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基于FA-LSTM的燃气轮机燃烧室故障演化趋势预估

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汽轮机技术 2024年第5期66卷 368-372,378页

作者：卿硕袁国凯吴伟秋傅颖林朝靖周之豪龙振华清洁高效透平动力装备全国重点实验室德阳618000 东方汽轮机有限公司德阳618000 哈尔滨工业大学能源科学与工程学院哈尔滨150001

燃气轮机高温部件的故障发生率高、隐蔽性强、破坏性大,且故障发生后维修成本高、维修难度大。研究一种故障演化趋势预估方法对于维修人员及时维修和制定维修决策具有重大意义。介绍了一种基于FA-LSTM的故障演化趋势预估方法,结合燃烧... 详细信息

燃气轮机高温部件的故障发生率高、隐蔽性强、破坏性大,且故障发生后维修成本高、维修难度大。研究一种故障演化趋势预估方法对于维修人员及时维修和制定维修决策具有重大意义。介绍了一种基于FA-LSTM的故障演化趋势预估方法,结合燃烧室退化机理采用因子分析法(FA)构建健康因子(HI)用于衡量燃机燃烧室的健康状态。利用长短时记忆神经网络(LSTM)特有的处理时间序列数据的能力,预测燃烧室故障演化趋势。以某型燃气轮机为研究对象,并将所提方法与其它6种传统机器学习方法对比,本方法的预测结果MAE和RMSE均最低,能实现准确的退化趋势预测,为短期维护提供有效依据。

关键词：燃气轮机故障演化趋势因子分析长短时记忆神经网络

Efficacy and safety of albumin-bound paclitaxel in treating recurrent advanced non-small-cell lung cancer

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Chinese Journal of Cancer Research 2013年第2期25卷 200-205页

作者： Pu-yuan Xing jun-Ling Li Yan Wang Xue-Zhi Hao Bin Wang Lin Yang yuan-Kai Shi Xiang-Ru Zhang Cancer Institute and Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective： To observe the efficacy and safety of albumin-bound paclitaxel （ABP） monotherapy in treating recurrent advanced non-small-cell lung cancer （NSCLC）. Methods： We retrospectively analyzed the short-term efficacy and toxicities of ABP monotherapy in treating 21 patients who had previously undergone multiple cycles of therapy for their advanced NSCLC in our hospital since 2010. The treatment-related survival was also analyzed. Results： Of these 21 patients, the best overall response was partial response （PR） in 6 patients （28.6%）, stable disease （SD） in I0 patients （47.6%）, and progressive disease （PD） in 5 patients （23.8%）. The overall response rate （ORR） was 28.6% and the disease control rate （DCR）（PR ＋ SD） was 76.2%. The median progression-flee survival （PFS） was 4.0 months （95% CI, 5.0-7.0 months）. The main grade 3/4 toxicities included neutropenia （11.1%）, peripheral nerve toxicity （5.6%）, muscle and joint aches （5.6%）, and fatigue （5.6%）. Conclusions： The ABP monotherapy can achieve good objective response in advanced NSCLC patients who have previously received multiple cycles of treatment and be well tolerated.

关键词： Albumin-bound paclitaxel paclitaxel advanced non-small cell lung cancer chemotherapy

Framework of SAGI Agriculture Remote Sensing and Its Perspectives in Supporting National Food Security

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Journal of Integrative Agriculture 2014年第7期13卷 1443-1450页

作者： SHI Yun JI Shun-ping SHAO Xiao-wei TANG hua-jun WU Wen-bin YANG Peng ZHANG Yong-jun Shibasaki Ryosuke Key Laboratory of Agri-Informatics Ministry of Agriculture/Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences Earth Observation Data Integration and Fusion Research Initiative The University of Tokyo School of Remote Sensing and Information Engineering Wuhan University

