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Inverse Calculation and Regularization Process for the Solar Aspect System(SAS) of HXI Payload on ASO-S Spacecraft

Research in Astronomy and Astrophysics 2024年第4期24卷 13-34页

作者： Ji-Rui yu Ping Ruan Yang Su Ying-Hong He Jin-You Tao zhe Zhang Song Guo Bin Xue Jian-Feng Yang Xi'an Institute of Optics and Precision Mechanics of Chinese Academy of Sciences Xi'an 710119China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 20034China School ofAstronomy and Space Science Universityof Science and Technology of ChinaHefei 230026China

For the ASO-S/HXI payload, the accuracy of the flare reconstruction is reliant on important factors such as the alignment of the dual grating and the precise measurement of observation orientation. To guarantee optimal functionality of the instrument throughout its life cycle, the Solar Aspect System (SAS) is imperative to ensure that measurements are accurate and reliable. This is achieved by capturing the target motion and utilizing a physical model-based inversion algorithm. However, the SAS optical system’s inversion model is a typical ill-posed inverse problem due to its optical parameters, which results in small target sampling errors triggering unacceptable shifts in the solution. To enhance inversion accuracy and make it more robust against observation errors, we suggest dividing the inversion operation into two stages based on the SAS spot motion model. First, the as-rigid-aspossible (ARAP) transformation algorithm calculates the relative rotations and an intermediate variable between the substrates. Second, we solve an inversion linear equation for the relative translation of the substrates, the offset of the optical axes, and the observation orientation. To address the ill-posed challenge, the Tikhonov method grounded on the discrepancy criterion and the maximum a posteriori (MAP) method founded on the Bayesian framework are utilized. The simulation results exhibit that the ARAP method achieves a solution with a rotational error of roughly±3 5 (1/2-quantile);both regularization techniques are successful in enhancing the stability of the solution, the variance of error in the MAP method is even smaller—it achieves a translational error of approximately±18μm (1/2-quantile) in comparison to the Tikhonov method’s error of around±24μm (1/2-quantile). Furthermore, the SAS practical application data indicates the method’s usability in this study. Lastly, this paper discusses the intrinsic interconnections between the regularization methods.

关键词： methods:data analysis Sun:flares Sun:X-rays gamma rays

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Impact of water table on hierarchically nested groundwater flow system

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Journal of Groundwater Science and Engineering 2024年第2期12卷 119-131页

作者： Jun Zhang Rong-zhe Hou Kun yu Jia-qiu Dong Li-he Yin Key Laboratory of Groundwater and Ecology in Arid and Semi-arid Areas Xi'an Center of Geological SurveyChina Geological SurveyXi'an 710054China

Water table configuration gives rise to hierarchically nested groundwater flow ***,there remains a lack of comprehensive understanding regarding the controlling factors of water table and its impact on flow ***,it remains challenging to identify characteristics of water table space variation through limited groundwater observations at the regional *** on two ideal two-dimensional cross-section analytical models,this study presents a simplified approach to preliminarily assess the nonlinear interactions between water table variation and three driving factors:Topography,geol-ogy and *** criteria,C1 and C2,are utilized to address issues at different scales ranging from basin to local:(i)the influence of various factors on water table configuration;and(ii)the influence of water table on groundwater flow ***,the Ordos Plateau is taken as an example to explore the role of the water table in nested groundwater systems using the provided approach and *** applica-tion of this approach in the Ordos Plateau demonstrates its appropriateness as a practical method for prelim-inarily determining the characteristics of water table configuration and its impact on flow *** study explores the mechanism influencing spatial variation in the water table and improves understanding of the interaction between topography,geology,and climate on groundwater flow patterns.

