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NbN quantum dots anchored hollow carbon nanorods as efficient polysulfide immobilizer and lithium stabilizer for Li-S full batteries

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Journal of Energy Chemistry 2024年第1期88卷 260-271,I0007页

作者： Fei Ma zhuo Chen Katam Srinivas Ziheng Zhang yu Wu Dawei Liu Hesheng yu yue wang Xinsheng Li Ming-qiang zhu Qi Wu yuanfu Chen School of Integrated Circuit Science and Engineering and State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and TechnologyChengdu 610054SichuanChina College of Science and Institute of Oxygen Supply Center of Tibetan Studies(Everest Research Institute)Tibet UniversityLhasa 850000TibetChina College of Mechanical and Electronic Engineering Northwest A&F UniversityXianyang 712100ShaanxiChina

The shuttle effect of lithium polysulfides(LiPSs)and uncontrollable lithium dendrite growth seriously hinder the practical application of lithium-sulfur(Li-S)*** simultaneously address such issues,monodispersed Nb N quantum dots anchored on nitrogen-doped hollow carbon nanorods(NbN@NHCR)are elaborately developed as efficient Li PSs immobilizer and Li stabilizer for high-performance Li-S full *** functional theory(DFT)calculations and experimental characterizations demonstrate that the sulfiphilic and lithiophilic NbN@NHCR hybrid can not only efficiently immobilize the soluble Li PSs and facilitate diffusion-conversion kinetics for alleviating the shuttling effect,but also homogenize the distribution of Li+ions and regulate uniform Li deposition for suppressing Li-dendrite *** a result,the assembled Li-S full batteries(NbN@NHCR-S||Nb N@NHCR-Li)deliver excellent long-term cycling stability with a low decay rate of 0.031%per cycle over 1000 cycles at high rate of 2 *** at a high S loading of 5.8 mg cm^(-2)and a low electrolyte/sulfur ratio of 5.2μL mg^(-1),a large areal capacity of 6.2 mA h cm^(-2)can be achieved in Li-S pouch cell at 0.1 *** study provides a new perspective via designing a dual-functional sulfiphilic and lithiophilic hybrid to address serious issues of the shuttle effect of S cathode and dendrite growth of Li anode.

关键词： Dual-functional host NbN quantum dots Shuttle effect Dendrite-free Li anode Li-S full batteries

Novel high-voltage cathode for aqueous zinc ion batteries:Porous K_(0.5)VOPO_(4)·1.5H_(2)O with reversible solid-solution intercalation and conversion storage mechanism

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Journal of Energy Chemistry 2024年第6期93卷 71-78,I0003页

作者： Liyu wang Mingliang Zhao Xiaoyu Zhang Menghua Wu yu Zong yu Chen Xinliang Huang Mingjie Xing Xin Ning Wen Wen Daming zhu Xiaochuan Ren Industrial Research Institute of Nonwovens&Technical Textiles College of Textiles&ClothingShandong Engineering Research Center for Specialty Nonwoven MaterialsQingdao UniversityQingdao 266071ShandongChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Cathode materials that possess high output voltage,as well as those that can be mass-produced using facile techniques,are crucial for the advancement of aqueous zinc-ion battery(ZIBs)applications,Herein,we present for the first time a new porous K_(0.5)VOPO_(4)·1.5H_(2)O polyanionic cathode(P-KIVP)with high output voltage(above 1.2 V)that can be manufactured at room temperature using straightforward coprecipitation and etching *** P-KVP cathode experiences anisotropic crystal plane expansion via a sequential solid-solution intercalation and phase co nversion pathway throughout the Zn^(2+)storage process,as confirmed by in-situ synchrotron X-ray diffraction and ex-situ X-ray photoelectron *** to other layered vanadium-based polyanionic materials,the P-KVP cathode experiences a progressive decline in voltage during the cycle,which is demonstrated to be caused by the irreversible conversion into amorphous VO_(x).By introducing a new electrolyte containing Zn(OTF)_(2) to a mixed triethyl phosphate and water solution,it is possible to impede this irreversible conversion and obtain a high output voltage and longer cycle life by forming a P-rich cathode electrolyte interface *** a proof-of-concept,the flexible fiber-shaped ZIBs based on modified electrolyte woven into a fabric watch band can power an electronic watch,highlighting the application potential of P-KVP cathode.

