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鄱阳湖平原直播稻CH_(4)通量及其与CO_(2)通量的综合温室效应

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环境科学 2023年第3期44卷 1572-1582页

作者：时元智崔远来才硕洪大林程婕南京水利科学研究院水文水资源与水利工程科学国家重点实验室南京210029 武汉大学水资源与水电工程科学国家重点实验室武汉430072 江西省灌溉试验中心站南昌330201

稻田是一个既排放CH_(4)又吸收CO_(2)的复杂生态系统,在全球水碳循环和碳收支中发挥着重要作用.利用涡度相关法得到2020年鄱阳湖平原双季直播稻田的CH_(4)和CO_(2)通量,定量揭示了稻田碳通量变化特征、累积量和2种温室气体的综合温室效... 详细信息

稻田是一个既排放CH_(4)又吸收CO_(2)的复杂生态系统,在全球水碳循环和碳收支中发挥着重要作用.利用涡度相关法得到2020年鄱阳湖平原双季直播稻田的CH_(4)和CO_(2)通量,定量揭示了稻田碳通量变化特征、累积量和2种温室气体的综合温室效应.结果表明,双季直播稻田为CH_(4)排放源,全生育期排放量为52.6 g·m^(-2),日均排放0.208 g·(m^(2)·d)^(-1).CH_(4)通量具有明显的季节变化特征,强排放期(排放峰)集中在早稻生长中期和晚稻生长前期,早稻85.5%和晚稻92.1%的CH_(4)在强排放期被释放,日尺度峰值分别为0.638 g·(m^(2)·d)^(-1)和1.282 g·(m^(2)·d)^(-1).CH_(4)通量日变化呈显著单峰型、不显著单峰型和无规律型,强排放期主要为单峰型,该型式下早稻季峰值0.453μmol·(m^(2)·s)^(-1)和晚稻季峰值0.977μmol·(m^(2)·s)^(-1)均出现在14:00~15:00,且在12:30~16:00维持较高排放速率.早稻和晚稻全生育期CO_(2)累积量分别为-990.4 g·m^(-2)和-1156.6 g·m^(-2),合计为-2147.0 g·m^(-2).双季稻田CH_(4)排放和CO_(2)交换的综合温室效应(以CO_(2)当量计)为-673.6 g·m^(-2),表现为降温效应.当评价稻田温室效应时若不考虑CH_(4)排放,将低估1473.4 g·m^(-2)的CO_(2)当量排放,占净CO_(2)吸收量的68.6%.

关键词：碳排放甲烷通量二氧化碳通量综合温室效应涡度相关(EC) 直播稻

Study of the puzzling abundance pattern of the neutron-capture elements in LMC star J053253.51–695915.1

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Research in Astronomy and Astrophysics 2020年第4期20卷 129-138页

作者： Wan-Qiang Han Lu Zhang Guo-Chao Yang Wen-yuan cui Fang Wen Bo Zhang Department of Physics Hebei Normal UniversityShijiazhuang 050024China Department of Physics Shijiazhuang UniversityShijiazhuang 050035China College of Mathematics and Information Science Hebei Normal UniversityShijiazhuang 050024China School of Sciences Hebei University of Science and TechnologyShijiazhuang 050018China

Object J053253.51–695915.1(J053253)in the Large Magellanic Cloud(LMC)is reported as a young stellar object(YSO).Its chemical abundances reflect the initial composition of the gas cloud in which the star ***,the discovery that this star shows the enhancement of the neutron(n)-capture elements and the higher ratio of the heavier n-capture elements relative to the lighter n-capture elements is *** an abundance decomposed method,we explore the astrophysical origins of the n-capture elements in this *** find that the abundance characteristic of the higher ratio of the heavier n-capture elements to the lighter n-capture elements can be explained by the pollution of the r-process event and the contamination of the s-process material.

