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Synthesis and anti-HBV evaluation of mono L-amino acid ester, mono non-steroid anti-inflammation drug carboxylic ester derivatives of acyclonucleoside phosphonates

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Chinese Chemical Letters 2014年第1期25卷 115-118页

作者： xiao-Zhong Fu Feng-Jie Jiang Yu Ou Sheng Fu Yu-Feng Cha Shun Zhang Zong-yuan Liu Wen Zhou Ai-Min Wang Yong-Lin Wang School of Pharmacy Guiyang Medical CollegeEngineering Research Center for the Development and Application of Ethnic Medicines and TCMMinistry of Education Provincial Key Laboratory of Pharmaceutics in Guizhou Province Guiyang Women and Children’s Hospital and Health Institute

A series of mono L-amino acid ester, mono non-steroid anti-inflammation drug （NSAID）, carboxylic ester derivatives of acyclonucleoside phosphonates were prepared by using a ＂one pot synthesis＂ method and their in vitro anti-HBV activity were evaluated in HepG 2.2.15 cells. Compound 9a exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with IC50 and selective index （SI） values of 0.48μmol/L and 763.72, respectively.

关键词： Acyclonucleoside phosphonate Non-steroid anti-inflammation drug Anti-HBV activity

Proteomics of serum exosomes identified fibulin-1 as a novel biomarker for mild cognitive impairment

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Neural Regeneration Research 2023年第3期18卷 587-593页

作者： Bo Chen Li Song Juan Yang Wei-Ying Zhou yuan-yuan Cheng Yu-Jie Lai College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology the First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Major Neurological and Mental DisordersChongqing Key Laboratory of NeurologyChongqingChina Department of Neurology The Third Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Mild cognitive impairment(MCI)is a prodrome of Alzheimer’s disease *** impairment patients often have a delayed diagnosis because there are no early symptoms or conventional diagnostic *** play a vital role in cell-to-cell communications and can act as promising biomarkers in diagnosing *** study was designed to identify serum exosomal candidate proteins that may play roles in diagnosing *** spectrometry coupled with tandem mass tag approach-based non-targeted proteomics was used to show the differentially expressed proteins in exosomes between MCI patients and healthy controls,and these differential proteins were validated using immunoblot and enzyme-linked immunosorbent *** of cognitive performance with the serum exosomal protein level was *** tracking analysis suggested that there was a higher serum exosome concentration and smaller exosome diameter in individuals with MCI compared with healthy *** identified 69 exosomal proteins that were differentially expressed between MCI patients and healthy controls using mass spectrometry ***-nine exosomal proteins were upregulated in MCI patients compared with those in control *** fibulin-1,with an area under the curve value of 0.81,may be a biomarker for an MCI *** exosomal protein signature from MCI patients reflected the cell adhesion molecule *** particular,higher exosomal fibulin-1 levels correlated with lower cognitive ***,this study revealed that exosomal fibulin-1 is a promising biomarker for diagnosing MCI.

关键词： Alzheimer’s disease biomarker diagnosis exosomes fibulin mass spectrometry mild cognitive impairment tandem mass tag cell adhesion molecule nanoparticle tracking analysis

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电解水析氢非铂催化剂的设计与发展

中国有色金属学报 2017年第6期27卷 1289-1301页

作者：熊昆高媛周桂林重庆工商大学废油资源化技术与装备教育部工程研究中心催化与环境新材料重庆市重点实验室重庆400067

氢能作为一种清洁、高能、无二次污染的"绿色能源",被认为是后石油时代解决能源危机和环境危机的理想能源之一。其中电解水析氢技术因反应高效、易控、无污染等特点而逐渐成为研究热点。目前析氢性能最好的催化剂依然是Pt基催化剂。然... 详细信息

氢能作为一种清洁、高能、无二次污染的"绿色能源",被认为是后石油时代解决能源危机和环境危机的理想能源之一。其中电解水析氢技术因反应高效、易控、无污染等特点而逐渐成为研究热点。目前析氢性能最好的催化剂依然是Pt基催化剂。然而Pt储量少、价格贵,无法满足大规模氢气生产的现实需求。因此,如何进一步提高现有非Pt催化剂的析氢性能或开发廉价高效的新型催化剂是实现电解水析氢规模化生产的关键。结合本课题组在电解水方面的研究工作,综述近几年非Pt析氢催化剂的研究新进展,重点介绍新型过渡金属化合物催化材料的结构设计与调控对析氢性能的影响,并对电解水析氢催化剂面临的挑战及发展方向进行展望。

关键词：电解水氢能析氢反应非铂催化剂

Exploring Gender Differences in Adolescent Dissociative Symptoms via A Structural Equation Model

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Biomedical and Environmental Sciences 2023年第8期36卷 773-778页

作者： CHENG Qing Lin DENG yuan yuan ZHAO Gang CHEN Jun Fang XIE Li WANG Le Hangzhou Center for Disease Control and Prevention Hangzhou 310021ZhejiangChina School of Medicine Hangzhou Normal UniversityHangzhou 310021ZhejiangChina

Adolescent dissociative disorders(ADDs)have been recognized as significant psychological issues with an estimated prevalence of 45.2%in psychiatric outpatient clinics^([1]).Previous studies have demonstrated that dissociative symptoms(DSs)manifest as early signs of dissociative disorders(DDs)^([2]).DSs are characterized as aberrations in one's feelings,experiences,and thoughts in the realm of awareness and memory^([3]).

