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Synthesize dual goals:A study on China's ecological poverty alleviation system

Journal of Integrative Agriculture 2021年第4期20卷 1042-1059页

作者： LEI Ming yuan Xuan-yu YAO Xin-yan Institute on Poverty Research Peking UniversityBeijing 100871P.R.China Guanghua School of Management Peking UniversityBeijing 100871P.R.China

How to break the vicious cycle of poverty and ecological degradation is widely concerned and *** the poverty alleviation practices in China,ecological poverty alleviation(EPA)is regarded as an important way to synthesize the dual goals of poverty reduction and environmental protection and to achieve the win-win *** Chinese researchers have fruitful research achievements on EPA yet they do not recognize that EPA is not a simple combination of various policies,but a complex system involving multiple policy instruments,governmental agencies,social forces,and ***,few studies abroad illustrate EPA in *** focus more on specific components of EPA such as payment for ecosystem services while overlooking the integral concept of EPA and practices from *** on field research in Guizhou Province,China,this paper proposes a framework of EPA with an effective multi-agent and co-government system,for demonstrating the concept and practice of *** case analysis,we illustrate key elements in this system and their relationships,and how they play a vital role in pursuing win-win outcomes in environmental protection and poverty *** three dimensions of this EPA system have been *** first is to strengthen the interaction among the *** efforts should be made for establishing an efficient communication routine and a stable relationship among their *** second is to reinforce the connection between diverse elements in each policy subsystem,such as the systematization and coordination of the ecological industry development,the systematization of the links before,during,and after the relocation of ecological immigrants,*** third is to promote the interactions between the three subsystems,so that ecological enhancement,ecological compensation,and industrial development,and migration and relocation can promote each other,and ultimately promote the coordination of poverty alleviation and ecological protec

关键词： poverty alleviation ecological poverty alleviation systematic characteristics China interaction

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Platelet-derived microvesicles deliver miR-30e and promote VSMC apoptosis after balloon injury

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Medicine in Novel Technology and Devices 2022年第1期13卷 22-30页

作者： Li Zi-Tong Chen yuan-Xiu Bao Han Liu Ji-Ting Zhuang Fei Li hai-Peng Yao Qing-Ping Jiang Zong-Lai Qi Ying-Xin Institute of Mechanobiology&Medical Engineering School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai200240China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing100083China

During vascular remodeling after intimal injury,circulating platelets are activated by exposed collagen and release platelet-derived microvesicles(PMVs),which may contribute to the injury-induced apoptosis of vascular smooth muscle cells(VSMCs).However,the mechanisms in this process are still *** a rat balloon injury model,platelet adhesion at the injured site was detected,and promoted medial VSMC apoptosis was revealed with dT-mediated dUTP nick-end labeling(TUNEL)in *** apoptosis was promoted by coincubation with PMVs in *** analysis indicated the abound expression of the microRNA-30(miR-30)family in platelets,and the expression of the miR-30 family in platelets and PMVs was confirmed with *** Pathway Analysis(IPA)software identified transcription factor 2(RUNX2)as a pivotal molecule linking miR-30 and cellular *** vitro,PMVs delivered miR-30e,an important member of the miR-30 family,into VSMCs and increased cell apoptosis.A dual-luciferase assay was adopted to verify the interaction of miR-30e with RUNX2,and fluorescence in situ hybridization(FISH)proved the cytoplasmic localization of miR-30e in *** apoptotic effect on VSMCs was further confirmed by using miR-30e mimics and RUNX2 ***,RUNX2 siRNA altered the expression of its downstream genes,Tnfrsf11b,Smad6 and Mmp13,which may participate in apoptosis,as suggested by *** results indicated that PMVs play important roles in the interactions between circulating elements and VSMCs by delivering miR-30e to VSMCs and then promoting *** and potential intercellular messages may be novel therapeutic targets for preventing pathological vascular remodeling after intimal injury.

关键词： Platelet-derived microvesicles Vascular smooth muscle cells Apoptosis miR-30e RUNX2 Intimal injury

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超声逆散射成像问题中的正则化方法研究

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浙江大学学报（工学版） 2005年第2期39卷 195-199,210页

作者：刘超刁现芬汪元美浙江大学生物医学工程学系浙江杭州310027

为提高成像质量,需反复地求解不适定逆散射方程,而不适定方程的求解需要正则化处理.将截断完全最小二乘正则化方法应用到迭代过程中,该方法同时考虑逆散射方程的系数矩阵和数据项均存在误差的情况,不仅适合于不适定性较弱的情况,而且适... 详细信息

为提高成像质量,需反复地求解不适定逆散射方程,而不适定方程的求解需要正则化处理.将截断完全最小二乘正则化方法应用到迭代过程中,该方法同时考虑逆散射方程的系数矩阵和数据项均存在误差的情况,不仅适合于不适定性较弱的情况,而且适合于不适定性较强的情况,提高了算法的收敛性以及成像的质量.对不同结构以及不同对比度图像的数值仿真结果显示,截断完全最小二乘正则化方法,较只考虑数据项存在误差的Tikhonov正则化方法成像质量高,且适用范围广.