Remote sensing, in particular satellite imagery, has been widely used to map cropland, analyze cropping systems, monitor crop changes, and estimate yield and production. However, although satellite imagery is useful within large scale agriculture applications （such as on a national or provincial scale）, it may not supply sufifcient information with adequate resolution, accurate geo-referencing, and specialized biological parameters for use in relation to the rapid developments being made in modern agriculture. Information that is more sophisticated and accurate is required to support reliable decision-making, thereby guaranteeing agricultural sustainability and national food security. To achieve this, strong integration of information is needed from multi-sources, multi-sensors, and multi-scales. In this paper, we propose a new framework of satellite, aerial, and ground-integrated （SAGI） agricultural remote sensing for use in comprehensive agricultural monitoring, modeling, and management. The prototypes of SAGI agriculture remote sensing are ifrst described, followed by a discussion of the key techniques used in joint data processing, image sequence registration and data assimilation. Finally, the possible applications of the SAGI system in supporting national food security are discussed.

关键词： SAGI agriculture remote sensing multi-platform data processing food security

隧道内长大坡道区段刚性接触网短电分相设计方案

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现代城市轨道交通 2024年第4期 16-21页

作者：钟源赖馨李明善马骏程泽华中铁二院工程集团有限责任公司四川成都610031 中国铁路昆明局集团有限公司滇西铁路建设指挥部云南大理671000 中国铁道科学研究院集团有限公司北京100081

刚性接触网锚段关节仅有8~12 m,可大幅缩短关节式电分相长度,为解决丽香铁路3处隧道内长大坡道的电分相设计难题,文章通过借鉴柔性接触网关节式电分相设计方案,重点考虑绝缘锚段关节绝缘间隙、锚段热胀冷缩等因素,修正刚性悬挂锚段关节... 详细信息

刚性接触网锚段关节仅有8~12 m,可大幅缩短关节式电分相长度,为解决丽香铁路3处隧道内长大坡道的电分相设计难题,文章通过借鉴柔性接触网关节式电分相设计方案,重点考虑绝缘锚段关节绝缘间隙、锚段热胀冷缩等因素,修正刚性悬挂锚段关节式电分相中性段和无电区长度,并结合工程实际条件,提出刚性接触网短分相设计方案,将电分相长度缩短至23 m,并通过弓网系统动态仿真验证其弓网动态特性可满足速度160 km/h要求。方案实施后,线路动态检测达速160 km/h,刚性接触网短电分段处无明显燃弧现象,各项动态指标满足标准要求。该方案的成功应用对速度120 km/h以上复杂工况线路的接触网电分相设计有重要借鉴意义。

关键词：轨道交通刚性接触网锚段关节电分相中性段

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Photorefractive Image Amplification and Beam Fanning with Inclusion of Random Volume Scattering

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Chinese Physics Letters 1997年第12期14卷 908-911页

作者： XIE Ping WANG Peng-ye DAI Jiari-hua ZHANG Hong-jun Laboratory of Optical Physics Institute of Physics&Center for Condensed Matter PhysicsChinese Acaderr1.v of SciencesBeijing 100080

Photorefractive effects,such as the image amplification and the beam fanning,can be described by a set of multivariable Langevin equations with inclusion of the random-phased volume scattering due to the inhomogeneities and/or defects in the *** image amplification by two-wave-coupling configuration was studied analytically in the undepleted-pump approximation and *** was found that the volume scattering can generate the beam fanning,as the surface scattering does.

关键词： scattering pump coupling

Novel cytotoxic steroidal glycosides from the roots of Liriope muscari

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Chinese Journal of Natural Medicines 2015年第6期13卷 461-466页

作者： LI Yong-Wei QI Jin ZHANG yuan-yuan huaNG Zhen KOU jun-Ping ZHOU Shui-Ping ZHANG Yu YU Bo-Yang State Key Laboratory of Natural Medicines Department of Complex Prescription of TCM China Pharmaceutical University Tasly Research and Development Institute Tasly Pharmaceutical Co. Ltd.

