检索结果-南通市图书馆

高速公路与区域经济发展协调性的DEA评价模型

在线全文

学校读者我要写书评

暂无评论

长安大学学报（社会科学版） 2009年第3期11卷 12-14,20页

作者：袁长伟吴群琪长安大学经济与管理学院陕西西安710064

为评价高速公路与区域社会经济的协调发展水平,采用多指标综合评价方法,建立了包括人口总数、GDP、人均收入等8项指标在内的高速公路与社会经济协调评价指标体系,建构了适用于相对有效性评价的DEA分析模型。利用DEA模型对陕西省进行了... 详细信息

为评价高速公路与区域社会经济的协调发展水平,采用多指标综合评价方法,建立了包括人口总数、GDP、人均收入等8项指标在内的高速公路与社会经济协调评价指标体系,建构了适用于相对有效性评价的DEA分析模型。利用DEA模型对陕西省进行了实例应用,分析得出人均收入、公路货运周转量过低等因素是导致陕西省高速公路与社会经济协调水平较低的主要原因。这一应用结果表明,采用DEA模型评价高速公路与区域社会经济发展的协调性能保证评价指标权重确定的客观性,并能识别出决策单元无效的原因,本模型可为高速公路建设规划与社会经济发展决策提供依据。

关键词：区域经济公路运输数据包络分析决策单元

Decision making module based on stochastic magnetic tunnel junctions

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 202-209页

作者： Yifan Miao Li Zhao Yajun Zhang Zhe yuan Center for Advanced Quantum Studies and Department of Physics Beijing Normal University Institute for Nanoelectric Devices and Quantum Computing Fudan University Interdisciplinary Center for Theoretical Physics and Information Sciences Fudan University

In biological neural systems, noise is ubiquitous but does not affect the correct decisions made in the complex cognitive ***-making in biological neural system is typically achieved by accumulating input information over a period of *** by recent developments in neurosciences, we design a decision-making module based on spintronic devices, utilizing superparamagnetic tunnel junctions as artificial neurons. The feasibility of this decision-making module is verified through circuit simulations. Taking a multi-layer perceptron as an example, the module significantly improves the accuracy of the perceptron in the handwritten digit recognition task. Furthermore, the spintronic decision-making module offers advantages over the conventional pooling methods, such as adaptive decision time, high performance and the absence of analog-to-digital conversion. The decision-making module is flexible to be integrated into artificial neural networks and provides a general yet effective solution to enhance performance against device noise.

关键词： neuromorphic computing spintronics magnetic tunnel junction neural networks

Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinrong Chen Ning Sun yuan Li Tifei yuan Daihui Peng Division of Mood Disorder Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major depressive disorder, chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response. Mitochondrial DNA may be an inflammatory trigger, after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation. This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder. Herein, we critically review the neuroinflammation theory in major depressive disorder, providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate, and that it constitutes the neuroinflammatory disease pathway. After its release, mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation. Detectable exosomes render encaged mitochondrial DNA relatively stable. This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice. These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder. This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers, to improve diagnostic precision in major depressive disorder.

关键词： biomarker cytokine exosomes inflammasome major depressive disorder microglia mitochondrial DNA mitochondrial dysfunction neuroinflammation Toll-like receptor

Rational design of lipid-activatable NIR-II probes for precisely imaging atherosclerotic plaque

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Xinyu Xu yuan Ma Hui Cao Li Xu Haoming Chen Sulai Liu wei Sun Guosheng Song Xiaobing Zhang State Key Laboratory for Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan University Department of Hepatobiliary Surgery/Central Laboratory Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University) Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical University Shenzhen Research Institute of Hunan University

Atherosclerosis(AS) is a prevalent condition associated with cardiovascular and cerebrovascular diseases, featuring lipid-laden plaque; however, the insufficient resolution and low sensitivity of traditional medical imaging techniques limit their application in lipid imaging. Currently, the second near-infrared(NIR-II) fluorescence imaging offers promising sensitivity and convenience. However, existing probes have limitations in terms of signal-to-background ratio, penetration depth, and tissue scattering. Herein, we use a molecular regulatory strategy to design a lipid-activatable probe Rh-965 with high specificity and NIR-II emission for improved imaging potential in deep tissues. The potential of Rh-965 for imaging plaque lipids in mice with AS is demonstrated by localizing carotid artery plaques using NIR-II imaging. The development of more stable lipid-activated NIR-II probes can significantly enhance atherosclerosis diagnosis and facilitate in vivo imaging in deeper tissues.

