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Puerarin mediated miR-30b-5p targeting fibroblast activation protein against oral submucous fibrosis

BIOCELL 2024年第4期48卷 591-599页

作者： SAIFEI XIE HUI XIE JINCAI GUO JIN TAN yulin yu MINYI ZHANG SHANG WEN Department of Periodontal Mucosa Hunan University of Chinese MedicineChangshaChina Department of Periodontal Mucosa Changsha Stomatology HospitalChangshaChina Department of Pharmacy Changsha Stomatology HospitalChangshaChina Department of Stomatology The First Hospital of Hunan University of Chinese MedicineChangshaChina

Background:Puerarin(Pue)has been reported to be a natural active ingredient with multiple antiﬁbrotic *** work aimed at exploring the function of Pue in oral submucousﬁbrosis(OSF)***:Human oral mucosaﬁbroblasts(hOMF)were induced with transforming growth factor beta1(TGF-β1)and intervened with *** ofﬁbrosis-related markers were analyzed by Western blot and IF *** viability was characterized by the CCK-8 *** of miR-30 family members were quantiﬁed by *** correlation betweenﬁbroblast activation protein(FAP)and miR-30 family expression was evaluated by the Pearson correlation coefﬁ*** prediction and dual-luciferase reporter assay were employed to verify the regulation between FAP and *** speciﬁc mechanism of Pue on OSF was explored through the promotion or inhibition of ***:After induction by TGF-β1,hOMF showed upregulated Collagen I,Collagen III,and FAP expressions,while miR-30 family expression was downregulated with miR-30b-5p being the most signiﬁ*** intervention inhibited the excessive proliferation of TGF-β1-induced hOMF,downregulated FAP,collagen type 3(COL3A1),collagen type 1(COL1A1),matrix metalloproteinase 1(MMP1),and matrix metalloproteinase 3(MMP3)expressions,and restored miR-30 family *** prediction and dual-luciferase reporter assay revealed that miR-30b-5p selectively inhibited FAP ***,miR-30b-5p mimic suppressed the excessive proliferation of TGF-β1-induced hOMF and declinedﬁbrosis *** intervention signiﬁcantly reversed the promotion of TGF-β1-induced OSF by miR-30b-5p ***:Pue mediated miR-30b-5p targeting FAP against OSF,which provided a theoretical basis for the pathogenesis research and Pue application in OSF.

关键词： Puerarin miR-30b-5p FAP Oral submucous fibrosis

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循证护理联合心理干预对急性创伤骨科患者围术期的效果研究

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科技与健康 2024年第5期3卷 97-100页

作者：余玉林商丘市第五人民医院河南商丘476000

研究循证护理联合心理干预对急性创伤骨科患者围术期的效果。随机挑选商丘市第五人民医院2021年8月—2022年8月收治的72例急性创伤骨科患者为研究对象,将患者分为对照组和观察组,每组36例。对照组使用基础护理干预,观察组使用循证护理... 详细信息

研究循证护理联合心理干预对急性创伤骨科患者围术期的效果。随机挑选商丘市第五人民医院2021年8月—2022年8月收治的72例急性创伤骨科患者为研究对象,将患者分为对照组和观察组,每组36例。对照组使用基础护理干预,观察组使用循证护理联合心理干预,对两组患者心理状态、护理满意率、生活质量、疼痛程度、睡眠质量进行观察。结果显示,心理状态方面,观察组患者情况更佳(P<0.05);护理满意率方面,观察组患者护理满意率更高(P<0.05);生活质量方面,观察组患者生活质量要明显高于对照组(P<0.05);疼痛程度和睡眠质量方面,观察组患者疼痛程度、睡眠质量均要优于对照组(P<0.05)。研究发现,在急性创伤骨科患者围术期应用循证护理联合心理干预具有确切效果,其对患者心理状态、生活质量、睡眠质量的改善具有较为积极的意义,且可以有效缓解患者疼痛感,患者的护理总满意率较高,值得临床应用。