The present study was designed to investigate the chemical constituents and bioactivities of the roots of Liriope muscari(Decne.) L.H. Bailey. The compounds were isolated through various chromatography techniques, including silica gel, Sephadex LH-20, and semi-preparative HPLC. The structures were elucidated by infrared(IR), mass spectrometric(MS), 1D- and 2D-NMR analyses in comparison with reference data. In addition, the cytotoxicity of these compounds against human breast cancer MDA-MB-435 cells was evaluated by the MTT assay. Two new steroidal glycosides, 25(R, S)-ruscogenin-1-O-[β-D-fucopyranosyl(1→2)]-[ β-D-xylopyranosyl(1→3)]-β-D-glucopyranoside(Liriopem I, 1) and 25(R, S)- ruscogenin-1-O-[β-D-fucopyranosyl(1→2)]-[β-D-xylopyranosyl(1→4)]-β-D-fucopyranoside(Liriopem II, 2) and two known compounds LM-S6(3) and DT-13(4) were isolated and identified. Liriopem I(1), liriopem II(2) and DT-13(4) showed remarkable cytotoxicity with IC50 values being(0.58 ± 0.08),(0.05 ± 0.10), and(0.15 ± 0.09) μg·m L-1, respectively. In summary, compounds 1 and 2 identified in the present study exerted cytotoxicity against breast cancer cells, providing a basis for future development of these compounds as novel anticancer agents.

关键词： Liriope muscari Steroidal glycosides Cytotoxicity

Salvianolic acid A attenuates vascular remodeling in pulmonary arterial hypertension rats induced by monocrotaline

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中国药理学与毒理学杂志 2018年第4期32卷 279-280页

作者： Lian-hua FANG Yu-cai CHEN Tian-yi yuan Yang LYU Guan-hua DU Beijing Key Laboratory of Drug Targets Identification and Drug Screening Beijing Key Laboratoryof Polymorphic Drugs Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

OBJECTIVE Salvianolic acid A(SAA) is one of the most bioactive compounds from a traditional Chinese medicine called Dan Shen(Salvia Miltiorrhiza Bunge) and exhibits many *** *** studies have indicated that SAA may inhibit endothelial dysfunction and vascular remodeling in spontaneously hypertensive ***,whether SAA improves vascular remodeling induced by pulmonary arterial hypertension(PAH) remains *** this study we examined whether SAA attenuated vascular remodeling in a PAH rat induced by monocrotaline(MCT),and elucidated the underlying *** PAH was induced in rats by injecting a single dose of monocrotaline(MCT 60 mg·kg^(-1)).The rats were orally treated with either SAA(0.3,1,3 mg·kg^(-1)·d^(-1)) or a positive *** Bosentan(30 mg·kg^(-1)·d^(-1)) for 4 *** and hemodynamic measurements were performed on d *** the hearts and lungs were harvested,the organ indices and pulmonary artery wall thickness were calculated,and biochemical and histochemical analysis were *** levels of apoptotic and signaling proteins in the lungs were measured using *** Treatment with SAA effectively ameliorated MCT-induced pulmonary artery remodeling,pulmonary hemodynamic *** and the subsequent increases of right ventricular systolic pressure(RVSP).Furthermore,the treatments significantly attenuated MCT-induced hypertrophic damage of myocardium,parenchymal *** and collagen deposition in the ***,the treatments attenuated MCT-induced apoptosis and fibrosis in the *** treatments partially restored MCT-induced reductions of bone *** protein type Ⅱ receptor(BMPR Ⅱ) and phosphorylated Smad1/5 in the *** SAA ameliorates the pulmonary arterial remodeling in MCT-induced PAH rats most likely via activating the BMPRII-Smad pathway and inhibiting ***,SAA may have therapeutic potential for the *** at high risk of PAH.