关键词： Aqueous zinc ion battery Cathode Porous material High voltage platform In-situ synchrotron X-ray diffraction

Development of a model based on the age-adjusted Charlson comorbidity index to predict survival for resected perihilar cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2023年第6期15卷 1036-1050页

作者： yu Pan Zhi-Peng Liu Hai-Su Dai Wei-yue Chen Ying Luo yu-zhu wang Shu-Yang Gao Zi-Ran wang Jin-Ling Dong yun-Hua Liu Xian-yu Yin Xing-Chao Liu Hai-Ning Fan Jie Bai Yan Jiang Jun-Jie Cheng Yan-Qi Zhang Zhi-yu Chen Department of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Clinical Research Center of Oncology Lishui Hospital of Zhejiang UniversityLishui 323000Zhejiang ProvinceChina Faculty of Education Southwest UniversityChongqing 400715China Department of General Surgery 903rd Hospital of People’s Liberation ArmyHangzhou 310000Zhejiang ProvinceChina Department of Clinical Pharmacy The General Hospital of Western Theater CommandChengdu 610000Sichuan ProvinceChina Department of Hepatobiliary Surgery Sichuan Provincial People's HospitalChengdu 610000Sichuan ProvinceChina Department of Hepatobiliary Surgery Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Health Statistics College of Military Preventive MedicineThird Military Medical University(Army Medical University)Chongqing 400038China

BACKGROUND Perihilar cholangiocarcinoma(pCCA)has a poor prognosis and urgently needs a better predictive *** predictive value of the age-adjusted Charlson comorbidity index(ACCI)for the long-term prognosis of patients with multiple malignancies was recently ***,pCCA is one of the most surgically difficult gastrointestinal tumors with the poorest prognosis,and the value of the ACCI for the prognosis of pCCA patients after curative resection is *** To evaluate the prognostic value of the ACCI and to design an online clinical model for pCCA *** Consecutive pCCA patients after curative resection between 2010 and 2019 were enrolled from a multicenter *** patients were randomly assigned 3:1 to training and validation *** the training and validation cohorts,all patients were divided into low-,moderate-,and high-ACCI ***-Meier curves were used to determine the impact of the ACCI on overall survival(OS)for pCCA patients,and multivariate Cox regression analysis was used to determine the independent risk factors affecting *** online clinical model based on the ACCI was developed and *** concordance index(C-index),calibration curve,and receiver operating characteristic(ROC)curve were used to evaluate the predictive performance and fit of this *** A total of 325 patients were *** were 244 patients in the training cohort and 81 patients in the validation *** the training cohort,116,91 and 37 patients were classified into the low-,moderate-and high-ACCI *** Kaplan-Meier curves showed that patients in the moderate-and high-ACCI groups had worse survival rates than those in the low-ACCI *** analysis revealed that moderate and high ACCI scores were independently associated with OS in pCCA patients after curative *** addition,an online clinical model was developed that had ideal C-indexes of 0.725 and 0.675 for predicting OS in the training and vali

关键词： Perihilar cholangiocarcinoma Age-adjusted Charlson comorbidity index Resection Survival Model Prognosis

Sparse Modal Decomposition Method Addressing Underdetermined Vortex-Induced Vibration Reconstruction Problem for Marine Risers

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China Ocean Engineering 2024年第2期38卷 285-296页

作者： DU Zun-feng zhu Hai-ming yu Jian-xing State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation School of Civil EngineeringTianjin UniversityTianjin 300350China

When investigating the vortex-induced vibration(VIV)of marine risers,extrapolating the dynamic response on the entire length based on limited sensor measurements is a crucial step in both laboratory experiments and fatigue monitoring of real *** problem is conventionally solved using the modal decomposition method,based on the principle that the response can be approximated by a weighted sum of limited vibration ***,the method is not valid when the problem is underdetermined,i.e.,the number of unknown mode weights is more than the number of known *** study proposed a sparse modal decomposition method based on the compressed sensing theory and the Compressive Sampling Matching Pursuit(Co Sa MP)algorithm,exploiting the sparsity of VIV in the modal *** the validation study based on high-order VIV experiment data,the proposed method successfully reconstructed the response using only seven acceleration measurements when the conventional methods failed.A primary advantage of the proposed method is that it offers a completely data-driven approach for the underdetermined VIV reconstruction problem,which is more favorable than existing model-dependent solutions for many practical applications such as riser structural health monitoring.

