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枸杞植物化学成分调节肠道菌群及相关生理功能的研究进展

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浙江大学学报（农业与生命科学版） 2024年第1期50卷 25-34页

作者：毕冉冉赵圆孙玉敬浙江工业大学食品科学与工程学院浙江杭州310014

枸杞含有多种营养和活性组分,具有一定的食用和药用价值。过去的研究发现,枸杞提取物具有调节免疫、抗肿瘤、抗癌等多种生物活性。最新的研究发现枸杞及其提取物还具有肠道菌群调节功能。本文对宁夏枸杞(红枸杞)和黑果枸杞果实中的枸杞... 详细信息

枸杞含有多种营养和活性组分,具有一定的食用和药用价值。过去的研究发现,枸杞提取物具有调节免疫、抗肿瘤、抗癌等多种生物活性。最新的研究发现枸杞及其提取物还具有肠道菌群调节功能。本文对宁夏枸杞(红枸杞)和黑果枸杞果实中的枸杞多糖、花色苷、甜菜碱、酚酸、黄酮类化合物、类胡萝卜素等植物化学成分进行了介绍,详述了枸杞全果及其提取物对肠道菌群及相关生理功能的影响,并对未来的研究方向进行了展望。

关键词：宁夏枸杞(红枸杞) 黑果枸杞植物化学成分肠道菌群

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Measurement of atmospheric non-reciprocity effects for satellite-based two-way time-frequency transfer

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Photonics Research 2024年第6期12卷 1274-1282页

作者： TING ZENG QI SHEN yuan CAO JIAN-YU GUAN MENG-ZHE LIAN JIN-JIAN HAN LEI HOU JIAN LU XIN-XIN PENG MIN LI WEI-YUE LIU JIN-CAI WU YONG WANG JUAN YIN JI-GANG REN HAI-FENG JIANG QIANG ZHANG CHENG-ZHI PENG JIAN-WEI PAN Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Shanghai Research Center for Quantum Science and CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaShanghai 201315China Hefei National Laboratory University of Science and Technology of ChinaHefei 230094China Faculty of Information Science and Engineering Ningbo UniversityNingbo 315211China Key Laboratory of Space Active Opto-Electronic Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

Future optical clock networks will require high-precision optical time-frequency transfer between satellites and ground ***,due to atmospheric turbulence,satellite motion and time delay between the satellite–ground transmission links will cause spatial and temporal variations,respectively,resulting in the breakdown of the time-of-flight reciprocity on which optical two-way time-frequency transfer is ***,we experimentally simulate the atmospheric effects by two-way spatio-temporally separated links between two stationary terminals located 113 km apart and measure the effects for optical two-way time-frequency *** experiment shows that the effect on the link instability is less than 2.3×10^(−19) at 10,000 *** indicates that when the link instability of satellite-ground optical time-frequency transfer is on the order of 10^(−19),it is not necessary to consider the atmospheric non-reciprocity effects.

关键词： breakdown transfer satellite

Alternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in Apoe^(-/-)mice

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Life Metabolism 2024年第3期3卷 46-59页

作者： Yajuan Deng Xiaoyu Yang Xueru Ye Youwen yuan Yanan Zhang Fei Teng Danming You Xuan Zhou Wenhui Liu Kangli Li Shenjian Luo Zhi Yang Ruxin Chen Guojun Shi Jin Li Huijie Zhang Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong Provincial Key Laboratory of Shock and Microcirculation Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China State Key Laboratory of Organ Failure Research National Clinical Research Center for Kidney DiseaseNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Endocrinology The Second Hospital of Shanxi Medical UniversityShanxi Medical UniversityTaiyuanShanxi 030001China Department of Endocrinology and Metabolism Guangdong Provincial Key Laboratory of DiabetologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China

