourth Steel Rolling Plant of Ma'anshan Iron and Steel Co. Ltd. Datong Coal Mine Tianjian Steel Co. Ltd. Nanjing Iron and Steel Co. Ltd.

Through long-term production and maintenance practice,various types of stacking steel in the 2250mm hot rolling coiler of Ma Steel were tracked and analyzed,and the causes of stacking steel were ***-responding measure... 详细信息

关键词： coiler stacking steel cause analysis measure

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不同侧基耐热聚硅乙炔树脂的制备及其热性能

高分子学报 2024年第11期55卷 1561-1574页

作者：徐欣玥董仕龙袁荞龙华东理工大学材料科学与工程学院特种功能高分子材料及相关技术教育部重点实验室上海200237

利用格氏试剂法合成了5种含不同侧基的端乙炔基硅乙炔树脂(ETSA),通过核磁共振氢谱(^(1)H-NMR)和傅里叶转换红外光谱(FTIR)对其结构进行了表征,用体积排除色谱法测其分子量,利用示差扫描量热仪(DSC)研究了ETSA树脂的固化行为,通过热失... 详细信息

利用格氏试剂法合成了5种含不同侧基的端乙炔基硅乙炔树脂(ETSA),通过核磁共振氢谱(^(1)H-NMR)和傅里叶转换红外光谱(FTIR)对其结构进行了表征,用体积排除色谱法测其分子量,利用示差扫描量热仪(DSC)研究了ETSA树脂的固化行为,通过热失重分析仪(TGA)研究了ETSA树脂固化物的热稳定性,并利用高分辨透射电镜(HRTEM)和小角X光散射(SAXS)研究了ETSA树脂固化物的微孔结构.另外,使用2种镍系催化剂对ETSA树脂的固化反应进行催化,并通过DSC、FTIR和TGA研究了催化剂对ETSA固化的催化效果.结果表明,ETSA树脂随主链中硅原子上侧基体积的增大,聚合度依次下降,固化放热峰峰值温度向高温方向移动,放热焓显著下降.ETSA固化树脂具有优异的热稳定性,氮气与空气中的5%热失重温度(T_(d5))都超450℃,800℃残留量(Y_(r800))分别超过80%和27%.ETSA固化树脂交联网络微孔随侧基体积增加而增大.镍系催化剂对ETSA树脂的固化反应具有较好的催化效果,降低起始固化温度大于50℃,催化固化树脂的Y_(r800)变化不大.ETSA树脂有望用作高耐热树脂基体和聚合物陶瓷前驱体.

关键词：聚硅乙炔树脂杂化树脂侧基固化反应热稳定性

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跨江钢—混组合梁桥顶推施工关键技术研究

公路 2024年第9期69卷 85-90页

作者：袁龙泉中铁十一局集团有限公司武汉市430061

依托某顶推施工的跨江钢—混组合梁桥项目,详细介绍了顶推方案和关键技术点,并通过有限元方法研究了永久结构和临时构件的受力性能。根据该桥的受力和施工要求,将顶推划分为3个阶段,顶推距离依次为20.05 m、57.95 m、90.1 m。顶推过程... 详细信息

依托某顶推施工的跨江钢—混组合梁桥项目,详细介绍了顶推方案和关键技术点,并通过有限元方法研究了永久结构和临时构件的受力性能。根据该桥的受力和施工要求,将顶推划分为3个阶段,顶推距离依次为20.05 m、57.95 m、90.1 m。顶推过程以位移控制为主,以压力控制为辅。在最不利状况下,钢箱梁、临时墩的强度、刚度和稳定性满足要求,导梁和钢箱梁的连接焊缝满足正应力和剪应力要求;导梁需要进一步增加横向和纵向加劲肋,方能满足局部稳定性要求。

关键词：桥梁工程跨江桥梁钢—混组合梁桥顶推法施工有限元分析