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Multimodal single-cell omics analysis identifies epithelium-immune cell interactions and immune vulnerability associated with sex differences in COVID-19

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2586-2599页

作者： yuan hou Yadi Zhou Michaela U.Gack Justin D.Lathia Asha Kallianpur Reena Mehra Timothy A.Chan Jae U.Jung Lara Jehi Charis Eng Feixiong Cheng Genomic Medicine Institute Lerner Research InstituteCleveland ClinicClevelandOHUSA Florida Research and Innovation Center Cleveland ClinicPort Saint LucieFLUSA Department of Cardiovascular and Metabolic Science Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA Department of Population and Quantitative Health Sciences Case Western Reserve UniversityClevelandOHUSA Neurological Institute Cleveland ClinicClevelandOHUSA Center for Immunotherapy and Precision Immuno-Oncology Cleveland ClinicClevelandOHUSA Department of Cancer Biology Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Genetics and Genome Sciences Case Western Reserve University School of MedicineClevelandOHUSA Case Comprehensive Cancer Center Case Western Reserve University School of MedicineClevelandOHUSA

Sex differences in the susceptibility of SARS-CoV-2 infection and severity have been controversial,and the underlying mechanisms of COVID-19 in a sex-specific manner remain *** we inspected sex differences in SARS-CoV-2 infection,hospitalization,admission to the intensive care unit(ICU),sera inflammatory biomarker profiling,and single-cell RNA-sequencing(scRNA-seq)profiles across nasal,bronchoalveolar lavage fluid(BALF),and peripheral blood mononuclear cells(PBMCs)from COVID-19 patients with varying degrees of disease *** propensity score-matching observations revealed that male individuals have a 29%elevated likelihood of SARS-CoV-2 positivity,with a hazard ratio(HR)1.32(95%confidence interval[Cl]1.18-1.48)for hospitalization and HR 1.51(95%Cl 1.24-1.84)for admission to *** from male patients at hospital admission had elevated neutrophil-lymphocyte ratio and elevated expression of inflammatory markers(C-reactive protein and procalcitonin).We found that SARS-CoV-2 entry factors,including ACE2,TMPRSS2,FURIN,and NRP1,have elevated expression in nasal squamous cells from male individuals with moderate and severe *** observed male-biased transcriptional activation in SARS-CoV-2-infected macrophages from BALF and sputum samples,which offers potential molecular mechanism for sex-biased susceptibility to viral ***-cell interaction network analysis reveals potential epithelium-immune cell interactions and immune vulnerability underlying male-elevated disease severity and mortality in ***,monocyte-elevated expression of Toll-like receptor 7{TLR7)and Bruton tyrosine kinase{BTK)is associated with severe outcomes in males with *** summary,these findings provide basis to decipher immune responses underlying sex differences and designing sex-specific targeted interventions and patient care for COVID-19.

关键词： elevated epithelium analysis

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HZSM-5 zeolites undergoing the high-temperature process for boosting the bimolecular reaction in n-heptane catalytic cracking

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Chinese Journal of Chemical Engineering 2024年第2期66卷 136-144页

作者： Chenggong Song Zhenzhou Ma Xu hou Hao Zhou Huimin Qiao Changchang Tian Li Yin Baitang Jin Enxian yuan School of Chemical Engineering Changchun University of TechnologyChangchun130012China Department of Chemical and Biomolecular Engineering North Carolina State UniversityRaleighNC 27606USA School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou225009China

High-temperature treatment is key to the preparation of zeolite ***,the effects of hightemperature treatment on the property and performance of HZSM-5 zeolites were studied in this work.X-Ray diffraction,N2physisorption,27Al magic angle spinning nuclear magnetic resonance(MAS NMR),and temperature-programmed desorption of ammonia results indicated that the hightemperature treatment at 650℃ hardly affected the inherent crystal and texture of HZSM-5zeolites but facilitated the conversion of framework Al to extra-framework Al,reducing the acid site and enhancing the acid ***,the high-temperature treatment improved the performance of HZSM-5 zeolites in n-heptane catalytic cracking,promoting the conversion and light olefins yield while inhibiting coke *** on the kinetic and mechanism analysis,the improvement of HZSM-5 performance caused by high-temperature treatment has been attributed to the formation of extra-framework Al,which enhanced the acid strength,facilitated the bimolecular reaction,and promoted the entropy change to overcome a higher energy barrier in n-heptane catalytic cracking.