关键词：循证护理心理干预急性创伤骨科患者围术期

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1例重度牙周炎患者牙周种植联合治疗5年观察

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口腔医学研究 2024年第6期40卷 555-558页

作者：文尚郭锦材张敏轶喻玉林马飞谢辉湖南中医药大学口腔医(学)院湖南长沙410006 长沙市口腔医院牙周黏膜科湖南长沙410006 长沙市口腔医院药剂科湖南长沙410006 长沙市口腔医院综合科湖南长沙410005

Ⅳ期C级牙周炎是临床上分期分级最严重的牙周炎类型,这类患者常伴有牙列缺损与软硬组织缺损,需要联合多学科针对病情设计个性化治疗方案。本文报道1例广泛型Ⅳ期C级牙周炎患者的序列治疗全过程,包括病情分析、治疗的个性化设计、多学科... 详细信息

Ⅳ期C级牙周炎是临床上分期分级最严重的牙周炎类型,这类患者常伴有牙列缺损与软硬组织缺损,需要联合多学科针对病情设计个性化治疗方案。本文报道1例广泛型Ⅳ期C级牙周炎患者的序列治疗全过程,包括病情分析、治疗的个性化设计、多学科联合手术过程、支持治疗以及5年随访观察。

关键词：重度牙周炎牙周序列治疗游离龈移植术牙种植

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喀斯特弃耕地草本植物根茎叶经济型谱间协调及其对极端降雨的响应

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生态学报 2024年第9期44卷 3676-3688页

作者：昝瑛马竟文索朗玉珍余钰淋万玛吉袁佳佳陶建平西南大学生命科学学院三峡库区生态环境教育部重点实验室重庆400715

植物功能性状之间的关系是反映植物在资源获取和资源保守策略之间权衡的有力指标。喀斯特是全球最脆弱的陆地生态系统之一,其中的植被长期遭受干旱的胁迫,对极端天气和极端降水高度敏感。在降雨极端化的背景下,喀斯特地区植物生态策略... 详细信息

植物功能性状之间的关系是反映植物在资源获取和资源保守策略之间权衡的有力指标。喀斯特是全球最脆弱的陆地生态系统之一,其中的植被长期遭受干旱的胁迫,对极端天气和极端降水高度敏感。在降雨极端化的背景下,喀斯特地区植物生态策略的变化还不得而知。以西南喀斯特弃耕地演替初期群落中12种草本植物为对象,通过保持年降水量不变,人为控制单次降水量以及降水频率,以自然降雨为对照组(CK),设置中雨频率增强处理组(T10),大雨频率增强处理组(T25)和暴雨频率增强处理组(T50)3个处理组。模拟在全球变化导致的降雨极端化情境下,研究植物根茎叶功能性状的响应特征及经济型谱之间的关系。主要结果如下:(1)根茎叶的功能性状对降雨极端化的响应不同,其中根的理论导水率随着降雨极端化增强而增加,而茎和叶的理论导水率仅在T25增加,根茎叶三种器官中对降雨极端化最敏感的是茎;(2)根茎叶各器官均有自身稳定的“快-慢”经济型谱。降雨极端化仅T50的植物会选择介于资源获取和资源保守策略之间稳定的经济型谱;(3)不同植物器官之间的经济型谱的协调并不一致,其中茎根经济型谱之间的相关系数在三个处理组中均变大,而叶根经济型谱之间的相关系数仅在T25变大,叶茎经济型谱之间的相关系数仅在T10变大。总之,喀斯特弃耕地演替初期群落中草本植物的根茎叶有自身稳定的经济型谱,降雨极端化导致了以根茎叶经济型谱所反映的植物地上和地下资源保存和获取策略的解耦;本研究中的植物最容易发生功能性状变异的器官是茎。本研究提高了对植物不同器官各功能性状之间关系和植物地上与地下部分关联性的理解,揭示了植物不同器官的“快-慢”植物经济型谱以及由此反映的植物适应能力的差异和功能策略的多样性,促进了对植物资源获取与环境响应策略的深入认识,为预测未来气候变化背景下喀斯特弃耕地草本植物的适应趋势和响应策略提供了新见解。