关键词： motion reconstruction vortex-induced vibration(VIV) marine riser modal decomposition method compressed sensing

Efficacy and safety of Y- 2 sublingual tablet for patients with acute ischaemic stroke: protocol of a phase III randomised double- blind placebo- controlled multicentre trial

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Stroke & Vascular Neurology 2024年第1期9卷 90-95页

作者： yu Fu Renhong Tang Rong Chen Anxin wang Jinsheng Ren Shunwei zhu Xiaofei Feng Dongsheng Fan Deparment of Neurology Peking University Third HospitalBeijingChina State Key Laboratory of Neurology and Oncology Drug Development NanjingJiangsuChina Simcere Pharmaceutical Group Limited NanjingJiangsuChina Neurodawn Pharmaceutical Co. LtdNanjingJiangsuChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose Clinical studies have demonstrated that edaravone dexborneol can improve the functional outcomes in patients with acute ischaemic stroke(AIS).The present clinical trial aimed at testing the efficacy and safety of Y-2 sublingual tablet on 90-day functional outcome in patients with *** and design This is a randomised,double-blind,placebo-controlled,multicentre,parallel-group trial of Y-2 sublingual tablet on patients with *** estimated 914 patients at age of 18–80 years with AIS within 48 hours after symptom onset from 40 hospitals will be randomly assigned to receive Y-2 sublingual tablet or placebo for 14 *** are at score 6–20 points on National Institutes of Health Stroke Scale(NIHSS)and had a modified Rankin Scale(mRS)≤1 before this stroke,except mechanical thrombectomy and neuroprotective agents *** outcomes The primary outcome is the proportion of patients with mRS≤1 on day 90 after *** efficacy outcomes include mRS score on day 90,the proportion of patients with mRS≤2 on day 90;the change of NIHSS score from baseline to day 14 and the proportion of patients with NIHSS score≤1 at the days 14,30 and *** This trial will provide valuable evidence for the efficacy and safety of Y-2 sublingual table for improving 90 days the functional outcomes in patients with *** registration number NCT04950920.

关键词： patients protective centre

Characterization of laser cooling in microgravity via long-term operations in TianGong-2 space lab

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National Science Review 2023年第4期10卷 69-75页

作者： De-Sheng Lü Wei Ren yuan Sun Tang Li Qiu-Zhi Qu Bin wang Lin Li Jian-Bo Zhao Xin Zhao Jing-Wei Ji Mei-Feng Ye Jing-Feng Xiang Wei-Biao Chen yu-zhu wang Liang Liu CAS Key Laboratory of Quantum Optics and Center of Cold Atom Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Aerospace Laser Engineering Department Shanghai Institute of Optics and Fine MechanicsChinese Academy of Sciences

The invention of laser cooling has fundamentally influenced the research frontier of atomic physics and quantum physics, and recently an intense focus has been on the studies of cold atom physics in microgravity environments. Herein, we report the results of our laser cooling experiment in Tian Gong-2 space lab, which operated for 34 consecutive months in orbit. Over such an extended operation time, the quality of laser cooling did not experience any significant decline, while the properties of laser cooling in orbital microgravity were systematically studied. In particular, we demonstrate magneto-optical trapping and polarization-gradient cooling in orbit and carefully examine their performances. A comparison of the in-orbit and on-ground results indicates that a higher cooling efficiency exists in microgravity, including a smaller loss rate during the trapping and cooling process and lower ultimate temperature of laser-cooled atoms. Our progress has laid the technical foundations for future applications of cold atoms in space missions with operation times of the order of years.

关键词： laser cooling polarization-gradient cooling orbital microgravity space lab

PCAF-mediated acetylation of METTL3 impairs mRNA translation efficiency in response to oxidative stress

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Science China(Life Sciences) 2024年第10期67卷 2157-2168页

作者： Cheng Liu Miao yu Mengyuan wang Siyuan Yang Yenan Fu Lei Zhang Chaoyang zhu Hongquan Zhang Program for Cancer and Cell Biology Department of Human AnatomyHistology and EmbryologySchool of Basic Medical SciencesPeking University International Cancer Instituteand State Key Laboratory of Molecular OncologyPeking University Health Science CenterBeijing 100191China Department of General Surgery and Urological Surgery Huaihe HospitalHenan UniversityKaifeng 100084China Department of Human Anatomy Histologyand EmbryologyShenzhen University School of MedicineShenzhen 518055China

METTL3 methylates RNA and regulates the fate of mRNA through its methyltransferase ***3 enhances RNA translation independently of its catalytic ***,the underlying mechanism is still ***,we report that METTL3 is both interacted with and acetylated at lysine 177 by the acetyltransferase PCAF and deacetylated by *** the methyltransferase activity nor the stability of METTL3 is affected by its acetylation at ***,acetylation of METTL3 blocks its interaction with EIF3H,a subunit of the translation initiation factor,thereby reducing mRNA translation ***,acetylation of METTL3 responds to oxidative ***,oxidative stress enhances the interaction of PCAF with METTL3,increases METTL3 acetylation,and suppresses the interaction of METTL3 with EIF3H,thereby decreasing the translation efficiency of ribosomes and inhibiting cell ***,we suggest a mechanism by which oxidative stress regulates RNA translation efficiency by the modulation of METTL3 acetylation mediated by PCAF.