Atherosclerosis is the major contributor to cardiovascular mortality *** day fasting(ADF)has gained growing attention due to its metabolic ***,the effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in atherosclerotic animal *** present study was designed to investigate the effects of ADF on atherosclerosis in apolipoprotein E-deficient(Apoe^(-/-))***-week-old male Apoe^(-/-)mice fed with Western diet(WD)were randomly grouped into ad libitum(AL)group and ADF group,and ADF aggravated both the early and advanced atherosclerotic lesion formation,which might be due to the disturbed cholesterol profiles caused by ADF *** significantly altered cholesterol metabolism pathways and down-regulated integrated stress response(ISR)in the *** hepatic expression of activating transcription factor 3(ATF3)was suppressed in mice treated with ADF and hepatocyte-specific overexpression of Aft3 attenuated the effects of ADF on atherosclerotic plaque formation in Apoe^(-/-)***,the expression of ATF3 could be regulated by Krüppel-like factor 6(KLF6)and both the expressions of ATF3 and KLF6 were regulated by hepatic cellular ISR *** conclusion,ADF aggravates atherosclerosis progression in Apoe^(-/-)mice fed on *** inhibits the hepatic ISR signaling pathway and decreases the expression of KLF6,subsequently inhibiting ATF3 *** suppressed ATF3 expression in the liver mediates the deteriorated effects of ADF on atherosclerosis in Apoe^(-/-)*** findings suggest the potentially harmful effects when ADF intervention is applied to the population at high risk of atherosclerosis.

关键词： alternate day fasting atherosclerosis cholesterol integrated stress response activating transcription factor 3

不同抽水转发电模式下抽蓄机组稳定性参数对比

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振动工程学报 2024年第1期37卷 104-112页

作者：张飞郑源赵毅锋王康生国网新源控股有限公司抽水蓄能技术经济研究院北京100761 河海大学能源与电气学院江苏南京211100 江西洪屏抽水蓄能有限公司江西宜春330603

新型电力系统建设要求缩短抽水蓄能机组的快速响应时间。以具体电站机组为例,研究了正常与快速抽水转发电模式下监控流程的主要差异和机组稳定参数的变化规律。在此基础上,引入反时限振动评价方法对两种模式下的振动峰峰值进行计算,评... 详细信息

新型电力系统建设要求缩短抽水蓄能机组的快速响应时间。以具体电站机组为例,研究了正常与快速抽水转发电模式下监控流程的主要差异和机组稳定参数的变化规律。在此基础上,引入反时限振动评价方法对两种模式下的振动峰峰值进行计算,评估了转换模式对机组的影响;采用频谱分析方法对无叶区压力脉动进行分析,发现了低转速下无叶区存在水力共振现象,并揭示了共振幅值、频率与转速的相关性。研究结果表明:抽水转发电快速流程优于正常流程,快速转换模式下的水力制动方式较正常转换模式下的电气制动加机械制动方式流程时间由438 s缩短至220 s,显著提高工况转换效率;在振动对机组损伤方面,14个振动、摆度监测点中13个监测点证明快速转换模式有利于延长机组预期寿命;同时,快速转换模式有利于机组快速通过低转速下无叶区产生的水力共振区,将水力共振时间由15 s缩减至5 s,共振转速区间压缩超过60%。

关键词：抽水转发电稳定性参数水力共振水力制动振动评价

Optimal concentration and time window for proliferation and differentiation of neural stem cells from embryonic cerebral cortex: 5% oxygen preconditioning for 72 hours

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Neural Regeneration Research 2015年第9期10卷 1516-1522页

作者： Li-li yuan Ying-jun Guan Deng-dian Ma hong-mei Du Department of Histology and Embryology Academy of Basic Medicine Jining Medical University Department of Histology and Embryology Academy of Basic Medicine Weifang Medical University Department of Otorhinolaryngology Affiliated Hospital of Jining Medical University

Hypoxia promotes proliferation and differentiation of neural stem cells from embryonic day 12 rat brain tissue, but the concentration and time of hypoxic preconditioning are controversial. To address this, we cultured neural stem cells isolated from embryonic day 14 rat cerebral cortex in 5% and 10% oxygen in vitro. MTT assay, neurosphere number, and immunofluorescent staining found that 5% or 10% oxygen preconditioning for 72 hours improved neural stem cell viability and proliferation. With prolonged hypoxic duration （120 hours）, the proportion of apoptotic cells increased. Thus, 5% oxygen preconditioning for 72 hours promotes neural stem cell prolif- eration and neuronal differentiation. Our findings indicate that the optimal concentration and duration of hypoxic preconditioning for promoting proliferation and differentiation of neural stem cells from the cerebral cortex are 5% oxygen for 72 hours.