关键词：降雨格局变化植物经济型谱喀斯特

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De novo engineering of nanoformulation from traditional Chinese medicine mixtures for psoriasis

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Nano Research 2023年第4期16卷 5279-5291页

作者： Yang Li Dan Zhang Tianzi Shi yulin yu Yinmei Tian Qi Xie Jingyu Shi Li Kong Conglian Yang Zhiping Zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Wuhan No.1 HospitalTongji Medical SchoolHuazhong University of Science and TechnologyWuhan 430022China Department of Pharmacy Liyuan HospitalTongji Medical SchoolHuazhong University of Science and TechnologyWuhan 430077China Hubei Engineering Research Centre for Novel Drug Delivery System Wuhan 430030China

Nanotechnology has been widely applied in the development of traditional Chinese medicine(TCM).Interestingly,we found that nanostructures intrinsically existed in 12 clinically applied TCM mixtures(TCMMs).However,the role of these nanostructures in TCMMs and their potential value in improving the development of TCMMs remain *** Qingxuechushi mixture as an example,we demonstrated that nanoparticles could be the most efficient part through the pharmacodynamics study on psoriasis *** imitating the physical properties and chemical composition of isolated nanoparticles in Qingxuechushi mixture,a novel nanoformulation with definite components and good therapeutic effect was developed,which not only mimicked the prescription composition rules in the original TCMMs but also possessed the advantage of *** novel nanoformulation could notably alleviate the psoriasis-like manifestations and reduce the levels of pro-inflammatory factors in serum in the psoriasis mouse *** work organically integrates the advantages of TCMMs and nanotechnology,which may provide a new approach and inspiration for the development of TCM.

关键词： traditional Chinese medicine nanotechnology psoriasis nanostructures glycyrrhiza protein

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Programmable silicon-photonic quantum simulator based on a linear combination of unitaries

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Photonics Research 2024年第8期12卷 1760-1767页

作者： yuE yu yulin CHI CHONGHAO ZHAI JIESHAN HUANG QIHUANG GONG JIANWEI WANG State Key Laboratory for Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Frontiers Science Center for Nano-optoelectronics&Collaborative Innovation Center of Quantum Matter Peking UniversityBeijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Yangtze Delta Institute of Optoelectronics Peking UniversityNantong 226010China Hefei National Laboratory Hefei 230088China Department of Electrical and Computer Engineering University of WashingtonSeattleWashington 98195USA China Mobile Research Institute Beijing 100053China

Simulating the dynamic evolution of physical and molecular systems in a quantum computer is of fundamental interest in many *** implementation of dynamics simulation requires efficient quantum *** Lie-Trotter-Suzuki approximation algorithm,also known as the Trotterization,is basic in Hamiltonian dynamics simulation.A multi-product algorithm that is a linear combination of multiple Trotterizations has been proposed to improve the approximation ***,implementing such multiproduct Trotterization in quantum computers remains challenging due to the requirements of highly controllable and precise quantum entangling operations with high success ***,we report a programmable integrated-photonic quantum simulator based on a linear combination of unitaries,which can be tailored for implementing the linearly combined multiple Trotterizations,and on the simulator we benchmark quantum simulation of Hamiltonian *** modify the multi-product algorithm by integrating it with oblivious amplitude amplification to simultaneously reach high simulation precision and high success *** quantum simulator is devised and fabricated on a large-scale silicon-photonic quantum chip,which allows the initialization,manipulation,and measurement of arbitrary four-qubit states and linearly combined unitary *** an example,the quantum simulator is reprogrammed to emulate the dynamics of an electron spin and nuclear spin coupled *** work promises the practical dynamics simulations of real-world physical and molecular systems in future large-scale quantum computers.