关键词：

显微外科手术与血管内栓塞治疗硬脊膜动静脉瘘临床疗效比较的meta分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

北京大学学报（医学版） 2022年第2期54卷 304-314页

作者：袁昌巍王盈进张书杰沈胜利段鸿洲北京大学第一医院神经外科北京100034

目的:通过meta分析比较显微外科手术与血管内栓塞治疗硬脊膜动静脉瘘的临床疗效。方法:计算机检索PubMed、Embase、Web of Science、Cochrane临床试验数据库、中国知网、万方数据库、中国生物医学文献数据库(Chinese BioMedical Literat... 详细信息

目的:通过meta分析比较显微外科手术与血管内栓塞治疗硬脊膜动静脉瘘的临床疗效。方法:计算机检索PubMed、Embase、Web of Science、Cochrane临床试验数据库、中国知网、万方数据库、中国生物医学文献数据库(Chinese BioMedical Literature Database,CBM),检索时间从数据库建库至2019年12月,纳入采用显微外科手术和血管内栓塞治疗硬脊膜动静脉瘘的所有中英文文献。使用RevMan 5.3软件进行统计学分析,评估术后早期失败率、远期复发、神经功能恢复程度、并发症情况,比较两种治疗方式对硬脊膜动静脉瘘的临床疗效,并对血管内栓塞治疗进行亚组分析。结果:纳入文献46篇,共1958例硬脊膜动静脉瘘患者,其中935例采用显微外科手术治疗,1023例采用血管内栓塞治疗,漏斗图显示未见明显发表偏倚。经meta分析结果显示,显微外科手术早期治疗失败的发生率低于血管内栓塞治疗(OR=0.20,95%CI:0.13~0.30,P<0.05),远期复发率也低于血管内栓塞治疗(OR=0.36,95%CI:0.22~0.58,P<0.05),显微外科手术治疗后患者神经功能改善情况优于血管内栓塞治疗的患者(OR=2.86,95%CI:1.36~5.99,P<0.05),两种治疗方式患者并发症的发生率差异无统计学意义(OR=1.52,95%CI:0.88~2.64,P=0.14)。血管内栓塞治疗的患者中,使用Onyx胶进行栓塞比使用α-氰基丙烯酸正丁酯(n-butyl 2-cyanoacrylate,NBCA胶)有更高的治疗失败或复发风险,差异有统计学意义(OR=4.70,95%CI:1.55~14.28,P<0.05)。结论:虽然血管内栓塞治疗硬脊膜动静脉瘘的应用日趋广泛,但显微外科手术所获得的临床疗效仍明显优于血管内栓塞治疗。

关键词：硬膜动静脉瘘显微外科手术栓塞,治疗性 Meta分析

Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

同方期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng Li Meifeng Cai Shengjun Miao yuan Li Yu Wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

RNA干扰p21对肝癌细胞SMMC-7721增殖的影响

在线全文

学校读者我要写书评

暂无评论

世界华人消化杂志 2011年第8期19卷 827-831页

作者：谭晓虹徐恒韦长元曹骥崔凌飞刘斐广西医科大学附属肿瘤医院化疗三科广西壮族自治区南宁市530021 广西医科大学医学科学实验中心广西壮族自治区南宁市530021 广西医科大学附属肿瘤医院乳腺外科广西壮族自治区南宁市530021 广西医科大学附属肿瘤医院实验研究部广西壮族自治区南宁市530021 广西壮族自治区南溪山医院广西壮族自治区桂林市541002 广西壮族自治区人民医院医学实验中心广西壮族自治区南宁市530021

目的:探讨RNA干扰技术沉默p21基因对肝癌细胞SMMC-7721增殖及恶性表型变化的影响.方法:通过慢病毒载体将p21小干扰RNA片段稳定转染入SMMC-7721细胞,通过RT-PCR、Westernblot分别检测p21mRNA和蛋白表达变化,流式细胞仪检测7721-p21RNAi组... 详细信息