关键词： nerve regeneration brain injury neural stem cells low oxygen cerebral cortex apoptosis differentiation microtubule-associated protein 2 glial fibrillary acidic protein caspase-3 neuralregeneration

职业本科人才培养方案制定现状、问题与路径探索——基于6校电子商务专业人才培养方案的实证调查

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职业教育研究 2024年第4期 25-31页

作者：肖云梅刘琼陈小芹袁旭宏湖南软件职业技术大学湖南湘潭411100

文章以我国6所典型职业本科大学电子商务专业为例,对其人才培养方案进行实证研究。研究发现,职业本科人才培养方案的制定应从产业出发,有机融合产业链、人才链,确定职业本科高层次人才培养目标和规格,构建“四突出”课程体系,构建“五... 详细信息

文章以我国6所典型职业本科大学电子商务专业为例,对其人才培养方案进行实证研究。研究发现,职业本科人才培养方案的制定应从产业出发,有机融合产业链、人才链,确定职业本科高层次人才培养目标和规格,构建“四突出”课程体系,构建“五共同”深度产教融合校企合作模式,打造职业本科“双师型”教学团队,建设多维立体化教学资源库,构建适合中国国情的本科层次职业教育人才培养方案,推动人才供给侧结构性改革。

关键词：职业本科人才培养方案课程体系产教融合

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Ginkgo biloba derivative ginkgetin inhibits breast cancer growth by regulating the miRNA-122-5p/GALNT10 axis

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中华医学杂志(英文版) 2024年第19期137卷 2024 Aug 26页

作者： Alu Aqu Jiang Zedong Han Xuejiao Cheng yuan Qin Furong Ni Yanghong Zeng Hao Li Qingfang Song Yanlin Ma Xuelei Department of Biotherapy Cancer Center State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu Sichuan China Department of Gynecology and Obstetrics Development and Related Disease of Women and Children Key Laboratory of Sichuan Province Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of Education West China Second Hospital Sichuan University Chengdu Sichuan China

Protein-protein Interaction Between Domains of PDZ and BAR from PICK1

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Chemical Research in Chinese Universities 2007年第2期23卷 191-195页

作者： XIAO hong SHI Ya-wei WANG Li-li yuan Jing-ming Institute of Biotechnology Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education Shanxi University Taiyuan 030006 P. R. China

Two DNA fragments encoding PDZ domain （21-110 residues） and BAR domain （ 150-360 residues） from PICK1 （1-416 residues） were amplified by PCR and then introduced into vectors, pET-32M and pMAL-e2X respectively to generate recombinant plasmids, pE-pdz and pM-bar. Having been separately transferred into the hosts E. coli BL21 and E. coli JM109, these two strains can express fusion proteins： His-tagged PDZ（PDZ domain） and maltose binding protein-BAR（ MBP-BAR domain） respectively, as confirmed by both SDS-PAGE and Wostem blotting. The interaction between these two domains is dose-dependence, as identified by a pull-down test. Moreover, it has been shown from the ELISA analysis that the actual amount of PDZ bound to MBP-BAR-amylose beads reaches （ 16 ± 0. 5）%, as calculated by the molar ratio of PDZ to MBP-BAR. In addition, the interaction between BAR（bait） and PDZ（prey） in vivo was also examined with a yeast two-hybrid system.

关键词： BAR domain PDZ domain PICK1 Protein-protein interaction Pull-down test Yeast two-hybrid

不可降解微塑料对重金属环境行为的影响研究进展

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化学与生物工程 2024年第4期41卷 9-17页

作者：雷诗涵时晓雨陈珂怡高原袁鸣武汉工程大学环境生态与生物工程学院湖北武汉430205

作为一种持久性环境污染物,微塑料对环境生态造成了较大的风险并引起了广泛关注。与可降解微塑料相比,不可降解微塑料因持久、耐用、经济和应用广泛等特点而具有更大的危害性。不可降解微塑料可作为载体吸附包括重金属在内的环境污染物... 详细信息

作为一种持久性环境污染物,微塑料对环境生态造成了较大的风险并引起了广泛关注。与可降解微塑料相比,不可降解微塑料因持久、耐用、经济和应用广泛等特点而具有更大的危害性。不可降解微塑料可作为载体吸附包括重金属在内的环境污染物,并可能影响它们在环境中的迁移转化和生物有效性等环境行为。纵使重金属在环境中的迁移转化已经得到了广泛的关注与研究,但微塑料对重金属环境行为的影响机制及相互作用的危害仍未被系统阐明。综述了不可降解微塑料对重金属环境行为的影响,探讨了微塑料影响重金属环境行为的作用机制,分析了微塑料吸附重金属的影响因素,为微塑料与重金属复合污染的修复治理提供了参考依据。

关键词：微塑料重金属迁移转化环境行为金属形态

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