关键词： quantum Hamiltonian linearly

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A Predictive Energy Management Strategies for Mining Dump Trucks

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Energy Engineering 2024年第3期121卷 769-788页

作者： Yixuan yu yulin Wang Qingcheng Li Bowen Jiao College of Mechanical and Electrical Engineering Qingdao UniversityQingdao266071China

The plug-in hybrid vehicles(PHEV)technology can effectively address the issues of poor dynamics and higher energy consumption commonly found in traditional mining dump ***,plug-in hybrid electric trucks can achieve excellent fuel economy through efficient energy management strategies(EMS).Therefore,a series hybrid system is constructed based on a 100-ton mining dump truck in this *** inspired by the dynamic programming(DP)algorithm,a predictive equivalent consumption minimization strategy(P-ECMS)based on the DP optimization result is *** on the optimal control manifold and the SOC reference trajectory obtained by the DP algorithm,the P-ECMS strategy performs real-time stage parameter optimization to obtain the optimal equivalent factor(EF).Finally,applying the equivalent consumption minimization strategy(ECMS)realizes real-time *** simulation results show that the equivalent fuel consumption of the P-ECMS strategy under the experimentally collected mining cycle conditions is 150.8 L/100 km,which is 10.9%less than that of the common CDCS strategy(169.3 L/100 km),and achieves 99.47%of the fuel saving effect of the DP strategy(150 L/100 km).

关键词： Mining dump truck energy management strategy plug-in hybrid electric vehicle equivalent consumption minimization strategy dynamic programming

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Diving dynamics identification and motion prediction for marine crafts using field data

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Journal of Ocean Engineering and Science 2024年第4期9卷 391-400页

作者： Yiming Zhong Caoyang yu yulin Bai Zheng Zeng Lian Lian School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China Key Laboratory of Polar Ecosystem and Climate Change Ministry of EducationShanghai Jiao Tong UniversityShanghai 200030China Shanghai Key Laboratory of Polar Life and Environment Sciences Shanghai Jiao Tong UniversityShanghai 200030China State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Ensuring accurate parameter identification and diving motion prediction of marine crafts is essential for safe navigation,optimized operational efficiency,and the advancement of marine *** this,this paper proposes an instrumental variable-based least squares(IVLS)***,aiming to balance complexity with accuracy,a decoupled diving model is constructed,incorporating nonlinear actuator characteristics,inertia coefficients,and damping ***,a discrete parameter identification matrix is designed based on this dedicated model,and then a IVLS algorithm is innovatively derived to reject measurement ***,the stability of the proposed algorithm is validated from a probabilistic point of view,providing a solid theoretical ***,performance evaluation is conducted using four depth control datasets obtained from a piston-driven profiling float in Qiandao Lake,with desired depths of 30 m,40 m,50 m,and 60 *** on the diving dynamics identification results,the IVLS algorithm consistently shows superior performance when compared to recursive weighted least squares algorithm and least squares support vector machine algorithm across all depths,as evidenced by lower average absolute error(AVGAE),root mean square error(RMSE),and maximum absolute error values and higher determination coefficient(R2).Specifically,for desired depth of 60 m,the IVLS algorithm achieved an AVGAE of 0.553 m and RMSE of 0.655 m,significantly outperforming LSSVM with AVGAE and RMSE values of 8.782 m and 11.117 m,***,the IVLS algorithm demonstrates a remarkable generalization capability with R2 values consistently above 0.95,indicating its robustness in handling varied diving dynamics.