关键词： stars:abundances stars:chemically peculiar stars:individual:J053253.51–695915.1

Glycnsisitin A:A promising bicyclic peptide against heart failure that facilitates TFRCmediated uptake of iron in cardiomyocytes

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3125-3139页

作者： Jichao Zhou yuanyuan Liu Xiaoli Wei Meng yuan Xu Zhang Lingfeng Qin Bing cui Pingping Li Jing Zhang Ziming Feng Jianshuang Jiang Xiang yuan Ruibing Xu Zhimeng Zhang Peicheng Zhang Xiaowei Zhang Yanan Yang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Zhigancao decoction is a traditional prescription for treating irregular pulse and palpitations in *** the monarch drug of Zhigancao decoction,the bioactive molecules of licorice against heart diseases remain *** established the HRESIMS-guided method leading to the isolation of three novel bicyclic peptides,glycnsisitins A-C(1-3),with distinctive C-C and C-O-C side-chain-toside-chain linkages from the roots of Glycyrrhiza uralensis(Licorice).Glycnsisitin A demonstrated stronger cardioprotective activity than glycnsisitins B and C in an in vitro model of doxorubicin(DOX)-induced cardiomyocyte *** A treatment not only reduced the mortality of heart failure(HF)mice in a dose-dependent manner but also significantly attenuated DOX-induced cardiac dysfunction and myocardial *** set enrichment analysis(GSEA)of the differentially expressed genes indicated that the cardioprotective effect of glycnsisitin A was mainly attributed to its ability to maintain iron homeostasis in the ***,glycnsisitin A interacted with transferrin and facilitated its binding to the transferrin receptor(TFRC),which caused increased uptake of iron in *** findings highlight the key role of bicyclic peptides as bioactive molecules of Zhigancao decoction for the treatment of HF,and glycnsisitin A constitutes a promising therapeutic agent for the treatment of HF.

关键词： Glycyrrhiza uralensis Bicyclic peptides Myocardial energy metabolism Iron homeostasis TFRC

MreBCD-associated Cytoskeleton is Required for Proper Segregation of the Chromosomal Terminus during the Division Cycle of Escherichia Coli

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Chinese Medical Journal 2015年第9期128卷 1209-1214页

作者： Yu-Jia Huo Ling Qiao Xiao-Wei Zheng Cheng cui yuan-Fang Ma Feng Lu Henan Engineering Laboratory of Antibody Medicine Medical School of Henan University Kaifeng Henan 475001 China

Background：In prokaryotic organisms,the mechanism responsible for the accurate partition of newly replicated chromosomes into daughter cells is incompletely *** of the replication terminus of the circular prokaryotic chromosome poses special problems that have not previously been *** aim of this study was to investigate the roles of several protein components （MreB,MreC,and MreD） of the prokaryotic cytoskeleton for the faithful transmission of the chromosomal terminus into daughter ***：Strain LQ1 （mreB：：cat）,LQ2 （mreC：：cat）,and LQ3 （mreD：：cat） were constructed using the Red recombination ***11/pLAU53,LQ12/pLAU53,LQ13/pLAU53,LQ14/pLAU53,and LQ15/pLAU53 strains were generated by Pltransduction of （tetO）240-Gm and （lacO）240-Km cassettes from strains IL2 and *** microscopy was performed to observe localization pattern of fluorescently-labeled origin and terminus foci in wild-type and mutant *** induction was monitored as gfp fluorescence from PsulA-gfp in log phase cells grown in Luria-Bertani medium at 37℃ by measurement of emission at 525 nm with excitation at 470 nm in a microplate fluorescence ***：Mutational deletion of the mreB,mreC,or mreD genes was associated with selective loss of the terminus region in approximately 40％ of the cells within growing *** was accompanied by significant induction of the SOS DNA damage response,suggesting that deletion of terminus sequences may have occurred by chromosomal cleavage,presumably caused by ingrowth of the division septum prior to segregation of the replicated ***：These results imply a role for the MreBCD cytoskeleton in the resolution of the final products of terminus replication and/ or in the specific movement of newly replicated termini away from midcell prior to completion of septal *** would identify a previously unrecognized stage in the overall process of chromosome segregation.