关键词： METTL3 acetylation PCAF m^(6)A oxidative stress translation SIRT3

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Evolution of MnO–SiO2–Al_(2)O_(3)–MgO inclusions during heat treatment at 1100℃

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Journal of Iron and Steel Research International 2024年第5期31卷 1221-1231页

作者： Xu-bo Lei Jian-li Li Qiang Zeng Hang-yu zhu yue yu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina

To investigate the evolutionary behavior of the MnO–SiO_(2)–Al_(2)O_(3)–MgO inclusions during heat treatment,water quenched samples were isothermally held at 1100°C for 120 min in Ar and air atmosphere,and the obtaining samples were analyzed by X-ray diffraction,scanning electron microscopy and energy dispersive *** showed that 3MnO·Al_(2)O_(3)·3SiO_(2)and MnO·SiO_(2)were detected in the 5 wt.%MgO system after isothermal holding in Ar atmosphere,while MgO·Al_(2)O_(3),MnO·SiO_(2)and Mn7O8·SiO4 were detected in air *** evolutionary behavior of the 10,15 and 20 wt.%MgO systems after isothermal holding in different atmosphere were *** affected the solid phase transformation of the low MgO content *** calculation results of FactSage 8.1 showed that MgO·Al_(2)O_(3)was formed in the 5 wt.%MgO system with air *** solid phase transformation was accompanied by grain coarsening during the isothermal holding *** differences in the solid phase transformation in different atmosphere of the 5 wt.%MgO system indicated that it was a gas-phase transport grain coarsening *** enrichment of Al element in the liquid phase region at the grain edges,the homogeneous distribution of Mg element and the disappearance of the liquid phase within the crystal revealed that other MgO content systems were liquid–solid transport grain coarsening mechanism.

关键词： Evolution Glassy phase Inclusion Heat treatment MgO·Al_(2)O_(3)

Inhibition of EGFR attenuates EGF-induced activation of retinal pigment epithelium cell via EGFR/AKT signaling pathway

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1018-1027页

作者： yu-Sheng zhu Si-Rui Zhou Hui-Hui Zhang Tong wang Xiao-Dong Chen Faculty of Life Sciences and Medicine Northwest UniversityXi’an 710069Shaanxi ProvinceChina First Affiliated Hospital of Northwest University Northwest UniversityXi’an 710069Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710002Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Shaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi ProvinceXi’an 710002Shaanxi ProvinceChina

AIM:To explore the effect of epidermal growth factor receptor(EGFR)inhibition by erlotinib and EGFR siRNA on epidermal growth factor(EGF)-induced activation of retinal pigment epithelium(RPE)***:Human RPE cell line(ARPE-19 cells)was activated by 100 ng/mL *** and EGFR siRNA were used to intervene EGF *** viability,proliferation,and migration were detected by methyl thiazolyl tetrazolium(MTT)assay,bromodeoxyuridine(BrdU)staining assay and wound healing assay,***/protein kinase B(AKT)pathway proteins and N-cadherin,α-smooth muscle actin(α-SMA),and vimentin were tested by Western blot *** was also determined by immunofluorescence ***:EGF treatment for 24h induced a significant increase of ARPE-19 cells’viability,proliferation and migration,phosphorylation of EGFR/AKT proteins,and decreased total EGFR *** suppressed ARPE-19 cells’viability,proliferation and migration through down regulating total EGFR and AKT protein *** also inhibited EGF-induced an increase of proliferative and migrative ability in ARPE-19 cells and clearly suppressed EGF-induced EGFR/AKT proteins phosphorylation and decreased expression of N-cadherin,α-SMA,and vimentin ***,EGFR inhibition by EGFR siRNA significantly affected EGF-induced an increase of cell proliferation,viability,and migration,phosphorylation of EGFR/AKT proteins,and up-regulation of N-cadherin,α-SMA,and vimentin ***:Erlotinib and EGFR-knockdown suppress EGF-induced cell viability,proliferation,and migration via EGFR/AKT pathway in RPE *** inhibition may be a possible therapeutic approach for proliferative vitreoretinopathy(PVR).

关键词： erlotinib epidermal growth factor receptor protein kinase B epithelial-mesenchymal transition retinal pigment epithelium cell