关键词： HZSM-5 n-Heptane Catalytic cracking High-temperature treatment Extra-framework Al

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Lossless Compression Method for the Magnetic and Helioseismic Imager(MHI)Payload

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Research in Astronomy and Astrophysics 2024年第4期24卷 214-221页

作者： Li-Yue Tong Jia-Ben Lin yuan-Yong Deng Kai-Fan Ji Jun-Feng hou Quan Wang Xiao Yang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Key Laboratory of Solar Activity and Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650216China

The Solar Polar-orbit Observatory(SPO),proposed by Chinese scientists,is designed to observe the solar polar regions in an unprecedented way with a spacecraft traveling in a large solar inclination angle and a small ***,one of the most significant challenges lies in ultra-long-distance data transmission,particularly for the Magnetic and Helioseismic Imager(MHI),which is the most important payload and generates the largest volume of data in *** this paper,we propose a tailored lossless data compression method based on the measurement mode and characteristics of MHI *** background out of the solar disk is removed to decrease the pixel number of an image under *** predictive coding methods are combined to eliminate the redundancy utilizing the correlation(space,spectrum,and polarization)in data set,improving the compression *** results demonstrate that our method achieves an average compression ratio of *** compression time is also less than the general observation *** method exhibits strong feasibility and can be easily adapted to MHI.

关键词： methods:data analysis techniques:image processing Sun:magnetic fields Sun:photosphere

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连通图的度距离和Wiener指数

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福州大学学报（自然科学版） 2014年第1期42卷 12-17页

作者：侯远福州大学至诚学院福建福州350002

令P+(n)表示圈没有公共边的n阶连通图的集合,P+(n,m)表示P+(n)中具有m(m≥1)个极小圈的连通图集合.证明了当n≥6时,P+(n,m)中具有最小度距离的图是花F(n,m),它是m个具有一个公共顶点的三角形并在公共顶点粘上n-1-2m条悬挂边的图;同时证... 详细信息

令P+(n)表示圈没有公共边的n阶连通图的集合,P+(n,m)表示P+(n)中具有m(m≥1)个极小圈的连通图集合.证明了当n≥6时,P+(n,m)中具有最小度距离的图是花F(n,m),它是m个具有一个公共顶点的三角形并在公共顶点粘上n-1-2m条悬挂边的图;同时证明P+(n)中具有最小度距离的图是F(n,1),它是一个三角形并在一个顶点上粘n-3条悬挂边的图.

关键词：连通图 Wiener指数度距离图变换

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长扁圆形烟囱应力分析

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空间结构 2009年第2期15卷 86-89页

作者：袁子厚武汉科技学院理学院湖北武汉430073 重庆交通大学(桥梁)结构工程重点实验室重庆400074

分析了长扁圆形烟囱宽面迎风时风压和平台荷载对烟囱受力的影响,运用ANSYS和ABAQUS软件进行了仿真计算,计算中考虑了几何非线性的影响,并考虑最不利受力情形,计算了烟囱沿高度方向应力、环向应力、位移,详细比较了两软件计算的竖向拉应... 详细信息

分析了长扁圆形烟囱宽面迎风时风压和平台荷载对烟囱受力的影响,运用ANSYS和ABAQUS软件进行了仿真计算,计算中考虑了几何非线性的影响,并考虑最不利受力情形,计算了烟囱沿高度方向应力、环向应力、位移,详细比较了两软件计算的竖向拉应力、环向拉应力的变化规律,发现计算结果比较接近,相互验证了计算的正确性.应力计算结果可供长扁圆形烟囱配筋计算时参考.