关键词：超声逆散射成像截断完全最小二乘正则化

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Implementation Framework and Validation of Cluster-Nuclei Based Channel Model Using Environmental Mapping for 6G Communication Systems

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China Communications 2022年第4期19卷 1-13页

作者： Li Yu Yuxiang Zhang Jianhua Zhang Zhiqiang yuan State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

With the research of the upcoming sixth generation(6 G) systems, new technologies will require wider bandwidth, larger scale antenna arrays and more diverse wireless communication scenarios on the future channel modeling. Considering channel model is prerequisite for system design and performance evaluation of 6 G technologies, we face a challenging task: how to accurately and efficiently model 6 G channel for various scenarios? This paper tries to answer it. Firstly, the features of cluster-nuclei(CN) and principle of cluster-nuclei based channel model(CNCM) are introduced. Then, a novel modeling framework is proposed to implement CNCM,which consists four steps: propagation environment reconstruction, cluster-nuclei identification, multipath parameters generation, and channel coefficients generation. Three-dimensional environment with material information is utilized to map CN with scatterers in the propagation pathway. CN are identified by geometrical and electric field calculation based on environmental mapping, and multipath components within CN are calculated by statistical characteristics of angle, power and delay domains. Finally, we present a three-level verification structure to investigate the accuracy and complexity of channel modeling comprehensively. Simulation results reveal that CNCM can perform higher accuracy than geometrybased stochastic model while lower complexity compared with ray-tracing model for practical propagation environment.

关键词： channel model 6G cluster-nuclei environmental mapping scatterer ray-tracing geometrybased stochastic model

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Response of BRCA1-mutated gallbladder cancer to olaparib: A case report

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World Journal of Gastroenterology 2016年第46期22卷 10254-10259页

作者： yuan Xie Yan Jiang Xiao-bo Yang An-qiang Wang Yong-chang Zheng Xue-shuai Wan Xin-ting sang Kai Wang Da-Dong Zhang Jia-Jia Xu Fu-gen Li hai-tao Zhao Department of Liver Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Precision Medicine 3D Medicines Inc Center for Precision Medicine Zhejiang University International Hospital

gallbladder cancer(gbc), although considered as a relatively rare malignancy, is the most common neoplasm of the biliary tract system. the late diagnosis and abysmal prognosis present challenges to treatment. the overall 5-year survival rate for metastatic gbc patients is extremely low. BRC A1 and BRCA2 are the breast cancer susceptibility genes and their mutation carriers are at a high risk for cancer development, both in men and women. Olaparib, an oral poly ADP-ribose polymerase inhibitor, has been approved by the Food and Drug Administration and the European commission for the treatment of ovarian cancer with any BRCA1/2 mutations. the first case of BRCA1-mutated gbc patient who responded to olaparib treatment is reported here.

关键词： BRCA Mutation Olaparib Poly ADP-ribose polymerase inhibitor gallbladder cancer

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Orexin Receptor Antagonists as Emerging Treatments for Psychiatric Disorders

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Neuroscience Bulletin 2020年第4期36卷 432-448页

作者： Ying Han Kai yuan Yongbo Zheng Lin Lu National Institute of Drug Dependence and Beijing Key Laboratory of Drug Dependence Peking UniversityBeijing 100191China Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Beijing 100191China Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China

Orexins comprise two neuropeptides produced by orexin neurons in the lateral hypothalamus and are released by extensive projections of these neurons throughout the central nervous system. Orexins bind and activate their associated G protein-coupled orexin type 1 receptors(OX1Rs) and OX2Rs and act on numerous physiological processes, such as sleep-wake regulation, feeding, reward,emotion, and motivation. Research on the development of orexin receptor antagonists has dramatically increased with the approval of suvorexant for the treatment of primary insomnia. In the present review, we discuss recent findings on the involvement of the orexin system in the pathophysiology of psychiatric disorders, including sleep disorders,depression, anxiety, and drug addiction. We discuss the actions of orexin receptor antagonists, including selective OX1R antagonists (SORA1s), selective OX2R antagonists(SORA2s), and dual OX1/2R antagonists (DORAs), in the treatment of these disorders based on both preclinical and clinical evidence. SORA2s and DORAs have more pronounced efficacy in the treatment of sleep disorders,whereas SORA1s may be promising for the treatment of anxiety and drug addiction. We also discuss potential challenges and opportunities for the application of orexin receptor antagonists to clinical interventions.

关键词： Orexin Insomnia Depression Anxiety Drug addiction

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Public Policy Supply for Successful Practice of the Xin’anjiang River Ecological Compensation Mechanism

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学术界 2020年第1期 228-235页

作者： Lu Weiling yuan Weihai Anhui Institute of Economic Management

The ecological protection of the inter-provincial river basin of Xin’anjiang River takes the ecological compensation mechanism as the starting point and achieves good *** success of the mechanism is best reflected in its innovation of public policy supply,which is not only a vivid practice of Xi Jinping’s ecological civilization thought in the new era,but also establishes a model for absorption,transformation and export of policy *** effective supply of public policies on ecological environment is the realistic choice for the construction of ecological civilization in the new era.