关键词： Water table configuration Groundwater flow pattern Analytical models Top boundary condi-tions Ordos Plateau

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Camrelizumab,apatinib and hepatic artery infusion chemotherapy combined with microwave ablation for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3481-3495页

作者： Meng-Xuan Zuo Chao An yu-zhe Cao Jia-yu Pan Lu-Ping Xie Xin-Jing Yang Wang Li Pei-Hong Wu Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Interventional Ultrasound Chinese General PLA HospitalBeijing 100853China Department of Medical Imaging and Interventional Radiology Sun Yatsen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Hepatic arterial infusion chemotherapy and camrelizumab plus apatinib(TRIPLET protocol)is promising for advanced hepatocellular carcinoma(Ad-HCC).However,the usefulness of microwave ablation(MWA)after TRIPLET is still *** To compare the efficacy and safety of TRIPLET alone(T-A)vs TRIPLET-MWA(TM)for *** From January 2018 to March 2022,217 Ad-HCC patients were retrospectively *** them,122 were included in the T-A group,and 95 were included in the T-M group.A propensity score matching(PSM)was applied to balance *** survival(OS)was compared using the Kaplan-Meier curve with the log-rank *** overall objective response rate(ORR)and major complications were also *** After PSM,82 patients were included both the T-A group and the T-M *** ORR(85.4%)in the T-M group was significantly higher than that(65.9%)in the T-A group(Phan T-A.

关键词： Hepatic arterial infusion chemotherapy Hepatocellular carcinoma Molecular targeting agent Programmed cell death protein 1 inhibitors Microwave ablation

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Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin

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Genes & Diseases 2024年第1期11卷 397-412页

作者： zhe Chen Qian Guo Shichen Huang Lei Li Feng Wu Zhilong Liu Zhigang Li Tao Chen Guanbin Song Shuangnian Xu Jieping Chen yu Hou Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Institute of Life Sciences Chongqing Medical UniversityChongqing 400016China Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing Foreign Language School Chongqing 400039China

Therapeutic targeting FOxO3A(a forkhead transcription factor)represents a prom-ising strategy to suppress acute myeloid leukemia(AML).However,the effective inhibitors that target FOXO3A are lacking and the adaptive response signaling weakens the cytotoxic effect of FOxO3A depletion on AML ***,we show that FOxO3A deficiency induces a compensa-tory response involved in the reactive activation of mTOR that leads to signaling rebound and adaptive *** metabolism acts downstream of mTOR to provoke activa-tion of JNK/c-JUN via reactive oxygen species(ROS).At the molecular level,FOXO3A directly binds to the promoter of G protein gamma subunit 7(GNG7)and preserves its expression,while GNG7 interacts with mTOR and restricts phosphorylated activation of ***,combinatorial inhibition of FOXO3A and mTOR show a synergistic cytotoxic effect on AML cells and prolongs survival in a mouse model of *** a structure-based virtual screening,we report one potent small-molecule FOxO3A inhibitor(Gardenoside)that exhibits a strong effect of anti-FOXO3A DNA *** synergizes with rapamycin to substantially reduce tumor burden and extend survival in AML patient-derived xenograft *** results demonstrate that mTOR can mediate adaptive resistance to FOxO3A inhibition and validate a combinatorial approach for treating AML.

关键词： AML Combinatorial inhibition FOXO3A GNG7 mTOR

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Photocatalytic dicarboxylation of strained C-C bonds with CO_(2) via consecutive visible-light-induced electron transfer

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Chinese Chemical Letters 2024年第6期35卷 268-273页

作者： Yi Liu zhe-Hao Wang Guan-Hua Xue Lin Chen Li-Hua yuan Yi-Wen Li Da-Gang yu Jian-Heng Ye Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Dicarboxylic acids have a wide range of applications in the polymer industry to construct valuable *** has recently emerged as an efficient and sustainable strategy to generate dicarboxylic ***,photocatalytic dicarboxylation with CO_(2) is mainly limited to unsaturated bonds,and the dicarboxylation of C-C single bonds still remains a ***,we report a photocatalytic dicarboxylation of C-C single bonds in strained rings with CO_(2) units via consecutive photo-induced electron transfer(ConPET).It is also the first photocatalytic reductive ring-opening reaction of ***,this transition-metal-free protocol exhibits good functional group tolerance,broad substrate scope,facile scalability,and easy product ***,diacids can easily be derivatized to mainchain liquid crystalline polyesters.