关键词：烟囱风压应力 ANSYS ABAQUS

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Antimicrobial Resistance Analysis and Whole-Genome Sequencing of Salmonella Isolates from Environmental Sewage — Guangzhou City, Guangdong Province, China, 2022–2023

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China CDC weekly 2024年第13期6卷 254-260页

作者： Bihui Su Guanghong Du Shuiping hou Zongqiu Chen Xiaoying Wu Gang He Jun yuan Chaojun Xie Tuberculosis Management and Treatment Department Guangzhou Chest HospitalGuangzhou CityGuangdong ProvinceChina School of Public Health Guangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Guangzhou Center for Disease Control and Prevention Guangzhou CityGuangdong ProvinceChina Office of the Director Huadu District Center for Disease Control and PreventionGuangzhou CityGuangdong ProvinceChina

What is already known about this topic?S.1,4,[5],12:i:-and *** are emerging serotypes of Salmonella that require close monitoring for antimicrobial resistance and containment of their *** is added by this report?The study aimed to identify antimicrobial resistance genes(ARGs)in S.1,4,[5],12:i:-and *** strains isolated from environmental sewage in Guangzhou City,Guangdong Province,China.A phylogenetic tree was constructed using single nucleotide polymorphism data to assess genetic relatedness among strains,offering insights for Salmonella infection outbreak investigations in the *** are the implications for public health practice?It is crucial to implement strategies,such as integrating different networks,to control the spread of drugresistant *** technologies must be utilized to disinfect sewage and eliminate *** food safety and proper sewage disinfection are essential to curb the dissemination of Salmonella.

关键词： Whole offering integrating

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核矩阵逼近的贪心算法

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模式识别与人工智能 2007年第1期20卷 138-143页

作者：杜京义侯媛彬西安科技大学电气与控制工程学院西安710054

在综合考虑数据之间的相关性与残差范数最小的基础上,本文分别提出向前贪心算法、向后贪心算法和混合贪心算法寻踪最佳低秩逼近.为此提出一种稀疏回归算法(SRA).SRA 能有效减少"训练样本",并具备良好的推广能力.将 SRA 应用于2个实际的... 详细信息

在综合考虑数据之间的相关性与残差范数最小的基础上,本文分别提出向前贪心算法、向后贪心算法和混合贪心算法寻踪最佳低秩逼近.为此提出一种稀疏回归算法(SRA).SRA 能有效减少"训练样本",并具备良好的推广能力.将 SRA 应用于2个实际的模式识别问题,并与支持向量机(SVM)、核主元回归(KPCR)和关键算法(KA)进行比较,验证 SRA 的有效性.

关键词：核算法核矩阵低秩矩阵贪心算法

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High-static-low-dynamic stiffness isolator based on an electromagnetic negative stiffness spring with long linear stroke

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Science China(Technological Sciences) 2024年第3期67卷 740-752页

作者： yuan ShuJin WU YaJun SONG DaiPing PU HuaYan MOU LiSheng hou Lei ZHAO JingLei LI XuePing LUO Jun WU Jie HUANG XiaoXu State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China China Aerodynamics Research and Development Center Mianyang 621000China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Negative stiffness mechanisms can improve low-frequency vibration isolation performance and have been widely used in the vibration isolation of precision equipment. However, the negative stiffness mechanism usually introduces a nonlinear stiffness,resulting in a nonlinear response and worsening the vibration isolation performance, especially under large amplitude *** this paper, an electromagnetic spring with linear negative stiffness(ESLNS) is proposed, in which the antagonistic ampere forces of the energized coils are used to generate negative stiffness within a long linear stroke. The magnetic field distribution is improved through the design of the magnetic circuit, thereby increasing the stiffness generation efficiency. The stiffness can be adjusted bidirectionally by current within the range of positive and negative stiffness. An electromagnetic stiffness model was established based on the equivalent magnetic circuit method. Experimental measurements verified the accuracy of the model and proved the linearity of the electromagnetic spring. A vibration isolator with high static and low dynamic stiffness(HSLDS) based on the ESLNS is designed and tested. The experimental results prove that the introduction of the ESLNS can effectively expand the isolation frequency band without changing the equilibrium position. Moreover, the vibration isolator with ESLNS does not produce nonlinear response. The proposed electromagnetic spring with linear negative stiffness extends the application range of HSLDS isolators to a large amplitude vibration environment.