关键词： Equation Ado realm

Comparison of immersion ultrasound and low coherence reflectometry for ocular biometry in cataract patients

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International Journal of Ophthalmology(English edition) 2018年第6期11卷 966-969页

作者： Yan Li Hong-Xun Li Yang-Chen Liu Ya-Tu Guo Jian-Min Gao Bin Wu Nan Zhang Dong Liu xiao-Yong yuan Tianjin Medical University Clinical College of Ophthalmology Tianjin Eye Hospital Tianjin Key Laboratory of Ophthalmology and Visual Science

AIM： To compare the results of axial length （AL） biometry in cataract eyes by three methods： immersion B-ultrasound （IB） biometry, immersion A-ultrasound （IA） biometry and optical low coherence reflectometry. METHODS： In this prospective observational study of eyes with cataract AL measurements were performed using immersion ultrasound and optical low coherence reflectometry device. The results were evaluated using Bland-Altman analyses. The differences between both methods were assessed using the paired t-test, and its correlation was evaluated by Pearson coefficient. RESULTS： Eighty eyes of 80 patients （39 men and 41 women） for cataract surgery were included in the study. The values of AL could be got from all 80 eyes by IB and IA, the difference of AL measurements between IA and IB was of no statistical significance （P=0.97）; the mean difference in AL measurements was -0.031 mm （P=0.26; 95%CI, -0.09 to 0.02）; linear regression showed an excellent correlation （r=0.98, P〈0.0001）. Forty-five of eighty eyes with results of AL measurements, which can be obtained by three methods; the difference of AL measurements was of no statistical significance （IA vs IB, P=0.18; IA vs Lenstar, P=0.51; IB vs Lenstar, P=0.07）; linear regression showed an excellent correlation （IA vs IB, r=0.99; IA vs Lenstar, r=0.96; IB vs Lenstar, r=0.96）; Bland-Altman analysis also showed good agreement between the two methods [IA vs IB, 95% limits of agreement （LoA）, -0.36 to 0.28 mm; IA vs Lenstar, 95% LoA, -0.65 to 0.69 mm; IB vs Lenstar, 95% LoA, -0.55 to 0.68 mm]. CONCLUSION： Measurements with the optical low coherence reflectometry correlated well with IB and IA. In the eyes with serious refractive medium opacity, the measurements of AL could not be achieved or existed deviations when using optical low coherence reflectometry device. Under such circumstances, we should choose IA or IB as the optimization method to obtain measurements, in order to get much more accurate results.

关键词： ultrasonography immersion axial length biometry

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结冰对飞机飞行动力学特性影响的仿真研究

系统仿真学报 2007年第9期19卷 1929-1932页

作者：袁坤刚曹义华北京航空航天大学航空科学与工程学院北京100083

采用一种计算飞机结冰后气动系数和气动导数的工程方法,引入几个结冰参数,建立结冰后飞机飞行动力学模型。根据这些参数计算了飞机结冰后阻力系数以及典型气动导数的变化,并计算了结冰前后飞机的飞行包线;同时对结冰前后飞机的纵向、横... 详细信息

采用一种计算飞机结冰后气动系数和气动导数的工程方法,引入几个结冰参数,建立结冰后飞机飞行动力学模型。根据这些参数计算了飞机结冰后阻力系数以及典型气动导数的变化,并计算了结冰前后飞机的飞行包线;同时对结冰前后飞机的纵向、横侧动稳定性以及升降舵、副翼和方向舵阶跃操纵响应进行仿真计算。这种方法除了简单、物理概念明显、耗费少之外,采取将外界结冰条件与飞机本体分开处理的思路,具有广泛的适应性。结冰参数值随时间变化,可为实时监控结冰影响提供数据。

关键词：飞机结冰飞行性能飞行力学稳定性操作性

Increased Preoperative Glucose Variability Is Associated with Adverse Perioperative Outcomes Following Orthopedic Surgery in Patients with Type 2 Diabetes Mellitus

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Current Medical Science 2020年第3期40卷 523-529页

作者： Si-jie yuan Jie SHEN Department of Endocrinology and Metabolic Diseases The Third Affiliated HospitalSouthern Medical UniversityGuangzhou510630China