关键词： Consecutive photo-induced electron transfer Visible-light catalysis Dicarboxylation Carbon dioxide Cyclopropanes

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Summary Analysis of National Surveillance on Kashin-Beck Disease from 1990 to 2023

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Biomedical and Environmental Sciences 2024年第9期37卷 1056-1066页

作者： Silu Cui Hui Liu Junrui Pei Jiaxin Li zhe Jiao Qing Deng Ning Liu Yanhong Cao Jun yu Center for Endemic Disease Control Chinese Center for Disease Control and PreventionHarbin Medical UniversityHarbin 150081China NHC Key Laboratory of Etiology and Epidemiology(Harbin Medical University) Key Laboratory of Etiology and EpidemiologyEducation Bureau of Heilongjiang ProvinceHarbin Medical UniversityHarbin 150081China

Objective To analyze the epidemiological characteristics and epidemic situation of children with Kashin-Beck disease(KBD)in China,and provide the basis for formulating prevention and control *** Fixed-point monitoring,moving-point monitoring,and full coverage of monitoring were promoted successively from 1990 to *** children(7-12 years old)underwent clinical and right-hand X-ray examinations every *** to the KBD diagnosis criteria,clinical and X-ray assessments were used to confirm the *** In 1990,the national KBD detectable rate was 21.01%.X-ray detection decreased to below 10%in 2003 and below 5%in *** 2010 and 2018,the prevalence of KBD in children was less than 0.4%,which fluctuated at a low level,and has decreased to 0%since *** epidemiological analysis indicated a spatial clustering of adult patients prevalence rate in the KBD *** The evaluation results of the elimination of KBD in China over the last 5 years showed that all villages in the monitored areas have reached the elimination *** the adult KBD patients still need for policy consideration and care.

关键词： Kashin-Beck disease Geographic Information System National surveillance X-ray detective rate

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Intelligent diagnostic model for pterygium by combining attention mechanism and MobileNetV2

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1184-1192页

作者： Mao-Nian Wu Kai He Yi-Bei yu Bo zheng Shao-Jun Zhu Xiang-Qian Hong Wen-Qun Xi zhe Zhang School of Information Engineering Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina zhejiang Province Key Laboratory of Smart Management and Application of Modern Agricultural Resources Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina School of Mathematical Information Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina

AIM:To evaluate the application of an intelligent diagnostic model for ***:For intelligent diagnosis of pterygium,the attention mechanisms—SENet,ECANet,CBAM,and Self-Attention—were fused with the lightweight MobileNetV2 model structure to construct a tri-classification *** study used 1220 images of three types of anterior ocular segments of the pterygium provided by the Eye Hospital of Nanjing Medical *** classification models—VGG16,ResNet50,MobileNetV2,and EfficientNetB7—were trained on the same dataset for *** evaluate model performance in terms of accuracy,Kappa value,test time,sensitivity,specificity,the area under curve(AUC),and visual heat map,470 test images of the anterior segment of the pterygium were ***:The accuracy of the MobileNetV2+Self-Attention model with 281 MB in model size was 92.77%,and the Kappa value of the model was 88.92%.The testing time using the model was 9ms/image in the server and 138ms/image in the local *** sensitivity,specificity,and AUC for the diagnosis of pterygium using normal anterior segment images were 99.47%,100%,and 100%,respectively;using anterior segment images in the observation period were 88.30%,95.32%,and 96.70%,respectively;and using the anterior segment images in the surgery period were 88.18%,94.44%,and 97.30%,***:The developed model is lightweight and can be used not only for detection but also for assessing the severity of pterygium.

关键词： deep learning attention mechanism pterygium intelligent diagnosis

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Measurement of atmospheric non-reciprocity effects for satellite-based two-way time-frequency transfer

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Photonics Research 2024年第6期12卷 1274-1282页

作者： TING ZENG QI SHEN yuAN CAO JIAN-yu GUAN MENG-zhe LIAN JIN-JIAN han LEI HOU JIAN LU XIN-XIN PENG MIN LI WEI-yuE LIU JIN-CAI WU YONG WANG JUAN YIN JI-GANG REN HAI-FENG JIANG QIANG ZhanG CHENG-ZHI PENG JIAN-WEI PAN Hefei National Research Center for Physical Sciences at the Microscale and School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Shanghai Research Center for Quantum Science and CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaShanghai 201315China Hefei National Laboratory University of Science and Technology of ChinaHefei 230094China Faculty of Information Science and Engineering Ningbo UniversityNingbo 315211China Key Laboratory of Space Active Opto-Electronic Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China