关键词： Cytoskeleton Escherichia Coli MreBCD Segregation of Chromosomal Terminus

Homoharringtonine promotes heart allograft acceptance by enhancing regulatory T cells induction in a mouse model

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Chinese Medical Journal 2024年第12期137卷 1453-1464页

作者： Xia Qiu Hedong Zhang Zhouqi Tang Yuxi Fan Wenjia yuan Chen Feng Chao Chen Pengcheng cui Yan cui Zhongquan Qi Tengfang Li Yuexing Zhu Liming Xie Fenghua Peng Tuo Deng Xin Jiang Longkai Peng Helong Dai Medical College Guangxi UniversityNanningGuangxi 530004China Department of Kidney Transplantation Center of Organ TransplantationThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China National Clinical Research Center for Metabolic Diseases and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Organ Transplantation The Fifth Clinical Medical College of Henan University of Chinese Medicine(Zhengzhou People’s Hospital)ZhengzhouHenan 450000China

Background:Homoharringtonine(HHT)is an effective anti-inflammatory,anti-viral,and anti-tumor protein synthesis inhibitor that has been applied ***,we explored the therapeutic effects of HHT in a mouse heart transplant ***:Healthy C57BL/6 mice were used to observe the toxicity of HHT in the liver,kidney,and hematology.A mouse heart transplantation model was constructed,and the potential mechanism of HHT prolonging allograft survival was evaluated using Kaplan-Meier analysis,immunostaining,and bulk RNA sequencing *** HHT-T cell crosstalk was modeled ex vivo to further verify the molecular mechanism of HHT-induced regulatory T cells(Tregs)***:HHT inhibited the activation and proliferation of T cells and promoted their apoptosis ex *** of 0.5 mg/kg HHT for 10 days significantly prolonged the mean graft survival time of the allografts from 7 days to 48 days(P<0.001)without non-immune *** allografts had long-term survival after continuous HHT treatment for 28 *** significantly reduced lymphocyte infiltration in the graft,and interferon-γ-secreting CD4^(+)and CD8^(+)T cells in the spleen(P<0.01).HHT significantly increased the number of peripheral Tregs(about 20%,P<0.001)and serum interleukin(IL)-10 *** downregulated the expression of T cell receptor(TCR)signaling pathway-related genes(CD4,H2-Eb1,TRAT1,and CD74)and upregulated the expression of IL-10 and transforming growth factor(TGF)-βpathway-related genes and Treg signature genes(CTLA4,Foxp3,CD74,and ICOS).HHT increased CD4^(+)Foxp3^(+)cells and Foxp3 expression ex vivo,and it enhanced the inhibitory function of inducible ***:HHT promotes Treg cell differentiation and enhances Treg suppressive function by attenuating the TCR signaling pathway and upregulating the expression of Treg signature genes and IL-10 levels,thereby promoting mouse heart allograft *** findings may have therapeutic implications for organ tr

关键词： Heart transplantation Homoharringtonine Immunosuppressive agents T-lymphocytes,Regulatory Graft acceptance

The Active Compensation Technique for Large Reflector Antennas Based on Quadratic Curve Fitting

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Research in Astronomy and Astrophysics 2024年第7期24卷 229-237页

作者： Tian-Xiang Zheng Bin-Bin Xiang Han-Wei cui Wei Wang Pei-yuan Lian Shang-Ming Lin Yang Zhang Jian-Ping Zhou Kai Li School of Mechanical Engineering Xinjiang University School of Mechano-Electronic Engineering Xidian University Xi'an Institute of Optics and Precision Mechanics Chinese Academy of Sciences

Active reflectors are often used to compensate the surface distortion caused by environmental factors that degrade the electromagnetic performance of large high-frequency reflector antennas. This is crucial for maintaining high gain operation in antennas. A distortion compensation method for the active reflector of a large dual-reflector antenna is proposed. A relationship is established between the surface deformation and the optical path difference for the primary reflector by geometric optics. Subsequently, employing finite element analysis, a polynomial fitting approach is used to describe the impact of adjusting points on the reflector surface based on the coordinates of each node. By standardizing the positions of various panels on the reflector, the fitting ns can be applied to the reflector panels of similar shapes. Then, based on the distribution characteristics of the primary reflector panels, the adjustment equation for the actuators is derived by the influence matrix method. It can be used to determine the adjustment amount of actuators to reduce the rms of the optical path difference. And, the least squares method is employed to resolve the matrix equation. The example of a 110 m aperture dual-reflector antenna is carried out by finite element analysis and the proposed method. The results show that the optical path difference is reduced significantly at various elevation cases, which indicates that the proposed method is effective.