关键词： ecological civilization Xin’anjiang River ecological compensation mechanism public policy supply

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Frequency and Correlation of Nearest Neighboring Nucleotides in Human Genome

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Chinese Journal of Chemical Physics 2009年第1期22卷 27-33页

作者： Neng-zhi Jin Zi-xian Liu Wen-yuan Qiu Department of Chemistry State Key Laboratory of Applied Organic Chemistry Lanzhou Universiry. Lanzhou 730000 China

Zipf＇s approach in linguistics is utilized to analyze the statistical features of frequency and correlation of 16 nearest neighboring nucleotides （AA, AC, AG, …, TT） in 12 human chro- mosomes （Y, 22, 21, 20, 19, 18, 17, 16, 15, 14, 13, and 12）. It is found that these statistical features of nearest neighboring nucleotides in human genome：（i） the frequency distribution is a linear function, and （ii） the correlation distribution is an inverse function. The coefficients of the linear function and inverse function depend on the GC content. It proposes the correlation distribution of nearest neighboring nucleotides for the first time and extends the descriptor about nearest neighboring nueleotides.

关键词： Zipf's law Nearest neighboring nucleotide Frequency distribution Correlation distribution

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Integrating 16S sequencing and metabolomics study on anti-rheumatic mechanisms against collagen-induced arthritis of Wantong Jingu Tablet

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Chinese Journal of Natural Medicines 2022年第2期20卷 120-132页

作者： LI Zhao-Dong QI Fang-yuan LI Fan Department of Pathogenobiology the Key Laboratory of ZoonosisMinistry of Education of ChinaSchool of Basic MedicineJilin UniversityChangchun 130000China Key Laboratory for Bionics Engineering Ministry of Education of ChinaJilin UniversityChangchun 130000China Engineering Research Center for Medical Biomaterials of Jilin Province Jilin UniversityChangchun 130000China Key Laboratory for Biomedical Materials of Jilin Province Jilin UniversityChangchun 130000China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaUrumqi 830000China

Wantong Jingu Tablet(WJT),a mixture of traditional Chinese medicine,was reported to relieve the symptoms of rheumatoid arthritis(RA),but its pharmacological mechanism was not completely *** aim of this study was to investigate the therapeutic mechanisms of WJT for RA in *** effects of WJT on joint pathology,as well as the levels of Bax,Bcl-2,caspase-3,cleaved-caspase-3,ERK1/2,pERK1/2,TNF-α,IL-1β,and IL-6 were measured using collagen-induced arthritis(CIA)*** intestinal flora composition and the metabolites alteration were analyzed by 16S rDNA sequencing and metabolomics method,*** found that WJT ameliorated the severity of the CIA rats which might be mediated by inducing apoptosis,inactivating the MEK/ERK signals and reducing the production of pro-inflammatory ***,in part,relieved the gut microbiota dysbiosis,especially bacterial phylum Bacteroidetes,Tenericutes and Deferribacteres,as well as bacterial genus Vibrio,Macrococcus and Vagococcus.3’-N-debenzoyl-2’-deoxytaxol,tubulysin B,and magnoline were significantly associated with the specific *** identified serotonin,glutathione disulfide,N-acetylneuraminic acid,naphthalene and thromboxane B2 as targeted molecules via *** findings contributed to the understanding of RA pathogenesis,and WJT played essential roles in gut microbiota health and metabolite modulation in the CIA rats.

关键词： Rheumatoid arthritis 16S rDNA sequencing Metabolomics Pathogenesis Wantong Jingu Tablet

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Numerical simulation of surface charge inhibition performance on epoxy insulator under DC voltage by flexible coating strategy

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High Voltage 2022年第3期7卷 553-563页

作者： Yu Gao Huicun Zhao Xiaochen yuan Huan Wang School of Electrical and Information Engineering Tianjin UniversityTianjinChina

Epoxy insulator is affected by surface charge accumulation under a strong electric field,which causes a decrease in the surface flashover voltage,threatening the safe operation of power *** study reports on a flexible coating strategy for the insulator to inhibit the charge accumulation through numerical *** experiment was con-ducted initially to reveal the charge accumulation ***,the flexible coating method was proposed,in which the insulator surface was divided into three parts,and surface coatings with various conductivities were painted on the designated areas to adjust the charge ***,the efficiency of such a coating strategy was estimated considering the temperature *** results presented that the homo-charge was mostly deposited on the non-planar area of the *** maximum charge density first decreased and then increased with increasing surface *** charge accumulation could be restrained by increasing the surface conductivity of insulator effectively.A sig-nificant suppression was achieved by properly coating with high conductivity at the non-planar region and with low conductivity at the planar *** suppression perfor-mance of such a strategy became reduced as the temperature gradient *** results indicate that the flexible coating can balance charge deposition in the non-planar region and restrain charge injection near the electrode,thereby inhibiting the charge accumulation.

关键词： coating charge insulator

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