The association between glucose variability(GV)and adverse perioperative outcomes in type 2 diabetes mellitus(T2DM)patients undergoing orthopedic surgery was investigated.A retrospective cohort study was performed by analyzing data on T2DM patients receiving continuous blood glucose(BG)monitoring and continuous subcutaneous insulin infusion treatment due to poorly controlled preoperative BG prior to orthopedic *** was assessed with coefficient of variation(CV).Postoperative and perioperative CV,hypoglycemia cases,and other perioperative outcomes(diabetes preparation time[DPT],length of stay[LOS],and perioperative and infective complication cases)were *** showed that a total of 168 patients were grouped into preoperative CV tertiles:1st(n=56):0–0.2921,2nd(n=58):0.2922–0.3779,and 3rd(n=54):0.3780–*** blood glucose(FBG),perioperative CV,rate of hypoglycemia cases(OR:5.53,95%CI:2.43–12.59)(all P<0.001)and DPT(P=0.024)were higher in the 3rd than in the 1st *** adjustments of covariates,regression analysis indicated that the 3rd tertile was associated with increased perioperative CV(adjusted coefficient=0.515,P<0.001),DPT(adjusted coefficient=0.169,P=0.073),rate of hypoglycemia cases(OR:6.72,95%CI:2.69−16.82,P<0.001)and perioperative complication cases(OR:2.50,95%CI:0.90−7.01,P=0.080).In conclusion,preoperative GV is associated with increased perioperative GV and adverse perioperative outcomes including longer DPT and higher rates of hypoglycemia and perioperative complications.

关键词： glycemic variability orthopedics perioperative period type 2 diabetes mellitus

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中国潮剧的生存现状与出路

深圳大学学报（人文社会科学版） 2009年第3期26卷 157-160页

作者：刘琨陈媛深圳大学师范学院艺术系．广东深圳518060 深圳市文联广东深圳518034

潮剧孕育于潮汕文化,用潮州方言演唱、以潮州音乐伴奏,是极富潮汕地域特色的地方戏曲。历史上,潮剧经历了三次大的变革,曾经取得过辉煌的成就。目前的发展存在着城市戏院衰落、专业剧团困顿、乡里广场戏兴起的特点。今后的发展出路应以... 详细信息

潮剧孕育于潮汕文化,用潮州方言演唱、以潮州音乐伴奏,是极富潮汕地域特色的地方戏曲。历史上,潮剧经历了三次大的变革,曾经取得过辉煌的成就。目前的发展存在着城市戏院衰落、专业剧团困顿、乡里广场戏兴起的特点。今后的发展出路应以广场戏为主要依托,在潮剧的创作中,迎合观众的欣赏习惯和欣赏水平,为广大观众服务;不断提高剧目质量,实施精品战略;着力培养更多的优秀演员;并通过走出去扩展潮剧的发展空间,使潮剧能够进入长足发展的轨道。

关键词：潮剧广场戏传统文化

Lysine acetylsalicylate ameliorates lung injury in rats acutely exposed to paraquat

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Chinese Medical Journal 2011年第16期000卷 2496-2501页

作者： HUANG Wei-dong WANG Jie-zan LU yuan-qiang DI Ya-min JIANG Jiu- kun ZHANG Qin Department of Emergency Medicine First Alliliated HospitalZhejiang University School of Medicine Hangzhou Zhejiang310003 China Institute of Drug and Instrument Control of Health Department General Logistic Department of Pepole's Liberation Army Beijing100071 China

Background Paraquat （PQ）, an effective and widely used herbicide, has been proven to be safe when appropriately applied to eliminate weeds. However, PQ poisoning is an extremely frustrating clinical condition with a high mortality and with a lack of effective treatments in humans. PQ mainly accumulates in the lung, and the main molecular mechanism of PQ toxicity is based on redox cycling and intracellular oxidative stress generation. The aim of this study was to evaluate whether lysine acetylsalicylate （LAS） could protect the lung from the damage of PQ poisoning and to study the mechanisms of protection. Methods A model of PQ poisoning was established in 75 Sprague-Dawley rats by intragastric administration of 50 mg/kg PQ, followed by treatment with 200 mg/kg of LAS. The rats were randomly divided into sham, PQ, and PQ＋LAS groups, with 25 in each group. We assessed and compared the malonaldehyde （MDA） content, superoxide dismutase activity （SOD）, glutathion peroxidase （GSH-Px）, and catalase （CAT） in serum and lung and the hydroxyproline （HYP） content, pathological changes, apoptosis and expression of Bcl-2/Bax protein in lung of rats on days 1, 3, 7, 14 and 21 after PQ poisoning and LAS treatment. Results Compared to the PQ group rats, early treatment with LAS reduced the MDA and HYP contents, and increased the SOD, GSH-Px, and CAT activities in the serum and lung on days 1, 3, 7, 14, and 21 after PQ poisoning （all P〈0.05）. After early LAS treatment, the apoptotic rate and Bax expression of lung decreased, the Bcl-2 expression increased, and the Bcl-2/Bax ratio increased, compared to the PQ group rats. Furthermore, the pathological results of lungs revealed that after LAS treatment, early manifestations of PQ poisoning, such as hemorrhage, edema and inflammatory-cell infiltration, were improved to some degree, and collagen fibers in the pulmonary interstitium were also obviously reduced. Conclusion In this rat model of PQ poisoning, LAS effectively ameliorated the l

关键词： acetylsalicylic acid lysinate paraquat lung injury