关键词： Methods: analytical Methods: numerical Telescopes

High-performance liquid metal electromagnetic actuator fabricated by femtosecond laser

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International Journal of Extreme Manufacturing 2024年第2期6卷 511-521页

作者： Yiyu Chen Hao Wu Rui Li Shaojun Jiang Shuneng Zhou Zehang cui yuan Tao Xinyuan Zheng Qianqian Zhang Jiawen Li Guoqiang Li Dong Wu Jiaru Chu Yanlei Hu CAS Key Laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230027People’s Republic of China Key Laboratory of Testing Technology for Manufacturing Process of Ministry of Education Southwest University of Science and TechnologyMianyang 621010People’s Republic of China Department of Mechanical Engineering The University of Hong KongHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Small-scale electromagnetic soft actuators are characterized by a fast response and simplecontrol,holding prospects in the field of soft and miniaturized *** use of liquid metal(LM)to replace a rigid conductor inside soft actuators can reduce the rigidity and enhance the actuation performance and *** research efforts,challenges persist in the flexible fabrication of LM soft actuators and in the improvement of actuation *** address these challenges,we developed a fast and robust electromagnetic soft microplate actuator based on a laser-induced selective adhesion transfer *** with unprecedentedly thin LM circuit and customized low Young’s modulus silicone rubber(1.03 kPa),our actuator exhibits an excellent deformation angle(265.25?)and actuation bending angular velocity(284.66 rad·s^(-1)).Furthermore,multiple actuators have been combined to build an artificial gripper with a wide range of *** actuator presents new possibilities for designing small-scaleartificial machines and supports advancements in ultrafast soft and miniaturized robotics.

关键词： soft actuators femtosecond laser liquid metal

Treatment Efficacy and Safety of Bortezomib Combined with Dexamethasone and Lenalidomide Chemotherapy Regimen for Multiple Myeloma

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Journal of Clinical and Nursing Research 2024年第5期8卷 7-12页

作者： Changyong yuan Na cui Shumei Liu Department of Hematology Dezhou HospitalQilu HospitalShandong UniversityDezhou 253000Shandong ProvinceChina School of Clinical Medicine Shandong Second Medical UniversityWeifang 261000Shandong ProvinceChina

Objective:To analyze the effect of bortezomib combined with dexamethasone and lenalidomide in the treatment of multiple ***:60 cases of multiple myeloma patients admitted to our hospital from January 2022 to December 2023 were selected randomly,with 30 cases in each *** combined with dexamethasone was administered in the control group,and bortezomib combined with dexamethasone and lenalidomide was given to the observation group,and the treatment effect was ***:After treatment,CD^(3+)and CD^(4+)of the observation group were higher than that of the control group,CD^(8+)was lower than that of the control group,and the total treatment efficiency was higher,which was statistically significant(P0.05).Conclusion:Bortezomib combined with dexamethasone and lenalidomide is effective in the treatment of multiple myeloma as it regulates the immune function and is safe,thus it can be promoted in clinical practice.

关键词： Multiple myeloma Bortezomib Dexamethasone Lenalidomide Efficacy Safety

基于四边形最优圈内最短路径的旅行商问题割边方法

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计算机科学 2022年第S1期49卷 199-205页

作者：王永崔源华北电力大学新能源学院北京102206 塔里木大学信息工程学院新疆阿拉尔843300

随着旅行商问题规模的增长,完全图上最优解的搜索空间呈指数增长。为了减小最优解的搜索空间,提出一种针对旅行商问题的割边算法。推导出四边形最优圈内的最短路径包含一般边与最优哈密顿圈边的不同概率,采用一定数量的四边形最优圈内... 详细信息

随着旅行商问题规模的增长,完全图上最优解的搜索空间呈指数增长。为了减小最优解的搜索空间,提出一种针对旅行商问题的割边算法。推导出四边形最优圈内的最短路径包含一般边与最优哈密顿圈边的不同概率,采用一定数量的四边形最优圈内的最短路径计算边频率,根据所有边的平均边频率割边,基于建立的二项分布模型推导出最优哈密顿圈内边的保留概率。任给一个完全图,割边算法有4个步骤:1)随机选取包含每条边的若干个四边形;2)采用所选四边形最优圈内的最短路径计算各边的边频率;3)步删除5/6条最小边频率的边;4)对度数小于2的节点进行添边操作。计算实验表明:保留边数为完全图上边数量的1/6左右,采用精确算法求解割边后旅行商问题的计算时间也有所减少。

关键词：旅行商问题割边方法四边形最优圈最短路径边频率