关键词： linear negative stiffness mechanism low-frequency vibration isolation electromagnetic spring vibration control

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直馏柴油加氢改质多产优质乙烯裂解原料

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石化技术与应用 2024年第2期42卷 88-92页

作者：王燕张占全雷俊伟郭荣王春燕吴培李荣观侯远东中国石油石油化工研究院北京102206

采用柴油缓和加氢裂化技术对直馏柴油进行改质,考察不同工艺条件对直馏柴油转化率以及加氢裂化产物性质的影响。结果表明:在反应压力为7.0MPa,体积空速为2.0h^(-1)的条件下,随着反应温度由340℃升高至350℃,直馏柴油的转化率由16%提高至... 详细信息

采用柴油缓和加氢裂化技术对直馏柴油进行改质,考察不同工艺条件对直馏柴油转化率以及加氢裂化产物性质的影响。结果表明:在反应压力为7.0MPa,体积空速为2.0h^(-1)的条件下,随着反应温度由340℃升高至350℃,直馏柴油的转化率由16%提高至50%;随着转化率的提高,全馏分柴油的芳烃指数降低,链烷烃质量分数增加;在反应温度为345℃的条件下,初馏点~91.0℃石脑油馏分段的链烷烃质量分数为78%,用作乙烯裂解原料时,乙烯收率为29.2%,乙烯+丙烯+丁二烯(三烯)收率为62.0%;大于234℃~终馏点柴油窄馏分段的链烷烃质量分数大于60%,用作乙烯裂解原料时,乙烯收率为31.9%,三烯收率为64.6%。

关键词：直馏柴油乙烯裂解原料加氢改质分子炼油链烷烃乙烯收率

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Analysis of the acoustoelectric response of SAW gas sensors using a COM model

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Microsystems & Nanoengineering 2024年第3期10卷 87-96页

作者： Yang yuan Tao Yang Xi Chen Linglang Yu Xiaoxiao hou Guangzu Zhang Wen Dong Zixiao Lu Honglang Li Leonhard Reindl Wei Luo School of Integrated Circuits Huazhong University of Science and Technology430074 WuhanPeople’s Republic of China CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology100190 BeijingPeople’s Republic of China Department of Microsystems Engineering Laboratory for Electrical Instrumentation and Embedded SystemsUniversity of Freiburg79110 FreiburgGermany Research Institute of Huazhong University of Science and Technology in Shenzhen 518057 ShenzhenPeople’s Republic of China

Surface acoustic wave(SAW)gas sensors based on the acoustoelectric effect exhibit wide application prospects for in situ gas ***,establishing accurate models for calculating the scattering parameters of SAW gas sensors remains a ***,we present a coupling of modes(COM)model that includes the acoustoelectric effect and specifically explains the nonmonotonic variation in the center frequency with respect to the sensing film’s sheet *** sensing parameters of the gas sensors,including the center frequency,insertion loss,and phase,were experimentally compared for accuracy and ***,the frequency of the phase extremum(FPE)shift was determined to vary monotonically,and the range of selectable test points was wide,making the FPE an appropriate response parameter for leveraging in SAW gas *** simulation results of the COM model were highly consistent with the experimental *** study is proposed to provide theoretical guidance for the future development of gas SAW sensors.

关键词： COM SAW establishing

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