目的:探讨RNA干扰技术沉默p21基因对肝癌细胞SMMC-7721增殖及恶性表型变化的影响.方法:通过慢病毒载体将p21小干扰RNA片段稳定转染入SMMC-7721细胞,通过RT-PCR、Westernblot分别检测p21mRNA和蛋白表达变化,流式细胞仪检测7721-p21RNAi组(感染p21siRNA慢病毒载体组)、7721-NC组(感染阴性对照慢病毒载体组)、7721组(未转染组)细胞生长周期,MTT法检测转染后SMMC-7721细胞生长情况,细胞克隆形成实验检测单细胞锚定依赖性成克隆能力.结果:慢病毒载体可有效介导p21小干扰RNA片段进入SMMC-7721细胞,经RT-PCR及West-ernblot检测,p21小干扰RNA可以明显降低SMMC-7721细胞p21mRNA和蛋白的表达.流式细胞仪检测细胞周期发现,各组G0/G1期比例分别为32.82%±3.27%、61.25%±0.76%、57.77%±4.08%,S期比例分别为42.56%±5.62%,22.91%±1.53%,25.13%±5.11%.经统计学分析,7721-p21RNAi组G0/G1期比例较其余两组下降(P<0.05),S期比例较其余两组升高(P<0.05),而7721-NC组与7721组相比差异无显著性.MTT法检测细胞生长速度发现,与7721-NC和7721组细胞相比,7721-p21RNAi组细胞的生长速度较快,每天的活细胞数目均多于另外两种细胞系(P<0.05).细胞克隆形成实验发现7721-p21RNAi组、7721-NC组及7721组克隆形成数分别为81.24±1.5、51.67±2.08、52.73±1.53个.7721-p21RNAi组克隆形成数明显多于7721-NC组、7721组(P<0.05),7721-NC组克隆形成数与7721组无明显差异.表明p21表达下降可加速SMMC-7721细胞从G1期进入S期,细胞生长速度加快,单细胞锚定依赖性成克隆能力增强.结论:本研究通过RNA干扰技术反向验证了p21具有抑制肝癌细胞生长及细胞周期进程的作用,为下一步深入研究p21抑制细胞增殖的机制及在肝癌发生发展中所起的作用打下了基础.

关键词： RNA干扰 p21基因肝细胞癌细胞周期

Insight Into the Separation-of-Variable Methods for the Closed-Form Solutions of Free Vibration of Rectangular Thin Plates

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2025年第1期142卷 329-355页

作者： Yufeng Xing Ye yuan Gen Li Institute of Solid Mechanics Beihang University(BUAA)Beijing100191China

The separation-of-variable(SOV)methods,such as the improved SOV method,the variational SOV method,and the extended SOV method,have been proposed by the present authors and coworkers to obtain the closed-form analytical solutions for free vibration and eigenbuckling of rectangular plates and circular cylindrical *** taking the free vibration of rectangular thin plates as an example,this work presents the theoretical framework of the SOV methods in an instructive way,and the bisection–based solution procedures for a group of nonlinear eigenvalue ***,the explicit equations of nodal lines of the SOV methods are presented,and the relations of nodal line patterns and frequency orders are *** is concluded that the highly accurate SOV methods have the same accuracy for all frequencies,the mode shapes about repeated frequencies can also be precisely captured,and the SOV methods do not have the problem of missing roots as well.

关键词： Separation-of-variable method Rayleigh quotient nodal line eigenvalue equation bisection method

Reconstruction characteristics of gut microbiota from patients with type 1 diabetes affect the phenotypic reproducibility of glucose metabolism in mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 176-188页

作者： Zhiyi Wang Mengxue Gong yuanyuan Fang Huijuan yuan Chenhong Zhang State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong University Department of Endocrinology Henan Provincial People's HospitalPeople's Hospital of Zhengzhou University

The human microbiota-associated(HMA) mice model, especially the germ-free(GF)-humanized mice, has been widely used to probe the causal relationships between gut microbiota and human diseases such as type 1 diabetes(T1D). However, most studies have not clarified the extent to which the reconstruction of the human donor microbiota in recipient mice correlates with corresponding phenotypic reproducibility. In this study, we transplanted fecal microbiota from five patients with T1D and four healthy people into GF mice, and microbiota from each donor were transplanted into 10 mice. Mice with similar microbiota structure to the donor exhibited better phenotypic reproducibility. The characteristics of the microbial community assembly of donors also influenced the phenotypic reproducibility in mice, and individuals with a higher proportion of stochastic processes showed more severe disorders. Microbes enriched in patients with T1D had a stronger colonization potential in mice with impaired glucose metabolism, and microbiota functional features related to T1D were better reproduced in these mice. This indicates that assembly traits and colonization efficacy of microbiota influence phenotypic reproducibility in GF-humanized mice. Our findings provide important insights for using HMA mice models to explore links between gut microbiota and human diseases.

关键词： gut microbiome human microbiota-associated animal model type 1 diabetes