Future optical clock networks will require high-precision optical time-frequency transfer between satellites and ground ***,due to atmospheric turbulence,satellite motion and time delay between the satellite–ground transmission links will cause spatial and temporal variations,respectively,resulting in the breakdown of the time-of-flight reciprocity on which optical two-way time-frequency transfer is ***,we experimentally simulate the atmospheric effects by two-way spatio-temporally separated links between two stationary terminals located 113 km apart and measure the effects for optical two-way time-frequency *** experiment shows that the effect on the link instability is less than 2.3×10^(−19) at 10,000 *** indicates that when the link instability of satellite-ground optical time-frequency transfer is on the order of 10^(−19),it is not necessary to consider the atmospheric non-reciprocity effects.

关键词： breakdown transfer satellite

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Increased Incidence of Severe Adverse Events in Non-Small Cell Lung Cancer Patients with Previous Tuberculosis Episode Treated with PD-1 Inhibitors

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Biomedical and Environmental Sciences 2024年第7期37卷 785-789页

作者： Hui Zhang Jinfeng yuan yuanyuan Xu Mengjie Yang Jialin Lyu Xinjie Yang Shuyan Sheng zhe Qian Qunhui Wang yu Pang Ying Hu Department of Medical Oncology Beijing Chest HospitalCapital Medical University&Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing 101149China Department of Bacteriology and Immunology Beijing Key Laboratory on Drug-Resistant Tuberculosis ResearchBeijing Chest HospitalCapital Medical University/Beijing Tuberculosis&Thoracic Tumor Research InstituteBeijing 101149China Chinese Center for Disease Control and Prevention Beijing 102206China

Lung cancer is the top cause of cancer deaths *** in immune checkpoint inhibitors(ICIs)have transformed cancer treatment,but their use in lung cancer has led to more side *** study examined if past pulmonary tuberculosis(TB)affects ICIs’effectiveness and safety in lung cancer *** reviewed lung cancer patients treated with ICIs at Beijing Chest Hospital from January 2019 to August 2022.

关键词： Lung lung Cancer

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A von-Neumann-like photonic processor and its application in studying quantum signature of chaos

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Light(Science & Applications) 2024年第4期13卷 672-681页

作者： Shang yu Wei Liu Si-Jing Tao Zhi-Peng Li Yi-Tao Wang Zhi-Peng Zhong Raj BPatel yu Meng yuan-Ze Yang Zhao-An Wang Nai-Jie Guo Xiao-Dong Zeng zhe Chen Liang Xu Ning Zhang Xiao Liu Mu Yang Wen-Hao Zhang Zong-Quan Zhou Jin-Shi Xu Jian-Shun Tang Yong-Jian han Chuan-Feng Li Guang-Can Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China. CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China. Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China. Research Center for Quantum Sensing Zhejiang LabHangzhou 310000China. Quantum Optics and Laser Science Blackett LaboratoryImperial College LondonPrince Consort RdLondon SW72AZUK. Clarendon Laboratory Department of PhysicsOxford UniversityParks Road OX13PUOxfordUK

Photonic quantum computation plays an important role and offers unique *** decades after the milestone work of Knill-Laflamme-Milburn,various architectures of photonic processors have been proposed,and quantum advantage over classical computers has also been *** is now the opportune time to apply this technology to real-world ***,at current technology level,this aim is restricted by either programmability in bulk optics or loss in integrated optics for the existing architectures of processors,for which the resource cost is also a *** we present a von-Neumann-like architecture based on temporal-mode encoding and looped structure on table,which is capable of multimode-universal programmability,resource-efficiency,phasestability and *** order to illustrate these merits,we execute two different programs with varying resource requirements on the same processor,to investigate quantum signature of chaos from two aspects:the signature behaviors exhibited in phase space(13 modes),and the Fermi golden rule which has not been experimentally studied in quantitative way before(26 modes).The maximal program contains an optical interferometer network with 1694 freely-adjustable *** current state-of-the-art,our architecture stands as the most promising candidate for real-world applications.

关键词： quantum signature chaos

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