关键词：丹酚酸中药丹参治疗方法

A non-surgical suturing strategy for rapid cardiac hemostasis

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Nano Research 2023年第1期16卷 810-821页

作者： yuan Gao jun Zhang Nan Cheng Zhong Liu yuan-Bin Wu Qian-Qian Zhou Chen-Yan Li Miao Yu Seeram Ramakrishna Rong Wang Yun-Ze Long Collaborative Innovation Center for Nanomaterials&Devices College of PhysicsQingdao UniversityQingdao 266071China Department of Adult Cardiac Surgery the Sixth Medical Center of PLA General HospitalBeijing 100084China Institute of Health Service and Transfusion Medicine Beijing 100850China Center for Nanofibers&Nanotechnology Department of Mechanical EngineeringNational University of SingaporeSingapore 117574Singapore State Key Laboratory of Bio-Fibers&Eco-Textiles Qingdao 266071China

As the central organ of the human body,once the heart is damaged,it will cause devastating damage to the circulation system of the whole body,often leading to rapid ***,the only treatment option to stop bleeding in penetrating cardiac injuries is surgical suturing,which is extremely complex and *** addition,it is difficult to implement this kind of treatment in battlefields with poor medical ***,there is an urgent need to develop an effective cardiac hemostasis *** this work,we propose a two-step hemostasis strategy that can effectively stop bleeding for penetrating heart *** is,cardiac hemostatic plug(CHP)is made from the nanocomposite(polylactic acid/gelatin/absorbable hemostatic particles,PLA/GEL/AHP)with high biosafety,excellent hemostatic performance,and degradability which is used to block cardiac bleeding,and then wound surface is sealed by in-situ electrospun medical glue fibers(N-octyl-2-cyanoacrylate,interfacial toughness:221±23 J·m−2),thus completing cardiac hemostasis(porcine heart with 1 cm diameter penetrating wound).The hemostasis process is simple and quick(<2 min).In addition,it is worth mentioning that we have also proposed a new composite method based on solution blow spinning that is suitable for doping various functional particles,and the PLA/GEL/AHP composite nanofiber membrane prepared by this method is also a promising hemostatic material.

关键词： heart cardiac hemostasis nanocomposite solution blow spinning electrospinning

Mitochondrial protective and anti-apoptotic effects of Rhodiola crenulata extract on hippocampal neurons in a rat model of Alzheimer's disease

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Neural Regeneration Research 2017年第12期12卷 2025-2034页

作者： jun-mei Wang Ze-qiang Qu Jin-lang Wu Peter Chung yuan-shan Zeng Department of Histology and Embryology Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China Department of Electron Microscope Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China Shanghai Ninth People's Hospital Shanghai liao Tong University School of Medicine Shanghai China Institute of Spinal Cord In)ury Sun Yat-sen University Guangzhou Guangdong Province China Co-innovation Center of Neuroregeneration Nantong University Nantong Jiangsu Province China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China

In our previous study, we found that the edible alcohol extract of the root of the medicinal plant Rhodiola crenulata（RCE） improved spatial cognition in a rat model of Alzheimer＇s disease. Another study from our laboratory showed that RCE enhanced neural cell proliferation in the dentate gyrus of the hippocampus and prevented damage to hippocampal neurons in a rat model of chronic stress-induced depression. However, the mechanisms underlying the neuroprotective effects of RCE are unclear. In the present study, we investigated the anti-apoptotic effect of RCE and its neuroprotective mechanism of action in a rat model of Alzheimer＇s disease established by intracerebroventricular injection of streptozotocin. The rats were pre-administered RCE at doses of 1.5, 3.0 or 6.0 g/kg for 21 days before model establishment. ATP and cytochrome c oxidase levels were significantly decreased in rats with Alzheimer＇s disease. Furthermore, neuronal injury was obvious in the hippocampus, with the presence of a large number of apoptotic neurons. In comparison, in rats given RCE pretreatment, ATP and cytochrome c oxidase levels were markedly increased, the number of apoptotic neurons was reduced, and mitochondrial injury was mitigated. The 3.0 g/kg dose of RCE had the optimal effect. These findings suggest that pretreatment with RCE prevents mitochondrial dysfunction and protects hippocampal neurons from apoptosis in rats with Alzheimer＇s disease.

关键词： nerve regeneration Alzheimer's disease intracerebroventricular injection streptozotocin neuronal apoptosis neuroprotection cytochrome c oxidase adenosine triphosphate caspase-3 NeuN neural regeneration