关键词： Marine craft Parameter identification Motion prediction Instrumental variable-based least-squares algorithm Diving dynamics model

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Spatiotemporal Evolution and Linkage Analysis of Mutton Price in Xinjiang

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Journal of Systems Science and Information 2024年

作者： yulin YANG Jian XU Lean yu School of Economics and Management University of Chinese Academy of Sciences Business School Sichuan University School of Business Shenzhen Institute of Technology

The mutton industry plays a pivotal role in the animal husbandry industry of Xinjiang Uygur Autonomous Region. To better monitor the volatility movement and risk warning of mutton price, the fluctuation characteristics of mutton prices and the future trend of prices are analyzed systematically. On the one hand, the Hodrick Prescott(HP) filter method is used to analyze the longterm trends and cyclical characteristics of mutton prices in Xinjiang and explored the spatial evolution characteristics of mutton price fluctuations in various regions of Xinjiang. On the other hand, the Threshold Auto-Regressive(TAR) model is used to analyze the linkage relationship between mutton prices and the prices of other livestock products. The empirical results show that(1) the overall volatility of mutton price in Xinjiang is high, showing a trend of rising first, then falling and then rising from the temporal perspective.(2) At the regional level, the price in the south is higher than that of the north, showing a decreasing trend from south to north on the whole from the spatial viewpoint.(3) From the linkage relationship perspective, mutton and beef are complementary in the short term,but they are substitutes each other in the long term. This paper explores the characteristics of mutton price fluctuations in Xinjiang from the single time series of mutton prices and the linkage with other livestock products, which provides a reliable basis for the monitoring and risk warning of mutton price fluctuation.

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补肾清热方对牙周炎大鼠牙槽骨吸收的影响及作用机制

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中国当代医药 2024年第19期31卷 22-25页

作者：文尚张敏轶喻玉林郭锦材陈卫民张璋谢辉湖南中医药大学口腔医(学)院湖南长沙410006 长沙市口腔医院药剂科湖南长沙410006 长沙市口腔医院牙周黏膜科湖南长沙410006 长沙市口腔医院八方门诊部湖南长沙410006

目的探讨补肾清热方对大鼠牙槽骨吸收的影响及其潜在机制。方法选取54只SD大鼠,按随机数字表法分为空白对照组、模型对照组、阳性对照组、实验组(A1、A2、A3)共6组,每组9只。除空白对照组外,其余五组均采用结扎左上颌第一磨牙+10%糖水... 详细信息

目的探讨补肾清热方对大鼠牙槽骨吸收的影响及其潜在机制。方法选取54只SD大鼠,按随机数字表法分为空白对照组、模型对照组、阳性对照组、实验组(A1、A2、A3)共6组,每组9只。除空白对照组外,其余五组均采用结扎左上颌第一磨牙+10%糖水饮用的方法诱导牙周炎大鼠模型。造模成功后,实验组(A1、A2、A3)分别用3.5、7、14 ml/(kg·d)等剂量补肾清热方灌胃,4周后取各组SD大鼠左上颌第一磨牙及其牙周组织。检测各组大鼠的左上第一磨牙探诊深度(PD),并采用Micro CT检测左上颌第一磨牙釉牙骨质界(CEJ)-牙槽嵴顶(ABC)的距离,采用Western Blot检测骨保护素(OPG)、核因子-κB受体活化因子(RANK)、核因子-κB受体活化因子配体(RANKL)蛋白表达。结果干预4周后,阳性对照组及实验组(A2、A3)的PD小于模型对照组,差异有统计学意义(P0.05)。Micro CT检测结果显示,模型对照组的CEJ-ABC距离大于空白对照组,差异有统计学意义(P0.05)。模型对照组的RANK及RANKL表达水平均高于空白对照组,阳性对照组、实验组(A1、A2、A3)的RANK及RANKL表达水平均低于模型对照组,实验组(A2、A3)的RANK及RANKL表达水平均低于阳性对照组,差异有统计学意义(P<0.05)。结论补肾清热方可抑制牙周炎大鼠牙槽骨的吸收,其潜在机制可能是通过OPG/RANK/RANKL信号系统参与。

关键词：牙周炎补肾清热方骨保护素/核因子-κB受体活化因子/核因子-κB受体活化因子配体牙槽骨吸收

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